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Euro Chemistry 2016June 16-18, 2016

Volume 7, Issue 2(Suppl)Chem Sci J 2016

ISSN: 2150-3494, CSJ an open access journal


June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressUnnatural fluoro-oxindole alkaloids produced by Uncaria guianensis plantlets Adriana A Lopes, Bruno Musquiari, Suzelei de C França and Ana Maria S PereiraUniversidade de Ribeirão Preto, Brazil

Natural products and their analogues have been sources of numerous important therapeutic agents. The medicinal plant U. guianensis (Rubiaceae) cultured in vitro produce four oxindole alkaloids that displays anti-tumoral activity. Natural

products can be modified by several approaches, one of which is precursor-directed biosynthesis (PDB). Thus, the aim of this work was apply precursor-directed biosynthesis approach to obtain oxindole alkaloids analogues using in vitro Uncaria guianensis. Plantletes were cultivated into culture medium supplemented with 1mM of 6-fluoro-tryptamine, the indol precursor of alkaloids biosynthesis. U. guianensis explants were maintained at 25±2°C, 55-60% relative humidity under the same photoperiod and light intensity. After 30 days, a methanolic extract from U. guianensis was obtained and analysed by HPLC-DAD analytical procedure. The chromatogram showed four natural alkaloids (mitraphylline, isomitraphylline, rhynchophylline and isorhynchophylline and four additional peaks. Semi-preparative HPLC allowed isolation and purification of these four oxindole alkaloids analogues and the identity of the peaks was confirmed from high-resolution MS data (HRESIMS/MS in positive mode). All data confirmed that Uncaria guianensis produced fluoro-oxindole alkaloids analogues.

BiographyAdriana A Lopes is from Universidade de Ribeirão Preto, Brazil.

[email protected]

Adriana A Lopes et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003

mailto:[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressSpectrophotometric investigation of early lanthanide(III) porphyrin complexesMelitta Patrícia Kiss, Muhammad Imran, Zsolt Valicsek and Ottó HorváthUniversity of Pannonia, Hungary

Larger-sized metal ions are not able to coplanarly fit into the cavity of the porphyrin ring; they are located out of the ligand plane, resulting in out-of-plane (OOP or sitting-atop=SAT) complexes OOP position promotes the formation of bis- or

oligoporphyrins, so-called sandwich complexes. Lanthanide(III) ions offer good opportunities to fine tune the out-of-plane distances, utilizing the well-known lanthanide contraction. The UV-Vis absorption bands of SAT complexes represent redshift compared to the free-base ligand. SAT complexes can be used as photocatalysts in redox reactions, as photosensors in the medical science in luminescence imaging and as polymer diodes in cancer treatment. We investigated the reaction between the 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin and early lanthanide(III) ions (La-Gd), as well as the effect of the ionic strenght, the temperature and the potential axial ligands on these processes. The structures of different complexes were identified on the basis of their UV-Vis absorption spectra. The bidentate O-donor acetate and glycol, as well as the monodentate ethanol and chloride can enhance the coordination of the first porphyrin ligand, due to their axial effect, but they can hinder the connection of an additional porphyrin. In the presence of non-coordinating perchlorate anion, bisporphyrins can form, too. At lower temperatures, the lanthanide(III) ions were not able to coordinate into the cavity of the macrocycle, to the softer pyrrolic nitrogens, rather to the sulfonato groups, to the harder oxygens; resulting in the formation of the free-base ligands’ tail-to-tail dimer. So the coordination position of metal ion can be influenced by temperature.

BiographyMelitta Patrícia Kiss got her MSc degree in Chemistry at University of Pannonia, Veszprém, Hungary. Now, she is a PhD student at the Department of General and Inorganic Chemistry at the same university. In her research work, she studies the formation of lanthanide porphyrin complexes from equilibrial and kinetic aspects since 6 years.

[email protected]

Melitta Patrícia Kiss et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressPhotoinduced heterogenous catalysis with TiO2 and kaoliniteOrsolya Fónagy1, Balázs Zsirka2, Erzsébet Szabó-Bárdos1, Erzsébet Horváth2 and Ottó Horváth1

1University of Pannonia, Hungary2Institute of Environmental Engineering, Hungary

Heterogeneous photocatalysis is a worldwide researched Advanced Oxidation Process. It can be successfully applied for degradation of various organic pollutants into harmless or less harmful compounds. The efficiency of this technology can

be increased in multiple ways, thus it has the flexibility for being used in practical application. The efficiency can be significantly enhanced by the combination with other oxidative procedures such as ozonation and by using new kind of catalysts or modifing their surface with precious metals. The latter helps the charge separation therefore slows down the recombination of holes and electrons. Furthermore with the “coloring” of the semiconductor there is a possibilty to extend the light absorption range of the catalyst to the visible light wave lengths. Our research group studied TiO2 and kaolinite based heterogenous photocatalysis by the degradation of different model compounds. In this work, we summarize our results regarding the mineralization of benzenesulfonic acid and oxalic acid on the previous two catalysts.

BiographyOrsolya Fónagy has started her PhD in 2014 at University of Pannonia. Her PhD topic is “Investigation and development of water treatment procedures based on heterogeneous photocatalysis”. She is a co-author in two publications at scientific journals.

[email protected]

Orsolya Fónagy et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressPhotocatalytic decomposition of a nonionic detergentHegedűs Péter, Erzsébet Szabó-Bárdos, Krisztián Horváth and Ottó HorváthUniversity of Pannonia, Hungary

The newer chemicals that appears nowdays can’t always be treated with the current sewage treatment methods. Keeping the environmental aspects in mind, new procedures should be developed. Triton X-100 is one of the most widely applied man-

made nonionic surfactants. This detergent is utilized as both household and industrial cleaning agent. Triton X-100 can hardly be degraded by biological treatment under anaerobic conditions, and even in aerobic systems it can be just partly mineralized. Thus, it can reach natural waters, damaging various living organisms there. Hence, application of a more efficient degradation method is indispensable for the total mineralization of this surfactant. A possible solution of this problem is the application of heterogeneous photocatalysis. It is an advanced oxidation process that uses UV irradiaton to form highly reactive radicals on the surface of a semiconductor catalyst.

We have thoroughly examined the photocatalytic degradation of Triton X-100 under various circumstances. The process was monitored by following the spectral changes, the organic carbon content, and the actual concentration (UHPLC method).

It has been established that Triton X-100 could be mineralized by TiO2 mediated heterogeneous photocatalysis However, one obstacle to the in field use is that if the catalyst is used in slurry form, the catalyst separation from the liquid phase is difficult and makes the technology more expensive. This problem can be eliminated if the catalyst is immobilized. We managed to create a foil catalyst from poli(vinyl-alcohol) and Degussa P25 TiO2 which is capable of breaking down the modell compound.

BiographyPéter Hegedűs has completed his M.Sc. in Environmental Engineering at the age of 25 years from University of Pannonia. He is a first year PhD student at University of Pannonia Department of General and Inorganic Chemistry. His subject is: The preparation and characterisation of immobilised photocatalyst, and application for the degradation of pollutants.

[email protected]

Hegedűs Péter et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressPatented method-based evaluation of the toxicity of some uncoupling dinitrophenol-like compoundsMarius Zaharia Alexandru Ioan Cuza University, Romania

Although the dinitrophenols and related compounds are deeply poisonous, they are still used as pesticides, drugs or even weight loss agents. Today, DNP is used by bodybuilders, often illegally, to rapidly lose body fat before contests.

Numerous pesticides act as uncoupling agents of oxidative phosphorylation at low concentrations, and inhibit the electron transport chains, probably before cytochrome C at higher concentrations. Dinitrophenol disrupts the H+ gradient reducing ATP synthesis. The permeability of mitochondrial membranes to protons is increased by the conversion failure from ADP to ATP. Under these conditions, much of our food that we eat could not use for ATP synthesis leads to weight loss. The difference between weight loss and death is only a small concentration change in dinitrophenol, making the drug dangerous. The level of toxicity of dinitrophenyl derivatives is closely related to inhibition of ATP production even in the presence of oxygen, which leads to alcohol formation in yeast and plant cells. Since the level of toxicity of dinitrophenyl derivatives depends on their property of uncoupling the respiration from ATP synthesis, we have recently patented a method to identify the uncoupling agents as well as to quantify the intensity of such activity by determining the ethanol produced in living cells of some biological materials. The simplest way to do that is to measure the ethanol liberated in presence of the uncoupling agents. We have colorimetrically determined alcohol by the reduction of the orange-colored potassium dichromate (K2Cr2O7) to green colored salts of chromium (III), in the presence of sulfuric acid (H2SO4). A well-defined volume of sample is taken from the green colored solution, diluted with distilled water, and its absorbance measured in a spectrophotometer or colorimeter. The calibration curve is carried out with different concentrations of ethanol.

BiographyMarius Zaharia is a 2015 graduate of Alexandru Ioan Cuza University of Iasi, Department of Chemistry, and pursuing his doctoral study in Doctoral School "Chemistry and Life and Earth Sciences". Consequently, he is the Director of project Grants for young researchers of UAIC (Contract 21754/03.12.2015), project from Alexandru Ioan Cuza University of Iasi. He has published 8 papers and 4 papers accepted to be published in reputed journals and presented several research papers at various national and international conferences.

[email protected]

Marius Zaharia , Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressSynthesis, antiproliferative activity and molecular docking of new colchicine derivativesAdam Huczynski1, Urszula Majcher1, Sabrina Redermozer1, Ewa Maj2, Joanna Wietrzyk2, Mahshad Moshari3 and Jack A Tuszynski31Adam Mickiewicz University, Poland2Ludwik Hierszfeld Institute of Immunology and Experimental Therapy, Poland3University of Alberta, Canada

Colchicine is a plant alkaloid that shows antimitotic effects on a number of cancer cell lines. It binds to tubulin, inhibiting the formation of microtubuli and, thus, blocks mitosis. Herein, we report that colchicine can be functionalized at C-ring by

a simple reaction with benzyl amines to yield various active derivatives. These compounds were characterised spectroscopically and their antiproliferative activity against four human tumour cell lines (HL-60, HL-60/vinc, LoVo, LoVo/DX) was evaluated. Additionally, the activity of the studied compounds was theoretically predicted using computational methods involving molecular docking of the colchicine derivatives to β-tubulin. The experimental and computational results are in very good agreement indicating that the antimitotic activity of colchicine derivatives can be readily predicted using computational modeling methods.

BiographyAdam Huczynski graduated from the Adam Mickiewicz University in Poznan with MSc (2004, Physics), MSc (2004, Chemistry) DSc (2008, Chemistry) and DSc habilitation (2013, Chemistry) degrees. Actually he is an Associate Professor at the Faculty of Chemistry, Adam Mickiewicz University. His major research interests are organic and bioorganic chemistry, spectroscopy and medicinal chemistry, mainly ionophore antibiotics and other natural compounds.

[email protected]

Adam Huczynski et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressAntimycobacterial activity and QSAR studies of 2H-chromene and coumarin based hydrazonesViolina T Angelova1, Rosen Buyukliev1, Ivan Dimitrov1, Violeta Valcheva2, Nikolay Vassilev2, Boris Shivachev2 and Georgi Momekov1

1Medical University of Sofia, Bulgaria2Bulgarian Academy of Sciences, Bulgaria

A series of 2H-chromene based hydrazones 5a-m, 6a-c and 7a-c were synthesized by condensation of 2H-chromene-3-carbaldehydes with varied substituted hydrazides. The structure of the newly synthesized compounds were confirmed by

1H NMR, 13C NMR, FTIR and HRMS (ESI) spectroscopy and the E-configuration of the compounds 7a and 7c was proven by X-ray crystal structure analysis.

In vitro antimycobacterial activity of the newly synthesized hydrazones was tested against Mycobacterium tuberculosis H37Rv and compared to that of first-line antituberculous drugs isoniazid (INH) and ethambutol (EMB). The most active compounds 5j, 5h, 5l, 7b, 7c demonstrated a nanomolar inhibitory potency with MICs 0.13-0.74 μM, but noteworthy they proved to exert minimal associated cytotoxicity in the human embryonal kidney cell line 293 T. Hydrazone 5j was the most potent antituberculous agent with a minimal inhibitory concentration (MIC) of 0.13 µM. The activity of the tested compounds varied depending on the substituents and the log P values. Quantitative structure-activity relationship (QSAR) model was derived to guide the further lead optimization. Low log P values and 5 rings in the molecules proved to be optimal for nanomolar activity. These results could be considered a good starting point for further studies to develop new lead compounds.

BiographyViolina T Angelova has completed his PhD in 2004 from Bulgarian Academy of Sciences, Institute of Organic Chemistry with Centre of Phytochemistry, Sofia, Bulgaria. She is an Assistant Professor of Medical University of Sofia, Faculty of Pharmacy, Department of Chemistry. She has published more than 15 papers in reputed journals.

[email protected]

Violina T Angelova et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003

MIC (exp) 0.13 µM MIC (exp) 0.18 µM MIC (exp) 0.17 µM

IC50 90.66 µM IC50 21.21 µM IC50 76.32 µM

SI 697.38 SI 117.83 SI 448.94


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressSelective and stoichiometric fatty acids sensing with a polydiacetylene liposomeChang Wook Song, Yong-Suk Cho, Dong Hee Ma and Kyo Han AhnPohang University of Science and Technology, Republic of Korea

Fatty acids play important roles in biological processes, functioning as a cell membrane component, growth and survival pathways, signalling for metabolic regulation, and inflammatory and metabolic responses. Unsaturated fatty acids exert

various biological processes depending on their overall shape due to cis and trans isomerism. Therefore, selective detection of fatty acids by their shape is of interest but is a challenging goal. Herein, we report the liposome sensing system as a simple yet efficient assay tool for discrimination of cis-fatty acids from trans- and saturated fatty acids. The liposome showed a turn-on type fluorescence change and distinct color change. The molecular interactions between the liposome and cis-fatty acids showed 1:2 and 1:1 (liposome component/fatty acids) binding stoichiometries in the cases of mono- and di-oleyl fatty acids, respectively. The colorimetric response indicated that it has good linearity up to the equivalent point. Furthermore, we applied liposome for monitoring residual cis-fatty acids in soybean oil product after heating at 200ºC.

