Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

Embed Size (px)

Citation preview

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    1/27

    Tutor :

    Dr. Tigor P. Simanjuntak, SpOG

    Presented by :

    Corianty Dewi Monica

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    2/27

    Postpartum hemorrhage remains the

    leading cause of maternal mortality

    worldwide and the main component of

    severe maternal morbidity in Western

    countries.

    Most postpartum hemorrhages are the

    result of uterine atony.

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    3/27

    Two categories of explanatory factors can

    be considered:

    The individual characteristics of women

    Deliveries and factors related to medical care

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    4/27

    The aim of this study :

    Identify factors associated with postpartum

    hemorrhage severity in women with

    postpartum hemorrhage resulting from

    uterine atony after vaginal delivery.

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    5/27

    The study population : women with

    postpartum hemorrhage.

    The main objective : to evaluate a

    multifaceted educational intervention for

    reducing the rate of severe postpartum

    hemorrhage.

    Data collected : December 2004 - November

    2006.

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    6/27

    Postpartum hemorrhage :

    The estimated postpartum blood loss >

    500 mL or peripartum change in Hb > 2

    g/dL (considered equivalent to the loss of

    more than 500 mL of blood).

    The postpartum Hb level : 3 days after

    delivery.

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    7/27

    During the 1-year data

    collection period, 9,365cases of postpartum

    hemorrhage occurred

    among 146,876

    deliveries.

    Finally, the study

    population included

    4,550 women.

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    8/27

    Severe postpartum hemorrhage :

    Peripartum change in Hb of 4 g/dL or more

    (considered equivalent to the loss of 1,000 mL

    or more of blood).

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    9/27

    Risk factors for severe postpartum

    hemorrhage :

    Characteristics of the women and aspects of

    labor and delivery before postpartum

    hemorrhage.

    Components of initial postpartum hemorrhage

    management. Organizational characteristics of the units.

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    10/27

    Women and Pregnancy

    Age in years at

    delivery

    Body mass index atconception

    Parity and previous

    cesarean delivery

    History of postpartumhemorrhage

    Multiple pregnancy

    Hydramnios

    Fibroma

    Labor

    Onset of labor

    Epidural analgesia

    Prolonged labor

    Oxytocin during labor

    Prolonged expulsive efforts

    Delivery

    Gestational age at delivery

    Birth weight Delivery

    Prophylactic uterotonics

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    11/27

    Oxytocin administration

    Manual examination of the uterine cavity

    The calls for assistance from a senior

    obstetrician and an anesthesiologist

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    12/27

    Status

    Level of care

    Number of deliveries annually

    24-h presence of obstetrician and an

    anesthesiologist

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    13/27

    A logistic regression analysis

    Separate multilevel models

    The association of eachorganizational characteristic

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    14/27

    Among 4,550 women with postpartum

    hemorrhage in the study population, 952

    (20.9%) had severe postpartum

    hemorrhage.

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    15/27

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    16/27

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    17/27

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    18/27

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    19/27

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    20/27

    When we controlled for the characteristics of

    women, labor, and delivery, severe

    postpartum hemorrhage was not

    significantly associated with the annual

    number of deliveries, the level of care, or the

    on-site presence of an obstetrician or an

    anesthesiologist

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    21/27

    Several of these characteristics

    previous cesarean delivery

    cervical ripening

    episiotomy

    related to the management of labor and

    delivery.

    51% had at least 1 of these 3 characteristics Efforts to these procedures may the

    incidence of severe postpartum hemorrhage.

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    22/27

    Episiotomy is associated with risk of

    severe postpartum hemorrhage

    The risk of severe postpartum

    hemorrhage in women who received

    preventive oxytocin > women with who

    had no prophylaxis.

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    23/27

    Epidural anesthesia had a protective effect

    Delay in initial postpartum hemorrhage care

    was associated with risk of severepostpartum hemorrhage.

    The risk of severe blood loss is in public

    nonuniversity hospitals compared with other

    public university or private hospitals.

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    24/27

    Identifying factors that influence the

    course of postpartum hemorrhage has

    direct potential implications.

    Delayed initial care for postpartum

    hemorrhage and place of delivery the

    risk of heavy postpartum bleeding caused

    by atony.

