Power Point Kuno

8/9/2019 Power Point Kuno

1/79

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tt dododottthahahannn by thoby thoby those

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BroBroBroncncnchihihial Astal Astal Asthmhmhma

aa(((AlterAlterAlteratatatiiiononon iiinnnOxOxOxygeygeygennnat

atatiiiononon)))

Nia Alma M. Bianson RNLyceum of the Philippines UniversityBatangas City

04/13/04/13/04/13/090909


4/79

Asthma-Pathology -3

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Shashi


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Asthma-Pathology -4

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10/79

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Shashi


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Asthma-Pathology -5

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Shashi

aaaccompaccompaccompanininied by paed by paed by paininin...


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Asthma-Pathology -6

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17/79

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Asthma-Pathology -7

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Asthma-Pathology -8

AsAsAsthm

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21/79

oovavavariousriousrious stststimulimulimuli (i (i (a

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f cf chhhildrenildrenildren & 5%& 5%& 5%-7%-7%-7%

aaadududultltltsss .

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Shashi


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Asthma-Pathology -9

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wwithithith aaasssthmathmathma ssshhho

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..

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SomeSomeSomeone wone wone withithith aaast

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.

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Asthma-Pathology -10Shashi04/13/0904/13/09Percent Change in Age-Percent Change in Age-Adjusted Death Rates, U.S.,Adjusted Death Rates, U.S.,1965-19981965-19980

0.51.01.52.02.53.0Proportion of 1965 Rate1965 -1998 1965 -1998 1965 -1998 1965 -1998 1965 -199859% 64% 35% +163% 7%CoronaryHeartDiseaseStroke Other CVD COPD All Other

CausesPercent Change in Age-Percent Change in Age-Adjusted Death Rates, U.S.,Adjusted Death Rates, U.S.,1965-19981965-199800.51.01.52.02.53.0Proportion of 1965 Rate1965 -1998 1965 -1998 1965 -1998 1965 -1998 1965 -1998

59% 64% 35% +163% 7%CoronaryHeartDiseaseStroke Other CVD COPD All OtherCauses


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Asthma-Pathology -11

Anatomy PhysiologyAnatomy Physiology04/13/04/13/04/13/09

0909

Shashi


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.

HumaHumaHuman Rn Rn Respiraespiraespiratorytorytory SySySystststememem

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eses. T. T. Thhhe


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31/79

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celcellll

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oo ttthehehe lu


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ee nnnooos


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sseee aaannndddmmmo

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ccarryarryarry aaair


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irir intintintooo eaceaceachhh lunlunlunggg.

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rightright mamamaiiinnn ssstttememem

Shashi

04/13/04/13/04/13/090909bronbronbronchuchuchusss fffooorrr the

thethe leleleftftft anananddd rightrightright lunlunlungggs,s,s,

ively.


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AnAnAnatom

atomatomyyy anananddd PPPhhhyyysiolsiolsiologogogyyy

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AsthmaAsthma04/13/04/13/04/13/09

0909

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Asthma-Pathology -1604/13/09 ShashiINFLAMMATIONAirflow LimitationSYMPTOMSCough Wheeze

DyspneaTRIGGERSAllergens, Exercise,Cold Air, SO2 ParticulatesPathophysiology:AirwayHyperresponsivenessGenetic*INDUCERSAllergens,Chemical sensitizers,Air pollutants, Virus infections


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Asthma-P holog 1704/13/09 ShashiPredisposing Factor.Atopy.Female genderCausal Factors

>Exposure to indoorAnd outdoor allergens>OccupationalsensitizersContributing Factors>Respriratory infections>Air pollution>Active/passive smoking>Others diet, small sizeat birthInflammationHyperresponsiveness

of airways Airflow limitationRisk Factors forExacerbations.Allergens.Respiratory infections.Exercise and hyperventilation.Weather changes.Exposure to sulfur dioxide.Exposure to food, additives,medicationsSymptoms.Wheezing.Cough

.Dyspnea

.Chest tightness


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PathPathPathogogoge

eennnesesesiiisss - A- A- AtttooopicpicpicAsAsAsthmthmthma

aa:::04/13/04/13/04/13/090909

Shashi


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MasMasMast ct ct cells

ellsells ininin AsthmaAsthmaAsthmaPatPatPathohohogggeeennneeesssiiis

ss:::

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Shashi


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EEEooos

ssinophiinophiinophilslsls ininin AAAsssthmathmathmaPatPatPathohohogggeeen

nneeesssiiisss:::

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Shashi


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Lung Morphology in AsthmaLung Morphology in Asthma.Bro

BroBronchialnchialnchialinflainflainflammmmmmatatationionion

.

