Postgraduate Medical JournalEditor

IAN GILLILAND M.D. F.R.C.P.

Assistant EditorB. I. HOFFRAND M.A. D.M. M.R.C.P.

Advisory Editorial BoardA. G. Apley F.R.C.S.D. Barltrop B.Sc. M.D. F.R.C.P. D.C.H.E. M. M. Besterman M.A. M.D. F.R.C.P.A. M. Breckenridge B.Sc. M.R.C.P.E. H. Brown D.M. F.R.C.P. D.C.H.A. E. R. Buckle F.R.C.S. F.R.C.O.G.J. O. Craig F.R.C.SJ. D.M.R.D. F.F.R.A. H. Crisp M.D. M.R.C.P. F.R.C.P.Ed. F.R.C.Psych.

D.P.M.Sir Robert Drew K.C.B. C.B.E. F.R.C.P. F.R.A.C.P.R. Eban M.A. M.R.C.P. F.F.R.H. Ellis M.A. D.M. F.R.C.S.R. Goulding B.Sc. M.D. F.R.C.P.

J. P. Hopewell F.R.C.S.D. G. James M.A. M.D. F.R.C.P.S. B. Karani D.P.H. F.R.C.P. F.A.C.C.P.R. S. Kocen T.D. F.R.C.P.D. M. Krikler M.D. F.R.C.P. F.R.C.P.Ed. F.A.C.C.B. Lewis Ph.D. M.D. M.R.C.P. M.R.C.Path.C. E. Newman C.B.E. M.D. F.R.C.P.K. I. Nissen F.R.C.S.J. W. Paulley M.D. F.R.C.P.T. A. J. Prankerd M.D. F.R.C.P.D. A. Pyke M.D. F.R.C.P.J. H. Swallow M.D. F.R.C.P.P. Turner B.Sc. M.D. F.R.C.P.

Editorial Representative for North AmericaCharles G. Roland M.D.

Editorial Representative for AustraliaProfessor Thomas Stapleton M.A. D.M. M.R.C.P. D.C.H.

Editorial AssistantsMrs J. M. Coops B.Sc. & Mrs L. Edmondston-Low

Postgraduate Medical Jornal is published monthlyfor the Fellowship of Postgraduate Medicine byBlackwell Scientific Publications Ltd. The annualsubscription is £10.00 ($34.00) post free, and the priceof single issues £1.00 ($3.00) postage extra. If pay-ments are made by bank transfer, all charges shallbe at the remitter's expense. Orders and businesscorrespondence should be addressed to BlackwellScientific Publications Ltd, Osney Mead, OxfordOX2 OEL (tel: Oxford 40201).

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The Fellowship of Postgraduate Medicine wasfounded by a group of London consultants after theFirst World War to assist postgraduates, particularlythose coming to London from the Commonwealth,to pursue their studies. The Fellowship first publishedthe Postgraduate Medical Journal to give informa-tion about lectures, conferences and courses and toprovide a monthly review ofall branches ofmedicine.

Postgraduate Medical Journal publishes originalpapers on subjects of current clinical importanceand welcomes review articles with extensive, up-to-date bibliographies as guides to further reading.Several symposia are published every year, eachdevoted to a single subject and written, by invitation,by specialists in different disciplines. Most issuesinclude authoritative Current Surveys of clinicalproblems, as well as well documented Reports ofcases of particular interest, Correspondence andBook Reviews.A 'Notice to Contributors' is published on the

inside back cover of this issue. The Editor reservesthe right to make changes which may clarify orcondense papers where this is considered desirable.

( The contents of this Journal are copyright and,subject to the provisions of Section 7 of the Copy-right Act, 1956, they may not be copied, adapted orreproduced without permission. Requests for per-mission to reproduce material elsewhere, either inwhole or in part, should be addressed to The Editor,Postgraduate Medical Journal, Chandos House,2 Queen Anne Street, London W1M 9LE. ThisJournal is covered by Current Contents and Bio-logical Abstracts.

Postgraduate Medical Journal (December 1974) 50, 777-780.

Books received

A Handbook of Venereal Diseases. By WILLIAM M. PLATTS.Pp. 120, Cr. 8vo, paperback. Christchurch, N.Z.: N. M.Peryer Ltd, 1974. $2.50 (N.Z.).

Health Education Theory and Practice in Cancer Control-A Collection of Original Papers. UICC Technical ReportSeries, Vol. 10. Pp. 105. Geneva: International UnionAgainst Cancer, 1974.

Multiple Choice Questions in Dermatology. By S. GOOLAMALI.ix+ 91 pp. Edinburgh and London: Churchill Livingstone,1974. £1.00 (paperback).

Drug Treatment in Psychiatry-Social and PsychologicalAspects of Medical Practice. By T. SILVERSTONE AND P.TURNER. vii+ 223 pp. London: Routledge and Kegan Paul,1974. £4.00 (cloth), £2.25 (paperback).

Principles of Chemical Pathology. By T. A. HYDE AND T. F.DRAISEY. Pp. 656. England: Butterworths, 1974. £9.50.

Materia Medica and Pharmacology for Nurses. By J. S. PEEL.Pp. 206. Christchurch, N.Z.: N. M. Peryer Ltd, 1974.$4.50 (N.Z.).

Medicine in Old Age (Articles published in the B.M.J.).Pp. 178. London: B.M.A., 1974. £2.00, $6.00 (U.S.A.).

The Kidneys and the Internal Environment. By R. J. HARVEY.viii+167 pp. London: Chapman and Hall, 1974. £3.00(hardback), £1.75 (paperback).

Recent Advances Series No. 9. Physiology. Ed. by R. J.LINDEN. ix+467 pp. London: Churchill Livingstone, 1974.£9.50.

The Work of Primary Medical Care (No. 49 of series oncurrent health problems). Pp. 44. London: Office of HealthEconomics. 25p.

Undesirable Drug Interactions. By SOLOMON GARB. Revisededition. xiii+ 578 pp. London: Harvey Miller and MedcalfLtd, 1974. £7.00.

Blood Flow in Arteries. By DONALD A. MCDONALD. Secondedition. xviii+496 pp., illustrated. London: EdwardArnold, 1974. £12.00.

Aids to Postgraduate Medicine. By J. L. BURTON. Secondedition. vii+136 pp., illustrated. Edinburgh and London:Churchill Livingstone, 1974. £1.25 (paperback).

Operating Theatre Technique. By RAYMOND J. BRIGDEN.Third edition. vi+698 pp., illustrated. Edinburgh andLondon: Churchill Livingstone, 1974. £12.50.

Computers in Radiotherapy-Physical Aspects. By R. G.WOOD. ix+112 pp., illustrated. London: Butterworths,1974. £2.45 (paperback).

Psychiatric Illness. By H. MERSKEY AND W. LAWTON TONGE.Second edition. viii+292 pp. London: Baillere Tindall,1974. £2.80 (paperback).

Obstetrics Illustrated. By GARREY, GOVAN, HODGE ANDCALLANDER. Second edition. Pp. 538. Edinburgh: ChurchillLivingstone, 1974. £3.75.

Bonney's Gynaecological Surgery. By HOWKINS AND STALL-WORTHY. Eighth edition. x+868 pp., illustrated. London:Baillere Tindall, 1974. £11.00.

Tenth Symposium on Advanced Medicine. Royal College ofPhysicians of London, 18-22 Fcbruary, 1974. Ed. byJ. G. G. LEDINGHAM. xii+475 pp., illustrated. London:Pitman Medical, 1974. £6.00 (paperback).

Mounting the Health Guard. (Handbook for CommunityHealth Members). By J. HALLAS AND BERNADETTE FALLON.viii+43 pp. London: Nuffield Provincial Hospitals Trust,1974. £0.90.

A Colour Atlas of Rheumatology. By A. C. BOYLE. Pp. 128,illustrated. London: Wolfe Publishing Ltd, 1974. £3.50.

Book reviews

Anatomy, Regional and AppliedBy R. J. LAST. Fifth edition. Pp. xvi+925. Edinburgh andLondon: Churchill Livingstone, 1972. £8.00.

It is a pleasure to welcome yet another edition of this populartextbook of Anatomy. The book has come to be widely readby postgraduate students preparing for the Primary Fellow-ship Examinations of the Royal College of Surgeons, and itis difficult to think of any other work which deals with theirrequirements so adequately and so compactly.The book has inevitably increased in size since the first

edition, but the additional pages, particularly those devotedto osteology, have served to enhance the usefulness of thebook.As one would expect in a book which sets out to cover a

vast and detailed subject such as Human Anatomy in soshort a space, there is some imbalance in the treatment ofthe various organs and systems of the body, but instances ofthis are remarkably few.The illustrations-especially the photomicrographs-and

the production of the book generally are of a high quality.The book can be recommended, not only to those preparing

for examinations in Anatomy, but to clinicians who mayfrom time to time wish to refresh their knowledge andunderstanding of anatomical details and principles. Thebook should have a place on the shelves of every hospitallibrary.

Surgical Disorders of the Peripheral Nerves

By SIR HERBERT SEDDON. Pp. 332. Edinburgh and London:Churchill Livingstone, 1972. £8.00.

Sir Herbert Seddon is a world famous Orthopaedic Surgeon,a scholar, and a master craftsman of his art and a bookwritten by such a distinguished and well informed personcan truly be regarded as a masterwork. This is such a book.It delights as much as it informs and is an outstanding con-tribution to knowledge of trauma to the peripheral nerves.The first four chapters deal with the structure of the

peripheral nerves, the processes involved in the degenerationand regeneration of nerve fibres and to clinical and electricalmethods of examining the nerves and recording the findings.The next eight chapters deal with the common causes ofnerve injury, neurovascular and compressive damage to thenerves, other topics of nerve injuries, nerve tumours andclinical assessment of individual nerves of the upper andlower limbs. A chapter is devoted to forms of treatmentrequired apart from surgery. Indications for surgical inter-vention, practical details of exploration, suture, neurolysisand repairs of large gaps in nerve troubles are describedlucidly and with remarkable reasoning. The seventeenth andlast chapter shrewdly summarizes the results of nerve repairs.

It has been a pleasure to review this book not only becauseof the mature and masterly way in which the facts are pre-sented but because it is written by a scholar who is an

Subject Index

PageAbdominal-Solitary cyst of the liver presenting asan ... emergency ... S. C. Sood and A. Watson 48

Abscesses-Radiological changes in left lobe liver... S. Ramachandran 685

Accident-road traffic accident fatalities (review of142 post mortem reports) ... B. A. Kamdar andG. P. Arden 131

Accident-Traumatic aortic incompetence follow-ing road traffic ... J. B. Irving 725

Achalasia-endoscopy in ... W. Roesch 211Achalasia-Oesophago-cardiac fistula complicating

... R. W. Strong 41Achalasia of the cardia-pathophysiology of...

J. J. Misiewicz 207Achalasia: symptoms and radiology... D. A. W.Edwards 209

Acidosis-Lactic... and hyperamylasaemia asso-ciated with phenformin therapy ... D. N.Williams, A. H. Knight and D. M. Goldberg 765

Action-Study of the lipid-lowering... of chol-oxin and Nilevar in patients with chronic renalfailure... E. N. Wardle, W. Schardt and P. R.Uldall 737

Acute emphysematous cholecystitis ... A. McKib-bin and T. G. Parks 50

Additives-Food... Michael Spencer 620Adrenergic-a comparisonof beta adrenergic block-

ing drugs in the treatment of hypertension...T. O. Morgan, J. Sabto, S. N. Anavekar, W. J.Louis and A. E. Doyle 253

Adult-Lipomatous pseudohypertrophy of thepancreas associated with chronic pulmonarysuppuration in an ... D. I. M. Siegler 53

Aetiology of duodenal ulcer: an investigation intothe buffering action and effect on pepsin of branand unrefined carbohydrate foods ... Frank I.Tovey 683

Agent-An evaluation of sotalol, a beta-blocking... in patients with angina pectoris ... P. G.Gooding and E. Berman 734

Allergy-Mites and house dust mite... in bron-chial asthma in Northern Zambia ... D. J.Buchanan and I. G. Jones 680

Alpha-1-trypsin deficiency-neonatal hepatitis and... an epidemiological study in South-EastEngland ... K. Cottrall, P. J. L. Cook and A. P.Mowat 376

Alpha-1-trypsin deficient individuals-pathologyand pathogenesis of liver disease in ... 0.Aagenaes, M. Fagergol, K. Elgjo, E. Muntheand T. Hovig 365

Amoebic-Radiological changes in left lobe...liver abscesses . . . S. Ramachandran 685

Amoxycillin: pharmacokinetic studies in normalsubjects, patients with pernicious anaemia andthose with renal failure ... D. H. Lawson, A. K.Henderson and R. R. McGeachy 500

Anaemia-Amoxycillin: pharmacokinetic studies innormal subjects, patients with pernicious anaemia

Pageand those with renal failure... D. H. Lawson,A. K. Henderson and R. R. McGeachy 500

Anaemia-megaloblastic-associated with the oralcontraceptive pill ... M. M. Meguid and W. Y.Loebl 470

Anaemia-oxymethalone in aplastic ... M. A. Mirand I. W. Delamore 166

Anaemia-Purpura fulminans with haemolytic ...N. A. Nagi and A. R. A. Al-Hasso 750

Analgesics in cancer pain: results of a questionnaire... D. S. Robbie and A. T. Mennie 150

Angina pectoris-An evaluation of sotalol, a beta-blocking agent, in patients with... P. G.Gooding and E. Berman 734

Antepartum diagnosis of vasa praevia-report of acase causing sudden foetal death... C. S.Pallewela 723

Antibiotics ... L. P. Garrod 96Anticoagulant-Retroperitoneal haemorrhage and

neuropathy complicating... therapy... P. V.Curry and P. A. Bacon 37

Anticoagulants-the use of... in bacterial endo-carditis... J. A. Kanis 312

Antigen-acquisition of hepatitis B antigen in thenewborn period ... Y. E. Cossart 334

Antigen-viral hepatitis and hepatitis B antigen:recent advances ... S. Krugman 327

Aorto-coronary saphenous vein bypass graft-thetreatment of malignant ventricular tachycardiaby... H. Ikram, A. R. Makey, R. M. Jeffery,E. R. J. Emery, R. A. Parkins and D. L. Stone 177

Aplastic anaemia-oxymetholone in... M. A.Mir and I. W. Delamore 166

Appendix-malignant mucocele of the... in afemoral hernia... I. M. Nayak 246

Appendix-Villous papilloma of the ... associatedwith mucocele and intussusception... A. J.Darby and A. Doctor 650

Aortic-Traumatic ... incompetence followingroad traffic accident . . . J. B. Irving 725

Arterial hypertension-coma following treatmentof very severe arterial hypertension, with im-provement after dexamathasone therapy...L. J. Farrow and J. B. Wood 517

Arteritis: giant cell arteritis .. . R. G. Turner, A. I.Friedmann, J. Henry and D. G. James 265

Arthritis-Gonococcaemia with ..., dermatitis andmyocarditis... H. S. Fraser, A. L. Liburd, J. P.Figueroa, G. A. Nicholson, O. B. O'L. James, F.Whitbourne and G. A. O. Alleyne 759

Asthma-Mites and house dust mite allergy inbronchial... in Northern Zambia . . . D. J.Buchanan and I. G. Jones 680

Atherosclerosis-abnormal fatty acid compositionand human atherosclerosis ... K. J. Kingsbury,C. Brett, R. Stovold, A. Chapman, J. Andersonand D. M. Morgan 425

198 Au liver scan in assessing the therapeutic effectof penicillamine in Wilson's disease, The use of... T. Chajek 56

iv Postgraduate Medical Journal

Autoimmune thyroiditis-primary acquired hypo-gammaglobulinaemia and... A M. Hilton andL. Doyle 303

Autoimmunity-Coeliac diseas: and... M. J.Lancaster-Smith, J. Perrin, E. T. Swarbrick andJ. T. Wright 45

Bacillus cereus-Clostridium welchii and . . . infec-tion and intoxication ... B. C. Hobbs 597

Bacterial challenges in food . . . J. G. Collee 636Bacterial endocarditis-the use of anticoagulantsin... J. A. Kanis 312

Bacteriuria-prevalence and site of... in diabetesmellitus ...B. S. Ooi, B. T. M. Chen and M. Yu 497

Barbiturate poisoning in young epileptics-acute... B. W. Hancock 242

Bendrofluazide-Blood lipids and the treatment ofessential hypertension with methyldopa and. . .