BiographyChang Wook Song received his BS in 2013 from the department of Chemistry, Busan National University and MS in 2015 from POSTECH. He is currently pursuing his PhD at the department of Chemistry, POSTECH, under the supervision of Professor Kyo Han Ahn.

[email protected]

Chang Wook Song et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressNovel two-photon dyes: Minimal autofluorescence in tissue imagingJuryang Bae, Hyunsoo Moon, Dokyoung Kim and Kyo Han Ahn Pohang University of Science and Technology, Republic of Korea

The advantage of fluorescent imaging for biomaterials is operationally simple, cost-effective, noninvasive, high sensitive detection and visualization of organisms at a subcellular level. In tissue imaging, however, autofluorescence from biological

molecules under excitation at UV−Vis wavelengths lowers signal to noise ratio. Most of biomolecules absorb and emit light of green region. So, a novel class of fluorophores excited in the near-infrared region is necessary to suppress this critical issue. Two-photon absorbing dyes are one of the methods to satisfy this criterion. They have several advantages not only reduced autofluorescence, but also increased penetration depth, and high special-resolution. In addition, they diminish photodamage and photobleaching as well. Acedan, 6-acetyl-2-(dimethylamino) naphthalene, and its derivatives are widely used for two-photon dyes. But their maximum absorption wavelengths (~370 nm) are rather short for two-photon excitation (~740 nm) which shows strong autofluorescence and limits the depth in tissue in microscopic imaging of tissues. Herein, we have developed compact π-extended acedan derivatives. They have the longer maximum absorption wavelengths more than 400 nm and sufficient two-photon absorption properties. One of the new dyes that can be excitable at 1000 nm under two photon excitation condition is photochemically stable and biocompatible. Also it has environment-sensitivity and readily penetrate the blood-brain barrier, allowing in vivo fluorescence imaging of Aβ plaques in a live mouse model of Alzheimer’s disease.

BiographyJuryang Bae received her BS from Pusan National University in 2013. Currently, she is a PhD candidate at Pohang University of Science and Technology (POSTECH).

[email protected]

Juryang Bae et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressLysosomal zinc ions imaging with two-photon fluorescent probeHyeonjin Park, Hyo-Jun Lee, Subhankar Singha and Kyo Han AhnPohang University of Science and Technology, Republic of Korea

Detecting lysosomal Zn(II) is an important issue because it acts as downstream marker for the LMP process. Development of fluorescent probe which can detect lysosomal Zn(II) ions is necessary to study the oxidative stress levels in biological

systems. Herein, we have developed innovative two-photon probe using naphthalimide dye composed of N,N-di-(2-picolyl)ethylenediamine (DPEN) ligand and a morpholine unit. The probe can detect Zn(II) ions in lysosomes with high sensitivity and selectivity over the most competing Cd(II) ions. The probe can also enabled fluorescence imaging of mouse brain tissues under two-photon excitation at 900 nm. The probe can be an effective tool for studying biological processes related to lysosomal Zn(II) ions by two-photon microscopy.

BiographyHyeonjin Park, Pohang University of Science and Technology, South Korea.

[email protected]

Hyeonjin Park et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressHow to enhance fluorescence and two-photon properties of typical dipolar dyes in aqueous media?Hyerim Kim, Subhankar Singha, Dokyoung Kim and Kyo Han AhnPohang University of Science and Technology, Republic of Korea

The donor-acceptor (D–A) type dipolar dyes have been widely used as fluorophores in molecular probes and biological tags.1 In general, this type fluorophores emit strongly in organic solvents but poorly in aqueous media. To enhance the

poor emission behaviour of dipolar dyes in aqueous media, we carried out a systematic structure variation of the donor, amino substituent of acedan which is an important two-photon dye.2 We have identified several factors that influence the emission behaviour of the diopolar dyes in aqueous media by inhibiting the liable factors for poor emission: 1,3-allylic strain, rotational freedom, and hydrogen bonding with water. This rational approach can be applied to other dipolar fluorophores, as demonstrated for naphthalimide, coumarin, and (4-nitro-2,1,3-benzoxadiazol-7-yl)amine (NBD) dyes. The new acedan and naphthalimide dyes thus allow us to obtain much brighter two-photon fluorescent images in cells and tissues than in their conventional forms. As an application of these findings, a thiol probe was synthesized based on naphthalimide dye, which showed greatly enhanced fluorescence from the widely used N,N-dimethylamino forms. The results indicated that our approach has great potential for the development of efficient dipolar dyes and fluorescence probes for studying biological systems, particularly by two-photon microscopy.

Figure 1. Three factors that affect the emission behavior of acedan, a representative dipolar dye (Taken from ref 2).

BiographyHyerim Kim is from Pohang University of Science and Technology, Republic of Korea

[email protected]

Hyerim Kim et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003

CH3

NH3C

O

CH3

HO H

HO

HHO

H

SuppressingICT; also cause

noradiative decay

EnhancingICT

H

2) Allylic 1,3-strain

3) Rotational freedom

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressIonic conductivity on cyano-bridged bimetal assembliesKosuke Nakagawa, Kenta Imoto and Shin-ichi OhkoshiThe University of Tokyo, Japan

Various interesting functionalities have been reported on Prussian blue analogues, such as humidity sensitive magnetism. Prussian blue analogues have two types of cubic crystal structures. One of them is MA

II[MBIII(CN)6]2/3•zH2O type (MA, MB:

transition metal ions). There are vacancies of [MB(CN)6] in MA[MB(CN)6]2/3•zH2O, and water molecules are coordinated to MA ions and/or exist in the vacancy sites. Herein we report high ionic conductivities (σ) of 1.2×10−3 S cm−1 for Co[Cr(CN)6]2/3•zH2O (1) and 1.6×10−3 S cm−1 for V[Cr(CN)6]2/3•zH2O (2) at 293 K, 100%RH, respectively. As the humidity decreased, σ of 1 drastically decreased to 3.2×10−8 S cm−1 at 8%RH. This result indicates that the origin of ionic conduction is explained by Grotthuss mechanism, i.e., proton transfer is mediated by hydrogen-bonding network of water molecules. σ at 100%RH of 1 and 2 increased as temperature was increased. The plot of ln(σT) vs T−1 of 1 was linear and gave an activation energy (Ea) of 0.22 eV, whereas, the slope of the plot of 2 changed at an intermediate temperature. The Ea values in the high- and low-temperature regions were 0.10 and 0.19 eV, respectively. The folding point of 313 K corresponds to the magnetic transition temperature of 2, which indicates that an interference effect between magnetic ordering and proton conduction was observed.

BiographyK. Nakagawa has completed his PhD at the age of 27 years from The University of Tokyo. He studies as a postdoctoral researcher at The University of Tokyo, School of Science.

[email protected]

Kosuke Nakagawa et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressA fluorenyl-based metal-organic framework with photocatalytic propertyRong-Xin YuanChangshu Institute of Technology, P R China

Metal-organic frameworks (MOFs) have potential applications in the fields of sorption and separation, catalysis and luminescence. Here, a 3D compound {[Zn2(BPF)(NH2-BDC)2]}n (1) was constructed with 2,7′-bis(4-pyridyl)fluorine

(BPF) and 2-aminoterephthalic acid (NH2-BDC ) as bridging ligand. The single crystal X-ray study showed that compound 1 displays pillar-layered structure. The solid-state emission spectra of the compound have been studied at room temperature. Compound 1 shows strong emission at 495 nm, which is stronger than that observed in the free BPF (424 nm). The enhancement of luminescence may be attributed to the chelation of ligand with metal center, which effectively increases the rigidity of the ligand and reduces the loss of energy by radiation decay. The band gap (2.75 eV) was measured by a solid state visible light diffuse reflection measurement method at room temperature. We select methylene blue (MB) as a model of dye contaminant to evaluate the photocatalytic effectiveness. Approximately 50% of MB was degraded in four hours under neon light at 500 W.

BiographyRong-Xin Yuan has completed his PhD in 2002 at Nanjing University. From 2002 to 2004, he worked at University of Bielefeld and University of Nottingham as a Postdoctoral fellow. Now, he is the Director of Jiangsu Provincial Key Laboratory of Advanced Functional Materials. He has published more than 50 papers in reputed journals and has been serving as an Editorial Board Member of the Journal of Soochow University (Natural Science Edition ).

[email protected]

Rong-Xin Yuan, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressPalladium nanoparticles supported on four different materials as efficient catalysts for suzuki cross-coupling reactionsBilgehan Guzel, Burcu Darendeli and Fatma UlusalUniversity of Cukurova, Turkey

Palladium-catalyzed carbon−carbon bond-forming reactions developed by Heck, Negishi and Suzuki, among others have made a critical impact on synthetic organic chemistry. In this regard, coupling reactions present wide applications in the

production of polymers, agrochemicals, pharmaceutical intermediates, and high-tech materials. Palladium nanoparticles (Pd NPs) provide high activity in catalyzing Suzuki cross coupling reactions, due to their high surface to area ratio. Silica, activated carbon, carbon nanotubes and alumina are used as support materials for Pd NPs to provide heterogeneous catalysis for the reaction. Four different support materials have been used and their catalytic activities were investigated. Pd NPs were prepared by supercritical carbon dioxide deposition method and vic-dioxime derivative Palladium complexes were used as precursors. Supported Pd nanoparticles were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM) and scanning electron microscopy (SEM). XRD patterns showed that the size of nanoparticles changes between 2 and 10 nm.

Figure 1. Suzuki-Miyaura cross-coupling reaction results of various Pd(0) nanoparticles (Pd NPs)

The catalytic activities of Pd NPs were performed in Suzuki-Miyaura cross-coupling reactions. The reactant/product ratio was determined with gas chromotography (GC) and almost %100 conversion was got from alumına supported Pd NPs.

BiographyBilgehan Güzel has completed his PhD at Çukurova University and Postdoctoral studies from Texas A&M University. He has published more than 9 papers in reputed journals and his research areas are organometallic complexes, catalysts, nanomaterials and scCO2 media.

[email protected]

Bilgehan Guzel et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressSynthesis of ScCO2 soluble perfluorinated chiral shiff-base ligand and its metal complexesBurcu Darendeli and Bilgehan GuzelUniversity of Cukurova, Turkey

Asymmetric reactions carried out using homogeneous catalysts are used in the preparation of many chiral compounds especially in pharmaceutical industry. Enantiopure chiral complexes play a major role in performing asymmetric

synthesis in homogeneous catalysis reactions. There is a lot of interesting about chiral binaphthyl Schiff base complexes for using asymmetric reactions. Due to difficulties in separation of catalyst from products in purification steps and high cost of catalyst, researchers are seeking more convenient methods for synthesis. Hence researches continue to focus on supercritical fluids, ionic liquids and biphasic liquid systems as new reaction media. Especially homogeneous catalysts in supercritical carbon dioxide (ScCO2) are often preferred in very common organic synthesis.

Figure 1. Reaction of chiral ligand synthesis

In this work, Schiff base ligands were prepared from condensation of perfluorinated aldehydes with binaphthyl amines (Fig.1.). For this step, firstly perfluorinated aldehydes were synthesized, then the condensation was occurred. Transition metal complexes of this ligand were prepared as chiral catalyst for various asymmetric reactions in ScCO2. Effect of reaction parameters such as pressure, temperature, reaction time, catalyst/substrate ratio on the enantio selectivity of catalyst were also be investigated.

BiographyBurcu Darendeli has completed her BSc from Hacettepe University and completed her MSc from Çukurova University. She still continues her PhD at the same university. Her research areas are organometallic complexes, catalysts, nanomaterials and ScCO2 media.

[email protected]

Burcu Darendeli et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressSynthesis and enzyme inhibition study of dihydrofurocumarin and dihydrofuropyrane compunds Asli Ustalar and Mehmet Yilmaz Kocaeli University, Turkey

Coumarin derivatives such as Scopoletin, Esculatin, Fercoprolone, Hohneliacoumarin, Angelicin, Psoralen and Aureptene have been found in nature and they possess many biological activities varying from anticancer, antioxidant, antibacterial,

antifungal and anticougulant. It is well known that Mn(OAc)3 have been used as radical oxidant in the synthesis of dihydrofuran derivatives forming C-C bond between active methylene compounds and alkenes. In here, we performed the reaction of of 4-hydroxycoumarin and 4-hydroxypyrane with conjugated amide and esters promoted by Mn(OAc)3 leading to dihydrofurocoumarins and dihydrofuropyranes in moderate to good yields. All new compounds were characterisized by spectroscopic techniques. Also, we investigated enzyme (cGMP PDE- cyclic guanozine mono phosphate phosphodiesterase) inhibitions of these compounds.

