Embed Size (px)
Citation preview
Prebiotic chicory root fibres support digestive health and beyond
Food Matters Live
November 20, 2018Silke Ullmann, MPH, RD
Manager Nutrition Communication
The BENEO-Institute
Who we are and what we do
© 2018 BENEO
Weekly grocery shopping
© 2018 BENEO
Consumer buys more than fruits and vegetables
There are many options to make foods “better for you“
© 2018 BENEO
It‘s the ingredients that make the difference!
Smart ingredients from natural sources Interdisciplinary expertise
© 2018 BENEO
BENEO’s mission
© 2018 BENEO
Three pillars of expertise within the BENEO-Institute
Founded in November 2009
© 2018 BENEO
Topics of the BENEO-Institute
We focus on topics that are important to our customers. This enables us to provide knowledge that is
relevant to successfully develop food and beverages for tomorrow’s consumers.
Dental health
Weight management
Digestive well-being
Bone health
Sports nutrition
Infant & small children nutrition
Low glycaemic concept
Available carbohydrates
and their metabolism
Dietary fibres
The prebiotic
concept
© 2018 BENEO
Worldwide presentations, conferences, events and publications
Low GI carbs – Can sugars play a role?
The example of Palatinose™ (isomaltulose)
© 2018 BENEO
Dedicated dietary fibre website developed by BENEO for
healthcare professionals and interested consumers
www.dietaryfiber.org
Dietary fibre gap
Europe
© 2018 BENEO
Dietary fibre gap between recommendation and actual intake
European (males and females)
Literature search by BENEO-Institute (2011); updated Aug 2016
Bridging the so called
fibre gap is essential to
improve digestive health
Fib
re
ga
p
And inulin can help
bridge this fibre gap!
© 2018 BENEO
Consumers are interested in digestive health
Health Focus International 2018, global
BENEO’s consumer research on prebiotics, 2017, in the US n= 1214 | Western Europe n=2428 (UK n= 809 | Germany n= 810 | Italy n= 809) | Russia n=810
consumers have read some pieces
lately on the topic of digestive health
Almost 1 in 3 (30%)
Almost 1 in 4 (23%)
Globally
1 in 2 (51%) expresses to be
very/extremely interested in the
gut microbiome(how good and bad bacteria in your gut impacts your overall health)
Gut health books
Social media
Scientific developments in the media
What are prebiotic fibres and why should they
be a part of our fibre intake?
© 2018 BENEO
Prebiotics and probiotics are both beneficial for health
But what is the difference?
• What are prebiotics?
• Food/feed for beneficial microbes
that live in our colon
• Eaten by the ‘good’ gut microbes as
their “favorited dish”
• Positive impact on the gut environment,
with an overall health benefit
• What are probiotics?
• Live microorganisms from other
sources than the human gut
• Swallowed and need to survive the
stomach and small intestine passage
• Need to provide strain-specific evidence
in humans about their health benefit
https://isappscience.org/prebiotic-definition-updated-isapp/
https://isappscience.org/probiotics/
© 2018 BENEO
0
100
200
300
400
500
600
700
800
900
1000
199
5
199
6
199
7
199
8
199
9
200
0
200
1
200
2
200
3
200
4
200
5
200
6
200
7
200
8
200
9
201
0
201
1
201
2
201
3
201
4
201
5
201
6
201
7
Publications
Significant attention has been given to the beneficial effects of
prebiotics
• Since the concept was first defined, it has been subject of intensive research
• Prebiotic research has continued at a rapid pace with >3000 research articles published
over the past few years*>3000 articles
*Pubmed search
© 2018 BENEO
Scientific milestones in the prebiotic research
BENEO a pioneer since the 1990s
First observations that beneficial bifidobacteria
are specifically stimulated by fructo-
oligosaccharides
First prebiotic definition published:
Roberfroid & Gibson
20102008200419951980s 2017
"The prebiotic effect is now a
well established scientific fact"*
ISAPP: International Scientific Association
for Probiotics and Prebiotics review
The prebiotic concept becomes global
BENEO-Orafti has supported microbiota research
of European scientists for more than 20 years
*Roberfroid et al. (2010) Br J Nutr 104(S2):S1-S63. https://www.ncbi.nlm.nih.gov/pubmed/20920376
© 2018 BENEO
ISAPP – Latest update of the prebiotic definition
Selectivity remains and is stronger than ever!
GOS: Galacto-oligosaccharides
Gibson et al. (2017) Nat Rev Gastroenterol Hepatol 14(8). http://www.nature.com/nrgastro/journal/vaop/ncurrent/pdf/nrgastro.2017.75.pdf
A substrate that is selectively utilised by host
microorganisms conferring a health benefit.