L. J. Libman, D. E. Arrowsmith, T. L. Dormandy,Joanna Heal and B. I. Hoffbrand 671

Beta adrenergic blocking drugs in the treatment ofhypertension-a comparison of... T. O. Mor-gan, J. Sabto, S. N. Anavekar W. J. Louis andA. E. Doyle 253

Beta-Blocking-An evaluation of sotalol, a . . .

beta-blocking agent, in patients with angina pec-toris ... P. G. Gooding and E. Berman 734

Bile peritonitis-a report of fifteen patients . . . H.Ellis and H. M. Adair 713

Bicarbonate-successful resuscitation in diabeticketoacidosis: ... N. G. Soler, M. A. Bennett,M. G. Fitzgerald and J. M. Malins 465

Bile retention syndrome-pathology with referenceto... J. L. Emery 344

Bile salts and liver disease in childhood... N. B.Javitt 354

Bleeding-female genital self-mutilation as a causeof vaginal bleeding.. M. A. Simpson andB. H. Anstee 308

Blepharospasm-treatment of blepharospasm withlevodopa... N. K. Chakravorty 521

Blockade-pharmacological . . . G. E. Hale En-derby 572

Blood lead levels-Lead poisoning with low ... P.Torkington and K. K. Bhalla 240

Blood lipids and the treatment of essential hyper-tension with methyldopa and bendrofluazide... L. J. Libman, D. E. Arrowsmith, T. L. Dor-mandy, Joanna Heal and B. I. Hoffbrand 671

Blood pressure control during maintenance haemo-dialysis with isonatric (high sodium) dialysate... W. K. Stewart and L. W. Fleming 260

Body weight loss-the effects of intravenous pro-tein-calorie supplementation on the tissue com-position of postoperative body weight loss...E. A. Elebute 454

Botulism-Staphylococcal food poisoning and...R. J. Gilbert 603

Bran-Aetiology of duodenal ulcer: an investigationinto the buffering action and effect on pepsin of

. .. and unrefined carbohydrate foods ... FrankI. Tovey 675

Bronchial-gastro-bronchial fistula... A. J. B.Missen, J. Pemberton and A. Boon 504

Bowel-psychological characteristics of patientswith irritable bowel syndrome ... R. L. Palmer,E. Stonehill, A. H. Crisp, S. L. Waller and J. J.Misiewicz 416

Bronchial-Mites and house dust mite allergy in ...asthma in Northern Zambia ... D. J. Buchananand I. G. Jones 680

Buffering-Aetiology of duodenal ulcer: an investi-gation into the . . . action and effect on pepsin ofbran and unrefined carbohydrate foods...Frank I. Tovey 675

Calorie-the effect of intravenous protein-caloriesupplementation on the tissue composition ofpostoperative body weight loss . E. A.Elebute 454

Cancer pain-analgesics in...: results of aquestionnaire.. . D. S. Robbie and A. T.Mennie 150

Cadavers-Incidence of Meckel's diverticulum in100 ... M. S. Rojhan and R. Hejazi 694

Canal-Malignant mesothelioma invading thespinal... D. Cooper 718

Carbohydrate-Aetiology of duodenal ulcer: aninvestigation into the buffering action and effecton pepsin of bran and unrefined... foods...Frank I. Tovey 675

Cardiac-Oesophago-... fistula complicatingachalasia... R. W. Strong 41

Challenges-Bacterial ... in food ... J. G. Collee 636Cholecystectomy-Spontaneous ... J. C. Mc-Gregor and D. J. Sammon 655

Clinical trials . . . J. C. Garnham 114Coma-non-ketotic hyperglycaemic coma-death

following ... during diazoxide therapy and peri-toneal dialysis ... M. Lancaster-Smith, N. I.Leigh and H. H. Thompson 175

Carbon monoxide poisoning: recovery associatedwith a transient dyskinetic syndrome ... J. A.Sills, E. Vivori and L. Rosenbloom 519

Carcinoma of the oesophagus-surgical treatmentof... W. P. Cleland 229

Carcinoma of the oesophagus and fundus...D. A. W. Edwards 223

Carcinoma-the association between webs, ironand post-cricoid carcinoma ... M. Chisholm 215

Cardia-carcinoma of the oesophagus and cardia-endoscopy... W. Roesch 227

Cardia-pathophysiology of achalasia of the .J. J. Misiewicz 207

Cardiac conduction system in man-the effect ofVerapamil on the ... P. R. Roy, R. A. J. Spur-rell and E. Sowton 270

Cardiac involvement in idiopathic haemochroma-tosis and the effect of venesection ... S. J.Jachuck, G. S. Rai and C. Fossard 276

Index to Volume 50 v

Caucasians-complications of dietary deficiency ofVitamin B12 in young Caucasians ... M. H.Gleeson and P. S. Graves 462

Cell arteritis-giant . . . R. G. Turner, A. I. Ried-mann, J. Henry and D. G. James 265

Cerebral circulation ... J. E. Eckenhoff 566Cerebral-A case of primary ... venous throm-

bosis... D. S. K. Brookfield 767Childhood-an unusual case of farmer's lung in

childhood ... B. M. Amsari and S. H. Carter 306Childhood-bile salts and liver disease in ... N. B.

Javitt 354Childhood-Chronic liver disease associated withchildhood ulcerative colitis . P. J. Toghill, P.Benton and P. G. Smith 9

Childhood-clinical problems in hepatitis in. . :King's College Hospital experience 1970-1973... A. P. Mowat and R. Williams 324

Childhood-liver disease in...: principles ofmanagement... R. Williams 381

Childhood-viral infections of the liver in child-hood... A. J. Zuckerman 338

Children-treatment of chronic active hepatitis in... R. S. Dubois and A. Silverman 386

Cholecystitis-Acute emphysematous... A. Mc-Kibbin and T. G. Parks 50

Cholesterol-serum . . . and serum triglycerides inmental retardation ... T. Lawlor, F. O'Haraand D. T. Birtwistle 140

Choloxin-Study of the lipid-lowering action of... and Nilevar in patients with chronic renalfailure... E. N. Wardle, W. Schardt and P. R.Uldall 737

Chronic liver disease associated with childhoodulcerative colitis . . . P. J. Toghill, P. Benton andP. G. Smith 9

Chronic-A study of the pharmacokinetics of clin-damycin in normal subjects and patients with... renal failure ... J. B. Eastwood and P. E.Gower 710

Chronic-Pericarditis during ... haemodialysistherapy... A. G. Mitchell 741

Chronic-Treatment of active ... hepatitis withcyclophosphamide... R. Naccarato, R. Farini,M. Chiaramonte, U. Fagiolo and G. C. Sturniolo 16

Circulation-cerebral ... J. E. Eckenhoff 566Circulation-pulmonary-and ventilation ... J. M.

Leigh 562Clindamycin-A study of the pharmacokinetics of

... in normal subjects and patients with chronicrenal failure .. . J. B. Eastwood and P. E. Gower 710

Clinical pharmacological studies with indoramin,with observations on its therapeutic usefulness,Some... C. de B. White, R. B. Royds and P.Turner 729

Clinical pharmacologist-the ... P. Turner 93Clinical-Comparative ... trial of diazepam with

other conventional drugs in tetanus ... NaliniT. Vassa, H. V. Doshi, V. H. Yajnik, S. S. Shah,K. R. Joshi and S. H. Patel 755

Clinical problems in hepatitis in childhood: King'sCollege Hospital experience 1970-1973 ... A. P.Mowat and R. Williams 324

Clostridium welchii and Bacillus cereus infectionand intoxication ... B. C. Hobbs 597

Coeliac disease and autoimmunity... M. J.Lancaster-Smith, J. Perrin, E. T. Swarbrick andJ. T. Wright 45

Colitis-Chronic liver disease associated withchildhood ulcerative colitis.... P. J. Toghill, P.Benton and P. G. Smith 9

Colon-The high fibre diet in the treatment of di-verticular disease of the ... N. S. Painter 629

Coma following treatment of very severe arterialhypertension, with improvement after dexa-methasone therapy... L. J. Farrow and J. B.Wood 517

Combination products ... B. W. Cromie 103Comparative clinical trial of diazepam with other

conventional drugs in tetanus ... Nalini T.Vassa, H. V. Doshi, V. H. Yajnik, S. S. Shah,K. R. Joshi and S. H. Patel 755

Contaminants-Food... G. Kazantzis 625Contraceptive pill-oral-megaloblastic anaemia

associated with the ... M. M. Meguid and W. Y.Loebl 470

Cortical necrosis-renal-survival in ... due tosnake bite... S. Ramachandran and M. V. F.Perera 314

Co-trimoxazole therapy-transient erythroid hypo-plasia in a patient on long-term... M. E. M.Stephens 235

Cricoid-the association between webs, iron andpost-cricoid carcinoma ... M. Chisholm 215

Cutaneous ureterostomies in adults-experienceswith... W. M. Lien 155

Cyanide poisoning-the use of dicobalt edetate(Kelocyanor)... B. Hillman, K. D. Bardhanand J. T. B. Bain 171

Cyclophosphamide-Treatment of active chronichepatitis with cyclophosphamide... R. Nac-carato, R. Farini, M. Charamonte, U. Fagioloand G. C. Sturniolo 16

Cyst-Solitary... of the liver presenting as anabdominal emergency ... S. C. Sood and A.Watson 48

Death-Antepartum diagnosis of vasa praevia-report of a case causing sudden foetal ... C. S.Pallewela 723

Deficiency-dietary-complications of... of vita-min B12 in young Caucasians ... M. H. Gleesonand P. S. Graves 462

Deficiency-neonatal hepatitis and alpha-1-trypsindeficiency: an epidemiological study in South-East England ... K. Cottrall, P. J. L. Cook andA. P. Mowat 376

Department of Health ... G. Cornah 77Dermatitis-Gonococcaemia with arthritis ... and

myocarditis... H. S. Fraser, A. L. Liburd, J. P.Figueroa, G. A. Nicholson, O. B. O'L. James,F. Whitbourne and G. A. O. Alleyne 759

vi Postgraduate Medical Journal

Dexamethasone therapy-coma following treat-ment of very severe arterial hypertension, withimprovement after dexamethasone therapy...L. J. Farrow and J. B. Wood 517

Diabetes-epidemiological and virological observa-tions on juvenile diabetes . . . D. R. Gamble 538

Diabetes insipidus and marked elevation of foetalhaemoglobin in a case of acute leukemia...W. J. K. Cumming and A. S. D. Spiers 468

Diabetes mellitus-post-mortem histology of theislets of langerhans in ... I. Doniach 544

Diabetes mellitus-prevalence and site of bacteriuriain diabetes mellitus ... B. S. Ooi, B. T. M. Chenand M. Yu 497

Diabetes-viruses in experimental and humandiabetes ... K. W. Taylor 546

Diabetic-anti-diabetic drugs . . . D. G. Galton 112Diabetic ketoacidosis-successful resuscitation in

... : a strong case for the use of bicarbonate ...N. G. Soler, M. A. Bennett, M. G. Fitzgeraldand J. M. Malins 465

Diabetes mellitus in Rhodesia: a comparative study... A. C. B. Wicks and J. J. Jones 659

Diabetic population-glucose tolerance and the... J. M. Malins 529

Diabetic-Triamcinolone-augmented glucose toler-ance in non-diabetic patients with chronic pan-creatitis .. B. I. Joffe, W. P. U. Jackson andS. Bank 25

Diagnosis-Antepartum ... of vasa praevia-re-port of a case causing sudden foetal death...C. S. Pallewela 723

Diagnosis of pulmonary embolism, The ...S.Talbot and P. D. Griffiths 675

Dialysate-blood pressure control during main-tenance haemodialysis with isonatric (highsodium) dialysate... W. K. Stewart and L. W.Fleming 260

Dialysis bath fluid-the use of... as a vehicle fora drug with a narrow therapeutic index-Lithiumchloride ... H. F. Oakeley, W. F. Clarke and V.Parsons 511

Dialysis-peritoneal-death following non-ketotichyperglycaemic coma during diazoxide therapyand... M. Lancaster-Smith, N. I. Leigh andH. H. Thompson 175

Diazepam-Comparative clinical trial of... withother conventional drugs in tetanus ... NaliniT. Vassa, H. V. Doshi, V. H. Yajnik, S. S. Shah,K. R. Joshi and S. H. Patel 755

Diazoxide therapy-death following non-ketotichyperglycaemic coma during . . . and peritonealdialysis . . . M. Lancaster-Smith, N. I. Leigh andH. H. Thompson 175

Dicobalt edetate (Kelocyanor)-the use of... incyanide poisoning ... B Hillman, K. D. Bard-han and J. T. B. Bain 171

Dieska-Professor Dieska-an appreciation 483Diet-The high fibre... in the treatment of di-

verticular disease of the colon ... N. S. Painter 629Dietary deficiency of vitamin B12 in young Cauca-

sians ... M. H. Gleeson and P. S. Graves 462Digoxin affair-the ... T. R. D. Shaw 98

Dilutional hyponatremia-the syndrome of...D. P. Misra 309

Disease-Coeliac ... and autoimmunity... M. J.Lancaster-Smith, J. Perrin, E. T. Swarbrick andJ. T. Wright 45

Disease-Use of the 198 Au liver scan in assessingthe therapeutic effect of penicillamine in Wilson's... T. Chajek 56

Disease-The high fibre diet in the treatment ofdiverticular ... of the colon ... N. S. Painter 629

Diverticular-The high fibre diet in the treatmentof ... disease of the colon ... N. S. Painter 629

Diverticulum-Incidence of Meckel's... in 100cadavers ... M. S. Rojhan and R. Hejazi 694

Doctors-How ... prescribe and why ... G. Teel-ing-Smith 65

Doppler ultrasound-trial of a single low dose ofheparin in the prevention of post-operative deep-vein thrombosis monitored by doppler ultra-sound . . . T. Bates 135

Drug-The use of dialysis bath fluid as a vehicle fora drug with a narrow therapeutic index-Lithiumchloride ... H. F. Oakeley, W. F. Clarke and V.Parsons 511

Drugs-a comparison of beta adrenergic blockingdrugs in the treatment of hypertension ... T. O.Morgan, J. Sabto, S. N. Anavekar, W. J. Louisand A. E. Doyle 253

Drugs-anti-diabetic drugs . . . D. G. Galton 112Drugs-anti-rheumatic drugs . . . H. L. F. Currey 109Drugs-Comparative clinical trial of diazepam

with other conventional... in tetanus ... NaliniT. Vassa, H. V. Doshi, V. H. Yajnik, S. S. Shah,K. R. Joshi and S. H. Patel 755

Drugs for rare diseases . . . W. H. Lyle 107Drugs for the treatment of hypercalcaemia...