BiographyAsli Ustalar has completed his MS from Kocaeli University. She is a PhD student in Kocaeli University.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressSignaling of Hg(II) ions by reaction-based probes based on depro-tection of dithianeIn Jung Chang, Keum Saem Hwang and Suk-Kyu ChangChung-Ang University, Republic of Korea

A new reaction-based probe for the fluorescence signaling of Hg2+ ions using dithiane derivative of ESIPT probe has been investigated. Probe showed prominent off-on type fluorescence signaling behaviour towards Hg2+ ions in aqueous DMSO

solution. The interfering response of Cu2+ ions was efficiently removed by using a citrate buffer as a masking agent. By using citrate buffer, the selective signaling behaviour is not affected by the presence of other metal ions that are usually present in environmental samples. Hg2+ ions signaling by a large fluorescence enhancement (66-fold) was possible with a detection limit of 1.8 ×10-7 M.As a test of a practical use for the designed probe, we created a test strip that could be used to detect Hg2+ ions in aqueous solution.

BiographyIn Jung Chang obtained his Bachelor’s degree from the department of chemistry at Chung-Ang University in 2015. She is currently a master student in the department of chemistry at the same University. Her research field is design of chemical probes for metal ions and anions. Her research interest is development of chromogenic and fluorogenic chemosignaling probes.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressSmartphone-based fluorescence signaling of hypochlorite in tap water by oxidative hydrolysis of sulfonhydrazoneMin Jeoung Cho, Hyein Ryu and Suk-Kyu ChangChung-Ang University, Republic of Korea

Detection and control of biological and/or organic pollutants in drinking and industrial waters are of the utmost importance, especially if the final usage is for daily human consumption or the production of foodstuffs. Hypochlorite, ionized form

of hypochlorous acid (HOCl), is particularly important because it is widely used in household and industrial area as cleaning agent, disinfectants, and sanitizers. Because of its widespread usage and an excess level of OCl- is potentially harmful to the health of human and animals, development of simple and convenient signaling methods for its industrial and environmental applications is imperative. Based on a sulfonhydrazone of 2-acetyl-6-methoxynaphthone, a new hypochlorite signaling probe 1 was developed. The designed probe exhibited prominent off-on type fluorescence signaling behavior toward hypochlorite in aqueous solution by hypochlorite-triggered oxidative hydrolysis of sulfonhydrazone. Hypochlorite signaling by a large fluorescence enhancement (76-fold) was possible with a detection limit of 3.8 × 10-8 M. The signaling of hypochlorite was not affected by the presence of other practical oxidants as well as common metal ions and representative anions. As a practical application, signaling of 1 for determination of hypochlorite levels in practical sample of tap water was conducted by using an easy-to-use smartphone as a detection tool.

BiographyMin Jeoung Cho is currently a master student in the department of chemistry at Chung-Ang University. Her research field is design of chemical probes for metal ions, anions and oxidative species.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressDual signaling of the water content of biofuel-relevant ethanol and butanol by pyraninesYun-uk Jung, Myung Gil Choi and Suk-Kyu ChangChung-Ang University, Republic of Korea

A simple optical sensor for the measurement of the water content of biofuel-relevant ethanol and 1-butanol based on the pyranine fluorophore was investigated. The diethylsulfonamide derivative showed pronounced absorption and

fluorescent signaling in response to changes in the water content of ethanol and 1-butanol. The signaling is based on the increased dissociation of the hydroxyl group of pyranine in response to the increasing water content of the alcohol solutions. The signaling behavior of the sensors was analyzed readily by ratiometric measurements using the absorption and fluorescence characteristics of the undissociated and dissociated form. Upon derivatization to diethylsulfonamide, the signaling became more sensitive than that for its parent pyranine. The detection limit of the pyranine and diethylsulfonamide derivative for the measurement of the water content in ethanol was 1.0% and 0.03%, respectively. On the other hand, the detection limit of the diethylsulfonamide derivative for the determination of water content in 1-butanol was 0.02%, while underivatized pyranine was not useful due to the limited solubility of the sensor. The practical application of the measurement of the water content in ethanol and 1-butanol by a smartphone as an easy-to-use colorimetric device was also explored.

BiographyYun-uk Jung obtained his Bachelor’s degree from the department of chemistry at Chung-Ang University in 2015. He is currently master candidate in same university. His research interest is development of chromogenic and fluorogenic probes for biologically important species.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressPhotophysical properties of boron trifluoride complexes based on 2(2’,4’-dihydroxyphenyl) benzothiazole and benzimidazoleSang Hun Lee and Suk-Kyu ChangChung-Ang University, Republic of Korea

New boron triflouride-introduced 2(2',4'-dihydroxyphenyl) benzothiazole (2,4-DHBT) and benzimidazole (2,4-DHBI) was synthesized and its photophysical characteristic were investigated. Each compound was generated well by using

2-aminophenol or ortho-phenylenediamine with 2,4-dihydroxybenzaldehyde. 2,4-DHBT and 2,4-DHBI have difference flourescence patterns on the basis of the excited-state intra-molecular proton transfer (ESIPT) system. It is well known that ESIPT is significantly affected by the properties of solvent. UV-Vis data and emission spectra of each compound were observed in various type of solvent such as dichloromethane, acetonitrile, dimethyl sulfoxide and they showed stokes shift of 60-70 nm approximately. Furthermore, difference of spectra was noticed by comparing new compound to those without boron trifluoride. Absorption and fluorescence intensity depending on pH, in water with small amount of ethanol were also tracked and pKa value of individual derivatives were calculated.

BiographySang Hun Lee studied chemistry which is his major for 6 years at Chung-Ang University, and completed bachelor’s degree on chemistry in 2015. He is presently on a master’s candidate. His main research area is organic synthesis of sensors signaling chemical species such as metal ion or oxidants which can be harmful for human and environment, or important in modern industry.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressPhytochemical screening and antitumor effect of ethanol extract of Egyptian wild plantsThoria Diab and Thoria DoniaTanta University, Egypt

It was proposed for decades that natural products are more safe in therapeutics as compared to synthetic drugs. The aim of this study was to screen ethanol extracts of four Egyptian plants (Varthemia candicans, Peganum harmala, Suaeda

vermiculata and Conzya dioscoridis) to study their antioxidant activity in vitro using DDPH (50% DDPH inhibition) and phosphomolybdate assays (as equivalent ascorbic acid/g dry weight), in addition to the total phenolic and flavonoid contents were estimated to find possible sources for future novel antioxidants in food and pharmaceutical formulations. Moreover, the anticancer activity of plants extracts against HepG2 cells using MTT assay was studied. The results revealed that Varthemia candicans extract was the highest one in both polyphenol and flavonoid contents. Furthermore, 50% DDPH inhibition showed that Suaeda vermiculata extract exhibit lowest IC50 against DDPH indicating it is the most effective. Taken together, the four investigated plants extract showed a potent antioxidant and antitumor activities that hold great promise to identify new natural therapeutic drugs. Further work is needed to study the mode of action of different extracts and more analyses to study their in vivo anticancer activities.

BiographyThoria Diab did her PhD from Paul Sabatier University, Toulouse, France. She has 3 papers in reputed journals, Journal of Hepatology is one amongst them. She ahs presented a abstract in a conference in France, and a chapter in an electronic book (Advnces in Genome Science, Chapter 6).

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressTitle: Calcineurin levels and activity in breast cancer: Relation to apoptosis Abeer A A Khamis3, Manal Basyouni Ahmed1, Maha Imam Ahmed1 and Muneera Al-Sheeha2

1Ain Shams University, Egypt2Qassim University, Saudi Arabia3Tanta University, Egypt

Background: Calcineurin (CN) is a Ca2+/calmodulin- dependent phosphatase and has been implicated in both transcription-dependent and transcription-independent apoptosis. Objectives: We aim to interpret the correlation between calcineurin

and apoptosis in relation to pathogenesis of breast cancer. Design and methods: Both calcineurin level and activity as well as caspas-3 activity were evaluated in tissue homogenate of 50 breast cancer patients, 20 patients with fibroadenoma and 15 healthy women. Results: Calcineurin activity was significantly low in malignant compared to benign and normal groups (P=0.00) without significant changes in its level (P> 0.05). While caspase-3 showed a significant higher activity in malignant group compared to other groups (P<0.05). Moreover, there was a significant negative correlation between calcineurin activity with grade, stage (P=0.01), caspase-3 (P=0.002) and a significant positive correlation with its level (P=0.039). Conclusion calcineurin activity but not its level has an important role in breast neoplasia, restoration of its normal activity may be act as adjuvant factor of apoptosis and control breast cancer pathogenesis.

BiographyAbeer Abdel Hamid Ahmed Khamis is from the department of Biochemistry from Tanta University, Egypt.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressProtection and functionalization of magnetic iron oxide nanoparticles with phthalic acid for the efficient removal of Reactive Black 5 from aqueous solutionsGehan M Nabil, Mohamed E Mahmoud, Nabila M El-Mallah and Hind M Hassouba Alexandria University, Egypt

The objective of this work is the study of adsorption of the reactive dye RB5 by magnetic iron oxide nanoparticles (NPs) coated with phthalic acid prepared by co-precipitation method. This adsorbent was characterized by scanning electron microscope

(SEM), transmission electron microscope (TEM), thermal gravimetric analysis (TGA) and fourier transform infrared (FT-IR) spectra. In batch adsorption procedure variables including the amount of adsorbent, initial dye concentration, contact time, pH and temperature had a great effect on the removal percentage of the dye. The application of magnetite nanoparticles loaded with phthalic acid as an adsorbent of RB5 removal has been successfully tested. The maximum removal percentage is 92% at pH=2, shaking time 20 min., adsorbent dose 25 mg per 10 mgL-1 initial dye concentration at 25°C. Different kinetic models: pseudo-first-order kinetic, pseudo-second-order kinetic, intraparticle and Elovich kinetic models were applied to examine the mechanism of adsorption. The data kinetically followed the pseudo-second-order kinetic model. Equilibrium adsorption capacities were determined by fitting experimental data to isotherm models: Langmuir, Freundlich, Dubinin-Radushkevich isotherm and Temkin models. Based on the calculated thermodynamic parameters ΔG, ΔH and ΔS, it was noticeable that the adsorption was a spontaneous and an endothermic process. The potential application of phthalic acid-loaded magnetite for the adsorptive removal of RB5 dye from real water samples was discussed.

BiographyGehan M Nabil is a faculty member in department of chemistry at Alexandria University, Egypt.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressA new polymeric membrane Fe (III) ion-selective sensor based on Fe (III)-Morin (3, 5, 7, 2', 4'-Pentahydroxyflavone) schiff baseTugba Ozer and Ibrahim IsildakYildiz Technical University, Turkey

Fe (III)-morin (3,5,7,2',4'-pentahydroxyflavone) complex was synthesized and utilized as an ionophore for PVC-based polymeric membrane (PME) for detection of Fe3+ ions. The sensor exhibited over Nernstian response for Fe3+ ions with a

slope of 58±2 mV per decade over a wide concentration range 1.0 x10-1 -1.0x10-6 M and relatively low detection limit (3x10-6 M). It had a short response time, less than 15 s, particularly high selectivity towards iron (III) ions among various heavy metal ions and displayed stable and reproducible potential over a period of 120 days. It was concluded that the potential response of the proposed sensor was independent of the pH of the test solutions within the pH working range from 6.5 to 11.0. The sensor was used successfully as an indicator electrode for direct determination of Fe3+ in several synthetic samples. The analytical applicability of the sensor was also approved by employing in potentiometric titration of Fe+3 with EDTA.

BiographyTugba Ozer has completed her MSc in Marmara University. She is a PhD student in Yildiz Technical University, Department of Bioengineering. Her areas of specialization are: electrochemistry, environmental chemistry, analytical chemistry, heavy metals, sensors, crop science, biopolymer, bioinformatics, systems biology.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressA novel iron(II) selective membrane electrode based on 2-cyanomethyl N-methyl-N-phenyl dithiocarbamate and its applicationsTugba Ozer and Ibrahim IsildakYildiz Technical University, Turkey

A novel iron (II) selective membrane electrode based on 2-cyanomethyl N-methyl-N-phenyl dithiocarbamate and its applications: Iron has a vital role in all living systems including transportation and storage of oxygen, electron transport

and production of enzymes. It can be hazardous for health if its concentration has excess level in the body causing liver and kidney damage, irritation in stomach. Also, iron deficiency results in anaemia. There is increasing need to determine iron ion concentration in medicinal, clinical, environmental and industrial samples. Solid contact PVC based membrane electrode provides an alternative platform by eliminating inner reference solution to achieve better response properties such as selectivity, sensitivity, response, pH range, and response time of ISE as well. The effects of different parameters such as the quantity of plasticizer, the type of plasticizer, pH of the sample solution, and coexisting ions on the potentiometric responses of the electrode were investigated. 2-Cyanomethyl N-Methyl-N-Phenyl Dithiocarbamate has strong affinity toward Fe (II) ions and thus it was assigned as an ionophore for designing a Fe2+ selective electrode with a slope of 31.55 mV per decade over a wide concentration range of 1.0 × 10−7− 1.0 × 10−1 M Fe2+. The obtained potential values remains constant between the pH ranges 4.5-7.5. The response time was found to be 25 seconds. The electrode revealed good selectivity for Fe2+ in the presence of different coexisting cations and anions. Detection of Fe (II) ions was successfully carried out in water samples with the proposed electrode.

BiographyTugba Ozer has completed her MSc in Marmara University. She is a PhD student in Yildiz Technical University, Department of Bioengineering. Her areas of specialization are: electrochemistry, environmental chemistry, analytical chemistry, heavy metals, sensors, crop science, biopolymer, bioinformatics, systems biology.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressComputer simulation of the molecules of thermotropic substituted biphenyls Abulyaissova L KBuketov State University of Karagandy, Kazakhstan

The conformational properties of thermotropic 4-alkyl- or 4-alkoxy-4'-cyanobiphenyl have been studied. The substances are in a variety of leading companies producing liquid crystal materials due to the absence of color, low viscosity,

stability, low melting temperatures. The geometry of the molecules of 4-n-pentyl-4'-cyanobiphenyl (BP-5), 4-n-pentoxy-4'-cyanobiphenyl (OBP-5), 4-n-octyl-4'-cyanobiphenyl (BP-8) and 4-n-decyl-4'-cyanobiphenyl (BP-10) was optimized by the molecular- mechanical method with force field MM2 and quantum-chemical method B3LYP/6-31G(d). The dependence of the mesomorphic properties of substances and the structural parameters of molecules on the length and nature of the non-rigid fragments has been examined.