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    25/27

    Reducing the use cervical ripening,

    episiotomy, or cesarean delivery, in particular

    situations in which these interventions do not

    provide clear benefits as well improving the

    rapidity of first care, may reduce the

    incidence of severe postpartum hemorrhage.

  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    26/27

    1. Brace V, Penney G, Hall M. Quantifying severe maternal morbidity: a Scottish population study. BJOG2004;111: 4814.

    2. Callaghan WM, Mackay AP, Berg CJ. Identification of severe maternal morbidity during deliveryhospitalizations, United States, 19912003. Am J Obstet Gynecol 2008;199:133.e18.

    3. Zhang WH, Alexander S, Bouvier-Colle MH, Macfarlane A. Incidence of severe pre-eclampsia,postpartum haemorrhage and sepsis as a surrogate marker for severe maternal morbidity in a Europeanpopulation-based study: the MOMS-B survey. BJOG 2005;112:8996.

    4. Zwart JJ, Richters JM, Ory F, de Vries JI, Bloemenkamp KW, van Roosmalen J. Severe maternalmorbidity during pregnancy, delivery and puerperium in the Netherlands: a nationwide population-basedstudy of 371,000 pregnancies. BJOG 2008;115:84250.

    5. Elbourne DR, Prendiville WJ, Carroli G, Wood J, McDonald S. Prophylactic use of oxytocin in the third

    stage of labour. The Cochrane Database of Systematic Reviews 2001, Issue 4. Art. No.: CD001808. DOI:10.1002/14651858.CD001808.

    6. Department of health New South Wales Government Australia. Postpartum haemorrhageframework forprevention, early recognition and management. 2005. Available at: www.health.nsw.gov.au/policies/PD/2005/PD_264.html. Accessed on May 31, 2010.

    7. National Guideline Clearinghouse. Postpartum haemorrhage. American College of Obstetricians andGynecologists. 2006. Available at: www.guideline.gov/summary/pdf.aspx?doc_ id10922&stat1&string.

    Accessed on May 31, 2010.

    8. The Society of Obstetricians and Gynecologists of Canada (SOGC). Prevention and management ofpostpartum haemorrhage. 2000. Available at: www.sogc.org/guidelines/public/ 88E-CPG-April2000.pdf.

    Accessed on May 31, 2010.9. World Health Organization. WHO recommendations for the prevention of postpartum haemorrhage.

    Geneva (Switzerland): World Health Organization Department of Making Pregnancy Safer; 2007.Available at: www.who.int/making_pregnancy_safer/publications/WHORecommendationsforPPHaemorrhage. pdf. Accessed on May 31, 2010.

    10. Lalonde A, Daviss BA, Acosta A, Herschderfer K. Postpartum hemorrhage today: ICM/FIGO initiative20042006. Int J Gynaecol Obstet 2006;94:24353.

    11. Goffinet F, Mercier F, Teyssier V, Pierre F, Dreyfus M, Mignon A, et al. Postpartum haemorrhage:recommendations for clinical practice by the CNGOF (December 2004) [in French]. Gynecol Obstet Fertil

    2005;33:26874.

    http://www.guideline.gov/summary/pdf.aspx?doc_http://www.sogc.org/guidelines/public/http://www.who.int/making_pregnancy_http://www.who.int/making_pregnancy_http://www.who.int/making_pregnancy_http://www.who.int/making_pregnancy_http://www.who.int/making_pregnancy_http://www.who.int/making_pregnancy_http://www.sogc.org/guidelines/public/http://www.sogc.org/guidelines/public/http://www.sogc.org/guidelines/public/http://www.sogc.org/guidelines/public/http://www.sogc.org/guidelines/public/http://www.guideline.gov/summary/pdf.aspx?doc_http://www.guideline.gov/summary/pdf.aspx?doc_http://www.guideline.gov/summary/pdf.aspx?doc_http://www.guideline.gov/summary/pdf.aspx?doc_http://www.guideline.gov/summary/pdf.aspx?doc_http://www.guideline.gov/summary/pdf.aspx?doc_http://www.guideline.gov/summary/pdf.aspx?doc_
  • 8/10/2019 Postpartum Hemorrhage Resulting From Uterine Atony After Vaginal

    27/27

    12. Callaghan WM, Kuklina EV, Berg CJ. Trends in postpartum hemorrhage: United States, 19942006. AmJ Obstet Gynecol 2010;202:353.e16.