C. R. Paterson 158Duodenal-Aetiology of... ulcer: an investiga-

tion into the buffering action and effect on pepsinof bran and unrefined carbohydrate foods...Frank I. Tovey 675

Duodenum-retroperitoneal rupture of the ... dueto blunt trauma ... J. C. M. Strachan 180

Dust-Mites and house ... mite allergy in bron-chial asthma in Northern Zambia ..D. J.Buchanan and I. G. Jones 680

Dyskinetic syndrome-carbon monoxide poison-ing: recovery associated with a transient dys-kinetic syndrome ... J. A. Wills, E. Vivori andL. Rosenbloom 519

Embolism-The diagnosis of pulmonary ... S.Talbot and P. D. Griffiths 675

Emergency-Solitary cyst of the liver presenting asan abdominal ... S. C. Sood and A. Watson 48

Emetic-fatal outcome from administration of asalt emetic . . . C. J. C. Roberts and M. J.Noakes 513

Emphysematous-Acute . . . cholecystitis . . . A.McKibbin and T. G. Parks 50

Index to Volume 50 vii

Encephalopathy-eosinophilic leukemia terminat-ing with an ... G. M. Yuill, R. G. Lascelles andC. Scholtz 473

Endocarditis-bacterial-the use of anticoagulantsin... J. A. Kanis 312

Endocarditis-staphylococcal-double valve re-placement after ... C. C. Smith and A. P.Ball 299

Endoscopy-carcinoma of the oesophagus andcardia... W. Roesch 227

Endoscopy-gastro-oesophageal reflux and hiatushernia... W. Roesch 199

Endoscopy in achalasia ... W. Roesch 211Eosinophilic leukemia terminating with an en-cephalopathy... G. M. Yuill, R. G. Lascellesand C. Scholtz 473

Epidemiological and virological observations onjuvenile diabetes ... D. R. Gamble 538

Epidemiological study in South-East England: neo-natal hepatitis and alpha-1-trypsin deficiency ...K. Cottrall, P. J. L. Cook and A. P. Mowat 376

Epileptics-acute barbiturate poisoning in young..W.. . Hancock 242

Ergotamine-induced venous thrombosis... U.Mintz, S. Bar-Meir and A. de Vries 244

Erythroid hypoplasia-transient-in a patient onlong-term co-trimoxazole therapy ... M. E. M.Stephens 235

Escherichia coli-Rifampicin therapy in ... gastro-enteritis ... Yehezkel Naveh and AbrahamFriedman 707

Essential hypertension-Blood lipids and the treat-ment of ... with methyldopa and bendrofluazide... L. J. Libman, D. E. Arrowsmith, T. L. Dor-mandy, Joanna Heal and B. I. Hoffbrand 671

Ethanol poisoning-acute-treated by haemo-dialysis ... R. W. Elliott and P. R. Hunter 515

Europe... H. S. Grainger 73Evaluation of sotalol, a beta-blocking agent, in

patients with angina pectoris, An ... P. G.Gooding and E. Berman 734

Failure-A study of the pharmacokinetics of clin-damycin in normal subjects and patients withchronic renal ... J. B. Eastwood and P. E.Gower 710

Familial-Possible genetic influences in ... sarcoi-dosis ... D. Geraint James, E. Neville, K. H. G.Piyasena, A. N. Walker and A. N. Hamlyn 664

Familial spontaneous pneumothorax . J. C.Delaney, A. Gale and B. A. Walker 648

Farmer's lung in childhood-an unusual case of... B. M. Ansari and S. H. Carter 306

Fatalities-road traffic accident fatalities (review of142 post mortem reports) ... B. A. Kamdar andG. P. Arden 131

Fatty acid-abnormal fatty acid composition andhuman atherosclerosis ... K J. Kingsbury, C.Brett, R. Stovold, A. Chapman, J. Anderson andD. M. Morgan 425

Female genital self-mutilation as a cause of vaginalbleeding ... M. A. Simpson and B. H. Anstee 308

Femoral hernia-malignant mucocele of the appen-dix in a ... I. M. Nayak 246

Fibre-The high ... diet in the treatment of di-verticular disease of the colon ... N. S. Painter 629

Fistula-gastro-bronchial ... A. J. B. Missen, J.Pemberton and A. Boon 504

Fistula-Oesophago-cardiac ... complicating ach-alasia... R. W. Strong 41

Foetal-Antepartum diagnosis of vasa praevia-report of a case causing sudden... death...C. S. Pallewela 723

Foetal haemoglobin... diabetes insipidus andmarked elevation of... in a case of acute leu-kaemia ... W. J. K. Cumming and A. S. D.Spiers 468

Food additives ... Michael Spencer 620Food-Bacterial challenges in ... J. G. Collee 636Food contaminants ... G. Kazantzis 625Food poisoning-Staphylococcal ... and botulism

... R. J. Gilbert 603Foods-Aetiology of duodenal ulcer: an investiga-

tion into the buffering action and effect on pepsinof bran and unrefined carbohydrate... FrankI. Tovey 675

Foods-The production of safe... A. C. Baird-Parker 644

Formulation-prescribing and the regulation of ...A. H. Beckett 125

Gastro-bronchial fistula ... A. J. B. Missen, J.Pemberton and A. Boon 504

Gastroenteritis-Rifampicin therapy in Escherichiacoli... Yehezkel Naveh and Abraham Fried-man 707

Gastro-oesophageal reflux and hiatus hernia-endoscopy... W. Roesch 199

General hospital-the incidence of the shock syn-drome in a general hospital ... I. McA. Leding-ham, W. D. Fisher, C. S. McArdle and M.Maddern 420

General practitioner ... T. L. Venables 88Genetic aspects of the Pi system ... P. J. L. Cook 362Genetic-Possible . . . influences in familial sarcoi-

dosis ... D. Geraint James, E. Neville, K. H. G.Piyasena, A. N. Walker and A. N. Hamlyn 664

Genital self-mutilation-female-as a cause ofvaginal bleeding... M. A. Simpson and B. H.Anstee 308

Glucose tolerance and the diabetic population ...J. M. Malins 529

Glucose-Triamcinolone-augmented glucose toler-ance in non-diabetic patients with chronic pan-creatitis ... B. I. Joffe, W. P. U. Jackson and S.Bank 25

Gonococcaemia with arthritis, dermatitis and myo-carditis... H. S. Fraser, A. L. Liburd, J. P.Figueroa, G. A. Nicholson, O. B. O'L. James,F. Whitbourne and G. A. O. Alleyne 759

viii Postgraduate Medical Journal

Graft-the treatment of malignant ventriculartachycardia by aorto-coronary saphenous veinbypass graft ... H. Ikram, A. R. Makey, R. M.Jeffery, E. R. J. Emery, R. A. Parkins and D. L.Stone 177

Haematuria of unknown origin ... Patrick H.O'Reilly 746

Haemochromatosis-idiopathic-cardiac involve-ment in ... and the effect of venesection . . . S. J.Jachuck, G. A. Rai and C. Fossard 276

Haemodialysis-acute ethanol poisoning treated byhaemodialysis... R. W. Elliott and P. R.Hunter 515

Haemodialysis-blood pressure control duringmaintenance haemodialysis with isonatric (highsodium) dialysate ... W. K Stewart and L. W.Fleming 260

Haemodialysis-Pericarditis during chronic...therapy... A. G. Mitchell 741

Haemodialysis-treatment of pulmonary tuber-culosis in a patient on maintenance ... F. W.Smith, G. R. D. Catto and M. Macleod 478

Haemoglobin-diabetes insipidus and markedelevation of foetal haemoglobin in a case of acuteleukaemia .. W. J. K Cummings and A. S. D.Spiers 468

Haemolytic-Purpura fulminans with .. anaemia... N. A. Nagi and A. R. A. Al-Hasso 750

Haemorrhage-Retroperitoneal ... and neuro-pathy complicating anticoagulant therapy...P. V. Curry and P. A. Bacon 37

Haemorrhage-Subarachnoid ... in pseudoxan-thoma elasticum ... N. G. K. Sharma, S. KGhosh, P. C. Beohar and P. S. Gupta 774

Hazards-Microbiological and other . .. from sea-foods with special reference to Vibrio para-haemolyticus... G. I. Barrow 612

Health-Department of ... G. Cornah 77Heparin-trial of a single low dose of heparin in the

prevention of post-operative deep-vein throm-bosis monitored by doppler ultra-sound ... T.Bates 135

Hepatitis-controlled trials of immunosuppressivetherapy in hepatitis . . .R. B. Stern and R.Williams 392

Hepatitis in childhood-clinical problems in-King's College Hospital experience 1970-1973A. P. Mowat and R. Williams 324

Hepatitis in children-treatment of chronic activehepatitis in children . R. S. Dubois and A.Silverman 386

Hepatatis-neonatal hepatitis and alpha-1-trypsindeficiency: an epidemiological study in South-East England ... K Cottrall, P. J. L. Cook andA. P. Mowat 376

Hepatitis-the role of immunological mechanismsin acute and chronic hepatitis . . .A. L. W. F.Eddleston 348

Hepatitis B antigen in the newborn period-acqui-sition of ... Y. E. Cossart 334

Hepatitis B antigen-viral hepatitis and .. . :recentadvances... S. Krugman 327

Hepatitis-Treatment of active chronic hepatitiswith cyclophosphamide... R. Naccarato, R.arini, M. Charamonte, U. Fagiolo and G. C.Sturniolo 16

Hepatitis-viral-and hepatitis B antigen: recentadvances . . . S. Krugman 327

Hernia-gastro-oesophageal reflux and hiatushernia-endoscopy... W. Roesch 199

Hernia-hiatus hernia reflux syndrome...D. A. W. Edwards 189

Hernia-hiatus-the medical management of...Sir Francis Avery-Jones 203

Hernia-malignant mucocele of the appendix in afemoral hernia... I. M. Nayak 246

Heroin-Lumbar plexitis and rhabdomyolysis fol-lowing abuse of... R. J. Greenwood 772

Hiatus hernia reflux syndrome ... D. A. W.Edwards 189

Hiatus hernia-the medical management of... SirFrancis Avery-Jones 203

High fibre diet in the treatment of diverticulardisease of the colon, The . . . N. S. Painter 629

Histology-post-mortem-of the islets of Langer-hans in juvenile diabetes mellitus ... I. Doniach 544

Hospital pharmacist... J. A. Baker 83House dust-Mites and ... mite allergy in bron-

chial asthma in Northern Zambia . . . D. J.Buchanan and I. G. Jones 680

Hydrarthrosis-Periodic synoviosis (intermittent... ) with observations and studies on a patient... Hobart A. Reimann 33

Hyperamylasaemia-Lactic acidosis and ... asso-ciated with phenformin therapy.. . D. N.Williams, A. H. Knight and D. M. Goldberg 765

Hypertension-Blood lipids and the treatment ofessential... with methyldopa and bendroflu-azide... L. J. Libman, D. E. Arrowsmith, T. L.Dormandy, Joanna Heal and B. I. Hoffbrand 671

Hypertension-coma following treatment of verysevere arterial hypertension, with improvementafter dexamethasone therapy . . . L. J. Farrowand J. B. Wood 517

Hypertension-value of routine intravenous pyelo-graphy in the investigation of hypertension...M. J. Fairman, J. E. Harpur and M. Hamilton 508

Hypotensive agent-the use of sodium nitroprus-side as a ... in plastic surgery ... J. B. Hester 582

Human atherosclerosis-abnormal fatty acid com-position and... K. J. Kingsbury, C. Brett, R.Stovold, A. Chapman, J. Anderson and D. M.Morgan 425

Hyperglycaemic coma-death following non-ketotic... during diazoxide therapy and peritoneal di-alysis... M. Lancaster-Smith, N. I. Leigh andH. H Thompson 175

Hypercalcaemia-drugs for the treatment of...C. R. Paterson 158

Hypertension-a comparison of beta adrenergicblocking drugs in the treatment of... T. O.Morgan, J. Sabto, S. N. Anavekar, W. J. Louisand A. E. Doyle 253

Index to Volume 50 ix

Hypogammaglobulinaemia primary acquired-and autoimmune thyroiditis... A. M. Hiltonand L. Doyle 303

Hyponatremia-dilutional-the syndrome of...D. P. Misra 309

Hypoplasia-transient erythroid hypoplasia in apatient on long-term co-trimoxazole therapy ...M. E. M. Stephens 235

Idiopathic haemochromatosis-cardiac involve-ment in ... and the effect of venesection ...