BiographyAbulyaissova L K is an Associate Professor of Chemistry in Faculty of Physical and Analytical Chemistry at the Karagandy State University, Republic of Kazakhstan. She has published more than 70 papers and presentations in both international and national journals and scientific conferences. She is the author/co-author of 2 textbooks and the member of the International Liquid Crystal Society.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressComparative study of corrosion of iron in cyanide and thiourea media in hydrometallurgical processesHugo Romero, Diana Tello and Cristhian VegaUniversidad Técnica de Machala, Ecuador

The aim of this investigation was to assess the potential of corrosion of ASTM A36 steel specimens means cyanide and thiourea in two different concentrations used in leaching processes, by polarization curves at room temperature (298 K).

Furthermore, evaluate the surface state of the accelerated corrosion caused by electrochemical measures of SEM microscopy studies. To develop the experiment was used as research material specimens ASTM A36 steel, obtained from pieces of this material are used in the manufacture of a leaching reactors industry processing plant. Square samples of 2 cm by side and 0.3 cm thick were used. The weight and dimensions necessary to calculate the surface area and the initial value of the weight for the corrosion tests samples and weight loss was determined. As corrosive medium was used cyanide and thiourea industrial grade obtained from a local company. The samples subjected to corrosion tests were analyzed using scanning electron microscopy to observe the characteristics of the surface with a Phenom Pro desktop Scanning electron microscope (SEM). Electrochemical tests were performed with a CH Instruments potentiostat model 700D. The results of the corrosion potential of -0.32 V was for steel in sodium cyanide 0.62 g/l and thiourea -0.47 v to 0.96 g/l. For his part for concentrations of sodium cyanide 0.80 g/L thiourea 1.24 g/L corrosion potentials were -0.34 V and -0.49 V respectively. This allows us to conclude that metal ASTM A36 steel samples have higher corrosivity thiourea solutions compared with solutions of sodium cyanide.

BiographyHugo Romero has completed the Master's program in Chemistry at the Catholic University of Valparaiso, Chile. He works as a researcher and Professor at the Faculty of Chemistry at the Technical University of Machala, Ecuador, where he has served as Director of Chemical Research Center and Director of the Center for Technology Development. His research lines are Corrosion and Applied Electrochemistry. He has published about 10 papers in reputed journals such as Progress in Organic Coutings, Talanta, Advances in Chemistry and Analytical Chemistry Research.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressAdsorption kinetics, isotherms and thermodynamic studies for Hg2+ adsorption from aqueous medium using alizarin red-S loaded amberlite IRA-400 resinMu NaushadKing Saud University, Saudi Arabia

Alizarin red-S modified amberlite IRA-400 resin (ARSA) was applied for Hg2+ removal from the aqueous medium which is highly toxic metal ion. The adsorption process which was pH dependent, showed maximum adsorption of Hg2+ in the

pH range 6 to 8. ARSA exhibited good monolayer adsorption capacity for Hg2+ (303.03 mg g-1) at 25°C and the isotherm was well fitted by the Langmuir model. Moreover, the adsorption was evaluated thermodynamically and the negative values of ∆Go revealed the spontaneity of adsorption process. The practical applicability of ARSA was explored for the adsorption of Hg2+ metal ion from a real water sample. The values of ΔH and ΔS were found 79.87 kJ mol-1 and 0.26 J mol-1 K-1, respectively.

BiographyMu Naushad is currently working as Assistant Professor, Department of Chemistry, King Saud University, Saudi Arabia. He did his Ph.D. degree in Analytical chemistry, A.M.U. Aligarh, India in 2007. He has extensive research experience in multi-disciplinarily fields of Material Science, Analytical Chemistry and Environmental Science. He is the author of more than 45 research articles, seven book chapters and two books of international repute. Moreover, he is the editorial member of more than 30 international journals.

[email protected]

Mu Naushad, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressIn situ preparation of nitrogen enriched hierarchically nanoporous carbon from polybenzoxazine precursor for CO2 capture and storage Nicharat Manmuanpom, Sujitra Wongkasemjit and Thanyalak ChaisuwanChulalongkorn University, Bangkok

Carbon dioxide capture and storage (CCS) is the technology by which carbon dioxide emissions from power plants are captured and stored for future use. The process could help reduce the greenhouse gas in the atmosphere which is the

cause of the climate change. Recently, porous carbons which have micro-mesopores structure, high surface area and high nitrogen sites can enhance the CO2 adsorption capacities because the basic nitrogen groups can interact with CO2 gas. In this study, micro-meso porous carbons with high nitrogen content were prepared from polybenzoxazine as a precursor and silica nanoparticles as a hard template to generate mesoporous structure. Polybenzoxazine, an additional cure phenolic resin is an excellent carbon precursor since the molecules can be easily designed to incorporate nitrogen functional groups without complicated synthesis procedures. The morphology of carbons was investigated by FE-SEM. The Autosorp 1-MP carried out to determine the surface area, particle size and pore volume of the resulting nanoporous carbon. The effect of pyrolysis temperature to obtain nitrogen enriched nanoporous carbon was confirmed by using XPS and elemental analyzers. As a result, activated carbon that using 40%wt. silica colloidal template and pyrolyzed at 800°C exhibited high CO2 uptake (1.233 mmol/g at 30ºC, 1 bar). The adsorption of CO2 was increased because the pyridine and pyridone types of nitrogen reacted with CO2 gas, as well as physical adsorption of the micro-meso porous structure.

BiographyNicharat Manmuanpom is a PhD student at Petroleum and Petrochemical College, Chulalongkorn University in major of polymer science. She graduated with Bachelor’s degree from Chulalongkorn University in Department of Chemistry. Much of her work focuses on polybenzoxazine synthesis and its application.

[email protected]@chula.ac.th

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressDirect voltammetric determination of redox-active iron in carbon nanotubesWei Zhe Teo and Martin PumeraNanyang Technological University, Singapore

With the advances in nanotechnology over the past decade, consumer products are increasingly being incorporated with carbon nanotubes (CNTs). As the harmful effects of CNTs are suggested to be primarily due to the bioavailable amounts

of metallic impurities, it is vital to detect and quantify these species using sensitive and facile methods. Therefore, in this study, we investigated the possibility of quantifying the amount of redox-available iron-containing impurities in CNTs with voltammetric techniques such as cyclic voltammetry. We examined the electrochemistry of Fe3O4 nanoparticles in phosphate buffer solution and discovered that its electrochemical behavior could be affected by pH of the electrolyte. By utilizing the unique redox reaction between the iron and phosphate species, the redox available iron content in CNTs was determined successfully using voltammetry.

BiographyWei Zhe Teo is a faculty member in Nanyang Technological University, School of Physical and Mathematical Sciences, division of Chemistry & Biological Chemistry, Singapore.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressPromotion of sorghum hybrids bran grown in Southern Italy for PHB ecological production by Sphingomonas cynaraeRoberta Romano1, Paola Pontieri2, Graziano Pizzolante1, Pietro Alifano1 and Luigi Del Giudice2

1University of Salento, Italy2Institute of Biosciences and Bioresources-UOS Portici, Italy

Sorghum is one of a major crop used for food, feed and industrial purposes worldwide. As such it has the potential to be a valuable source of biomaterials. Kafirin, the storage protein of sorghum, can form biodegradable plastic films. However,

producing the plastic from sorghum protein could be very expensive and time consuming. A cheaper alternative would be to produce biodegradable plastics from starch present in the bran of sorghum grains. Over the last years the environmental impact of plastic waste on the ecosystems represents a critical problem. Bacterial poly-3-hydroxybutyrate (PHB) is an ecological alternative. Food industry waste represents a sustainable medium for bacterial growth and PHB production. We are interested in producing PHB by bacteria grown in the presence of sorghum bran. Our preliminary studies focused on the use of the bran of sorghum hybrids grown in South of Italy as medium for Sphingomonas cynarae cells in order to produce PHB. The mean composition of these brans consisted of about 28% starch, 14% protein and 3% fat. The bran powder was resuspended in water (1:10 w/v) and autoclaved to make available the starch. Primarily, we detected the amylase activity of S. cynarae by plating methods. Transmission electron microscopy (TEM) analysis has confirmed the PHB accumulation in the cells and it was recovered by high pressure homogenization. The yield was approximately of 0.6 g/L. To our knowledge, this is the first report describing the production and green-recovery of PHB by S. cynarae utilizing sorghum bran as a nutritional source.

BiographyRoberta Romano graduated cum laude in Biotechnological Sciences at University of Salento in 2012. She worked as external collaborator for Eggplant srl, conducting her research in the production and green-recovery of PHB from olive mill wastewater using Azotobacter vinelandii. This activity was published in the Journal of Life Sciences with the title “Complete valorization of Olive Mill Wastewater through an integrated process for poly-3-hydroxybutyrate production”. She also conducted research at the Laboratory of Biochemistry and Microbiology of the University of Salento and worked in the Del Giudice’s lab of the University of Naples analyzing the properties of various sorghum hybrids.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressSynthesis of NiO nanoparticles for new nanocomposite materialsSevil Çetinkaya and Taner Özker Kirikkale University, Turkey

Nanostructured oxides are gaining continuous importance for various applications due to their unique physical and chemical properties based on the size-homogeneity and large specific surface area. Crystallography and size of the nano-

materials greatly affect their applications in designing optical, electronic, magnetic and catalytic materials. NiO is an important inorganic oxide extensively used in catalysis, battery cathodes, electrochromic films, and magnetic materials. Nanocrystalline NiO is believed to have many better properties than those of micrometer-sized NiO particles in terms of the volume effect, the quantum size effect, the surface effect. The present work represents an attempt to synthesize of suitable NiO-nanoparticle for the design of high performance novel nanocomposite materials. The effect of synthesis conditions on morphology development and surface area was experimentally investigated. Nano-NiO particles have been obtained by thermal decomposition method using NiCl2 and NH3.H2O as the raw materials. After calcination process of the Ni(OH)2 precursors at 400-500°C for 1 h, green Ni(OH)2 precursors have been transformed into black NiO nanoparticles. XRD patterns of NiO nanoparticles confirmed the conversion of Ni(OH)2 into NiO nanostructure. Nanostructures were also confirmed SEM, TEM, FTIR, Raman and Uv-vis analyses. Analysis results reveal that the synthesized nanoparticles have cubic particles with an average diameter of around 8-13 nm. The NiO nanoparticle obtained at 400°C with the highest surface area and small crystal size has been chosen as a suitable dopant to design new nanocomposite materials.

BiographySevil Çetinkaya is a Professor of Inorganic Chemistry in the Department of Chemistry at Kirikkale University. She obtained her PhD in Inorganic Chemistry at Hacettepe University in 2003. She was a TÜBİTAK/Royal Society visiting Research Fellow at Durham University in 2005. She received L´Oréal Turkey for Young Woman in Science Award in 2016. She joined the Kirikkale University as an Assistant Professor in 2006, and became an full Professor in 2013. Her current research interests focused on organometallic chemistry, design, preparation and applications of nanomaterials and porous carbon materials.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressAntioxidant activity of wild garlic extract (Allium ursinum) obtained by subcritical water extractionAlena Tomšik1, Jelena Vladić1, Marina Cindrić2 and Senka Vidović 1

1University of Novi Sad, Serbia2CEBB d.o.o. Center for Energy, Croatia

Allium species have been used as a source of health benefit compounds in the traditional medicine for many centuries thanks to its wide-spread distribution and popularity as edible and medicinal plant. In the past few years the interest for

wild garlic and its use for prevention, maintaining of the human health as well in nutrition is significantly growing. Subcritical water extraction, SWE, is recognized as one of the most potential extraction technologies for isolation of bioactive compounds, especially antioxidants. Therefore, optimization of subcritical water extraction was conducted in order to maximize antioxidant capacity of the extract. Antioxidant capacity was investigated by application of two test analysis, DPPH and ABTS test. The antioxidant activity for obtained A. ursinum extracts determined using DPPH test, was in the range from 0.04 to 0.47 mg/ml (calculated on IC50), while antioxidant activity measured by ABTS ranged from 0.96 to 11.78 mM TEX/100g DW. Additionaly total phenols and flavonoides were analyized which are responsile for antioxidant activity. Temperature shows to be the most important extraction parameter. The increase of temperature induces the increase of antioxidant activity of obtained extracts (expressed in DPPH and ABTS test). Antioxidant activity of extracts obtained using subcritical water extraction was much higher than activity of A. ursinum extracts obtained in our previous study.

BiographyAlena Tomšik is a PhD student at Department of Biotechnology and Pharmaceutical Engineering, Faculty of Technology, University of Novi Sad. Currently, she is employed as a research associated at Institute of Food Technology, University of Novi Sad.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressPreparation of biological active steroidsSevinc Ilkar Erdagi and Cavit UyanikKocaeli University, Turkey

Aphidicolin is a diterpene and possesses a 1,2-glycol at C-16;C-17 and a 1,3-glycol at C-3;C-18. It is a specific inhibitor of DNA polymerase-α and has attracted much interest because of potentially useful level of antitumor activity. In this study

we describe the synthesis of 13α-methyl and 13β-methyl steroids in which the functional groups associated with the biological activity of the tumour inhibitor, aphidicolin have been introduced onto the steroid backbone in order to attempt to combine the biological activity of the two classes of compound. The steroids possess a characteristic tetracarbocyclic carbon skeleton. The viridin family of steroidal antibiotics have a furan ring between rings A and B. These compounds have been named systematically as furanosteroids. Recent synthetic and biological studies of the viridin class of steroidal furans have revealed multiple opportunities for fundamental discoveries as well as advanced drug design. In this study we also describe attempts to construct a furan or a tetrahydrofuran ring between rings A and B of cholesterol.