    13. Joseph KS, Rouleau J, Kramer MS, Young DC, Liston RM, Baskett TF. Investigation of an increase inpostpartum haemorrhage in Canada. BJOG 2007;114:7519.

    14. Knight M, Callaghan WM, Berg C, Alexander S, Bouvier- Colle MH, Ford JB, et al. Trends in postpartumhemorrhage in high resource countries: a review and recommendations from the InternationalPostpartum Hemorrhage Collaborative Group. BMC Pregnancy Childbirth 2009;9:55.

    15. Roberts CL, Ford JB, Algert CS, Bell JC, Simpson JM, Morris JM. Trends in adverse maternal outcomesduring childbirth: a population-based study of severe maternal morbidity. BMC Pregnancy Childbirth

    2009;9:7.16. Al-Zirqi I, Vangen S, Forsen L, Stray-Pedersen B. Prevalence and risk factors of severe obstetric

    haemorrhage. BJOG 2008; 115:126572.

    17. Combs CA, Murphy EL, Laros RK Jr. Factors associated with postpartum hemorrhage with vaginal birth.Obstet Gynecol 1991;77:69 76.

    18. Sosa CG, Althabe F, Belizan JM, Buekens P. Risk factors for postpartum hemorrhage in vaginaldeliveries in a Latin-American population. Obstet Gynecol 2009;113:13139.

    19. Deneux-Tharaux C, Dupont C, Colin C, Rabilloud M, Touzet S, Lansac J, et al. Multifaceted interventionto decrease the rate of severe postpartum haemorrhagethe PITHAGORE6 cluster- randomized

    controlled trial. BJOG 2010;117:127887.20. French Ministry of Health. De cret 98-899. 1988. Available at:

    http://www.sante.gouv.fr/adm/dagpb/bo/1999/99 31/a0312082.htm. Accessed on May 31, 2010.

    21. Raudenbush SW, Bryk AS. Hierarchical linear models: applications and data analysis methods. 2nd ed.Thousand Oaks (CA): Sage Publications; 2002.

    22. Saunders NS, Paterson CM, Wadsworth J. Neonatal and maternal morbidity in relation to the length ofthe second stage of labour. Br J Obstet Gynaecol 1992;99:3815.

    23. Davis DA, Taylor-Vaisey A. Translating guidelines into practice. A systematic review of theoretic concepts,practical experience and research evidence in the adoption of clinical practice guidelines. CMAJ

    1997;157:40816.

    http://www.sante.gouv.fr/adm/dagpb/bo/1999/99%20%E2%80%9331/http://www.sante.gouv.fr/adm/dagpb/bo/1999/99%20%E2%80%9331/http://www.sante.gouv.fr/adm/dagpb/bo/1999/99%20%E2%80%9331/http://www.sante.gouv.fr/adm/dagpb/bo/1999/99%20%E2%80%9331/http://www.sante.gouv.fr/adm/dagpb/bo/1999/99%20%E2%80%9331/http://www.sante.gouv.fr/adm/dagpb/bo/1999/99%20%E2%80%9331/http://www.sante.gouv.fr/adm/dagpb/bo/1999/99%20%E2%80%9331/http://www.sante.gouv.fr/adm/dagpb/bo/1999/99%20%E2%80%9331/http://www.sante.gouv.fr/adm/dagpb/bo/1999/99%20%E2%80%9331/http://www.sante.gouv.fr/adm/dagpb/bo/1999/99%20%E2%80%9331/http://www.sante.gouv.fr/adm/dagpb/bo/1999/99%20%E2%80%9331/http://www.sante.gouv.fr/adm/dagpb/bo/1999/99%20%E2%80%9331/http://www.sante.gouv.fr/adm/dagpb/bo/1999/99%20%E2%80%9331/http://www.sante.gouv.fr/adm/dagpb/bo/1999/99%20%E2%80%9331/http://www.sante.gouv.fr/adm/dagpb/bo/1999/99%20%E2%80%9331/http://www.sante.gouv.fr/adm/dagpb/bo/1999/99%20%E2%80%9331/http://www.sante.gouv.fr/adm/dagpb/bo/1999/99%20%E2%80%9331/http://www.sante.gouv.fr/adm/dagpb/bo/1999/99%20%E2%80%9331/http://www.sante.gouv.fr/adm/dagpb/bo/1999/99%20%E2%80%9331/