S. J. Jachuck, G. S. Rai and C. Fossard 276Immunological mechanisms-the role of... in

acute and chronic hepatitis ... A. L. W. F.Eddleston 348

Immunosuppressive therapy in hepatitis-controlledtrials of ... R. B. Stern and R. Williams 392

Incidence of Meckel's diverticulum in 100 cadavers... M. S. Rojhan and R. Hejazi 694

Incompetence-Traumatic aortic ... followingroad traffic accident . . . J. B. Irving 725

Indoramin-Some clinical pharmacological studieswith ... with observations on its therapeutic use-fulness ... C. de B. White, R. B. Royds and P.Turner 729

Infantile nephrotic syndrome ... N. A. Nagi andL. Nouri 237

Infection-Clostridium welchii and Bacillus cereus. . and intoxication ... B. C. Hobbs 597

Infections of the liver-viral-in childhood...A. J. Zuckerman 338

Infectious diseases-annual review of significantpublications... H. A. Reimann 485

Influences-Possible genetic... in familial sar-coidosis... D. Geraint James, E. Neville,K. H. G. Piyasena, A. N. Walker and A. N.Hamlyn 664

Intermittent-Periodic synoviosis ( ... hydrarthro-sis) with observations and studies on a patient... Hobart A. Reimann 33

Internal fixation: spinal excision osteotomy inmyelomeningocele: with special reference to ...G. Walker and P. Cheong-Leen 145

Intoxication-Clostridium welchii and Bacilluscereus infection and ... B. C. Hobbs 597

Intravenous pyelography-value of routine... inthe investigation of hypertension ... M. J.Fairman, J. E. Harpur and M. Hamilton 508

Introduction (Deliberate hypotension) ... G. E.Hale Enderby 555

Introduction (Hepatitis in Childhood) ... C. E.Stroud 323

Intussusception-Villous papilloma of the appen-dix associated with mucocoele and ... A. J.Darby and A. Doctor 650

Investigation-Aetiology of duodenal ulcer: an ...into the buffering action and effect on pepsin ofbran and unrefined carbohydrate foods...Frank I. Tovey 675

Iron-Oral... tolerance... A. B. S. Mitchell 702

Iron-the association between webs, iron and post-cricoid carcinoma ... M. Chisholm 215

Irritable bowel syndrome-psychological charac-teristics of patients with . . .R. L. Palmer, E.Stonehill, A. H. Crisp, S. L. Waller and J. J.Misiewicz 416

Islets of Langerhans in juvenile diabetes mellitus-post-mortem histology of the ... I. Doniach 544

Juvenile diabetes-epidemiological and virologicalobservations on ... D. R. Gamble 538

Juvenile diabetes mellitus-post-mortem histologyof the islets of Langerhans in ... I. Doniach 544

Kelocyanor (dicobalt edetate)-the use of... incyanide poisoning... B. Hillman, K. D. Bard-han and J. T. B. Bain 171

Ketoacidosis-successful resuscitation in diabetic.. : a strong case for the use of bicarbonate ...N. G. Soler, M. A. Bennett, M. G. Fitzgerald andJ. M. Malins 465

King's College Hospital experience 1970-1973:clinical problems in hepatitis in childhood 324

Lactic acidosis and hyperamylasaemia associatedwith phenformin therapy ... D. N. Williams,A. H. Knight and D. M. Goldberg 765

Langerhans-post-mortem histology of the islets ofLangerhans in juvenile diabetes mellitus... I.Doniach 544

Lead levels-lead poisoning with low blood ... P.Torkington and K. K. Bhalla 240

Lead poisoning with low blood lead levels ... P.Torkington and K. K. Bhalla 240

Leukaemia-diabetes insipidus and marked eleva-tion of foetal haemoglobin in a case of acute leu-kaemia ... W. J. K. Cumming and A. S. D.Spiers 468

Leukaemia-eosinophilic-terminating with an en-cephalopathy... G. M. Yuill, R. G. Lascellesand C. Scholtz 473

Levodopa-treatment of blepharospasm with levo-dopa... N. K. Chakravorty 521

Lipids-Blood . . . and the treatment of essentialhypertension with methyldopa and bendroflu-azide... L. J. Libman, D. E. Arrowsmith, T. L.Dormandy, Joanna Heal and B. I. Hoffbrand 671

Lipid-lowering-Study of the ... action of chol-oxin and Nilevar in patients with chronic renalfailure... E. N. Wardle, W. Schardt and P. R.Uldall 737

Lipomatous pseudohypertrophy of the pancreasassociated with chronic pulmonary suppurationin an adult ... D. I. M. Siegler 53

x Postgraduate Medical Journal

Lithium chloride-the use of dialysis bath fluidas a vehicle for a drug with a narrow thera-peutic index ... H. F. Oakeley, W. F. Clarke andV. Parsons 511

Liver disease-bile salts and... in childhood ...N. B. Javitt 354

Liver disease-Chronic liver disease associated withchildhood ulcerative colitis ... P. J. Toghill, P.Benton and P. G. Smith 9

Liver disease in childhood: principles of manage-ment . . . R. Williams 381

Liver disease-pathology and pathogenesis of...in alpha-1-trypsin deficient individuals... 0.Aagenaes, M. Fagethol, K. Elgio, E. Munthe andT. Hovig 365

Liver disease-organisation of controlled trials inpaediatric liver disease... 0. P. Gray 396

Liver-Solitary cyst of the ... presenting as an ab-dominal emergency... S. C. Sood and A.Watson 48

Liver-Radiological changes in left lobe liverabscesses . . . S. Ramachandran 685

Liver-Use of the 198 Au liver scan in assessing thetherapeutic effect of penicillamine in Wilson'sdisease ... T. Chajek 56

Liver-viral infections of the liver in childhood ...A. J. Zuckerman 338

Lobe-Radiological changes in left ... amoebicliver abscesses . .. S. Ramachandran 685

Lumbar plexitis and rhabdomyolysis followingabuse of heroin . . . R. J. Greenwood 772

Lung-an unusual case of farmer's lung in child-hood ... B. M. Ansari and S. H. Carter 306

Lupus erythematosis-Parkinsonism and transientbilateral ptosis in systemic ... P. C. Teoh, A. T.Richard and P. K. Wong 163

Malignant mesothelioma invading the spinal canal. . D. Cooper 718

Malignant mucocele of the appendix in a femoralhernia... I. M. Nayak 246

Malignant ventricular tachycardia-the treatmentof ... by aorto-coronary saphenous vein bypassgraft... H. Ikram, A. R. Makey, R. M. Jeffery,R. A. Parkins and D. L. Stone 177

Mechanisms-immunological-the role of in acuteand chronic hepatitis ... A. L. W. F. Eddleston 348

Meckel's-Incidence of... diverticulum in 100cadavers ... M. S. Rojhan and R. Hejazi 694

Medical research-Whither virology? Trends andprospects in medical research ... Sir CharlesStuart-Harris 1

Megaloblastic anaemia associated with the oralcontraceptive pill ... M. M. Meguid and W. Y.Loebl 470

Mental retardation-serum cholesterol and serumtriglycerides in ... T. Lawlor, F. O'Hara andD. T. Birtwistle 140

Mesothelioma-Malignant ... invading the spinalcanal... D. Cooper 718

Methyldopa-Blood lipids and the treatment ofessential hypertension with. . . and bendro-fluazide... L. J. Libman, D. E. Arrowsmith,T. L. Dormandy, Joanna Heal and B. I. Hoff-brand 671

Microbiological and other hazards from seafoodswith special reference to Vibrio parahaemolyticus... G. I. Barrow 612

Middle age-Survival rate at . . . in developingand western populations ... Alexander R. P. 29Walker

Mite-Mites and house dust . . . allergy in bron-chial asthma in Northern Zambia ... D. J.Buchanan and I. G. Jones 680

Mites and house dust mite allergy in bronchialasthma in Northern Zambia .. D. J. Buchananand I. G. Jones 680

Mouth-to-mouth-Rupture of the stomach follow-ing... respiration ... M. Solowiejczyk, E.Koren, S. Wapnick and J. Mandelbaum 769

Mucocele-malignant-of the appendix in a fem-oral hernia... I. M. Nayak 246

Mucocoele-Villous papilloma of the appendixassociated with ... and intussusception . . . A. J.Darby and A. Doctor 650

Myelomeningocele-spinal excision oesteotomy in. : with special reference to internal fixation

... G. Walker and P. Cheong-Leen 145Myocarditis-Gonococcaemia with arthritis, der-

matitis and myocarditis ... H. S. Fraser, A. L.Liburd, J. P. Figueroa, G. A. Nicholson, O. B.O'L. James, F. Whitbourne and G. A. O.Alleyne 759

Myocardium-verapamil and the... W. G. Nay-ler and D. Krikler 441

Necrosis-renal cortical-survival in-due tosnake bite... S. Ramachandran and M. V. F.Perera 314

Neonatal hepatitis and alpha-1-trypsin deficiency:an epidemiological study in South-East Eng-land . . .K. Cottrall, P. J. L. Cook and A. P.Mowat 376

Nephrotic syndrome-infantile ... N. A. Nagi andL. Nouri 237

Neuropathy-Retroperitoneal haemorrhage and... complicating anticoagulant therapy ... P. V.Curry and P. A. Bacon 37

Newborn-acquisition of hepatitis B antigen in thenewborn period ... Y. E. Cossart 334

Nilevar-Study of the lipid-lowering action of chol-oxin and... in patients with chronic renalfailure... E. N. Wardle, W. Schardt and P. R.Uldall 737

Northern Zambia-Mites and house dust mite al-lergy in bronchial asthma in ... D. J. Buchananand I. G. Jones 680

Nortriptyline-plasma concentration of... as aguide to treatment . . . W. H. Lyle et al. 282

Nurse-the . . . J. Stevenson 91

Index to Volume 50 xi

Observations-Periodic synoviosis (intermittenthydrarthrosis) with ... and studies on a patient. .. Hobart A. Reimann 33

Observations-Some clinical pharmacologicalstudies with indoramin, with .. .on its thera-peutic usefulness ... C. de B. White, R. B.Royds and P. Turner 729

Oesophago-cardiac fistula complicating achalasia... R. W. Strong 41

Oesophageal-gastro-oesophageal reflux and hiatushernia . .. W. Roesch 199

Oesophageal sphincter-clinical pharmacology andtherapeutics of the oesophagus and the lower ...J. J. Misiewicz 194

Oesophagus-clinical pharmacology and thera-peutics of the oesophagus and the lower oeso-phageal sphincter . . . J. J. Misiewicz 194

Oesophagus-surgical treatment of carcinoma ofthe... W. P. Cleland 229

Oesophagus and cardia-carcinoma of the...endoscopy... W. Roesch 227

Oral contraceptive pill-megaloblastic anaemia as-sociated with the .. . M. M. Meguid and W. Y.Loebl 470

Oral iron tolerance . . . A. B. S. Mitchell 702Osteotomy-spinal excision... in myelomeningo-

cele: with special reference to internal fixation... G. Walker and P. Cheong-Leen 145

Oxymetholone in aplastic anaemia... M. A. Mirand I. W. Delamore 166

Paediatric liver disease-organisation of controlledtrials in ... O. P. Gray 396

Pain-analgesics in cancer ... : results of a ques-tionnaire ... D. S. Robbie and A. T. Mennie 150

Pancreas-Lipomatous pseudohypertrophy of the... associated with chronic pulmonary sup-puration in an adult ... D. I. M. Siegler 53

Pancreatitis-Triamcinolone-augmented glucosetolerance in non-diabetic patients with chronicpancreatitis ... B. I. Joffe, W. P. U. Jackson andS. Bank 25

Papilloma-Villous ... of the appendix associatedwith mucocoele and intussusception... A. J.Darby and A. Doctor 650

Parkinson and transient bilateral ptosis in systemiclupus erythematosus... P. C. Teoh, A. T.Richard and P. K. Wong 163

Parkinsonism-penile ... M. P. Osborne 523Paroxysmal supraventricular tachycardia-vera-

pamil in the treatment of... D. M. Krikler andR. A. J. Spurrell 447

Pathology and pathogenesis of liver disease inalpha-1-trypsin deficient individuals... 0.Aagebaes, M. Fagerhol, K. Elgjo, E. Muntheand T. Hovig 365

Pathology with reference to the bile retention syn-drome... J. L. Emery 344

Pathophysiology of achalasia of the cardia ... J. J.Misiewicz 207

Penicillamine-Use of the 198 Au liver scan inassessing the therapeutic effect of penicillaminein Wilson's disease ... T. Chajek 56

Penile Parkinsonism ... M. P. Osborne 523Pepsin-Aetiology of duodenal ulcer: and investi-

gation into the buffering action and effect on ...of bran and unrefined carbohydrate foods...Frank I. Tovey 675

Pericarditis during chronic haemodialysis therapyA. G. Mitchell 741

Periodic synoviosis (intermittent hydrarthrosis)with observations and studies on a patient...Hobart A. Reimann 33

Peritoneal dialysis-death following non-ketotichyperglycaemic coma during diazoxide therapyand... M. Lanacster-Smith, N. I. Leigh andH. H. Thompson 175

Peritonitis-Bile. . . -a report of fifteen patients... H. Ellis and H. M. Adair 713

Pernicious anaemia-Amoxycillin: pharmacokin-etic studies in normal subjects, patients with per-nicious anaemia and those with renal failure ...D. H. Lawson, A. K Henderson and R. R. Mc-Geachy 500

Pharmaceutical company ... R. G. Hoare 85Pharmacist-the hospital . . . J. A. Baker 83Pharmacist-the retail . . . G. R. Haberfield 81Pharmacokinetic studies in normal subjects, pa-

tients with pernicous anaemia and those withrenal failure-Amoxycillin ... D. H. Lawson,A. K Henderson and R. R. McGeachy 500

Pharmacokinetics-A study of the... of clinda-mycin in normal subjects and patients withchronic renal failure ... J. B. Eastwood andP. E. Gower 710

Pharmacological blockade ... G. E. Hale Enderby 572Pharmacological-Some clinical . . studies with

indoramin, with observations on its therapeuticusefulness ... C. de B. White, R. B. Royds andP. Turner 729

Pharmacologist-the clinical ... P. Turner 93Pharmacology-clinical-and therapeutics of the

oesophagus and the lower oesophageal sphincter... J. J. Misiewicz 194

Pharmacology of vascular control ... R. G. Shanks 560Phenformin-Lactic acidosis and hyperamyla-

saemia associated with ... therapy ... D. N.Williams, A. H. Knight and D. M. Goldberg 765

Pill-megaloblastic anaemia associated with theoral contraceptive pill ... M. M. Meguid andW. Y. Loebl 470

Pi system-genetic aspects of... P. J. L. Cook 362Plasma concentration of nortriptyline as a guide to

treatment ... W. H. Lyle and co-authors 282Plastic surgery-the use of sodium nitroprusside as

a hypotensive agent in plastic surgery ... J. B.Hester 582

Plexitis-Lumbar... and rhabdomyolysis follow-ing abuse of heroin ... R. J. Greenwood 772

Pneumothorax-Familial spontaneous ... J. C.Delaney, A. Gale and B. A. Walker 648

Poisoning-acute barbiturate poisoning in youngepileptics... B. W. Hancock 242

xii Postgraduate Medical Journal

Poisoning-acute ethanol poisoning treated byhaemodialysis ... R. W. Elliott and P. R.Hunter 515