What has been confirmed?
• Selectivity is key ( criterion that distinguishes prebiotics from
many other substances)
• Selective effect must evoke a health benefit
• Chicory root fibres are still considered the most researched,
proven prebiotics, next to GOS
© 2018 BENEO
Your colon matters
A healthy microbiota has many benefits
ColonActs as a
protective
barrier
Has its own
nervous system
(second brain)
Microbiota
as main
inhabitant
Major part of our
immune system
Produces
hormones
Manages stool
regularity
Regularity
Weight
management…and more
Bone health
Blood sugar
management
Inner
protection
© 2018 BENEO
Trusting your gut instinct
Gut-brain axis and the outreach of the microbiota
SCFA: Short-Chain Fatty Acids
Muscles
© 2018 BENEO
From gut-brain to gut-skin, gut-bone, gut-muscle axis etc.
https://www.nutraingredients.com/Article/2017/01/12/Heard-of-the-gut-brain-axis-Meet-the-gut-skin-axis
Chicory root fibres are proven prebiotics
© 2018 BENEO
Introducing chicory root fibres
Inulin & Oligofructose
DP: degree of polymerisation
© 2018 BENEO
How Orafti® Inulin & Oligofructose work
Chicory root fibre: not digested, but fermented
Small intestine
• No digestion by human enzymes
• No glucose release (non-glycaemic)
Large intestine
• Selected fermentation by the colonic microbiota,
stimulation in particular of microbes considered
as representative of a healthy microbiota
• Less calories (max. 2 kcal/g)
Chicory root fibres are soluble, prebiotic,
fermentable dietary fibres
© 2018 BENEO
Chicory root fibres are scientifically proven prebiotics!
Gibson et al. 2017. Nat Rev Gastroenterol Hepatol. 14(8):491-502. https://www.nature.com/articles/nrgastro.2017.75
Chicory root fibres are the most-well studied
and the only plant based prebiotics
Pro
ve
nP
ote
nti
al c
an
did
ate
s
Potential candidates:
Lack human studies showing the health benefit,
a crucial part of the definition for prebiotics
© 2018 BENEO
Increase in bifidobacteria is a marker for the prebiotic effect of
chicory root fibres (inulin, oligofructose/FOS)
0
2
4
6
8
10
12
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25
10lo
g f
aec
alb
ifid
ob
ac
teri
ac
ou
nt
per
ml
Individual studies
control/
baseline/
placebo
inulin/
oligofructose
Chicory inulin and oligofructose increase
bifidobacteria in adults from 5 g/day
© 2018 BENEO
Strong body of scientific evidence for prebiotic chicory root fibres
>30 studies in adults
with as low as 5 g chicory root fibre
per day the increase in
Bifidobacteria is demonstrated
>15 studies in infants and children
The prebiotic effect of chicory root fibres (inulin and oligofructose)
is a scientifically proven fact
*Link to the Art. 13(5) “bowel function” health claim
Chicory root fibres promote digestive health
and beyond
© 2018 BENEO
The mechanism behind chicory root fibres
Helping to improve regularity
Physiological mechanism fully accepted by EFSA –
the prebiotic fermentation of chicory inulin plays a key role!
EFSA positive opinion
EU approved health claim
*SCFA = Short-Chain Fatty Acids (acetate, propionate, butyrate)
© 2018 BENEO
Orafti® Inulin & normal bowel function
Approved claim, Art. 13(5)
“Chicory inulin contributes to
normal bowel function by
increasing stool frequency.”
proprietary use of the claim by BENEO-Orafti S.A. for five years
The Commission confirmed the
Legal Disclaimer: This information is presented in good faith and believed to be correct; nevertheless no responsibility/warranties as to the completeness or accuracy of this information are taken. This information is
supplied upon the condition that the persons receiving the same will make their own determination as to its suitability for their purposes prior to use. Confidential business information.
The 5 year period has started on 1st January 2016
© 2018 BENEO
Relevance between Art. 10(3) reference &
Art. 13(5) health claim – The perfect match
specific health claim
approved
Art. 13(1), 13(5), 14
(long, technical)
+ =Possible to claim
on pack
short, eye-catching reference to
general, non-specific benefits for
health related well-being (Art. 10(3))
Legal Disclaimer: This information is presented in good faith and believed to be correct; nevertheless no responsibility/warranties as to the completeness or accuracy of this information are taken. This information is
supplied upon the condition that the persons receiving the same will make their own determination as to its suitability for their purposes prior to use. Confidential business information.