BiographySevinc Ilkar Erdagi continues her PhD in Kocaeli University, Turkey under supervisior of Prof. Dr. Cavit Uyanik. She is a Research Assistant in Kocaeli Univeristy for five years. She studies organic chemistry especially in steroid chemistry and natural products.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressSynthesis of 4-amino-N-4-pyridin-1,8-naphthalimide, a new ligand for complexes and metalorganic frameworksUlisses Fiorin AngeloUniversity of São Paulo, Brazil

Naphthalic imides are usually fluorescent molecules, obtained by the reaction of 1,8-naphthalene anhydrides and primary amines. This class of compounds is interesting due to a series of chemical and physical properties such as chemical and

thermal stability, well defined and scaleable (by aromatic rings functionalization) spectroscopy and electrochemical properties as they are also electron acceptors, allowing them to mediate electron transfer processes. These molecules are generally solvatochromic and photoactive towards photoinduced eletron transfer, and they may be used in optical sensors. Due to this property, they behave like n-type semiconductors in solid state, allowing the construction of electronic devices like transistors and OLEDs too. They undergo reversible redox reactions at modest potential forming stable radical anions easily identified by (EPR). Bidentate naphthalimides, as 4-amino-N-4-pyridin-1,8-naphthalimide are also regarded as bridging ligands to prepare “Metal-organic Frameworks” (MOFs) whose properties and structure can be modulated by changing its substituents. 4-amino-N-4-pyridin-1,8-naphthalimide was synthesized for the first time, by the reaction between 4-nitro-1,8-naphthalic anhydride and 4-aminopyridine on ethanol reflux. The imide reduced on a stannous chloride acidic solution and purified by the recrystallization on methanol. High fluorescence was observed in organic solutions. Its structure was elucidated by NMR. Emission and absorption spectra were studied in different solvents and at several pHs, in aqueous solutions. We have noticed decreasing intensities of fluorescence spectra as well as a small bathochromic shift, as the polarity of solvent increases. Changing medium´s acidity, (pH range between 2.04 and 5.60) it was possible to indentify two pKa values (2.75 and 3.49) as predicted by theoretical calculations, using absorption data. We could also observe what seems to be an hypochromic shift as the pH increases, but this has to be confirmed by other measurements such as quantum yield, and excited-state lifetime.

BiographyUlisses Fiorin Angelo completed his chemistry degree from the University of São Paulo, his Masters degree, and currently, he is on course of the last period of his Doctoral studies in Molecular Materials and Interfaces Laboratory (MMIL) (http://sites.usp.br/lmim/) at the same University. He is a member of the Editorial Board of “CADERNOS CIMEAC”, a periodic specialized in popular education.

[email protected]

Ulisses Fiorin Angelo, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressIn vivo anti-wrinkle and anti-melasma activities of peptides isolated from Pigeon pea (Cajanus cajan L. Millsp) Tuanta Sematong, Ubon Rerk-am, Sarunya Laovitthayanggoon, Bantika Kongsombat and Sirinan ThubthimthedThailand Institute of Scientific and Technological Research, Thailand

The peptide was extracted by using alkaline from Pigeon pea (Cajanus cajan (L) Millsp). This work aimed to study antioxidant activity of peptide using in cosmetics. Antioxidant activities were measured by using DPPH assay, compared to ascorbic

acid. The IC50 value of peptide extracts were 61 µg/ml, considered higher than that in ascorbic acid (IC50= 1.37 µg/ml). Whereas the inhibition on dopa oxidase activities of mushroom tyrosinase were (IC50) 41 µg/ml which were weaker than arbutin (IC50 = 1.91 µg/ml). The stimulating effect of dermal fibroblasts (ATCC CRL-1474) on collagen type I synthesis were evaluated by the ELISA test kit. The peptide extracts resulted in the highest activity for stimulating collagen type I synthesis. The activities at concentration of 200 µg/ml were found in the range of 59.34±2.17. This effect was nearly the same ascorbic acid (59.51±3.17%) at concentration of 50 µg/ml. The anti-wrinkle and anti-melasma were evaluated for 8 weeks which subjected on 22 ±2 of Healthy Asian skin type female with their age between 35-65 years old. The anti-melasma was tested by using chromametry technique, the solution of 0.2 % peptide was able to significantly lighten the treated melasma after 8 weeks. Skin replica with Shadow casting analysis for anti-wrinkle effect on the crow’feet area, was significantly decreased the number of wrinkles (-11.0 of -17.4 %, p<0.01), and mean depth (-9.1µm or -8.9 %, p<0.05). The results showed that the peptides were extracted with alkaline from Pigeon pea were suitable as active ingredients in cosmetics.

BiographyTuanta Sematong has completed her degree from Chankasem Rajabhat University. Her excellent experience in Pharmaceutical and natural products safety evaluation as well as efficiency and safety of herbal products development and standardization for more than 30 years at Pharmaceutical and natural products department, Thailand institute of Scientific and Technological Research (TISTR), Thailand. Besides, her great specialize in animal model experimentation has supported SMEs, pharmaceutical companies and private sectors for products evaluation.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressEffect of porogen type and cationic, anionic and nonionic surfactant ratio on the properties of porous polymer supportsVesile Şima Ünnü and Sevil ÇetinkayaKirikkale University, Turkey

PolyHIPE is a porous polymer produced by polymerization of the continuous phase in a two phase system. The cell size and surface area of polyHIPE materials are strongly affected by the amount of surfactant and type of inert porogen. Our

previous studies has shown that porous polyHIPE can be used as a support material for the design of metathesis catalyst. The work presented here describes some of our recent results as part of our programme of work aimed at preparing polyHIPEs having high-surface area synthesized from divinylbenzene to be used as support for the preparation of new generation metathesis catalyst. Effects of triple surfactants ratio and porogen type on the properties of the polyHIPE were studied to select a suitable condition for preparation. Stable w/o HIPEs were prepared using mixtures of different amounts of cationic surfactant cetyltrimethylammonium bromide, anionic surfactant sodium dodecylbenzenesulfonate and nonionic surfactant sorbitan monolaurate (SPAN 20) for investigating the effect of surfactant type. PolyHIPE samples were synthesized by the polymerization of the continuous phase of w/o high internal phase emulsions. The effect of surfactant concentration on the morphologies of polyHIPEs was investigated by scanning electron microscopy and BET. Increasing the amount of cationic surfactant from 0.3% to 0.9% led to an increase in surface area while increasing the amount of anionic surfactant from 0.3% to 0.9% led to a decrease in surface area in the resulting porous materials. The presence of 1,2-dichlorobenzene instead of toluene or chlorobenzene as a porogenic solvent in the oil phase was found to increase the cell size and surface area remarkably. This work has been supported by Kirikkale University Scientific Research Projects Coordination Unit (Turkey) (Project No. 2015/70).

BiographyVesile Şima Ünnü is currently a MSc student in the Department of Chemistry at Kirikkale University (Turkey). In 2015, she graduated from the Kirikkale University with first-rank honours in chemistry. She is working on a research project as a scholar. Her research interest focuses on the design of porous polymers and new metathesis catalysts.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressPolyaniline–ionic liquid mixtures and their application in dye-sensitized solar cellsSang Jun Lee and In Tae KimKwangwoon University, Korea

In this study, we investigated the interactions between the ionic liquids (ILs) of ammonium and imidazolium families and polyaniline–emeraldine base [PANI (EB)]. PANI (EB) is one of the most studied conducting polymers owing to its

applications in electronics, optical devices, sensors, etc. However, there is a massive scope of improvement in this area. In order to increase the utility of PANI (EB), we studied the interactions between PANI (EB) and ILs by using various techniques. Further, we studied the conductivity, morphology, and roughness of PANI (EB)–IL mixtures. We observed that ammonium- and imidazolium-family ILs have the potential to interact with PANI (EB). However, after the interactions, the ammonium-family IL–PANI (EB) mixtures showed more conductivity than the imidazolium-family IL–PANI (EB) mixtures. We also determined the strength of hydrogen bonding between ILs and PANI (EB) from semiempirical calculations carried out using HyperChem 7. Finally, we demonstrated that PANI (EB)–IL additives can be used as electrolytes in dye-sensitized solar cells. This study provides an insight into the combined effect of a polymer [PANI (EB)] and ILs, and this insight may generate many theoretical and experimental opportunities.

BiographySang Jun Lee received his BS degree in Chemistry at Kwangwoon University in 2016. Currently, he is studying for his MS degree in chemistry at Kwangwoon University. His current research interests are mainly in the development of polymer chemistry under Professor In Tae Kim.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressAir-annealing technique to improve photoelectric properties of pristine grapheneDapeng Wei, Xuefen Song, Tai Sun, Leyong Yu, Jun Yang and Chunlei Du Chinese Academy of Sciences, PR China

Graphene is regard as one of the most promising candidate material for future electronics. In fact, graphene film, deposited on metal catalyst via CVD process, normally has poly-crystalline structures and need to be transferred onto a dielectric

surface for photoelectrical applications. The transfer process usually induces contaminations, winkles or even breakage of graphene, which hamper the practical applications of graphene in electronics. Annealing is a simple and feasible approach to tailor the electrical properties of intrinsic graphene. Meanwhile, thermal treatment of graphene could recombine the poly-crystal structures, burn off the contaminations and strengthen the adhesion of graphene and substrates. However, few studies focus on the influences of annealing atmosphere on graphene transparent electrode, that is, whether the thermal gas causes any changes in graphene intrinsic photoelectric performances. Here, we investigated the effects of annealing atmosphere, and developed a simple and effective approach to improve photoelectric properties of pristine graphene via an air-annealing process. In contrast to PGs, the mobility and carrier concentration of air-annealing graphene films (AAGs) were significantly enhanced. Thedele resistance was greatly reduced by more than 30 percent. At the same time, the air-annealing process has also promoted the transparency of PGs by about 3%. Importantly, the as-improved photoelectric properties of AAGs were extraordinarily stable, and the transmittance and resistance remained almost no changes when repeating the same measurements after 100 days. This stable enhancement method provides a simple pretreatment approach for the practical application of graphene transparent electrode.

BiographyDapeng Wei has completed his PhD from Peking University and Postdoctoral studies from Purdue University. Now, He works as a Professor at Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences. He has published more than 30 papers in reputed journals and His research interest is foucsed on the synthesis of graphene or other 2D materials.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressDevelopment of lateral-flow immunoassay for the diagnosis of laryngopharyngeal reflux diseaseJiyoon Kwon, Hae Ry Hyun and Jae Ho ShinKwangwoon University, Korea

A number of patients who complain of laryngopharyngeal reflux disease (LPR) is on the gradual increase due to changes in climate and environment. LPR causes hoarseness, frequent throat clearing, bitter taste in the mouth, referred ear pain,

chronic cough and even larynx cancer. However, the effective treatment of LPR is difficult because the treatment yet stay in the inhibition of gastric acid secretion as well as the symptoms persist after treatment. Therefore, appropriate treatment through accurate and rapid diagnosis is necessary. Since pepsin is proteolytic enzyme produced only in the stomach, detection techniques of pepsin in saliva is useful as a sensitive and non-invasive method for the reflux of stomach contents. Therefore, pepsin is one of the most important biomarkers to diagnose LPR. Herein, we report on a new approach to design an immunoassay based lateral flow immunochromatographic assay for the rapid detection of pepsin. The strip consisted of four main components: sample pad, conjugate pad, membrane and absorbent pad. Nitrocellulose membrane was separately coated with goat anti-rabbit antibodies (control line) and monoclonal anti-pepsin antibodies (test line). The detector reagent consisted of gold nanoparticles coated with polyclonal anti-pepsin antibodies, which saturated the conjugated pad. When pepsin-containing samples were applied to the sample pad, the antigen initially reacted with polyclonal antibody-coated gold nanoparticles and then reacted with the fixed monoclonal antibody on the membrane. These reactions resulted in red line at the test line, with intensity proportional to the pepsin concentration. In this ways, we investigate the utility of lateral immunoassay to determine pepsin in biological samples (i.e., saliva).

BiographyJiyoon Kwon is from Chemical Sensor Research Group, Department of Chemistry, Kwangwoon University, Korea.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressCharacteristics of the different S=O, S-O, N---H, O---H and Na---O bonds into the powerful laxative sodium picosulphate drug and their effects on the properties Silvia Antonia Brandán1, Davide Romani2 and Isabel Salas Tonello1 1Universidad Nacional de Tucumán, Argentina 2SST, Italia

In this work, the influence of the different S=O, S-O, N...H, O...H, Na...O bonds present in the structures of the powerful laxative drug, sodium picosulphate in gas and aqueous solution phases were studied combining the density functional theory (DFT)

calculations with the experimental available infrared, 1H-NMR and UV-visible spectra. The structural, topological, electronic and vibrational properties were investigated in both media by using the hybrid B3LYP/6-31G* method and the integral equation formalism variant polarised continuum model (IEFPCM). Here, the characteristics of the S=O, S-O, N...H, O...H, Na...O bonds were completely revealed by using atomic charges, natural bond orbital (NBO) and atoms in molecules (AIM) studies. The infrared, 1H-NMR, 13C-NMR and UV-visible spectra are in reasonable concordance with those experimental available in the literature. The following reactivity order it is observed when picosulphate is compared with other potential antimicrobial and antiviral drugs: thione > brincidofovir > sodium picosulfate > thiol > cidofovir. The vibrational analysis of sodium picosulphate was performed considering C3V symmetries for both SO42- groups and the complete assignments of the 126 vibration modes were reported in gas phase and aqueous solution together with their corresponding force fields. In addition, the reactivities of sodium picosulfate increase in solution due to their ionic characteristic which probably justifies their behaviour as a stimulant cathartic and their easy metabolic conversion, as reported in the literature.

