Presentation of the Presentation of the ClearPEM-Sonic ClearPEM-Sonic mammography mammography scannerscanner

ClearPEM-SonicClearPEM-Sonic

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Breast cancer:Breast cancer:

The most frequent cancer in women

One in nine women has breast cancer in her life

X-ray mammographyX-ray mammography

Standard in breast cancer diagnosis

Based in structural tissue changesBased in structural tissue changes

High rate of false-positiveHigh rate of false-positive

Less reliable in dense breasts Less reliable in dense breasts false negatives

Breast cancerBreast cancer

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PET mammography

X-ray mammography

PET mammographyPET mammography

PET and breast cancerPET and breast cancer•PET/FDG has good sensitivity in

breast cancer diagnosis

Radioactive tracerRadioactive tracer•FDG : glucose associated to

positron emitter F-18•Glucose has strong affinity to

cancer cells

PEM ScannerPEM Scanner•Positron Emission MammographyPositron Emission Mammography•PET equipment dedicated to breast PET equipment dedicated to breast

and axila examsand axila exams•Good spatial resolution ( ~ mm)Good spatial resolution ( ~ mm)•Good sensitivityGood sensitivity

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New technology based in fast crystals (LSO) and avalanche photodiodes (APD) associated to low-noise integrated electronics

The new electronics has the highest integration density available worldwide: compact detectors with DoI capability

Scanner with excellent spatial resolution (1.3 mm)

Integration with ultra-sound probe with elastography from company Supersonic Imagine.

ClearPEM-Sonic technologyClearPEM-Sonic technology

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ClearPEM scannerClearPEM scanner

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Detector and Front End ElectronicsDetector and Front End Electronics

LYSO:Ce 2x2x20 mm3

4x8 matrix (BaSO4 walls)S8550

16 Supermodules

32 Frond End Electronic Boards

Hamamatsu

Supermodules Integration Detector modules

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1. Water Cooling Plates 4. On-Detector Cabling

2. Supermodules 5. Service Board (LV distribution; HV regulation; Control & Monitoring)

3. Patch Panel 6. HV Matrix (HV distribution)

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45

6

12

3

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Detector Heads IntegrationDetector Heads Integration

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Service Rack

Workstation

DSS – Detector Safety System

DAE – Data Acquisition Electronics

HV Power Supply (500V)

LV Power Supply (3V2, 5V)

Service Manager

Acquisition Manager / Data Storage

Transformer

Data Acquisition and ServicesData Acquisition and Services

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Mechanical Integration and AssemblingMechanical Integration and Assembling

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ClearPEM scannerClearPEM scanner

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Spatial resolutionSpatial resolution

Resolution transaxial: 1.3 mm

DoI capability allows sharp imaging

With DoI

5 mm

1 mm

Without DoI

3.0 mm

2.5 mm2.0 mm

1.5 mm

1.2 mm

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Animal imagingAnimal imaging

tumorbladder

3D OSEM6 it. – 4 sub.

2D OSEM3 it. – 4 sub.

FDG scanF-18 scan

After injection

1h after

Bone scan

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First breast imagesFirst breast images

Na-22 source superimposed on breast data

PET mammography consortiumPET mammography consortium

Funded by

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R&D consortium of research institutes collaborating with PETsys