8/11/2019 Preparation and Characterisation of Sometransation
Metal Complexes of New [Butanal (5-Ethyl-1, 3, 4-Oxadiazol-
1/14
The Swedish Journal of Scientific Research (sjsr)
ISSN: 2001-9211. Volume 1. Issue 5. October 2014
23
www.sjsr.se
PREPARATION AND CHARACTERISATION OFSOMETRANSATION METAL
COMPLEXES OF
NEW [BUTANAL (5-ETHYL-1, 3, 4-OXADIA-ZOL-2-YL) HYDRAZONE]
*Bassam A.Hasan, ** Maitham M.Abdulridha
*Department of Pharmaceutical Chemistry, College of pharmacy,
Thi !ar "ni#ersity
** Technical institute of shatra
1. INTRODUCTION
1,3,4-Oxadiazole (1), is a he ero!"!li! !o#$o%&d !o&
ai&i&' a& ox"'e& a o# a&d wo &i ro'e& a
o#s i& a i e-#e#-*er ri&'. I is deri ed ro# %ra& *"
s%*s i % io& o wo #e h"le&e 'ro%$s (+C ) wi h wo
$"ridi&e "$e &i ro'e& (-N+) .There are hree
&ow& iso#ers 1,2,4-oxadiazole (2), 1,2,3-oxadiazole (3)
a&d 1,2,/-oxadiazole (4) . ow-e er,1,3,4-oxadiazole a&d
1,2,4-oxadiazole are *e er &ow&, a&d #ore widel" s
%died *" resear!hers *e!a%se o
heir #a&" i#$or a& !he#i!al a&d *iolo'i!al $ro$er
ies 01 .
Resis a&!e o &%#*er o a& i#i!ro*ial a'e& s
a#o&' a arie " o !li&i!all" si'&i i!a& s$e!ies o*a!
eria is *e!o#i&' i&!reasi&'l" i#$or a& 'lo*al
$ro*le# 02 .There are ario%s $ro*le#s arisi&' wi h he %se
oa& i#i!ro*ials s%!h as lo!al iss%e irri a io&, i& er
ere&!e wi h wo%&d heali&' $ro!ess, h"$erse&si i i "
rea! io&s,s"s e#i! oxi!i ", &arrow a& i#i!ro*ial s$e!
r%#, e#er'e&!e o resis a&!e 03 . o he i&!reasi&'
!li&i!al i#$or a&!eo dr%'-resis a& #i!ro*ial $a
ho'e&s has le& addi io&al %r'e&!" i&
#i!ro*iolo'i!al a&d a& i %&'al resear!h. wide
O
N N
O
N
NO
N
N
NO
N
1 2 3 4
TR CT
The solid !o#$lexes o 5e(II), Cr(III), Co(II), Ni(II),
a&dC%(II)) wi h "& hesis o 0 % a&al(/-e
h"l-1,3,4-oxadia-zol-2-"l)h"drazo&e ha e *ee& s"&
hesized a&d !hara! erized *" %si&' he s$e! ros!o$i! IR,1
N6R, 6ass aswell as *" ele#e& al a&al"ses C, ,N a&d
6olar !o&d%! a&!e he were s %died.I #a" *e !o&!l%ded ha
heli'a&d !oordi&a e hro%'h Ni ro'e& a o#s show&
i& !he#e (2). 5or all he !o#$lexes. The li'a&d a! s as
adide& a e li'a&d !oordi&a i&' hro%'h he oxadiazole
&i ro'e& a&d he &i ro'e& o C+N 'ro%$ .This iew
is
%r her s%$$or ed *" he a$$eara&!e o a *a&d
!orres$o&di&' o he #e al7&i ro'e& s re !hi&'
i*ra io& a/137/48 !#71 i& he !o#$lexes. The $h"si!o!he#i!al
da a s%''es he o! ahedral 'eo#e r" or all !o#-$lexes ex!e$ or Ni
a&d C% !o#$lexes whi!h were e rahedral res$e! i el".
$%&'()D + P)%PA)AT (-. CHA)ACT%) AT (-. C(MP %/% .
H&D)A0(-%. %TH& .
8/11/2019 Preparation and Characterisation of Sometransation
Metal Complexes of New [Butanal (5-Ethyl-1, 3, 4-Oxadiazol-
3/14
The Swedish Journal of Scientific Research (sjsr)
ISSN: 2001-9211. Volume 1. Issue 5. October 2014
2/
www.sjsr.se
The h"dra ed #e al !hloride sal s o The 5e(III), Cr(III),
Co(III), Ni(II) a&d C%(II) (8.81 #ol) was added o sol% io&
ohe li'a&d 2.21'# (8.81#ol) i& ho a*sol% e e ha&ol (48
#?) a&d he #ix %re was re l%xed o& a wa er *a h or 2
ho%rs a&d he sol e& was e a$ora ed i& a!%%# o hal o
he ori'i&al ol%#e a&d he& !ooled . The isola ed
!o#-$lexes were il ered o , washed se eral i#es wi h e ha&ol
a&d i&all" dried i& air. 02;
3. ER C NT FOR@
3.1 ER E R TION O5 ?I> ND
3.2 ER E R TION O5 CO6E?
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