BiographySilvia Antonia Brandán is a Faculty Biochemistry, Chemistry and Pharmacy, in Inorganic Chemistry Institute, University National of Tucumán (UNT), Tucumán, Argentina. She is Graduated in Chemistry (UNT); Chemical Engineer (UNT); PhD in Chemistry (UNT); Post-Doctorate in Alicante University, Spain. She is the Titular Professor of General Chemistry and Director of the Inorganic Chemistry Institute. She is the Editor Journal of Molecular Structure.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressMultiresidue analysis of selected pharmaceutical compounds in poultry manure by gas chromatography–mass spectrometryRamón AznarSpanish National Institute for Agricultural and Food Research and Technology (INIA), Spain

Spreading poultry manure as fertilizer on agricultural fields has been promoted by national authorities as an economic way of recycling. However, poultry manure may contain contaminants, which could be incorporated into crops and be distributed

in the environment. Among the different types of contaminants, emerging contaminants and particularly pharmaceutical compounds are rising concern due to their presence in different environmental matrices. In this work, an analytical method was developed for the simultaneous determination in poultry manure of 12 pharmaceutical compounds (acid, neutral or basic) belonging to different families (nonsteroidal anti-inflamatory drugs and analgesics among others). These compounds were extracted with acetonitrile by ultrasound assisted matrix solid phase dispersion in tree steps at different pHs and then purified with C18. The compounds were determined by gas chromatography with electron impact mass spectrometric detection in the selected ion monitoring mode (GC-MS-SIM), using matix matched standards to contra rest the matrix effect. Recoveries from spiked samples at tree levels (150, 75 and 25 ng g-1) were ≥ 70 % for most of the compounds with relative standard deviations ≤ 12 %. The limits of detection and quantification ranged from 0.8 to 2.8 ng g-1 and 3.0 to 9.3 ng g-1, respectively. The response obtained with this method was linear over the range assayed (0 to 500 ng g-1), with correlation coefficients ≥ 0.997. The validated method was applied to samples collected from different farms in Spain where salicylic acid was commonly found.

BiographyRamón Aznar is a professional Agronomist Engineer with two MSc and more than 5 years of experience working in laboratories in Ireland, Italy and Spain, developing a good knowledge in environmental chemistry. Currently, he is at the edge of his PhD at INIA (fellowship grant, RTA2014-00012-C03-01). He has published more than 6 papers in international journals and is looking forward to have new challenges after finishing his PhD.

[email protected]

Ramón Aznar, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressStudy on the micro pulsed electro-chemical machining of invar alloy according to electrolyte variablesSeong-Hyun Kim, Kwang-Ho Chun and Eun-Sang LeeInha University, Republic of Korea

Electro-chemical machining appears to be one of the rather promising micro-machining techniques in many fields. It offers some of advantages including higher machining rate, no tool wear and better precision. Recently, many researches have

investigated on special alloys. Invar alloy which is widely used in many industries such as aircraft, frontier display's shadow mask such as OLED, mobile display, biotechnology and aerospace has been applied in this study. Invar is a compound metal of Fe-Ni system and contain 36% Ni. The most distinction characteristic of Invar is the coefficient of thermal expansion is 1.0×10-6cm/°C. Its coefficient of expansion is a very low. Generally, when neutral solutions are used for electro-chemical machining of Invar alloy, debris are produced and stay between electrode and workpiece. It causes the stains on invar alloy and decrease the accuracy. In case of using acid solutions for electro-chemical machining on Invar alloy, there is no debris during the process. But, acid solution reacts with Fe ion in Invar alloy. For this reason, the corrosion is generated on the surface of Invar alloy. In this study, focused mixed electrolyte consists of eydrogen peroxide, acetic acid and sulfuric acid. The performance of each of solutions for electroc-hemical machining has been analyzed. Based on the study, the machinability is compared with each concentration and each solution. Therefore, ions in electrolyte are involved in the electro-chemical machining process to affect machinability characteristic.

BiographySeong-Hyun, Kim received BS degrees in Mechanical Engineering from HOWON University in 2010 and MS degrees in Mechanical Engineering from INHA University in 2012. He is currently a PhD candidate at the Graduate School of Mechanical Engineering at INHA University in Incheon, Korea. His research fields are in micromachining by using chemical reaction, electro-chemical manufacturing and the development of a ultra-precision machining system.

[email protected]

Seong-Hyun Kim et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressAntimicrobial activity of collagen/silver doped hydroxyapatite composites against gram-pozitive and gram-negative bacteriaA M Prodan1,2, C S Ciobanu3, S L Iconaru3, C L Popa3, G Voicu4 and D Predoi31Emergency Hospital Floreasca Bucharest, Romania2Carol Davila University of Medicine and Pharmacy, Romania3National Institute of Materials Physics, Romania.4University Politehnica of Bucharest, Romania

Synthetic hydroxyapatite (HAp) was studied in the last decades due to its crystallographical and chemical resemblance with the mineral part of the human hard tissue. It was proven that HAp has the ability to bond directly with bone tissue.

Recently, HAp was used extensively as a coating material in orthopaedic and orthodontic surgeries. In order to enhance the biocompatibility of HAp, researchers tried to dope it with divalent cations. Silver is well known for its microbiostatic and microbicidal properties. The size and dose of silver nanoparticles strongly influence the antimicrobial properties. Considering that the organic componet of bone tissue is collagen, researcher tried to combine the unique properties of hydroxyapatite, collagen and silver in order to obtain new biomaterials with improved properties with possible application in medicine. The aim of this study was to characterize the properties of collagen/silver doped hydroxyapatite composites (Coll/Ag:HAp). The Ag:HAp powders were obtained by co-precipitation method and Coll/Ag:HAp were obtained in agreement with previous studies. The obtained composites were investigated by XRD, showing that the structure of the sample belongs to hexagonal hydroxyapatite. The morphological studies revealead that the morphology of the composite is influenced by the precence of Ag. The antimicrobial activity of Coll/Ag:HAp composite angainst S. aureus and P. stuartii was evaluated, showing an efficient antibacterial activity against them. Antibacterial activity increased with the increase of Ag concentration in the samples. Our results suggest that Coll/Ag:HAp composite could be used in many biomedical applications.

BiographyA M Prodan is a young surgeon with a PhD and a postdoc fellowship in Chemical Engineering. Also, she is a PhD student in Medicine at Carol Davila University of Medicine and Pharmacy. Moreover, she is involved in research activities involving materials with biomedical applications. She is a co-author of more than 10 relevant papers in her field of work.

[email protected]@gmail.com

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressPhysico-chemical and biological evaluation of zinc doped hydroxyapatite in collagen matrix C L Popa1,2, S L Iconaru1, C S Ciobanu1, Mikael Motelica-Heino3, Régis Guegan3, A M Prodan and D Predoi1*

1National Institute of Materials Physics, Romania2University of Bucharest, Romania.3Université d’Orléans, France. 4Emergency Hospital Floreasca Bucharest, Romania5Carol Davila University of Medicine and Pharmacy, Romania

The human bone is an extracellular matrix composed of an inorganic part, where a major component is hydroxyapatite (HAp), Ca10(PO4)6(OH)2, and an organic part consisting of collagen fibrils [1]. In order to enhance the properties of

synthetic HAp, researchers have tried and succeeded in doping it with different metallic ions with specific properties.

Incorporation of zinc into implants facilitates the bone formation process around the material [2-4] due to its ability of stimulating bone formation in vivo and in vitro and of inhibiting osteoclastic bone resorption in vivo [5-6]. Therefore, our objective was to obtain a superior material comprised of zinc doped hydroxyapatite embedded in a collagen matrix.

Our goal was to achieve a material that could mimmic as good as possible the natural human hard tissue. The present study focuses on the physico-chemical and biological characterization of new material based on zinc doped hydroxyapatite in collagen matrix (Zn:HAp-CBc). XRD studies revealed that Zn:HAp-CBc nanocomposites generated a hexagonal structure characteristic to hydroxyapatite. Moreover, the optical properties evaluated by Raman and FTIR spectroscopy showed specific absorption bands associated to hydroxyl and phosphate groups characteristic to the hydroxyapatite structure. The mapping studies have evidenced an uniform distribution of the constituent elements. The cytotoxicity of Zn:HAp-CBc was studied on HeLa cells. Cell cycle distribution after treatment was examined by flow cytometry analysis. Our preliminary in vitro studies revealed that Zn:HAp-CBc have excellent biocompatibility and support their further characterization by in vivo approaches and development as a biomaterial used in bone regeneration.

BiographyCristina Liana Popa is a young scientific researcher graduated from the University of Bucharest with a Master degree in theoretical physics. She is a PhD student both at University of Bucharest (Romania) and University of Le Havre (France). She is involved in research activities in the field of multifunctional materials with medical applications, the synthesis, and structural, morphological as well as ultrasonic characterisation of bioceramic materials. She already has co-authored more than 15 relevant papers in her field of work. .

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressThe nitrogen cycle in air, soil and waterReza Pashaei1 and Mortaza Gholizadeh2

1University of Siena, Italy2Curtin University, Australia

Nitrogen is the most important gas in nature because of some reasons. Nitrogen is the vital source for providing food for organisms and microorganisms. Providing this prominent source need to cycle for transferring the nitrogen for all the

organisms in nature namely plants and animals in water and soil that this cycle called nitrogen cycle. This article mention to nitrogen cycle role in air, soil, and water.

BiographyReza Pashaei is a student of Master of Chemistry at Siena University. Mortaza Gholizadeh is a Post doctoral student at Curtin University. He published more than 10 ISI articles.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressTunable magnetic property and millimeter wave absorption property of ε-Fe2O3 by metal substututionAsuka Namai, Marie Yoshikiyo and Shin-ichi OhkoshiThe University of Tokyo, Japan

Epsilon-iron oxide (ε-Fe2O3) is one of the polymorphys of Fe2O3, which exists as a stable phase in nanometer-size ~ sub-micrometer-size region.[1] ε-Fe2O3 receives much attention as a hard mangeitc ferrite, since it exhibits the largest coercive

field (Hc > 20 kOe) among magnetic ferrites. In addition, it shows a high frequency millimeter wave absorption at 182 GHz due to zero-field ferromagnetic resonance.[2] Herein, we report the synthesis, magnetic properties, and millimeter wave absorption properties of metal substituted ε-Fe2O3 nanomagnets.[2,3]

A series of ε-MxFe2-xO3 (M= Al, Ga, In, and Rh) were prepared by several nanoparticle synthesis methods, such as a combining method between a reverse-micelle and a sol-gel methods. Crystal structure analyses based on X-ray diffraction pattern indicate that subsistution site differs between substitution metal. Among four non-equivalent sites in ε-Fe2O3 (FeA, FeB, FeC, and FeD), In3+ substitutes distorted octahedral FeA and FeB sites, Rh3+ substitutes regular octahedral FeC sites, and Al3+ and Ga3+ substitute tetrahedral FeD sites, which can be understood by the difference of ionic radii. Magnetic properties are also affected by metal substitution. The Hc value is reduced with Al3+, Ga3+, In3+ substitution from 20 kOe to 2 kOe, but Hc value is enlarged by Rh3+ substitution and a large Hc value of 31 kOe was observed. Millimeter wave absorption frequency decreased from 182 GHz (ε-Fe2O3) to 35 GHz by Al3+, Ga3+, In3+ subsutitution, but increased up to 222 GHz by Rh3+ substitution. Such a largely tunable magnetic property and millimeter wave absorption property of ε-Fe2O3 is useful from the viewpoint of material design.

BiographyAsuka Namai is currently an Assistant Professor of Department of Chemistry, School of Science at The University of Tokyo. She received her PhD. in Science at the University of Tokyo, Japan, in 2013. Her research focuses on the development and physical and chemical characterization of functionalized nanomaterials, with particular interest in iron oxide-based nanomagnets and magnetism.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressAnticonvulsant activity of newly synthesized benzoylhydrazones with 2H-chromene and coumarin moieties in ICR miceV Karabeliov1, Violina T Angelova1, Pavlina A Andreeva- Gateva2, Nikolay G Vassilev3, Yulian Voynikov1, Slavina Surcheva2, Jana Tchekalarova4

1,2Medical University, Sofia, Bulgaria3Institute of Organic Chemistry with Centre of Phytochemistry, Bulgaria4Bulgarian Academy of Sciences, Bulgaria

Several 2H-chromene and coumarin based hydrazones were synthesized and evaluated for their anticonvulsant activity and neurotoxicity. The structures of the newly synthesized compounds were confirmed by 1H and 13C NMR, FTIR and HRMS

(ESI) spectroscopy.

