Pradeep Et Al-2012-Australian Dental Journal

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1. NAMES OF THE RESEARCHERS DR. NISHTHA KUMAR

POST GRADUATE STUDENT

DEPARTMENT OF PERIODONTICS

GOVERNMENT DENTAL COLLEGE

AND RESEARCH INSTITUTE,

BANGALORE.

2. GUIDED BY DR. A.R.PRADEEP

PROFESSOR AND HEAD

DEPERTMENT OF PERIODONTICS

GOVERNMENT DENTAL COLLEGE

AND RESEARCH INSTITUTE,

BANGALORE.

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3. BRIEF RESUME OF THE INTENDED WORK:

3.1 NEED FOR THE STUDY: -

Gingivitis is a chronic inflammatory process limited to the gingiva, without either

attachment or alveolar bone loss. It is one of the most frequent oral diseases, affecting more

than 90% of the population, regardless of age, se or race. !he earliest clinical sign isbleeding, which is a sequel of the vasodilator effect caused by an inflammatory

response.!he prevention of gingivitis by daily and effective supragingival plaque control via

brushing the teeth and dental floss is necessary to arrest a possible progression to

periodontitis.

"ertain plants used in fol# medicine serve as a source of therapeutic agent by

having multi$potential effects in addition to their antimicrobial activity .1

Acacia arabicagum has been shown to ehibit antimicrobial properties.

Gumtone gel may be a useful herbal formulation for chemical plaque control agent

and improvement in plaque and gingival status.&

"alendula etract toothpaste reduces gingival inflammation and plaque formation

and therefore recommended as an ad'unctive procedure effective for improvement in

gingival inflammation.(

"alendula mouthwash is effective in reducing dental plaque and gingivitis

ad'unctive to scaling.)

!his study is designed with the aim of comparing clinical efficacy ofAcacia arabica

and "alendula gel in the reduction of gingival inflammation.

COMPARISON OF CLINICAL EFFICACY OF ACACIA ARABICA AND CALENDULA

GEL IN REDUCTION OF GINGIVAL INFLAMMATION : A RANDOMIZED

CONTROLLED CLINICAL TRIAL

3.2 REVIEW OF LITERATURE: -

*erbal formulations can provide an option for safe and long term use. Gumtone gel

+"hara# harma vt. -td, India is one such polyherbal formulation withAcacia arabica as

its main ingredient.1

Acacia arabicagum is a traditional oral hygiene substance which has been used for

centuries by many communities in the /iddle ast and orth 2frica. It consists mainly of

arabica, a comple miture of the calcium, magnesium and potassium salts of arabic acid.

!here are also other constituents such as tannins, cyanogenic glycosides, oidases,

peroidases and pectinases3 all of which have been shown individually to ehibit

antimicrobial properties.

In a study, ninety sub'ects diagnosed with chronic generali4ed gingivitis were

selected and randomly divided into three groups5 Group I 6 placebo gel, Group II 6 gumtone

gel and Group III 6 1% chlorheidine gel. "linical evaluation was underta#en using the

gingival inde of -oe and 7ilness and the plaque inde at baseline, wee#s, ( wee#s and 8wee#s.2 sub'ective evaluation was underta#en by questionnaire. Gumtone gel showed


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significant clinical improvement in gingival and plaque inde scores as compared to a

placebo gel. !his improvement was comparable to 1% chlorheidine gel.nli#e

chlorheidine gel, gumtone gel was not associated with any discolouration of teeth or

unpleasant taste.&

In a prospective, double$blind clinical study, a total of (0 volunteers with established

gingivitits +1 males an 19 females were included. !hey were randomly assigned to twotreatment groups5 Group 1+n:0$ treated with base dentifrice as control toothpaste3 Group

+n:0$ treated with "alendula flower etract toothpaste. ;ata was collected at baseline and

at increment of ,& and ( wee#s. !he data included laque inde+I, Gingival inde+GI

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(. Gingivitis with bleeding on probing +; A & mm

E"CLUSION CRITERIA: -

1. 7ub'ects with #nown allergies to the constituents of the formulation..

. 7ub'ects undergoing orthodontic therapy.

&. 7ub'ects having any haematological disorder.

(. 7ub'ects with a smo#ing habit.

). 7ub'ects with #nown systemic disease or any other systemic inflammationB infection

which can alter the course of periodontal disease.

8. regnantB lactating women.

C. 7ub'ects who are on any medicationB drugs which could influence periodontal status.

90 sub'ects +=n the basis of power analysis with 90% confidence at p?0.0). will be

selected randomly and categori4ed into & groups which are subdivided on the basis of theingredient of the gel

Group I5 &0 sub'ects will receive placebo gel.

Group II5 &0 sub'ects will receiveAcacia arabicagel

Group III5 &0 sub'ects will receive "alendula gel

=ral prophylais will be done and oral hygiene instructions will be given. 7ub'ects will

be instructed to apply a pea$si4ed amount of gel gently by finger or soft brush to the

gums for about an hour after regular brushing and to leave it for five minutes before

rinsing.7ub'ects will be assessed for gingivitis using the gingival inde +GI, for plaque,

using the plaque inde +I, and bleeding on probing in the same dental unit under

identical conditions at baseline, wee#s, ( wee#s and 8 wee#s. !he clinical

measurements will be carried out using a "$1) periodontal probe.

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#.

STATISTICAL ANALYSIS:

ower analysis was applied to calculate the appropriate sample si4e and the following

7tatistical tests will be carried out5

1. 2nalysis of variance.. aired t$test.

!.3 W$%% &'($)*% )%&*+*)& & '*$&/ 0+ + $4'$''$5

Dill be obtained from institutional ethical committee and review board,

G;"@I,


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#. LIST OF REFERENCES:

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6. SIGNATURES OF RESEARCHERS

7. REMARKS OF THE GUIDE

8. NAME AND DESIGNATION OF

8.1 GUIDE

8.2 SIGNATURE

DR A. R. PRADEEP

PROFESSOR AND HEAD,

DEPARTMENT OF PERIODONTICS,

GOVERNMENT DENTAL COLLEGE AND

RESEARCH INSTITUTE,

BANGALORE.

8.3 HEAD OF THE DEPARTMENT

8.! SIGNATURE

DR A.R. PRADEEP

C

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Pradeep Et Al-2012-Australian Dental Journal