Poisoning-carbon monoxide poisoning: recoveryassociated with a transient dyskinetic syndrome... J. A. Sills, E. Vivori and L. Rosenbloom 519

Poisoning-lead-with low blood lead levels...P. Torkington and K. K. Bhalla 240

Poisoning-Staphylococcal food... and botulism... R. J. Gilbert 603

Poisoning-the use of dicobalt edetate (Kelocya-nor) in cyanide poisoning ... B. Hillman, K. D.Bardhan and J. T. B. Bain 171

Populations-Survival rate at middle-age in de-veloping and Western ... Alexander R. P.Walker 29

Post-mortem histology of the islets of Langerhansin juvenile diabetes mellitus ... I. Doniach 544

Post-mortem reports . . . review of 142.. .-road traffic accident fatalities ... B. A. Kamdarand G. P. Arden 131

Postoperative body weight loss-the effects of in-travenous protein-calorie supplementation onthe tissue composition of postoperative bodyweight loss ... E. A. Elebute 454

Postoperative deep vein thrombosis-trial of asingle low dose of heparin in the prevention of...monitored by doppler ultrasound... T.Bates 135

Problem-Is this a world-wide... ?... C. C. B.Stevens 71

Prescribe-How doctors ... and why ... G. Teel-ing-Smith 65

Prescribe-how should we prescribe?... D. W.Vere 122

Prescribing and the regulation of formulation ...A. H. Beckett 125

Production of safe foods, The... A. C. Baird-Parker 644

Protein-the effects of intravenous protein-caloriesupplementation on the tissue composition ofpostoperative body weight loss . . . E. A.Elebute 454

Pseudohypertrophy-Lipomatous ... of the pan-creas associated with chronic pulonary suppura-tion in an adult ... D. I. M. Siegler 53

Pseudoxanthoma-Subarachnoid haemorrhage in... elasticum ... N. G. K. Sharma, S. K. Ghosh,P. C. Beohar and P. S. Gupta 774

Psychological characteristics of patients with theirritable bowel syndrome . .. R. L. Palmer, E.Stonehill, A. H. Crisp, S. L. Waller and J. J.Misiewicz 416

Ptosis-Parkinson and transient bilateral ptosis insystemic lupus erythematosis . . . P. C. Teoh,A. T. Richard and P. K. Wong 163

Pulmonary circulation and ventilation ... J. M.Leigh 562

Pulmonary-Lipomatous pseudohypertrophy ofthe pancreas associated with chronic . . sup-puration in an adult ... D. I. M. Siegler 53

Pulmonary-The diagnosis of ... embolism ...S. Talbot and P. D. Griffiths 675

Pulmonary tuberculosis in a patient on maintenancehaemodialysis... F. W. Smith, G. R. D. Cattoand M. Macleod 478

Purpura fulminans with haemolytic anaemia...N. A. Nagi and A. R. A. Al-Hasso 750

Pyelography-value of routine pyelography in theinvestigation of hypertension ... M. J. Fairman,J. E. Harpur and M. Hamilton 508

Radiological changes in left lobe amoebic liverabscesses... S. Ramachandran 689

Radiotherapy... A. M. Jelliffe 231Rare diseases-drugs for . . . W. H. Lyle 107Reflux-Gastro-oesophageal reflux and hiatus her-nia-endoscopy... W. Roesch 199

Reflux syndrome-hiatus hernia ... D. A. W.Edwards 189

Renal cortical necrosis-survival in-due to snakebite ... S. Ramachandran and M. V. F. Perera 314

Renal failure: Amoxycillin :pharmacokinetic studiesin normal subjects, patients with pernicous anae-mia and those with renal failure ... D. H. Law-son, A. K. Henderson and R. R. McGeachy 500

Renal-A study of the pharmacokinetics of clinda-mycin in normal subjects and patients withchronic ... failure ... J. B. Eastwood and P. E.Gower 710

Renal failure-Study of the lipid-lowering action ofcholoxin and Nilevar in patients with chronic ...failure... E. N. Wardle, W. Schardt and P. R.Uldall 737

Respiration-Rupture of the stomach followingmouth-to-mouth... M. Solowiejczyk, E. Koren,S. Wapnick and J. Mandelbaum 769

Resuscitation-successful-in diabetic ketoaci-dosis: a strong case for the use of bicarbonate ...N. G. Soler, M. A. Bennett, M. G. Fitzgerald andJ. M. Malins 465

Retail pharmacist ... G. R. Haberfield 81Retardation-serum cholesterol and serum tri-

glycerides in mental ... T. Lawlor, F. O'Haraand D. T. Birtwistle 140

Retroperitoneal haemorrhage and neuropathy com-plicating anticoagulant therapy ... P. V. Curryand P. A. Bacon 37

Retroperitoneal rupture of the duodenum due toblunt trauma ... J. C. M. Strachan 180

Rhabdomyolysis-Lumbar plexitis and ... follow-ing abuse of heroin ... R. J. Greenwood 772

Rheumatic-antirheumatic drugs ... H. L. F.Currey 109

Rifampicin therapy in Escherichia coli gastro-enteritis... Yehezkel Naveh and AbrahamFriedman 707

Rhodesia-Diabetes mellitus in... : a compara-tive study ... A. C. B. Wicks and J. J. Jones 659

Rings-strictures, ... webs and spasms ...D. A. W. Edwards 213

Road traffic accident fatalities (review of 142 post-mortem reports) ... B. A. Kamdar and G. P.Arden 131

Index to Volume 50 xiii

Road-Traumatic aortic incompetence following... traffic accident ... J. B. Irving 725

Rupture of the duodenum-retroperitoneal-due toblunt trauma ... J. C. M. Strachan 180

Rupture of the stomach following mouth-to-mouthrespiration... M. Solowiejczyk, E. Koren, S.Wapnick and J. Mandelbaum 769

Safe foods-The production of... A. C. Baird-Parker 644

Salt emetic-fatal outcome from administration ofa ... C. J. C. Roberts and M. J. Noakes 513

Saphenous vein bypass graft-the treatment ofmalignant ventricular tachycardia by aorto-coronary... H. Ikram, A. R. Makey, R. M.Jeffery, E. R. J. Emery, R. A. Parkins and D. L.Stone 177

Sarcoidosis-Possible genetic influences in familial... D. Geraint James, E. Neville, K. H. G. Piya-sena, A. N. Walker and A. N. Hamlyn 664

Scan-Use of the 198 Au liver ... in assessing thetherapeutic effect of penicillamine in Wilson'sdisease... T. Chajek 56

Self-mutilation-female genital-as a cause ofvaginal bleeding... M. A. Simpson and B. H.Anstee 308

Septicaemic shock-Report of three cases: a re-view of diagnosis and management ...G. C.Hanson 288

Serum cholesterol and serum triglycerides in mentalretardation ... T. Lawlor, F. O'Hara and D. T.Birtwistle 140

Serum triglycerides and serum cholesterol in mentalretardation ... T. Lawlor, F. O'Hara and D. T.Birtwistle 140

Shock-septicaemic-Report of three cases: a re-view of diagnosis and management ...G. C.Hanson 288

Shock syndrome-the incidence of the shock syn-drome in a general hospital .. . I. McA. Leding-ham, W. D. Fisher, C. S. McArdle and M.Maddern 420

Sodium-blood pressure control during mainten-ance haemodialysis with isonatric (high sodium)dialysate ... W. K. Stewart and L. W. Fleming 260

Sodium nitroprusside-the use of... as a hypo-tensive agent in plastic surgery . . . J. B.Hester 582

Sodium nitroprusside: theory and practice ... I. R.Verner 576

Solitary cyst of the liver presenting as an abdominalemergency ... S. C. Sood and A. Watson 48

Seafoods-Microbiological and other hazards from... with special reference to Vibrio parahaemo-lyticus... G. I. Barrow 612

Snake bite-survival in renal cortical necrosis dueto ... S. Ramachandran and M. V. F. Perera 314

Sotalol-An evaluation of..., a beta-blockingagent, in patients with angina pectoris ... P. G.Gooding and E. Berman 734

Spasma-strictures, rings, webs and... D. A. W.Edwards 213

Sphincter-clinical pharmacology and therapeuticsof the oesophagus and the lower oesophagealsphincter . . . J. J. Misiewicz 194

Spinal excision osteotomy in myelomeningocelewith special reference to internal fixation . . . G.Walker and P. Cheong-Leen 145

Spinal-Malignant mesothelioma invading the ...canal ... D. Cooper 718

Spontaneous-Familial... pneumothorax... J. C.Delaney, A. Gale and B. A. Walker 648

Spontaneous cholecystectomy... J. C. McGregorand D. J. Sammon 655

Staphyloccocal endocarditis-double valve replace-ment after ... C. C. Smith and A. P. Ball 299

Staphylococcal food poisoning and botulism...R. J. Gilbert 603

Stomach-Rupture of the ... following mouth-to-mouth respiration... M. Solowiejczyk, E. Ko-ren, S. Wapnick and J. Mandelbaum 769

Strictures, rings, webs and spasms ... D. A. W.Edwards 213

Studies-Some clinical pharmacological . . . withindoramin, with observations on its therapeuticusefulness ... C. de B. White, R. B. Royds andP. Turner 729

Study-Diabetes mellitus in Rhodesia: a compara-tive ... A. C. B. Wicks and J. J. Jones 659

Study of the pharmacokinetics of clindamycinin normal subjects and patients with chronicrenal failure, A ...J. B. Eastwood and P. E.Gower 710

Subarachnoid haemorrhage in pseudoxanthomaelasticum... N. G. K. Sharma, S. K. Ghosh,P. C. Beohar and P. S. Gupta 774

Substitution: right or wrong? ... J. C. Barfield 68Sudden foetal death-Antepartum diagnosis of vasa

praevia-report of a case causing ... C. S.Pallewela 723

Supplementation-the effects of intravenous pro-tein-calorie supplementation on the tissue com-position of postoperative body weight loss...E. A. Elebute 454

Suppuration-Lipomatous pseudohypertrophy ofthe pancreas associated with chronic pulmonary... in an adult ... D. I. M. Siegler 53

Supraventricular tachycardia-paroxysmal-vera-pamil in the treatment of... D. M. Krikler andR. A. J. Spurrell 447

Surgery-annual review of surgery 1973 ... H. Ellis 401Surgical treatment of carcinoma of the oesophagus

... W. P. Cleland 229Survival in renal cortical necrosis due to snake bite

... S. Ramachandran and M. V. F. Perera 314Synoviosis-Periodic ... (intermittent hydrarthro-

sis) with observations and studies on a patient... Hobart A. Reimann 33

Survival rate-Survival rate at middle age in de-veloping and western populations . . . AlexanderR. P. Walker 29

xiv Postgraduate Medical Journal

Tachycardia-the treatment of malignant ventricu-lar tachycardia by aorto-coronary saphenousvein bypass graft . . .H. Ikram, A. R. Makey,R. M. Jeffery, E. R. J. Emery, A. Parkins andD. L. Stone 177

Tachycardia-verapamil in the treatment of par-oxysmal supraventricular tachycardia . . D. M.Krikler and R. A. J. Spurrell 447

Tetanus-Comparative clinical trial of diazepamwith other conventional drugs in ... Nalini T.Vassa, H. V. Doshi, V. H. Yajnik, S. S. Shah,K. R. Joshi and S. H. Patel 755

Therapeutic-Use of the 198 Au liver scan in assess-ing the therapeutic effect of penicillamine inWilson's disease . . . T. Chajek 56

Therapeutic index-the use of dialysis bath fluid asa vehicle with a narrow therapeutic index-Lithium chloride... H. F. Oakeley, W. F.Clarke and V. Parsons 511

Therapeutics-clinical pharmacology and ... ofthe oesophagus and the lower oesophagealsphincter . . . J. J. Misiewicz 194

Therapeutic-Some clinical pharmacological studieswith indoramin, with observations on its ... use-fulness... C. de B. White, R. B. Royds and P.Turner 729

Therapy-controlled trials of immunosuppressivetherapy in hepatitis . . .R. B. Stern and R.Williams 392

Therapy-Lactic acidosis and hyperamylasaemiaassociated with phenformin . . . D. N. Williams,A. H. Knight and D. M. Goldberg 765

Therapy-Pericarditis during chronic haemodialy-sis... A. G. Mitchell 741

Therapy-Retroperitoneal haemorrhage and neuro-pathy complicating anticoagulant ... P. V.Curry and P. A. Bacon 37

Therapy-Rifampicin ... in Escherichia coligastroenteritis ... Yehezkel Naveh and AbrahamFriedman 707

Thrombosis-A case of primary cerebral venous... D. S. K. Brookfield 767

Thrombosis-deep vein thrombosis monitored bydoppler ultrasound-trial of a single low doseof heparin in the prevention of post-operative... T. Bates 135

Thrombosis-venous-ergotamine induced ... U.Mintz, S. Bar-Meir and A. de Vries 244

Thyroiditis-autoimmune-primary acquired hypo-gammaglobulinaemia ... A. M. Hilton and L.Doyle 303

Tissue composition of postoperative body weightloss-the effects of intravenous protein-caloriesupplementation on ... E. A. Elebute 454

Tolerance-Oral iron . . . A. B. S. Mitchell 702Traffic-Traumatic aortic incompetence following

road . . . accident . . . J. B. Irving 725Traumatic aortic incompetence following road traf-

fic accident . . . J. B. Irving 725Trauma-retroperitoneal rupture of the duodenum

due to blunt ... J. C. M. Strachan 180Treatment of active chronic hepatitis with cyclo-

phosphamide... R. Naccarato, R. Farini, M.Chiaramonte, U. Fagiolo and G. C. Sturnilio 16

Trial-Comparative clinical ... of diazapam withother conventional drugs in tetanus ... NaliniT. Vassa, H. V. Doshi, V. H. Yajnik, S. S. Shah,K. R. Joshi and S. H. Patel 755

Trials-controlled trials of immunosuppressivetherapy in hepatitis ... R. B. Stern and R.Williams 392

Trials-organisation of controlled trials in paedia-tric liver disease ... O. P. Gray 396

Triamcinolone - augmented-Triamcinolone - aug-mented glucose tolerance in non-diabetic patientswith chronic pancreatitis ... B. I. Joffe, W. P. U.Jackson and S. Bank 25

Tuberculosis-pulmonary-treatment of ... in apatient on maintenance haemodialysis . . . F. W.Smith, G. R. D. Catto and M. Macleod 478

Ulcer-Aetiology of duodenal... : an investiga-tion into the buffering action and effect on pepsinof bran and unrefined carbohydrate foods...Frank I. Tovey 675

Ulcerative-Chronic liver disease associated withchildhood ulcerative colitis . . . P. J. Toghill, P.Benton and P. G. Smith 9

