13
1

PowerPoint Presentation · Z Armstrong, K Mewis, C Strachan, SJ Hallam, 2015, Biocatalysts for biomass deconstruction from environmental genomics, Current opinion in chemical biology

  • Upload
    others

  • View
    0

  • Download
    0

Embed Size (px)

Citation preview

Page 1: PowerPoint Presentation · Z Armstrong, K Mewis, C Strachan, SJ Hallam, 2015, Biocatalysts for biomass deconstruction from environmental genomics, Current opinion in chemical biology

1

Page 2: PowerPoint Presentation · Z Armstrong, K Mewis, C Strachan, SJ Hallam, 2015, Biocatalysts for biomass deconstruction from environmental genomics, Current opinion in chemical biology

2

Page 3: PowerPoint Presentation · Z Armstrong, K Mewis, C Strachan, SJ Hallam, 2015, Biocatalysts for biomass deconstruction from environmental genomics, Current opinion in chemical biology
Page 4: PowerPoint Presentation · Z Armstrong, K Mewis, C Strachan, SJ Hallam, 2015, Biocatalysts for biomass deconstruction from environmental genomics, Current opinion in chemical biology

Falkowski et al., (2008) Science 320, 1034-1038 4

Page 5: PowerPoint Presentation · Z Armstrong, K Mewis, C Strachan, SJ Hallam, 2015, Biocatalysts for biomass deconstruction from environmental genomics, Current opinion in chemical biology

“The regulation of the pools and fluxes in biogeochemical cycles have their origins in thegenetic inventory of individual microbes, and the regulation of these genes within theorganism is determined by the environment. As such, one can look at the microbial food webas a collection of genomes whose expression and replication is coordinated through complexfeedback loops at the organismal, population, and ecosystem level.” Chisholm, 2000

Page 6: PowerPoint Presentation · Z Armstrong, K Mewis, C Strachan, SJ Hallam, 2015, Biocatalysts for biomass deconstruction from environmental genomics, Current opinion in chemical biology

Individuals

Populations

Communities

A > B > C >D

A > B > C

C >D

A > B

B > C

C >D

6

Page 7: PowerPoint Presentation · Z Armstrong, K Mewis, C Strachan, SJ Hallam, 2015, Biocatalysts for biomass deconstruction from environmental genomics, Current opinion in chemical biology
Page 8: PowerPoint Presentation · Z Armstrong, K Mewis, C Strachan, SJ Hallam, 2015, Biocatalysts for biomass deconstruction from environmental genomics, Current opinion in chemical biology

Ecological Design

8Wright, J.J. K. Konwar, and S.J. Hallam. 2012 Microbial s Ecology of Expanding Oxygen Minimum Zones Nat Rev Microbiology 10(6):381-94

Page 9: PowerPoint Presentation · Z Armstrong, K Mewis, C Strachan, SJ Hallam, 2015, Biocatalysts for biomass deconstruction from environmental genomics, Current opinion in chemical biology

9

cd09819cd09820 cd09821 cd09822 cd05396

100758

5

6497

5176

96

797

2

72 70

921

00

100

1001

00

10

0

100

93

96 91 72 66 77

71

91

82

98

100

90

100

100

10

0

100

97

7051

56

94

84

66

100

100

10

0

92

9658

7653

89

77 59

0.8

Environmental DNA

Microbial Community

Plating

Ligation

SequencingGene

Identi cationBiochemical

Testing

Functional Screen

Fosmid Library

Production

Strain

Engineering

Coal Ocean Mine Forest

Transfection

Z Armstrong, K Mewis, C Strachan, SJ Hallam, 2015, Biocatalysts for biomass deconstruction from environmental genomics, Current opinion in chemical biology 29, 18-25

Page 10: PowerPoint Presentation · Z Armstrong, K Mewis, C Strachan, SJ Hallam, 2015, Biocatalysts for biomass deconstruction from environmental genomics, Current opinion in chemical biology

10

OO

O

O

O

OO

OO

O

O

OO

O

O

O

H

H

H

H

HH

H

HH

O

O

O

O

O

O

HO

OO

O

O

OH OH

O

O

OH

O

OH

O

O

OH

O

OH

O

OH

O

OO

O

HO

OH

O

O

OH

O

HO

OH

HO

O

HO

O

O

HO

OH

OH

O

O

HO

OH

OH

OH

O

HO

OH

O

OO

O

OH

O

O

HO

OHO

HO

OH

OO

O

HO

O

O

O

HO

OH

OH

O

HO

OH

O

O

-O

O

HO

OH

OO

O-

O

HO

OH

OO

O-

O

HO

OH

OO

O-

O

+

a.

b.

c.

d.

e.

Microbial Community

Engineered Strains

Environmental Sequences

Biore ning Ecosystems

Biomass

Energy & Materials

Z Armstrong, K Mewis, C Strachan, SJ Hallam, 2015, Biocatalysts for biomass deconstruction from environmental genomics, Current opinion in chemical biology 29, 18-25

Page 11: PowerPoint Presentation · Z Armstrong, K Mewis, C Strachan, SJ Hallam, 2015, Biocatalysts for biomass deconstruction from environmental genomics, Current opinion in chemical biology
Page 12: PowerPoint Presentation · Z Armstrong, K Mewis, C Strachan, SJ Hallam, 2015, Biocatalysts for biomass deconstruction from environmental genomics, Current opinion in chemical biology

12

Page 13: PowerPoint Presentation · Z Armstrong, K Mewis, C Strachan, SJ Hallam, 2015, Biocatalysts for biomass deconstruction from environmental genomics, Current opinion in chemical biology

“The extension of ethics, so far studied only by philosophers, is actually a process inecological evolution. Its sequences may be described in ecological as well as inphilosophical terms. An ethic, ecologically, is a limitation on freedom of action in thestruggle for existence. An ethic philosophically is a differentiation of social from anti-socialconduct. These are two definitions of one thing. The thing has its origin in the tendency ofinterdependent individuals or groups to evolve modes of co-operation” Leopold, 1949

13