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inflainflainflationtiontion/

//AAAtttelec


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elecelectttasasasisisis.CCCOPD

OPDOPD

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Shashi


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LunLunLung

gg HHHyyyperiperiperinnnffflllatiatiatiooon inn inn in AAAsthsthsthm

mmaaa

04/13/04/13/04/13/090909

Shashi


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ThThThick bick bick br

rroooncncnchhhiii withwithwith MMMuuucoucoucoussspppl

lluuugggsss

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Shashi


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Asthma-Pathology -24Shashi04/13/0904/13/09Asthma MicroscopicAsthma MicroscopicPathologyPathologyObstructedInflammed

Bronchi


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AsAsAsttthm

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.inininffflalalammmmmmatatatioioionnn.

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51/79

luluggg inininlululummmenenen

.

HHHypypypertertertrororophy ofphy ofphy ofmmmu

uussscleclecle laylaylayererer

04/13/04/13/04/13/090909

Shashi


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AsAsAst

tthmhmhma - Bra - Bra - Brooonchialnchialnchial morpmorpmorphohoholllooogggyyy

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.

.

.04/13/04/13/04/13/090909

Shashi


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AsAsAst

tthmhmhma Ta Ta THHH2 l2 l2 lyyympmpmphohohocycycytetetesssiiimm

mmmmunounounossstttaiaiainingningning)))

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Shashi


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MuMuMuc

ccououous ps ps pllluuuggg ininin aaasthsthsthmmma:a:a:

04/13/04/13/04/13/090909

Shashi


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EEEosin

osinosinopopophilhilhilsss iiinnn AsthAsthAsthmmma:a:a:

04/13/

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MedMedMedical Man

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icickkk rrrelielielief (ef (ef (rereresssc

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04/13/04/13/04/13/090909

Shashi


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LLLongongong-term

-term-term cococontrolntrolntrolmmmedicedicedicatioatioationsnsns

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.


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inhinhinhalalaleeeddd stersterstero

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AccoAccolllate)ate)ate)

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oorrr nnneeedddooocrcrcromil

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nti-infnti-inflalalammammammatttororory ay ay andndndbro

brobroncncnchohohodddilailailatttororor,,, usingusingusing eeeithithitheeer

rr sepasepaseparrrateateate inhinhinhaleraleralersssooorrr aaa sssiiing

ngngle ile ile inhanhanhalerlerler (Advair(Advair(Advair DDDiiiskus)skus)skus)

04/13/04/13/04/13/090909

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QuQuQuicicick

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cationcationsss.-- used-- used-- used tttooo relirelirelieveveve sympte sympte symptooommmsss durin

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ProventProventililil,,, Ventolin


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VentolinVentolin,,, XXXopenopenopenexexex, and, and, ando

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vveeenousnousnous cccooortrtrtiiicccooostststeroeroeroidsidsids(e.

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NeNeNew Pathw Pathw Patholo

oloologggy & Drugy & Drugy & Drugsss inininAsAsAsttthmhmhma:a:a:

.

LLLeeeukukukotototrierieriencncnceees - signifs - signifs - significaicaicantntnt rolrolrole ine ine in

AAAsssttthmahmahma

.MaMaMasssttt cellcellcells as as andndnd EEEosiosiosinophinophinophil -l -l -CyCyCytttokokokiiinesnesnes...

.AAAr


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rraaaccchhhidoniidoniidoniccc acacacid

idid ---Lipo-oLipo-oLipo-oxxxyyygggenaenaenasesese LLLTDTDTD4

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astast &&& zazazaf


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ffirlukirlukirlukaaasssttt --- iiinhibi

nhibinhibitttCyCyCysLTsLTsLT111

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Asthma-Pathology -34ArachidonicAcidLeukotrienesCyclooxygenas5-LipoxygenaseProstaglandins

Cell DamageCell MembranePhospholipids SteroidsNSAIDProstacyclins

LTC4, D4, E4

5-LO inhibitorsAntileukotrienes

04/13/04/13/04/13/090909

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TheTheThe ReReRea

aalitylitylity ....AsAsAsttthmahmahma isisis nononottt yetyetyet c

ccurururableableable ***.UndUndUnderdierdierdiagnoagnoagnosssiiisss &&&

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HHHopopopeee ...

.

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