The initial anticonvulsant screening was performed using the maximal electroshock induced seizure tests (MES) and the subcutaneous pentylenetetrazol (scPTZ) test in ICR mice. All 2H-chromene (3a,b) and coumarin (3c,d) based hydrazones demonstrated potency in at least one seizure test. Among all the tested compounds, only 3b showed activity at the lowest dose of 30 mg/kg, which was comparable with the referent drug phenytoin, while compounds 3a and 3d suppressed tonic-clonic seizures in the MES test at the highest dose of 300 mg/kg. All agents demonstrated anticonvulsant effect at 0.5 h whereas 3c and 3d in both time points. No neurotoxicity of the tested agents was observed at the doses with activity in this test. Compound 3c was potent at 100 mg/kg, while the compounds 3a and 3d protected against clonic seizures at the highest dose of 300 mg/kg in the scPTZ test. This activity was shown at time interval of 0.5 h and lacked neurotoxicity compared to DZP showing an activity at the lowest dose of 30 mg/kg. Taken together, the results suggest that the newly synthesized 2H-chromene and coumarin based benzoylhydrazones could be efficient as adjuvants against secondarily generalized tonic-clonic seizures and primarily generalized seizures in humans.

BiographyV Karabeliov has completed his secondary education in 2013 from National High School of Maths and Science. Now he is studing in the Medical University of Sofia, Faculty of Pharmacy. He works as an assistant in a pharmacy from 2 years ago. He is interested in the fields of LC-MS, Mass secondary education, Bioanalysis, Chemical synthesis, Pharmacognosy and Medpharmacyicinal chemistry.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressPerpendicularly-oriented microdomain ordering of lamella-forming PS-b-PMMA thin film observed by tuning film thicknessWooseop Lee, Hyerin Yoon, Seongjun Jo, Sangwoo Kim and Du Yeol RyuYonsei University, Republic of Korea

Perpendicular orientation of block copolymer(BCP) thin film has advantage of achieving uniformly well-defined nanopattern. In this study, polystyrene-b-poly(methyl methacrylates) (PS-b-PMMAs) with various molecular weights were utilized to

investigate the effect of film thickness on the in-plane ordering, which was assessed via defect distance (D) and orientational correlational length(ξ) analysis to derive the power law relationships versus film thickness. The perpendicular orientation of BCP thin film was facilitated by the surface energy neutralization by hydroxyl-terminated random copolymer, PS-r-PMMA. Thin film morphology was verified by AFM (Atomic Force Microscope), SEM (Scanning Electron Microscope) and GISAXS (Grazing Incidence Small Angle X-ray Scattering). As a result, the PS-b-PMMA with molecular weight higher than 74 kg/mol exhibited the behavior that the lateral ordering was enhanced(D and ξ increased) as the film thickness increases. Whereas in the case of 50 kg/mol BCP film exhibited the tendency that the lateral ordering was enhanced as the film thickness decreases. This research provides an comprehensive guide to understand the thickness-dependent long-range ordering enhancement in BCP thin films.

BiographyWooseop Lee has achieved Bachelor’s degree of Chemical Engineering in year 2015 from Yonsei University, Korea. He is now studying in graduate school of Yonsei University, the chemical and biomolecular engineering department. His research is closely related to examining the fundamental properties of polymer brush and BCPs, and its application for the advanced materials.

[email protected]

Wooseop Lee et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressPhase transition behavior of Asymmetric Polystyrene-b-Poly(2-vinylpyridine) Thin Films under Strong Interfacial Interactions : A stable Hexagonally Modulated Layer (HML) StructureSungmin Park, Yeongsik Kim and Du Yeol RyuYonsei University, Korea

Phase transition behavior and self-assembly of block copolymer (BCP) have attracted much attention in material science and engineering, due to the periodic nanoarrays providing the platforms with various morphologies. BCP film is confined

on the substrate, uaually in thin film geometry, the phase transitions would be altered from those of the bulk, more than likely because the ordering and microdomain orientation are appreciably influenced by the interfaces at air/polymer and polymer/substrate, and commensurability of film thickness to the equilibrium period. In this study, the phase transition of an asymmetric polystyrene-b-poly(2-vinylpyridine) (PS-b-P2VP) with the minor PS block was investigated by grazing incidence small-Angle x-ray scattering (GISAXS) and transmission electron microscopy (TEM), particularly in the films subjected under the strong interfacial interactions. The resulting transitions in film geometry were dramatically changed with decreasing thickness due to the growing preferential interactions from the substrate. A thickness-dependent transition diagram exhibited a hexagonally modulated layer (HML) as a stable structure that was extended over the entire temperature range.

BiographySungmin Park received a BS in Chemical & Biomolecular Engineering at Yonsei University, Korea, in 2011. He is currently a PhD student at Yonsei University. His research interests include the self-assembly and phase transition behavior of block copolymer in thin films.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressInteraction between the hydroxyl functionalized PS and dPS in dry brush systemSeongjun Jo1, Hoyeon Lee1, Keiji Tanaka2 and Du Yeol Ryu1

1Yonsei University, Korea 2Kyushu University, Japan

Polymer brushes using end-functionality were studied for modifying the substrate to control interfacial interactions between the substrate and melt polymer layer. Interfacial interaction is a critical parameter for polymer thin film system, which

determines the thermal and physical properties of polymer films. With the different chemical structures of modified polymer brushes, the thermal dynamics of polymer films dynamically change, such as adhesion, lubrication, slip, and the wettability. Interestingly, the interfacial energy of grafted substrates with polymer chains are remarkably altered by simply controlling the grafting density, which has been referred to as autophobicity.

In this study, we controlled the molecular weight of hydroxyl-functionalized polystyrene (HO-PS) to modify the surface on a standard Si wafer. Grafting HO-PSs to a native oxide layer was performed simply by thermal annealing, followed by rinsing with toluene to thoroughly remove the un attached (or unreacted) polymer chains. Deutrated polystyrene (dPS) was prepared on the PS brush layer to develop the neutron contrast between the brush layer and top polymer films, and the double-layed films were subjected to Neutron Reflectivity (NR) experiments. Interfacial penetration and autophobicity will be discussed to characterize the interface between the PS brush layer and top dPS polymer films.

BiographySeongjun, Jo has completed his undergraduate course in 2015 from Chungnam National University, Korea and is currently studying for his combined PhD program in Yonsei University, Korea.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressSynthesis and characterization of new quaternary niobium selenitesBongsu Kim, Youngkwon Kim and Kang Min OkChung-Ang University, Republic of Korea

Single crystals and pure polycrystalline samples of new alkali metal niobium selenites have been prepared through hydrothermal and standard solid-state reaction techniques. Single crystal X-ray diffraction was used to determine crystal

structures of all four materials.While NaNbO(SeO3)2 is configured with corner-shared zigzag chains of NbO6 octahedra and SeO3 intrachain connectors,

three isostructural ANbO(SeO3)2 (A = K, Rb, and Cs) exhibit a layered structure that is composed of distorted NbO6 octahedra and SeO3 polyhedra.

Detailed structureal analysis suggests that the size and the coordination environment of alkali metal cations particularly affect the backbone geometries and the dimensions of this materials. Full characterizations including X-ray diffraction, Scanning Electron Microscopy (SEM), infrared and UV-Vis diffuse reflectance spectroscopies, thermal analyses, and dipole moment calculations for the new alkali metal niobium selenites will be presented.

Moreover, The future plan about similar compounds using Te4+ ;ANbO(TeO3)2 (A = Na, K, Rb, and Cs) will be described.

BiographyBongsu Kim has completed his bachelor degree at the age of 26 years from An-dong University School and now he has been studying for master degree from Chung-Ang University School of seoul. While His major is solid chemistry. He focus on the study about new materals of Non-Centro Symmetric(NCS) and Metal-Organic Frameworks(MOFs).

[email protected]

Bongsu Kim et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressPolar noncentrosymmetric ZnMoSb2O7 and nonpolar centrosymmetric CdMoSb4O10: d

10 transition metal size effect influencing the stoichiometry and the centricityHongil Jo and Kang Min OkChung-Ang University, Korea

Functional oxides have attracted attention owing to their various applications in electronics, catalyst and optical devices with superior thermal stability. One of them, noncentosymmetric (NCS) oxides have been studied by plenty of research group because they have diverse properties such as pyroelectricity, ferroelectricity, piezoelectricity and nonlinear optical properties at the same time. Thus, several strategies for synthesizing novel NCS materials have been continuously proposed. In this research, we successfully synthesized two novel NCS materials by combining Second-Order Jahn-Teller (SOJT) distortive d0 cations, lone pair cations, and polar displacive d10 cations, i.e, Mo6+, Sb3+, and Zn2+ (or Cd2+). Two new molybdenum antimonites have been synthesized by hydrothermal and standard solid state reactions. The ZnMoSb2O7 crystallizes polar space group P21 along with three-dimensional framework composed of MoO4, SbO4, and ZnO4 polyhedra. While CdMoSb4O10 crystallizes nonpolar centrosymmetric space group P21/m along with one-dimensional framework consisting of MoO4, SbO3, and CdO6 polyhedra. For ZnMoSb2O7, structural analysis suggests that it has a net polarization in the [0-10] direction due to parellel alignment of MoO4 distorted tetrahedra. Local dipole moment calculation is consistent with structural analysis. The result of synthetic experiments for ZnMoSb4O10 and CdMoSb2O7 show that the size of d10 cation affect stoichiometry as well as symmetry. The two molybdenum antimonites were also fully characterized by powder X-ray diffraction, IR spectroscopy, UV-vis spectroscopy, and powder second-harmonic generation measurements.

BiographyJo Hongil has completed his bachelor degree at the age of 26 years from Chung-Ang University and pursues his combined master’s and doctorate program at Chung-Ang University. He is studying solid chemistry and advised by Prof. Ok Kang Min. He has published 3 papers in reputed journals.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressEffective removal of rare earth metals using surface-active agentDzhevaga Natalia VladimirovnaNational Mineral Resources University, Russia

The investigation consists in applying the methods of removal rare earth metals from low concentrated solutions by adsorption and extraction methods. The benefits of these methods before the existing analogues are being able to selectively

target component removal from dilute solutions and use common surfactants. For the decision of tasks of scientific research is proposed as a surfactant, sodium dodecyl sulfate. Salt dodecyl sulfate acid has the following advantages in comparison with other surfactants: non-toxic (4th class); cheapness; the process requires a NaDS, the stoichiometry of chemical reactions; the NaDS in the wide ranges of pH of the liquid phase; possibility of regeneration of the products; compared with similar surfactant extract rare metals of sodium dodecyl sulfate are maximum values. The pilot objects of scientific research were fully explored using modern instrument base, original techniques and modern instrumental methods of analysis such as photometry, infrared spectroscopy, complexometric titration, potentiometry, conductivity. The scientific research ensured new data on termodinamics description of the adsorption-bubble process on the surface of the liquid-gas phase and results for effective recovery of rare earth metals with a composition of sublates.

BiographyDr. Dzhevaga Natalia Vladimirovna completed her PhD in physical chemistry in 2012 from National mineral resources university. Since then, successfully engaged in scientific research in the field of removal of rare earth metals from dilute solutions by flotation and extraction methods. Published more than 70 papers on this topic, including more than 15 articles in journals indexed in international databases. received eight patents on inventions.

[email protected]

Dzhevaga Natalia Vladimirovna, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressThermodynamic characteristics of sorption extraction of anionic complexes of erbium with trilon B on weakly basic anionitePonomareva MariyaNational Mineral Resources University, Russia

The adsorption of anionic complexes of erbium with Trilon B on D-403 anionite is studied at ionic strengths of 1 mol/kg (NaNO3) and temperatures of 298 and 343 K. D-403 anionite is Chinese-made weakly basic macroporous polystyrene

chelate anionite. Before the experiment anionite was transfered to nitrate form. Sorption was studied from erbium nitrates standard solutions. Trilon B was added as complexing agent with mole ratio of 1:1 in accordance with the following reaction stoichiometry. Formation of complexes with composition −][ErTr was proven by conductometric and potentiometric titration of 10 ml aliquot erbium nitrate (3+) with concentration of 0.05 mol/l with Trilon B solution with concentration of 0.05 mol/l. Values of the stability constants of anionic complexes of Er3+ with Trilon B, plus the Gibbs energies of the complexation reaction is Kstability=2.32·1018; kJ/mol4.18 -104.580

298 ±=∆ Gcompl. A thermodynamic description of the sorption isotherm was created

using a linear form of the law of mass action, modified for the ion exchange reaction. At a temperature of 298 K the total adsorption of anionite the total adsorption of anionite is Г∞=0.095±0.05 mol/kg, equilibrium constant K=42±2, and the Gibbs energy of ion exchange J/mol5002009-0

298 ±=∆G . At a temperature of 343 K the total adsorption of anionite is Г∞ = 0.15 ±0.05

mol/kg, equilibrium constant K=54±3, and the Gibbs energy of ion exchange J/mol600-114000298 ±=∆G . The following values

were obtained: J/mol326300343298 ±=∆ −H

KmolJ2330

298 ⋅±=∆S

KmolJ2350

343 ⋅±=∆S

BiographyDr. Ponomareva Maria has completed her PhD at the age of 24 years from National mineral resources university. She is the assistant of the department of general and physical chemistry of National mineral resources university. She is engaged in research in the field of adsorption and ion exchange of rare and rare-earth metals from complex salt solutions. She has published more than 20 papers in scientific journals.

[email protected]

Ponomareva Mariya, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressThe interaction of 1-nitro- and 1-bromo-1-nitro-3,3,3 trifluoro(chloro)propenes with phenylazideAlena KuzhaevaNational Mineral Resources University, Russia

One of the methods of obtaining functionalized heterocycles is the 1,3-dipolar cycloaddition reaction involving nitroalkenes as dipolarophiles containing a trihalogenmethyl group at β-position in their structure. 1,3 - dipolar cycloaddition of

phenylazide to 1 - nitro- and 1 - bromo - 1 - nitro - 3,3,3 - trifluoro(chlorine)propenes was carried out through the intermediate formation of regioisomeric triazolines, which under the reaction conditions underwent intramolecular transformation (denitration, dehydrogenation, dehydrohalogenation) culminating in the formation of the corresponding triazoles with or without nitro-group. The structure of obtained compounds is proved by modern physical-chemical research methods and the formation of these compounds does not contradict with reference data on such adducts obtaining in reaction of 1,3-dipolar cycloaddition with the same structure type nitroalkenes which contain CO2R and P(O)(OR)2 groups instead of the С(Hlg)3 substitute in their structure.