Ultrasound-trial of a single low dose of heparin inthe prevention of post-operative deep-vein throm-bosis monitored by doppler ultrasound ... T.Bates 135

Unrefined-Aetiology of duodenal ulcer: an in-vestigation into the buffering action and effect onpepsin of bran and . . . carbohydrate foods ...Frank I. Tovey 675

Ureterostomies in adults-cutaneous-experienceswith... W. M. Lien 155

Vaginal bleeding-female genital self-mutilation asa cause of... M. A. Simpson and B. H. Anstee 308

Valve replacement-double-after staphylococcalendocarditis ... C. C. Smith and A. P. Ball 299

Vasa praevia-Antepartum diagnosis of... -re-port of a case causing sudden foetal death ...C. S. Pallewela 723

Vascular control-pharmacology of... R. G.Shanks 560

Vascular control-principles of... E. Neil 557Vein-trial of a single low dose of heparin in the

prevention of post-operative deep-vein throm-bosis monitored by doppler ultrasound ... T.Bates 135

Venesection-cardiac involvement in idiopathichaemochromatosis and the effect of... S. J.Jachuck, G. A. Rai and C. Fossard 276

Venous-A case of primary cerebral . . .throm-bosis ... D. S. K. Brookfield 767

Index to Volume 50 xv

Ventilation-pulmonary circulation and ... J. M.Leigh 562

Ventricular tachycardia-the treatment of malig-nant... by aorto-coronary saphenous vein by-pass graft ... H. Ikram, A. R. Makey, R. M.Jeffery, E. R. J. Emery, R. A. Parkins and D. L.Stone 177

Venous thrombosis-ergotamine - induced ... U.Mintz, S. Bar-Meir and A. de Vries 244

Verapamil and the myocardium ... W. G. Naylerand D. Krikler 441

Verapamil in the treatment of paroxysmal supraven-tricular tachycardia... D. M. Krikler andR. A. J. Spurrell 447

Verapamil-the effect of... on the cardiac con-duction system in man... P. R. Roy, R. A. J.Spurrell and E. Sowton 270

Vibrio parahaemolyticus-Microbiological andother hazards from seafoods with special referenceto... G. I. Barrow 612

Villous papilloma of the appendix associated withmucocoele and intussusception ... A. J. Darbyand A. Doctor 650

Viral hepatitis and hepatitis B antigen: recent ad-vances ... S. Krugman 327

Viral infections of the liver in childhood . . . A. J.Zuckerman 338

Virological observations on juvenile diabetes-epi-demiological and... D. R. Gamble 538

Virology-Whither virology? Trends and prospectsin medical research ... Sir Charles Stuart-Harris 1

Viruses in experimental and human diabetes...K. W. Taylor 546

Vitamin B12-complications of dietary deficiency ofvitamin B12 in young Caucasians .. M. H.Gleeson and P. S. Graves 462

Webs-strictures, rings, ... and spasms...D. A. W. Edwards 213

Webs-the association between webs, iron and post-cricoid carcinoma ... M. Chisholm 215

Western populations-Survival rate at middle-agein developing and ... Alexander R. P. Walker 29

Wilson's disease-Use of the 198 Au liver scan inassessing the therapeutic effect of penicillaminein... T. Chajek 56

Zambia-Mites and house dust mite allergy inbronchial asthma in Northern. . D. J. Bucha-nan and I. G. Jones 680

Author Index

PageAagenaes, 0. (Fagerhol, M., Elgio, K., Munthe, E.and Hovig, T.): Pathology and pathogenesis ofliver disease in alpha-l-antitrypsin deficient indi-viduals 365

Adair, H.M. (and Ellis, H.): Bile peritonitis-areport of fifteen patients 713

Alleyne, G.A.O. (Fraser, H.S., Liburd, A.L.,Figueroa, J.P., Nicholson, G.A., James, O.B.O'L.and Whitbourne, F.): Gonococcaemia with arth-ritis, dermatitis and myocarditis 759

Anavekar, S.N. (Morgan, T.O., Sabto, J., Louis,W.J. and Doyle, A.E.): A comparison of betablocking drugs in the treatment of hypertension 253

Anderson, J. (Kingsbury, K.J., Brett, C., Stovold,R., Chapman, A. and Morgan, D.M.): Abnor-mal fatty acid composition and human athero-sclerosis 425

Ansari, B.M. (and Carter, S.H.): An unusual case offarmer's lung in childhood 306

Arden, G.P. (and Kamdar, B.A.): Road trafficaccident fatalities (review of 142 post mortemreports) 131

Arrowsmith, D.E. (Libman, L.J., Dormandy, T.L.,Heal, Joanna and Hoffbrand, B.I.): Blood lipidsand the treatment of essential hypertension withmethyldopa and bendrofluazide 671

Avery-Jones, F.: The medical management of hia-tus hernia 203

Bacon, P.A. (and Curry, P.V.): Retroperitonealhaemorrhage and neuropathy complicating anti-coagulant therapy 37

Bain, J.T.B. (Hillman, B. and Bardhan, K.D.): Theuse of dicobalt edetate (Kelocyanor) in cyanidepoisoning 171

Baird-Parker, A.C.: The production of safe foods 644Baker, J.A.: The hospital pharmacist 83Ball, A.P. (and Smith, C.C.): Double valve replace-ment after staphylococcal endocarditis 299

Bank, S. (Jackson, W.P.U. and Joffe, B.I.): Triam-cinolone-augmented glucose tolerance in non-diabetic patients with chronic pancreatitis 25

Bardhan, K.H. (Hillman, B. and Bain, J.T.B.): Theuse of dicobalt edetate (Kelocyanor) in cyanidepoisoning 171

Barfield, J.C.: Substitution: right or wrong? 68Bar-Meir, S. (Mintz, U. and de Vries, A.): Ergot-

amine-induced venous thrombosis 244Barrow, G.I.: Microbiological and other hazardsfrom seafoods with special reference to Vibrioparahaemolyticus 612

Bates, T.: Trial of a single low dose of heparin in theprevention of post-operative deep-vein throm-bosis monitored by doppler sound 135

Beckett, A.H.: Prescribing and the regulation offormulation 125

PageBennett, M.A. (Soler, N.G., Fitzgerald, M.G. and

Malins, J.M.): Successful resuscitation in diabeticketoacidosis: a strong case for the use of bi-carbonate 465

Benton, P. (Toghill, P.J. and Smith, P.G.): Chronicliver disease associated with childhood ulcerativecolitis 9

Beohar, P.C. (Sharma, N.G.K., Ghosh, S.K. andGupta, P.S.): Subarachnoid haemorrhage inpseudoxanthoma elasticum 774

Berman, E. (and Gooding, P.G.): An evaluation ofsotalol, a beta-blocking agent, in patients withangina pectoris 734

Bhalla, K.K. (and Torkington, P.): Lead poisoningwith low blood levels 240

Birtwistle, D.T. (Lawlor, T. and O'Hara, F.):Serum cholesterol and serum triglycerides inmental retardation 140

Boon, A. (Missen, A.J.B. and Pemberton, J.):Gastro-bronchial fistula 504

Brett, C. (Kingsbury, K.J., Stovold, R., Chapman,A., Anderson, J. and Morgan, D.M.): Abnormalfatty acid composition and human atherosclerosis 425

Brookfield, D.S.K.: A case of primary cerebralvenous thrombosis 767

Buchanan, D.J. (and Jones, I.G.): Mites and housedust mite allergy in bronchial asthma in NorthernNigeria 680

Carter, S.H. (and Ansari, B.M.): An unusual caseof farmer's lung in childhood 306

Catto, G.R.D. (Smith, F.W. and Macleod, M.):Treatment of pulmonary tuberculosis in a patienton maintenance haemodialysis 478

Chajek T.: Use of the 198 Au liver scan in assess-ing the therapeutic effect of penicillamine inWilson's disease 56

Chakravorty, N.K.: Treatment of blepharospasmwith levodopa 521

Chapman, A. (Kingsbury, K.J., Brett, C., Stovold,R., Anderson, J. and Morgan, D.M.): Abnormalfatty acid composition and human athero-sclerosis 425

Charamonte, M. (Farini, R., Naccarato, R.,Fagiolo, U. and Sturniolo, G.C.): Treatment ofactive chronic hepatitis with cyclophosphamide 16

Chen, B.T.M. (Ooi, B.S. and Yu, M.): Prevalenceand site of bacteriuria in diabetes mellitus 497

Cheong-Leen, P. (and Walker, G.): Spinal excisionosteotomy in myelomeningocele: with specialreference to internal fixation 145

Chisholm, M.: The association between webs, ironand post-cricoid carcinoma 215

Clarke, W.F. (Oakeley, H.K. and Parsons, V.): Theuse of dialysis bath fluid as a vehicle for a drugwith a narrow therapeutic index-Lithiumchloride 511

Index to Volume 50 xvii

Cleland, W.P.: Surgical treatment of carcinoma ofthe oesophagus 229

Collee, J.G.: Bacterial challenges in food 636Cook, P.J.L.: Genetic aspects of the Pi system 362Cook, P.J.L. (Cottrall, K and Mowat, A.P.): Neo-

natal hepatitis and alpha-1-antitrypsin deficiency:an epidemiological study in South East England 376

Cooper, D.: Malignant mesothelioma invading thespinal canal 718

Cornah, G.: The Department of Health 77Cossart, Y.: Acquisition of hepatitis B antigen in

the new born period 334Cottrall, K. (Cook, P.J.L. and Mowat, A.P.): Neo-

natal hepatitis and alpha-1-antitrypsin deficiency:an epidemiological study in South-East England 376

Crisp, A.H. (Palmer, R.L., Stonehill, E., Waller,S.L. and Misiewicz, J.J.): Psychological charac-teristics of patients with the irritable bowelsyndrome 416

Crombie, B.W.: Combination products 103Cumming, W.J.K. (and Spiers, A.S.D.): Diabetes

insipidus and marked elevation of foetal haemo-globin in a case of acute leukemia 468

Currey, H.L.F.: Anti-rheumatic drugs 109Curry, P.V. (and Bacon, P.A.): Retroperitonealhaemorrhage and neuropathy complicating anti-coagulant therapy 37

Darby, A.J. (and Doctor, A.): Villous papilloma ofthe appendix associated with mucocoele andintussusception 650

Delamore, I.W. (and Mir, M.M.): Oxymetholone inaplastic anaemia 166

Delaney, J.C. (Gale, A. and Walker, B.A.): Fami-lial spontaneous pneumothorax 648

De Vries, A. (Mintz, U. and Bar-Meir, S.): Ergot-amine-induced venous thrombosis 244

Doctor, A. (and Darby, A.J.): Villous papilloma ofthe appendix associated with mucocoele andintussusception 650

Doniach, I.: Post-mortem histology of the islets ofLangherans in juvenile diabetes mellitus 544

Dormandy, T.L. (Libman, L.J., Arrowsmith, D.E.,Heal, Joanna and Hoffbrand, B.I.): Blood Lipidsand the treatment of essential hypertension withmethyldopa and bendrofluazide 671

Doshi, H.V. (Vassa, Nalini T., Yajnik, V.H., Shah,S.S., Joshi, K.R. and Patel, S.H.): Comparativeclinical trial of diazapam with other conventionaldrugs in tetanus 755

Doyle, A.E. (Morgan, T.O., Sabto, J., Anavekar,S.N. and Louis, W.J.): A comparison of betaadrenergic blocking drugs in the treatment ofhypertension 253

Doyle, L. (and Hilton, A.M.): Primary acquiredhypogammaglobulinaemia and autoimmune thy-roiditis 303

Dubois, R.S. (and Silverman, A.): Treatment ofchronic active hepatitis in children 386

Eastwood, J.B. (and Gower, P.E.): A study of thepharmacokinetics of clindamycin in normal sub-jects and patients with chronic renal failure 710

Eckenhoff, J.E.: The cerebral circulation 566Eddleston, A.L.W.F.: The role of immunologicalmechanisms in acute and chronic hepatitis 348

Edwards, D.A.W.: Achalasia: symptoms and radi-ology 209

Edwards, D.A.W.: Hiatus hernia reflux syndrome 189Edwards, D.A.W.: Strictures, rings, webs andspasms 213

Edwards, D.A.W.: Carcinoma of the oesophagusand fundus 223

Elebute, E.A.: The effects of intravenous protein-calorie supplementation on the tissue composi-tion of postoperative body weight loss 454

Elgio, K. (Aagenaes, 0., Fagerhol, M., Munthe, E.and Hovig, T.): Pathology and pathogenesis ofliver disease in alpha-l-antitrypsin deficient indi-viduals 365

Elliott, R.W. (and Hunter, P.R.): Acute ethanolpoisoning treated by haemodialysis 515

Ellis, H.: Annual review of Surgery 1973 401Ellis, H. (and Adair, H.M.): Bile peritonitis-a re-

port of fifteen patients 713Emery, E.R.J. (Ikram, H., Makey, A.R., Jeffery,

R.M., Parkins, R.A. and Stone, D.L.): Thetreatment of malignant ventricular tachycardiaby aorto-coronary saphenous vein bypass graft 177

Emery, J.L.: Pathology with reference to the bileretention syndrome 344

Fagerhol, M. (Aagenaes, 0., Elgio, K., Munthe, E.and Hovig, T.): Pathology and pathogenesis ofliver disease in alpha-1-antitrypsin deficient indi-duals 365

Fagiolo, U. (Charamonte, M., Farini, R., Nacca-rato, R. and Stuniolo, G.C.): Treatment of activechronic hepatitis with cyclophosphamide 16

Fairman, M.J. (Harpur, J.E. and Hamilton, M.):Value of routine intravenous pyelography in theinvestigation of hypertension 508

Farini, R. (Naccarato, R., Charamonte, M., Fagio-lo, U. and Sturniolo, G.C.): Treatment of activechronic hepatitis with cyclophosphamide 16

Farrow, L.J. (and Wood, J.B.): Coma followingtreatment of a very severe arterial hyperten-sion with improvement after dexamethasonetherapy 517

Figueroa, J.P. (Fraser, H.S., Liburd, A.L., Nichol-son, G.A., James, O.B.O'L., Whitbourne, F. andAlleyne, G.A.O.): Gonococcaemia with arthritis,dermatitis and myocarditis 759

Fisher, W.D. (Ledingham, I.McA., McArdle, C.S.and Maddern, M.): The incidence of the shocksyndrome in a general hospital 420

Fitzgerald, M.G. (Soler, N.G., Bennett, M.A. andMalins, J.M.): Successful resuscitation in diabeticketoacidosis: a strong case for the use of bi-carbonate 465

xviii Postgraduate Medical Journal

Fleming, L.W. (and Stewart, W.K.): Blood pressurecontrol during maintenance haemodialysis withisonatric (high sodium) dialysate 260