© 2018 BENEO
Support of digestive health and well-being
Orafti® Inulin improves bowel function
Micka et al. (2017) Int J Food Sci Nutr 68(1):82–89. https://www.ncbi.nlm.nih.gov/pubmed/27492975
• Randomised, placebo-controlled, double-blind, cross-over design
• 44 healthy adults with mild constipation
• Bowel movement frequency after 4 week ingestion of 12 g/d (3x4 g)
• Orafti® Inulin compared to maltodextrin
• Inulin (and maltodextrin) was taken with 200 ml of drinks at breakfast,
lunch and dinner
• Primary outcome: Frequency of bowel movements
© 2018 BENEO
Improved regularity
Micka et al. (2017) Int J Food Sci Nutr 68(1):82–89. https://www.ncbi.nlm.nih.gov/pubmed/27492975
*significant difference
0
1
2
3
4
5
Maltodextrin Orafti® Inulin
Bo
we
l m
ove
me
nts
/we
ek
p = 0.038
*
Consumption of 12 g/d (3x4 g) Orafti® Inulin leads to a significantly higher
frequency of bowel movements per week compared to maltodextrin!
© 2018 BENEO
Assessed with a GI symptoms diary (5-point scale):
Gastrointestinal comfort
Micka et al. (2017) Int J Food Sci Nutr 68(1):82–89. https://www.ncbi.nlm.nih.gov/pubmed/27492975
GI = gastrointestinal
PI Inulin Maltodextrin
© 2018 BENEO
Health related QoL questionnaire specific for constipated subjects
Improved well-being!
Micka et al. (2017) Int J Food Sci Nutr 68(1):82–89. https://www.ncbi.nlm.nih.gov/pubmed/27492975
QoL = Quality of Life
• PAC-QOL (Patient-Assessment of Constipation
Quality of Life)
• A validated instrument to assess QoL in patients suffering from
constipation
• Selected validated test blocks: physical discomfort and
satisfaction dimension
Physical discomfort score:
No difference between chicory root fibre and placebo
Satisfaction:
Improvement with chicory root fibre
Compared to study start Orafti® Inulin intake showed
an improvement of quality of life scores
© 2018 BENEO
Chicory root fibres’ prebiotic effect
Evidenced with next generation technology
Vandeputte et al. (2017) Gut 66(11):1968–1974. http://gut.bmj.com/content/gutjnl/66/11/1968.full.pdf
• Randomised, placebo-controlled, double-blind, cross-over design
• 44 participants with mild constipation consuming 12 g/d Orafti® Inulin
(vs. maltodextrin) over 4 weeks
• Feacal samples for gut flora analysis using next generation technology
© 2018 BENEO
• Ecosystem-wide analysis of the effect of a dietary intervention with prebiotic inulin-type
fructans on colon microbiota
• Amongst almost 300 genera detected the abundance of only 3 genera changed significantly
with inulin intake
• Bifidobacterium increased
• Anaerostipes increased
• Bilophila decreased
Selective growth of bacteria
Prebiotic effect proven with state-of-the-art methodology
Vandeputte et al. (2017) Gut 66(11):1968–1974. http://gut.bmj.com/content/gutjnl/66/11/1968.full.pdf
Known for years and
now confirmed with highly
sophisticated methodologyP: placebo, I: inulin
Bilophila – described as
organism with pathogenic
potential!
© 2018 BENEO
• The consumption of inulin leads to reduced numbers of Bilophila which is linked to improved
well-being parameters
• Correlation analysis revealed
• Correlation between Bilophila abundance variation and changes in stool consistency
• Association between Bilophila and PACQoL-assessed physical discomfort and treatment of
satisfaction scores
• Softer stools1
• Reduced discomfort2
• Increased satisfaction2
Link between reduction of Bilophila and improved well-being
Vandeputte et al. (2017) Gut 66(11):1968–1974. http://gut.bmj.com/content/gutjnl/66/11/1968.full.pdf
1 assessed via Bristol Stool Scale (BSS)2 assessed via Patient Assessment of Constipation Quality of Life (PAC-QoL)
This is the first study showing a link
between a bacterium and softer stools as
well as quality of life after intake of
chicory root fibres.
© 2018 BENEO
BENEO’s prebiotic chicory root fibres support digestive health and bowel regularity by:
The power of prebiotic chicory root fibres
Improved digestive health and bowel regularity
Being a proven
prebiotic
… with strong
scientific evidence!
Improving overall
digestive well-being
Increasing fibre
intake
Softening stoolsIncreasing weekly
stool frequency
... several more
health benefits …
Chicory root
fibres show …
Approved EU
health claim
