PP29 - Interdisciplinary diabetes preven�on program in the primary health center of Neos Kosmos in GreeceAlexiou Eleni¹, Athanasopoulos Alexandros², Moumtzi Theofano¹, Panagiotopoulou Aikaterini¹, Soula Maria¹, Psaraki Eleni¹ ³

Introduc�onThe prevalence of type 2 diabetes (T2DM) and prediabetes is increasing worldwide [1] and is one of the most important public health challeng-es, o�en resul�ng in an increase sickness absence, morbidity and mortality [2]. Periodon�-�s is a mul�factorial chronic disease, that can lead, if untreated, to the non-reversible damage of suppor�ve �ssues surrounding the teeth [3]. The interrela�onship between the periodon��s and (pre)diabetes is well known and suggests the predisposi�on of systemic disease to oral infec�on and vice versa [4]. Preven�on of T2DM is a “whole-of life’’ task and requires an integrat-ed approach. In the Health Center of Neos Kosmos in Athens is implemented since 2016 an interdisciplinary intersectoral diabetes-periodon-tal disease preven�on program that aims to the early iden�fica�on of at risk individuals and to appropriate lifestyle interven�ons.

MethodsResults

Conclusions

References [1] Worldwide trends in diabetes since 1980: a pooled analysis of 751 popula�on-based studies with 4·4 million par�cipants. Lancet 2016;. [2] Dray-Spira R, Herquelot E, Bonenfant S, Guéguen A, Melchior M. Impact of diabetes mellitus onset on sickness absence from work--a 15-year follow-up of the GAZEL Occupa�onal Cohort Study. Diabet Med 2013. [3] Liccardo D, Cannavo A, Spagnuolo G, Ferrara N, Ci�adini A, Rengo C, et al. Periodontal Disease: A Risk Factor for Diabetes and Cardiovascu-lar Disease. Int J Mol Sci 2019;20. doi:10.3390/ijms20061414. [4] Deshpande K, Jain A, Sharma R, Prashar S, Jain R. Diabetes and periodon��s. J Indian Soc Periodontol 2010. [5] Salmerón D, Gómez García F, Pons-Fuster E, Pérez-Sayáns M, Lorenzo-Pouso AI, López-Jornet P. Screening for prediabetes and risk of periodontal disease. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 2019;.

At baseline all p a r � c i p a n t s completed a medi-cal-history ques�on-naire and underwent a physical examina-�on that included anthropometric and blood pressure measurements, an oral glucose-toler-ance test and dental e x a m i n a � o n . Furthermore, fas�ng plasma glucose and the levels of total c h o l e s t e r o l , high-density lipopro-tein cholesterol, triglycerides, uric acid and glycated h a e m o g l o b i n frac�on were meas-ured.

The median follow-up �me for this study was 1 year, and total of 63 subjects were included in this analysis. Enrolled subjects who did not complete blood pressure measurements, oral glucose-tolerance test and dental examina�on were excluded from the analysis. Demographic and diabetes-related characteris�cs of the study popula�on are presented in table 1. The HBA1c, waist circumference and Systolic blood pressure were sta�s�cally significantly higher in subjects with periodon��s than in controls.

¹ Health Center of Neos Kosmos, Machis Analatou and Lagoumitzi, Athens. ,²Ins�tute of Biosciences and Applica�ons, Na�onal Centre for Scien�fic Research "Demokritos", Patr. Grigoriou E & 27 Neapoleos St., 15341, Agia Paraskevi, Greece, ³Na�onal Health System, General Hospital of Chania

Our findings indicate the importance of this programme in the early detec�on of prediabetes and the avoidance of progression towards diabetes. Changes in lifestyle could improve the oral and gener-al health and prevent or delay the onset of type 2 diabetes in par�cipants with prediabetes.

ResultsTable 2 Study parameters measured at baseline and 12 months

Table 1 Background characteris�cs

The median follow-up �me for this study was 1 year, and total of 63 subjects were included in this analysis. Enrolled subjects who did not complete blood pressure measurements, oral glucose-tolerance test and dental examina�on were excluded from the analysis. Demographic and diabetes-related characteris�cs of the study popula�on are presented in table 1. The HBA1c, waist circumference and Systolic blood pressure were sta�s�cally significantly higher in subjects with periodon��s than in controls (Table 1). Mean HBA1c for the en�re study at baseline was 5.7 ±. 4. One year a�er the global mean of HBA1c was reduced significantly. At the 12 months follow up the mean body weight decreased by 0.40 kg and waist circumference by 1cm (Table 2). The fas�ng plasma glucose concentra�on and LDL decreased by 2.7 mg/dl and 7.3 mmol/L, respec�vely.

` Control Periodon��s p Value

Age (years) 62.4 ± 12.6 66.3 ± 10.5 .406

Sex. male (%) 16 (84.2) 3 (15.8) .943

Body mass index (kg/m2) 29.6 ± 6.9 33.9 ± 4.1 .092

HBA1c (%) 5.6 ± 0.3 6.0 ± 0.3 .036

Waist circumference (cm) 102.2 ± 16.6 115.3 ± 9.7 .034

HDL (mmol/L) 60.5 ± 14.9 48.7 ± 11.1 .340

Systolic blood pressure (mmHg) 125.9 ± 19.9 142.7 ± 18.5 .029

Diastolic blood pressure (mmHg) 74.6 ± 11.1 81.3 ± 6.9 .104

baseline12 months

p Value

HBA1c (%) 5.7 ±. 4 5.6 ± .4 .020

LDL (mmol/L)117.0 ±38.2

109.7 ±37.1 .321

Fas�ng plasma glucose (mg/dL)

102.9 ±13.5

100.2 ±10.4 .169

Waist circumference (cm)

103.9 ±17.5

102.9 ±15.5 .197

Body weight (Kg) 81.7 ± 21.181.3±20.9 .412