Fossard, C. (Jachuck, S.J. and Rai, G.S.): Cardiacinvolvement in idopathic haemochromatosis andthe effect of venesection 276

Fraser, H.S. (Liburd, A.L., Figueroa, J.P., Nichol-son, G.A., James, O.B.O'L., Whitbourne, F. andAlleyne, G.A.O.): Gonococcaemia with arthritis,dermatitis and myocarditis 759

Friedmann, A.I. (Turner, R.G., Henry, J. andJames, D.G.): Giant cell arteritis 265

Gale, A. (Delaney, J.C. and Walker, B.A.): Fami-lial spontaneous pneumothorax 648

Galton, D.G.: Anti-diabetic drugs 112Gamble, D.R.: Epidemiological and virological

observations on juvenile diabetes 538Garnham, J.C.: Clinical trials 114Garrod, L.P.: Antibiotics 96Ghosh, S.K. (Sharma, N.G.K., Beohar, P.C. and

Gupta, P.S.): Subarachnoid haemorrhage inpseudoxanthoma elasticum 774

Gilbert, R.J.: Staphylococcal food poisoning andbotulism 603

Gleeson, M.H. (and Graves, P.S.): Complicationsof dietary deficiency of Vitamin B12 in youngCaucasians 462

Goldberg, D.M. (Williams, D.N. and Knight,A.H.): Lactic acidosis and hyperamylasaemiaassociated with phenformin therapy 765

Gooding, P.G. (and Berman, E.): An evaluation ofsotalol, a beta-blocking agent, in patients withangina pectoris 734

Gower, P.E. (and Eastwood, J.B.): A study of thepharmacokinetics of clindamycin in normal sub-lects and patients with chronic renal failure 710

Grainger, H.S.: Europe 73Graves, P.S. (and Gleeson, M.H.): Complications

of dietary deficiency of Vitamin B12 in youngCaucasians 462

Gray, O.P.: Organisation of controlled trials inpaediatric liver disease 396

Greenwood, R.J.: Lumbar plexitis and rhabdo-myolysis following abuse of heroin 772

Griffiths, P.D. (and Talbot, S.): The diagnosis ofpulmonary embolism 675

Gupta, P.S. (Sharma, N.G.K., Ghosh, S.K. andBeohar, P.C.): Subarachnoid haemorrhage inpseudoxanthoma elasticum 774

Haberfield, G.R.: The retail pharmacist 81Hale Enderby, G.E.: Introduction (Deliberate

Hypotension) 55Hale Enderby, G.E.: Pharmacological blockade 572Hamilton, M. (Harpur, J.E. and Fairman, M.J.):Value of routine intravenous pyelography in theinvestigation of hypertension 508

Hamlyn, A.N. (Geraint James, D., Neville, E.,Piyasena, K.H.G. and Walker, A.N.): Possiblegenetic influences in familial sarcoidosis 664

Hancock, B.W.: Acute barbiturate poisoning inyoung epileptics 242

Hanson, G.C.: Septicaemic shock, Report of threecases: a review of diagnosis and management 288

Harpur, J.E. (Fairman, M.J. and Hamilton, M.):Value of routine intravenous pyelography in theinvestigation of hypertension 508

Heal, Joanna (Libman, L.J., Arrowsmith, D.E.,Dormandy, T.L. and Hoffbrand, B.I.): Bloodlipids and the treatment of essential hypertensionwith methyldopa and bendrofluazide 671

Hejazi, R. (Rojhan, M.S.): Incidence of Meckel'sdiverticulum in 100 cadavers 694

Henderson, A.K. (Lawson, D.H. and McGeachy,R.R.): Amoxycillin: pharmacokinetic studies innormal subjects, patients with pernicious anaemiaand those with renal failure 500

Henry, J. (Turner, R.G., Friedmann, A.I. andJames, D.G.): Giant cell arteritis 265

Hester, J.B.: The use of sodium nitroprusside as ahypotensive agent in plastic surgery 582

Hillman, B. (Bardhan, K.H. and Bain, J.T.B.): Theuse of dicobalt edetate (Kelocyanor) in cyanidepoisoning 171

Hilton, A.M. (and Doyle, L.): Primary acquiredhypogammaglobulinaemia and auto-immunethyroiditis 303

Hoare, R.G.: The pharmaceutical company 85Hobbs, B.C.: Clostridium welchii and Bacillus

cereus infection and intoxication 597Hoffbrand, B.I. (Libman, L.J., Arrowsmith, D.E.,Dormandy, T.L. and Heal, Joanna): Blood lipidsand the treatment of essential hypertension withmethyldopa and bendrofluazide 671

Hovig, T. (Aagenaes, 0., Fagerhol, M., Elgio, K.and Munthe, E.): Pathology and pathogenesis ofliver disease in alpha-1-antitrypsin deficient indi-viduals 365

Hunter, P.R. (and Elliott, R.W.): Acute ethanolpoisoning treated by haemodialysis 515

Ikram, H. (Makey, A.R., Jeffrey, R.M., Emery,E.R.J., Parkins, R.A. and Stone, D.L.): Thetreatment of malignant ventricular tachycardiaby aorto-coronary saphenous vein bypass graft 177

Irving, J.B.: Traumatic aortic incompetence follow-ing road traffic accident 725

Jachuck, S.J. (Rai, G.S. and Fossard, C.): Cardiacinvolvement in idiopathic haemochromatosis andthe effect of venesection 276

Jackson, W.P.U. (Joffe, B.I. and Bank, S.): Tri-amcinolone-augmented glucose tolerance in non-diabetic patients with chronic pancreatitis 25

Index to Volume 50 xix

James, D.G. (Neville, E., Piyasena, K.H.G.,Walker, A.N. and Hamlyn, A.N.): Possiblegenetic influences in familial sarcoidosis 664

James, D.G. (Turner, R.G., Friedmann, A.I. andHenry, J.): Giant cell arteritis 265

James, O.B.O'L. (Fraser, H.S., Liburd, A.L..Figueroa, J.P., Whitbourne, F. and Alleyne,G.A.O.): Gonococcaemia with arthritis, derma-titis and myocarditis 759

Javitt, N.B.: Bile salts and liver disease in childhood 354Jeffrey, R.M. (Ikram, H., Makey, A.R., Emery,

E.R.J., Parksin, R.A. and Stone, D.L.): Thetreatment of malignant ventricular tachycardiaby aorto-coronary saphenous vein bypass graft 177

Jelliffe, A.M.: Radiotherapy 231Joffe, B.I. (Jackson, W.P.U. and Bank, S.): Tri-

amcinolone-augmented glucose tolerance in non-diabetic patients with chronic pancreatitis 25

Jones, I.G. (and Buchanan, D.J.): Mites and housedust mite allergy in bronchial asthma in NorthernNigeria 680

Jones, J.J. (and Wicks, A.C.B.): Diabetes mellitusin Rhodesia: a comparative study 659

Joshi, K.R. (Vassa, Nalini T., Doshi, H.V., Yajnik,V.H., Shah, S.S. and Patel, S.H.): Comparativeclinical trial of diazepam with other conven-tional drugs in tetanus 755

Kamdar, B.A. (and Arden, G.P.): Road traffic acci-dent fatalities (review of 142 post mortem reports) 131

Kanis, J.A.: The use of anticoagulants in bacterialendocarditis 312

Kazantzis, G.: Food contaminants 625Kingsbury, K.J. (Brett, C., Stovold, R., Chapman,

A., Anderson, J. and Morgan, D.M.): Abnormalfatty acid composition and human athero-sclerosis 425

Knight, D.N. (Williams, D.N. and Goldberg,D.M.): Lactic acidosis and hyperamylasaemiaassociated with phenformin therapy 765

Koren, E. (Solowiejczyk, M., Wapnick, S. andMendelbaum, J.): Rupture of the stomach follow-ing mouth-to-mouth respiration 769

Krikler, D. (and Nayler, W.G.): Verapamil and themyocardium 441

Krikler, D.M. (and Spurrell, R.A.J.): Verapamil inthe treatment of paroxysmal supraventriculartachycardia 447

Krugman, S.: Viral hepatitis and hepatitis B anti-gen: recent advances 327

Lancaster-Smith, M. (Leigh, N.I. and Thompson,H.H.): Death following non-ketotic hyperglycae-mic coma during diazoxide therapy and peritonealdialysis 175

Lancaster-Smith, M.J. (Perrin, J., Swarbrick, E.T.and Wright, J.T.): Coeliac disease and auto-immunity 45

Lascelles, R.G. (Yuill, G.M. and Scholtz, C.):Eosinophilic leukaemia terminating with an en-cephalopathy 473

Lawlor, T. (O'Hara, F. and Birtwistle, D.R.):Serum cholesterol and serum triglycerides inmental retardation 140

Lawson, D.H. (Henderson, A.K. and McGeachy,R.R.): Amoxycillin: pharmacokinetic studies innormal subjects, patients with pernicious anaemiaand those with renal failure 500

Ledingham, L.McA. (Fisher, W.D., McArdle, C.S.and Maddern, M.): The incidence of the shocksyndrome in a general hospital 420

Leigh, J.M.: Pulmonary circulation and ventilation 562Leigh, N.I. (Lancaster-Smith, M. and Thompson,

H.H.): Death following non-ketotic hyperglycae-mic coma during diazoxide therapy and peri-toneal dialysis 175

Libman, L.J. (Arrowsmith, D.E., Dormandy, T.L.,Heal, Joanna and Hoffbrand, B.I.): Blood lipidsand the treatment of essential hypertension withmethyldopa and bendrofluazide 671

Liburd, A.L. (Fraser, H.S., Figueroa, J.P., Nichol-son, G.A., James, O.B.O'L., Whitbourne, F. andAlleyne, G.A.O.): Gonococcaemia with arthritis,dermatitis and myocarditis 759

Lien, W.M.: Experiences with cutaneous uretero-stomies in adults 155

Loebl, W.Y. (and Meguid, M.M.): Megaloblasticanaemia associated with the oral contraceptivepill 470

Louis, W.J. (Morgan, T.O., Sabto, J., Anavekar,S.N. and Doyle, A.E.): A comparison of beta-ad-renergic blocking drugs in the treatment of hyper-tension 253

Lyle, W.H.: Drugs for rare diseases 107Lyle, W.H. (with Braithwaite, R.A., Brooks, P.W.,

Cuthill, J.M., Early, D.F., Goulding, R., Leggett,W.P., Pearson, I.B., Silverman, G., Snaith, R.P.and Strang, G.E.): Plasma concentration of nor-triptyline as a guide to treatment 282

Maddern, M. (Ledingham, I.McA., Fisher, W.D.and McArdle, C.S.): The incidence of the shocksyndrome in a general hospital 420

Makey, A.R. (Ikram, H., Jeffery, R.M., Emery,E.R.J., Parkins, R.A. and Stone, D.L.): Thetreatment of malignant ventricular tachycardiaby aorto-coronary saphenous vein by-pass graft 177

Malins, J.M.: Glucose tolerance and the diabeticpopulation 529

Malins, J.M. (Soler, N.G., Bennett, M.A. and Fitz-gerald, M.G.): Successful resuscitation in diabeticketoacidosis: a strong case for the use of bi-carbonate 465

Meguid, M.M. (and Loebl, W.Y.): Megaloblasticanaemia associated with the oral contraceptivepill 470

Mendelbaum, J. (Solowiejczyk, M., Koren, E. andWapnick, S.): Rupture of the stomach followingmouth-to-mouth respiration 769

xx Postgraduate Medical Journal

Mennie, A.T. (and Robbie, D.S.): Analgesics in can-cer pain: results of a questionnaire 150

Mintz, U. (Bar-Meir, S. and de Vries, A.): Ergot-amine-induced venous thrombosis 244

Mir, M.A. (and Delamore, I.W.): Oxymetholone inaplastic anaemia 166

Misiewicz, J.J.: Clinical pharmacology and thera-peutics of the oesophagus and the lower oesopha-geal sphincter 194

Misiewicz, J.J.: Pathophysiology of achalasia ofthe cardia 207

Misiewicz, J.J. (Palmer, R.L., Stonehill, E., Crisp,A.H. and Waller, S.L.): Psychological characteris-tics of patients with the irritable bowel syndrome 416

Misra, D.P.: The syndrome of dilutional hypo-natremia 309

Missen, A.J.B. (Pemberton, J. and Boon, A.):Gastro-bronchial fistula 504

Mitchell, A.B.S.: Oral iron tolerance 702Mitchell, A.G.: Pericarditis during chronic haemo-

dialysis therapy 741Morgan, D.M. (Kingsbury, K.J., Brett, C., Stovold,

R., Chapman, A. and Anderson, J.): Abnormalfatty acid composition and human athero-sclerosis 425

Morgan, T.O. (Sabto, J., Anavekar, S.N., Louis,W.J. and Doyle, A.E.): A comparison of betablocking drugs in the treatment of hypertension 252

Mowat, A.P. (Cottrall, K. and Cook, P.J.L.): Neo-natal hepatitis and alpha-l-trypsin deficiency: anepidemiological study in South-East England 376

Mowat, A.P. (and Williams, R.): Clinical problemsin hepatitis in childhood: King's College Hospitalexperience 1970-1973 324

Munthe, E. (Aagenaes, 0., Fagerhol, M., Elgio, K.and Hovig, T.): Pathology and pathogenesis ofliver disease in alpha-l-antitrypsin deficient indi-viduals 365

McArdle, C.S. (Ledingham, I.McA., Fisher, W.D.and Maddern, M.): The incidence of the shocksyndrome in a general hosptial 420

McGeachy, R.R. (Lawson, D.H. and Henderson,A.K.): Amoxycillin: pharmacokinetic studies innormal subjects, patients with pernicious anaemiaand those with renal failure 500

McGregor, J.C. (Sammon, D.J.): Spontaneouscholecystectomy 655

McKibbin, A. (Parks, T.G.): Acute emphysema-tous cholecystitis 50

Macleod, M. (Smith, F.W. and Catto, G.R.D.):Treatment of pulmonary tuberculosis in a patienton maintenance haemodialysis 478

Naccarato, R. (Farini, R., Charamonte, M.,Fagiolo, U. and Sturniolo, G.C.): Treatment ofactive chronic hepatitis with cyclophosphamide 16

Nagi, N.A. (and Nouri, L.): Infantile nephroticsyndrome 237

Nayak, I.M.: Malignant mucocele of the appendixin a femoral hernia 246

Nayler, W.G. (and Krikler, D.): Verapamil and themyocardium 441

Neil, E.: Principles of vascular control 557Neville, E. (Geraint James, D., Piyasena, K.H.G.,

Walker, A.N. and Hamlyn, A.N.): Possiblegenetic influences in familial sarcoidosis 664

