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8/18/2019 Presentation 1 Pharmacology
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MECHANISM
OF ACTIONOF GENERAL
(INHALEDANESTHETICS)
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Presynaptic Neuron
NO ANESTHETIC
Chloride ion channel
Potassium ion channel
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Presynaptic Neuron
GA BA
r e c e p
t o r
Chloride ion channel
GABAor
Glycine
Potassium ion channel
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Presynaptic Neuron
Chloride ion channel
Potassium ion channel
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Presynaptic Neuron
Chloride ion channel
Potassium ion channel
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Presynaptic Neuron
Chloride ion channel
Potassium ion channel
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Presynaptic Neuron
Chloride ion channelPotassium ion channel
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Presynaptic Neuron
Chloride ion channelPotassium ion channel
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Presynaptic Neuron
Chloride ion channelPotassium ion channel
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Presynaptic Neuron
Chloride ion channelPotassium ion channel
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Presynaptic Neuron
Chloride ion channelPotassium ion channel
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Presynaptic Neuron
Chloride ion channel
ActionPotential
Binding of GABA causeschloride ion channel to open
CHLORIDE
Potassium ion channel
Leadin toH!PERPOLARI"ATION o#
P O TA S S
I U M
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Presynaptic Neuron
In presence of
INHALED ANESTHETIC
Chloride ion channelPotassium ion channel
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Presynaptic Neuron
GA BA
r e c e p
t o r
Chloride ion channel
GABAor
Glycine
Potassium ion channel
ANESTHETICS
8/18/2019 Presentation 1 Pharmacology
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Presynaptic Neuron
Chloride ion channelPotassium ion channel
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Presynaptic Neuron
Chloride ion channelPotassium ion channel
P i N
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Presynaptic Neuron
Chloride ion channelPotassium ion channel
P ti N
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Presynaptic Neuron
Chloride ion channelPotassium ion channel
P ti N
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Presynaptic Neuron
Chloride ion channelPotassium ion channel
P ti N
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Presynaptic Neuron
Chloride ion channelPotassium ion channel
P ti N
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Presynaptic Neuron
Chloride ion channelPotassium ion channel
Presynaptic Neuron
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Presynaptic Neuron
Chloride ion channelPotassium ion channel
Presynaptic Neuron
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Presynaptic Neuron
Chloride ion channelPotassium ion channel
Binding of GABA is enhanced yinhaled anesthetic resulting in a
greater entry of chloride ion
Presynaptic Neuron
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Presynaptic Neuron
Chloride ion channelPotassium ion channel
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GABA%receptor c$loride c$annel&!"here these anesthetic agents directly
and indirectly facilitate a GABA#$ediatedincrease in chloride %Cl&' conductance to
hyperpolari(e and inhiit neuronal$e$rane acti)ity*
Liand%ated pota&&i' c$annel&!"here these anesthetic agents increase
potassiu$ conductance to hyperpolari(eand inhiit neuronal acti)ity*
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THAN+ ,O-.
/repared y0 1aria 2e 3* Espina