Sources:

1. Gaskin DJ, Richard P. The Economic Costs of Pain in the United States. In: Institute of Medicine (US) Committee on Advancing Pain Research, Care, and Education. Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research. Washington (DC): National Academies Press (US); 2011. Appendix C. Available from: http://www.ncbi.nlm.nih.gov/books/NBK92521/

2. http://www.who.int/healthinfo/statistics/GlobalDALYmethods_2000_2011.pdf

3. http://www.asam.org/docs/default-source/advocacy/opioid-addiction-disease-facts-figures.pdf

4. Boston Scientific LUMINA data presented at the 19th annual meeting of the North American Neuromodulation Society

*in 1.5 Tesla environment when conditions of use are met

CHRONIC PAIN IN THE U.S.

PRECISION MONTAGE™ MRI SPINAL CORD STIMULATOR SYSTEM

Many with chronic pain lose the ability to sleep, work and function normally

An analysis by the World Health Organization shows back and neck pain to be the leading causeof disability- adjusted years lost worldwide 2

annually in the U.S.– that equals $2,000 for every U.S. resident 1

$635 billion Chronic pain costs society as much as

$ $ $ $ $ $ $ $ $

WHAT IS SCS? Also known as nerve stimulation, SCS sends electrical signals to the nerve fibers in the spinal cord, masking pain signals from reaching the brain and helping to provide long-lasting pain relief

ONE PROVEN SOLUTION: SPINAL CORD STIMULATION (SCS)

THE PRECISION MONTAGE™ MRI SYSTEM ADVANTAGE

These electrical signals can be thought of as waveforms, with each wave having different shapes, signal intensity, frequency, and duration

An alternative to opioids for some, SCS therapy provides personalized relief from chronic pain

Multiple waveform programming options designed to allow for flexibility in treating pain and helping to obtain better outcomes

Powered by the Illumina 3D™ Neural Targeting Algorithm, which is designed to allow physicians to more precisely target pain

In registry information from 800 SCS patients, 72% used multiple waveforms to customize their therapy and optimize pain relief

72% Patients showed 70% greater low-back pain relief using Illumina 3D™, as compared to our previous generation SCS system4

70%

Offers patients safe access to full body MRI*

Customizable therapy with MultiWave Technology™

An Effective and Alternative Therapy for Chronic Pain

Chronic pain persists – with pain signals firing in the nervous system for weeks, months, even years

While acute pain is a normal sensation triggered in the nervous system to alert you to possible injury and the need to take care of yourself, chronic pain is different

Americans live with chronic pain 1100 million MORE THAN

Americans either abused or were dependent on opioid pain relievers, a common treatment option for chronic pain3

2 million IN 2014, NEARLY