Nicholson, G.A. (Fraser, H.S., Liburd, A.L.,Figueroa, J.P., James, O.B.O'L., Whitbourne, F.and Alleyne, G.A.O.): Gonococcaemia witharthritis, dermatitis and myocarditis 759

Noakes, M.J. (and Roberts, C.J.C.): Fatal out-come from administration of a salt emetic 513

Nouri, L. (and Nagi, N.A.): Infantile nephroticsyndrome 237

Oakeley, H.F. (Clarke, W.F. and Parsons, V.): Theuse of dialysis bath fluid as a vehicle for a drugwith a narrow therapeutic index-Lithiumchloride 511

O'Hara, F. (Lawlor, T. and Birtwistle, D.T.): Serumcholesterol and serum triglycerides in mental re-tardation 140

Ooi, B.S. (Chen, B.T.M. and Yu, M.): Prevalenceand site of bacteriuria in diabetes mellitus 497

O'Reilly, Patrick H.: Haematuria of unknownorigin 746

Osborne, M.P.: Penile Parkinsonism 523

Painter, N.S.: The high fibre diet in the treatmentof diverticular disease of the colon 629

Pallewela, C.S.: Antepartum diagnosis of vasapraevia-report of a case causing sudden foetaldeath 723

Palmer, R.L. (Stonehill, E., Crisp, A.H., Waller,S.L. and Misiewicz, J.J.): Psychological charac-teristics of patients with the irritable bowelsyndrome 416

Parkins, R.A. (Ikram, H., Makey, A.R., Jeffery,R.M., Emery, E.R.J. and Stone, D.L.): Thetreatment of malignant ventricular tachycardiaby aorto-coronary saphenous vein bypass graft 177

Parks, T.G. (and McKibbin, A.): Acute emphy-sematous cholecystitis 50

Parsons, V. (Oakeley, H.W. and Clarke, W.F.):The use of dialysis bath fluid as a vehicle for adrug with a narrow therapeutic index-Lithiumchloride 511

Patel, S.H. (Vassa, Nalini T., Doshi, H.V., Yajnik,V.H., Shah, S.S. and Joshi, K.R.): Comparativeclinical trial of diazepam with other conven-tional drugs in tetanus 755

Paterson, C.R.: Drugs for the treatment of hyper-calcaemia 158

Pemberton, J. (Missen, A.J.B. and Boon, A.):Gastro-bronchial fistula 504

Perera, M.V.F. (and Ramachandran, S.): Survivalin renal cortical necrosis due to snake bite 314

Index to Volume 50 xxi

Perrin, J. (Lancaster-Smith, M.J., Wright, J.T. andSwarbrick, E.T.): Coeliac disease and autoimmu-nity 45

Piyasena, K.H.G. (James, D. Geraint, Neville, E.,Walker, A.N. and Hamlyn, A.N.): Possible gene-tic influences in familial sarcoidosis 664

Rai, G.S. (Jachuck, S.J. and Fossard, C.): Cardiacinvolvement in idiopathic haemochromatosis andthe effect of venesection 276

Ramachandran, S.: Radiological changes in leftlobe liver abscesses 685

Ramachandran, S. (and Perera, M.V.F.): Survivalin renal cortical necrosis due to snake bite 314

Reimann H.A.: Infectious Diseases. Annual Reviewof significant publications 485

Reimann, Hobart A.: Periodic synoviosis (inter-mittent hydrarthrosis) with observations andstudies on a patient 33

Richard, A.T. (Teoh, P.C. and Wong, P.K.): Par-kinsonism and transient bilateral ptosis insystemic lupus erythematosus 163

Robbie, D.S. (and Mennie, A.T.): Analgesics incancer pain: results of a questionnaire 150

Roberts, C.J.C. (and Noakes, M.J.): Fatal outcomefrom administration of a salt emetic 513

Roesch, W.: Endoscopy in achalasia 211Roesch, W.: Gastro-oesophageal reflux and hiatushernia-endoscopy 199

Roesch, W.: Carcinoma of the oesophagus andcardia-endoscopy 227

Rojhan, M.S. (and Hejazi, R.): Incidence ofMeckel's diverticulum in 100 cadavers 694

Rosenbloom, L. (Sills, J.A. and Vivori, E.): Carbonmonoxide poisoning: recovery associated with atransient dyskinetic syndrome 519

Roy, P.R. (Spurrell, R.A.J. and Sowton, E.): Theeffect of Verapamil on the cardiac conductionsystem in man 270

Royds, R.B. (White, C. de B. and Turner, P.): Someclinical pharmacological studies with indoramin,with observations on its therapeutic usefulness 729

Sabto, J. (Morgan, T.O., Anavekar, S.N., Louis,W.J. and Doyle, A.E.): A comparison of betablocking drugs in the treatment of hypertension 253

Sammon, D.J. (and McGregor, J.C.): Spontaneouscholecystectomy 655

Schardt, W. (Wardle, E.N. and Uldall, P.R.): Studyof the lipid-lowering action of choloxin andNilevar in patients with chronic renal failure 737

Scholtz, C. (Yuill, G.M. and Lascelles, R.G.):Eosinophilic leukaemia terminating with anencephalopathy 473

Shah, S.S. (Vassa, Nalini T., Doshi, H.V., Yajnik,V.H., Joshi, K.R. and Patel, S.H.): Comparativeclinical trial of diazepam with other conventionaldrugs in tetanus 755

Shanks, R.G.: Pharmacology of vascular control 560Sharma, N.G.K. (Ghosh, S.K., Beohar, P.C. andGupta, P.S.): Subarachnoid haemorrhage inpseudoxanthoma elasticum 774

Shaw, T.R.D.: The digoxin affair 98Siegler, D.I.M.: Lipomatous pseudohypertrophy of

the pancreas associated with chronic pulmonarysuppuration in an adult 53

Sills, J.A. (Vivori, E. and Rosenbloom, L.): Carbonmonoxide poisoning: recovery associated witha transient dyskinetic syndrome 519

Silverman, A. (and Dubois, R.S.): Treatment ofchronic active hepatitis in children 386

Simpson, M.A. (and Anstee, B.H.): Female genitalself-mutilation as a cause of vaginal bleeding 308

Smith, C.C. (and Ball, A.P.): Double valve replace-ment after staphylococcal endocarditis 299

Smith, F.W. (Catto, G.R.D. and Macleod, M.):Treatment of pulmonary tuberculosis in a patienton maintenance haemodialysis 478

Smith, P.G. (Toghill, P.J. and Benton, P.): Chronicliver disease associated with childhood ulcerativecolitis 9

Soler, N.G. (Bennett, M.A., Fitzgerald, M.G. andMalins, J.M.): Successful resuscitation in diabeticketoacidosis: a strong case for the use of bi-carbonate 465

Solowiejczyk, M. (Koren, E., Wapnick, S. andMendelbaum, J.): Rupture of the stomach follow-ing mouth-to-mouth respiration 769

Sood, S.C. (and Watson, A.): Solitary cyst of theliver presenting as an abdominal emergency 48

Sowton, E. (Spurrell, R.A.J. and Roy, P.R.): Theeffect of Verapamil on the cardiac conductionsystem in man 270

Spencer, Michael: Food additives 620Spiers, A.S.D. (and Cumming, W.J.K.): Diabetes

insipidus and marked elevation of foetal haemo-globin in a case of acute leukaemia 468

Spurrell, R.A.J. (and Krikler, D.M.): Verapamil inthe treatment of paroxysmal supraventriculartachycardia 447

Spurrell, R.A.J. (Roy, P.R. and Sowton, E.): Theeffect of Verapamil on the cardiac conductionsystem in man 270

Stephens, M.E.M.: Transient erythroid hypo-plasia in a patient on long-term co-trimoxazoletherapy 235

Stern, R.B. (and Williams, R.): Controlled trials ofimmunosuppressive therapy in hepatitis 392

Stevens, C.C.B.: Is this a world-wide problem? 71Stevenson, J.: The Nurse 91Stewart, W.K. (and Fleming, L.W.): Blood pressure

control during maintenance haemodialysis withisonatric (high sodium) dialysate 260

Stone, D.L. (Ikram, H., Makey, A.R., Jeffery, R.M.,Emery, E.R.J. and Parkins, R.A.): The treatmentof malignant ventricular tachycardia by aorto-coronary saphenous vein bypass graft 177

Stonehill, E. (Palmer, R.L., Crisp, A.H., Waller,S.L. and Misiewicz, J.J.): Psychological charac-teristics of patients with the irritable bowelsyndrome 416

xxii Postgraduate Medical Journal

Stovold, R. (Kingsbury, K.J., Brett, C., Chapman,A., Anderson, J. and Morgan, D.M.): Abnormalfatty acid composition and human athero-sclerosis 425

Strachan, J.C.M.: Retroperitoneal rupture of theduodenum due to blunt trauma 180

Strong, R.W.: Oesophago-cardiac fistula compli-cating achalasia 41

Stroud, C.E.: Introduction-Hepatitis in Child-hood 323

Stuart-Harris, Sir Charles: Whither virology?Trends and prospects in medical research 1

Sturniolo, G.C. (Fagiolo, U., Charamonte, M.,Farini, R. and Naccarato, R.): Treatment ofactive chronic hepatitis with cyclophosphamide 16

Swarbrick, E.T. (Wright, J.T., Perrin, J. andLancaster-Smith, M.J.): Coeliac disease andautoimmunity 45

Talbot, S. (and Griffiths, P.D.): The diagnosis ofpulmonary embolism 675

Taylor, K.W.: Viruses in experimental and humandiabetes 546

Teeling-Smith, G.: How doctors prescribe and why 65Teoh, P.C. (Richard, A.T. and Wong, P.K.): Parkin-

sonism and transient bilateral potsis in systemiclupus erythematosus 163

Thompson, H.H. (Lancaster-Smith, M. and Leigh,N.I.): Death following non-ketotic hyperglycae-mic coma during diazoxide therapy and peri-toneal dialysis 175

Toghill, P.J. (Benton, P. and Smith, P.G.): Chronicliver disease associated with childhood ulcerativecolitis 9

Torkington, P. (and Bhalla, K.K.): Lead poisoningwith low blood levels 240

Tovey, Frank I.: Aetiology of duodenal ulcer: aninvestigation into the buffering action and effecton pepsin of bran and unrefined carbohydratefoods 675

Turner, P.: The clinical pharmacologist 93Turner, P. (White, C. de B. and Royds, R.B.): Some

clinical pharmacological studies with indoramin,with observations on its therapeutic useful-ness 729

Turner, R.G. (Friedmann, A.I., Henry, J. andJames, D.G.): Giant cell arteritis 265

Uldall, P.R. (Wardle, E.N. and Schardt, W.): Studyof the lipid-lowering action of choloxin andNilevar in patients with chronic renal failure 737

Vassa, Nalini T. (Doshi, H.V., Yajnik, V.H., Shah,S.S., Joshi, K.R. and Patel, S.H.): Comparative

clinical trial of diazepam with other conven-tional drugs in tetanus 755

Venables, T.L.: The general practitioner 88Vere, D.W.: How should we prescribe? 122Verner, I.R.: Sodium nitroprusside: theory and

practice 576Vivori, E. (Sills, J.A. and Rosenbloom, L.): Carbonmonoxide poisoning: recovery associated with atransient dyskinetic syndrome 519

Walker, A.N. (James, D. Geraint, Neville, E.,Piyasena, K.H.G. and Hamlyn, A.N.): Possiblegenetic influences in familial sarcoidosis 664

Walker, Alexander R.P.: Survival rate at middleage in developing and western populations 29

Walker, B.A. (Delaney, J.C. and Gale, A.):Familial spontaneous pneumothorax 648

Walker, G. (and Cheong-Leen, P.): Spinal excisionosteotomy in myelomeningocele: with specialreference to internal fixation 145

Waller, S.L. (Palmer, R.L., Stonehill, E., Crisp,A.H. and Misiewicz, J.J.): Psychological charac-teristics of patients with the irritable bowelsyndrome 416

Wapnick, S. (Solowiejczyk, M., Koren, E. andMendelbaum, J.): Rupture of the stomach follow-ing mouth-to-mouth respiration 769

Wardle, E.N. (Schardt, W. and Uldall, P.R.): Studyof the lipid-lowering action of choloxin andNilevar in patients with chronic renal failure 737

Watson, A. (and Sood, S.C.): Solitary cyst of theliver presenting as an abdominal emergency 48

Whitbourne, F. (Fraser, H.S., Liburd, A.L.,Figueroa, J.P., Nicholson, G.A., James, O.B.O'L.and Alleyne, G.A.O.): Gonococcaemia witharthritis, dermatitis and myocarditis 759

White, C. de B. (Royds, R.B. and Turner, P.): Someclinical pharmacological studies with indoramin,with observations on its therapeutic usefulness 729

Wicks, A.C.B. (and Jones, J.J.): Diabetes mellitusin Rhodesia: a comparative study 659

Williams, D.N. (Knight, A.H. and Goldberg, D.M.):Lactic acidosis and hyperamylasaemia associatedwith phenformin therapy 765

Williams, R.: Liver disease in childhood: principlesof management 381

Williams, R. (and Mowat, A.P.): Clinical problemsin hepatitis in childhood: King's College Hospi-tal experience 1970-1973 324

Williams, R. (and Stern, R.B.): Controlled trials ofimmunosuppressive therapy in hepatitis 392

Wong, P.K. (Teoh, P.C. and Richard, A.T.):Parkinsonism and transient bilateral ptosis insystemic lupus erythematosis 163

Wood, J.B. (and Farrow, L.J.): Coma followingtreatment of a very severe arterial hypertensionwith improvement after dexamethasone therapy 517

Wright, J.T. (Perrin, J., Lancaster-Smith, M.J. andSwarbrick, E.T.): Coeliac disease and auto-immunity 45

Index to Volume 50 xxiii

Yajnik, V.H. (Vassa, Nalini T., Doshi, H.V., Shah,S.S., Joshi, K.R. and Patel, S.H.): Comparativeclinical trial of diazepam with other conventionaldrugs in tetanus 755

Yu, M. (Ooi, B.S. and Chen, B.T.M.): Prevalenceand site of bacteriuria in diabetes mellitus 497

Yuill, G.M. (Lascelles, R.G. and Scholtz, C.):

Eosinophilic leukemia terminating with an en-cephalopathy 473

Zuckerman, A.J.: Viral infections of the liver inchildhood 338

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gram(s) g second(s) seckilogram(s) kg cubic millimetre(s) mmsmilligram(s) millimetre(s) mm

(103 g) mg centimetre(s) cmmicrogram(s) millicurie(s) mCi

(10- g) tlg millilitre(s) mlnanogram(s) pound(s) lb

(10-' g) ng milliequivalent mEqpicogram(s)

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