Preliminary clinical results of adipose derived stem cell injection

for facet joint syndrome

Ralf D. Rothoerl 1,2, Christopher Alt 2, Alexander Preuss1, Christopher Muller3,

Peter Lackermeier3

1 Department for Neurosurgery, 2 Center for Regenerative Medicine and Sports Medicine 3 Department of Anesthesia

Isarklinikum Munich, Germany,

• 70 % suffer from chronic low back pain

• 50 % of days of sick leave are due to back pain

• Facet joint syndrome is a common cause

Facet joint syndrome

Facetten

Facet joint syndrome

• Degenerative disease

• Athrosis of the spinal joints

• Inflammatory activation

Athrosis

chronic inflammation

• Cortisol injections

• Physiotherapy

• NSAR

• Radiofrequency

• Treatment response 50-70 %

Weber et al 2015

Standard treatment

Immunsuppressive effect of ADSCs

W Nathaniel Brennen et al.

Endocr Relat Cancer

approx. 20min 45 min 15 min

Treatment process

Liposuction Separation Injection

InGeneron

• VAS 7-8 back pain

• No radiating pain

• Cortisol injections temporaryeffect

• SVF LWK 4/5 und 5/SWK1

Case Report

• VAS 1 back pain

• 30 months Follow-up

Back pain

• 19 male patients

• age range 31-78 years, mean 59

• Duration of symptoms > 1 year

• Positive test injection (Ropivacain)

75% pain relief

• Liposuction (mild sedation)

Material and methods

• Injection facet joints under fluoroscopic guidance

• VAS

• Oswestry Disability index

• Follow–up > 1 year

• Side effects

Materialis and methods

Pain relief after 48 hours

VAS 7.2 mean vs. VAS 1,8 mean postoperatively

ODI 74,3% vs. ODI 19,1%

Folllow-up13,2 months

Longest follow-up16 months.

Results

Results

0

10

20

30

40

50

60

70

80

ODI mean prä ODI mean post

Zeile 9

0

1

2

3

4

5

6

7

8

VAS mean prä VAS mean post

Zeile 9

• SVF may be used for regulating inflammatory responses in degenerative diseases of the musculoskeletal system characterized by chronic inflammation

• No side effects

• No long term data

.

Conclusions