BiographyAlena Kuzhaeva has completed her PhD from Herzen State Pedagogical University, Russia. She works in the National Mineral Resources University (Mining University) at the Department of General and Physical Chemistry. She has published more than 40 papers in reputed journals.

[email protected]

Alena Kuzhaeva, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressModern glassy phosphate fertilizersKirill KarapetianNational mineral resources university, Russia

Development of glassy phosphate fertilizers which dissolve at a predetermined rate for use in crop areas of high humidity. The monitoring of water status in the areas of active fertilizer use. Assessing the impact of traditional fertilizers and

fertilizer new sort on the state of coastal rivers. In this paper the authors propose measures to improve the environmental conditions of water protection zones through the use of new types of phosphate fertilizers. The results obtained by the use of glassy fertilizers in intensive nature meet the requirements of European Union. The fertilizer is intended for restoration of territories of former coal quarries and mines.

BiographyKirill Karapetian is an associate professor in National mineral resources university, Russia.

[email protected]

Kirill Karapetian, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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e-Posters

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressPhase densities determination in the mixtures of carbon dioxide and ethanol under high pressure Jona Keri1 and Altin Mele 2

University of Tirana, Albania

The phase behaviour of carbon dioxide + ethanol system has been investigated mainly in terms of the variables pressure, temperature and composition. With few exceptions the densities of the coexisting phases are neglected and even when

measured, they range in temperatures between 291,15 K to 313,15 K. For a complete description of the phase equilibrium in this system further measurements are needed, up to temperatures in the neighbourhood of the critical temperature of ethanol. In this study the densities and mutual solubility of carbon dioxide and ethanol were determined at the temperatures 333,15 K, 353,15 K, 413,15 K and 453,15 K and pressures from 4 MPa up to 14,5 MPa. The critical densities curve was constructed for the whole concentration range.

BiographyJona Keri is a Doctorate student and she has finished her MSc studies in Chemistry Department, Faculty of Natural Sciences at University of Tirana, and is currently working, since two years in the field of adsorption/desorption equilibrium study of different active compounds as diclofenac, mefenamic acid, meclofenamic acid etc. on the montmorillonite clays.

[email protected]

Jona Keri et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressThe potential of quantitative structure-retention-(Biological) activity relationship (QRAR) investigations in pharmaceutical researchBiljana Otašević, Ana Protić, Jelena Golubović, Janko Ignjatović and Mira ZečevićUniversity of Belgrade, Serbia

A large number of compounds can be synthesized during the drug development process, which are then processed and screened for specific properties of interest to obtain the best possible drug candidates. Physical-chemical screenings are

increasingly being used during the early stages of drug discovery to provide a more comprehensive understanding of the key properties that affect the biological disposition of promising leads – gastrointestinal absorption and blood brain barrier permeability, distribution in systemic circulation and tissues, metabolism, excretion as well as protein binding, interactions with receptor and toxicity. Lipophilicity parameters log P (logarithm of n-octanol–water partition coefficient) and log D (distribution coefficient) and dissociation constant pKa of a drug candidate are therefore of a primary concern. Determination of those parameters at the early stage of studies can help in eliminating those molecules that are unlikely to become drugs due to their poor pharmacokinetic properties. The reversed-phase liquid chromatography is especially suitable for these kinds of determinations since it was proven that compounds’ hydrophobicity measured as a retention factor obtained at different mobile phase compositions and extrapolated to neat water as an eluent, log kw, is well correlated with log P. Usually, the investigations consist of time/consuming and cost/demanding experimental work as well as animal bioavailability tests. In order to rationalise pharmaceutical research, the mathematical models able to predict chromatographic retention from chemical structure have been introduced (QSRR studies). Likewise, QRAR studies with the possibility to relate the descriptors of the compounds, chromatographic retention and pharmacokinetic properties evaluated in silico and/or biological activity measured in vivo have been evaluated. The authors have done some effort to prove the usefulness of this concept in investigation of selected antifungal agents and in future of novel potential antibiotics from endophytic fungi.

BiographyBiljana Otašević attended PhD studies at University of Belgrade – Faculty of Pharmacy, where she finished Doctoral thesis in field of pharmaceutical chemistry in the year 2011. Nowadays, she works as an Assistant Professor at the Department of Drug Analysis and participates in the research project financed by the Ministry of Education, Science and Technological Development of the Republic of Serbia (no. 172033). She is the author of 67 scientific publications among which 20 scientific papers were published in the international journals indexed in SCI list. She gave one lecture on an international scientific meeting.

[email protected]

Biljana Otašević et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressSynthesis and enzyme inhibition study of dihydrofurocumarin and dihydrofuropyrane compunds Asli Ustalar and Mehmet Yilmaz Kocaeli University, Turkey

Coumarin derivatives such as Scopoletin, Esculatin, Fercoprolone, Hohneliacoumarin, Angelicin, Psoralen and Aureptene have been found in nature and they possess many biological activities varying from anticancer, antioxidant, antibacterial,

antifungal and anticougulant. It is well known that Mn(OAc)3 have been used as radical oxidant in the synthesis of dihydrofuran derivatives forming C-C bond between active methylene compounds and alkenes. In here, we performed the reaction of of 4-hydroxycoumarin and 4-hydroxypyrane with conjugated amide and esters promoted by Mn(OAc)3 leading to dihydrofurocoumarins and dihydrofuropyranes in moderate to good yields. All new compounds were characterized by spectroscopic techniques. Also, we investigated enzyme (cGMP PDE- cyclic guanozine mono phosphate phosphodiesterase) inhibitions of these compounds.

BiographyAsli Ustalar has completed his MS from Kocaeli University. She is a PhD student in Kocaeli University.

[email protected]

Asli Ustalar et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressGemini surfactants corrosion inhibitorsBrycki B, Kaczerewska O, Drgas M, Materna P and Kowalczyk IAdam Mickiewicz University Poznan, Poland

The inhibitory action of surfactants in aqueous solutions is due to a physical adsorption or chemisorption of surfactant molecules onto the metal surface, depending on the charge on the solid surface and the free energy change of transferring

a hydrocarbon chain from water to the solid surface. The adsorption of a surfactant markedly changes the corrosion resisting property of a metal thus the study of the correlation between the adsorption and degree of a corrosion inhibition are of a considerable importance. Gemini surfactants are multifunctional surfactants which have two amphiphilic groups connected by a spacer. Spacer can be hydrophobic or hydrophilic, flexible or rigid, can contain heteroatoms (oxygen, nitro gen, sulphur) or groups with π-electrons. These compounds have attracted considerable interest in recent decades because of their exceptional structural feature and versatile applicability. Gemini surfactants exhibit properties superior to those of conventional surfactants (cmc, γ, MIC, solubility). During recent years, an increasing interest has been focused on the investigation of the corrosion inhibition behavior of gemini surfactants in various aggressive media. In the present paper, the efficiency of three novel gemini cationic surfactants as potential corrosion inhibitors were investigated by electrochemical methods.

BiographyBrycki B is an Associate Professor in Department of Chemistry at the Adam Mickiewicz University in Poznan. He has completed his PhD and habilitation from Adam Mickiewicz University in Poznan. He is the Head of Laboratory of Microbiocides of Chemistry in Faculty of Chemistry. He has published more than 90 papers in reputed journals.

[email protected]

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressVolatile alkylammonium corrosion inhibitorsKowalczyk I, Brycki B, Pospieszny T, Koenig H and Pakiet MAdam Mickiewicz University Poznan, Poland

Volatile corrosion inhibitors (VCI) are compounds which are transported in a closed environment to the site of corrosion by slowly volatilization from a carrier source. These inhibitors are mostly amine - based compounds, with free electron pair

on nitrogen atom. Amine part of molecule is strongly attracted to the polar metal surface and the hydrophobic rest of molecule repels water to significantly retard corrosion. Usually natural polymers (cellulose, cotton) are used as carriers of VCI. Series of monomeric and dimeric alkylamineammonium salts of different hydrocarbon chain length have been synthesized. The detailed spectroscopy analysis (FTIR, ESIMS, 1H NMR, 13C NMR, 2D NMR) has been carried out. Our research on volatile corrosion inhibitors will be conducted by comparing the effectiveness of their actions in an aggressive corrosive atmosphere with high moisture content.

BiographyKowalczyk I has completed his PhD and habilitation from Adam Mickiewicz University in Poznan. She work in Laboratory of Microbiocides Chemistry in Faculty of Chemistry. She has published more than 45 papers in reputed journals.

[email protected]

Kowalczyk I et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressSurveillance of antimicrobial resistance among clinical isolates of Acinetobacter baumannii and Staphylococcus aureus recovered from a teaching hospital in TaiwanLi-Yeh Chuang1, Pai-Wei Su 1 and Cheng-Hong Yang 2 1I-Shou University, Taiwan2National Kaohsiung University of Applied Sciences, Taiwan

Over the past decade, multiple drug resistance to antibiotics is an alarming reality worldwide. Relatively common strains of infectious bacteria such as Acinetobacter baumannii and Staphylococcus aureus are increasingly resistant to most presently

available drugs in Taiwan. This study aimed to investigate the antimicrobial susceptibility in clinical isolates to 10 antibiotics. A total of 286 bacterial strains were isolated from patients’ blood or sputum during 2006–2010 from Chia-Yi Christian Hospital in Taiwan and underwent susceptibility testing. According to Clinical Laboratory Standards Institute guidelines antimicrobial susceptibility testing was performed by disc diffusion method and agar dilution methods to determine the minimal inhibitory concentration (MIC). Each organism-antibiotic combination has different diameters signifying susceptible (S), intermediate (I), resistant (R). Among the 148 Staphylococcus aureus isolates, 29.05%, 100%, 88.5%, 94.5%, 71.62%, 68.24%, 40.5% and 96.6%, respectively, were resistant to Tetracyline, Penicillin G, Kanamycin, Amikacin, Erythromycin, Gentamycin, Sulfamethoxazole-Triethoprim, and Streptomycin. Among the 138 Acinetobacter baumannii isolates, overall rates of percent resistant were as follows: Tetracyline (65.2%), Penicillin G (100%), Cephalexin (99.28%), Gentamycin (62.33%), Sulfamethoxazole-Triethoprim (77.55%), Amikacin (64.16%), Streptomycin (71%), Ticarcillin (63.86%), Ceftazidime (68.9%) and Piperacillin (73.2%). The resistance levels to most of the antibiotics tested was very high with a range of MIC values between 16-32 µg/mL. This finding revealed a higher resistance among the Acinetobacter baumannii and Staphylococcus aureus isolates to a wide range of antimicrobial agents. It is necessary to monitor and optimize the antimicrobial use in order to reduce occurrence and spread of antimicrobial resistant pathogens.

BiographyLi-Yeh Chuang received her MS degree from Department of Chemistry at University of North Carolina, USA, in 1989 and PhD degree from Department of Biochemistry at North Dakota State University, USA, in 1994. She is a Professor of the Department of Chemical Engineering & Institute of Biotechnology and Chemical Engineering at I-Shou University, Kaohsiung, Taiwan. Her main areas of research are bioinformatics, biochemistry and genetic engineering.

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressThe importance of pump accuracy in sensitive chromatographic seperationRevital Krispin, Yousif Sahly and Arthur KomloshTeva Pharmaceutical Industries Ltd., Israel

The analytical testing of non-biological complex drugs (NBCD) is an ongoing challenge in the pharmaceutical world. Currently there are no clear guidelines that describe what is considered as a suitable set of tests for the release and monitoring

of such complex drugs. As a result, pharmaceutical companies are in pursuit of finding new characteristic analytical methods. Copaxone,® a synthetic polypeptide mixture, used for the treatment of Relapsing Remitting Multiple Sclerosis, is one such NBCD. For the past 9 years Teva has invested considerable efforts in developing new characterization analytical methods to further characterize the unique features of Copaxone.® Characterization of Copaxone by Cation exchange chromatography (CEX) technique is based on evaluation of ionic (cationic) strength of the sub-populations in polypeptides mixture. The typical chromatogram for Copaxone® shows separation of the mixture to 3 main sub-populations. Copaxone® is characterized by specific relative area of the three peaks. However, since separation based on cationic strength depends on the charge of the polypeptides, small changes in pH due to inaccuracy of gradient composition may lead to loss of separation. In this study we have shown that pump accuracy is a key element of the method. Major differences in method robustness were found using low and high pressure gradient pump system. The high accuracy binary pump used in UHPLC system was demonstrated to be superior to common HPLC pump system and was critical to obtain high resolution and robust results. This unique and sensitive method provides a powerful tool to characterize the complex mixture of Copaxone® and discriminate it from purported generic glatiramoids.

BiographyRevital Krispin has a practical engineer degree in engineering chemistry and a Bsc degree in life science from open university. she is a senior researcher with 22 years of experience in the discovery & product development analytical laboratory.

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressSimultaneous determination of pharmaceutical binary mixture using simple and selective spectrophotometric methodsHeba M MohamedCairo University, Egypt

Two smart and simple spectrophotometric methods are developed and validated for simultaneous determination of Itopride hydrochloride (IT) and Rabeprazole sodium (RB) in their binary mixture namely; Constant Center method (CC) and

Ratio difference method (RD). The calibration curves are linear over the concentration range of 10-110 µg /µL for Itopride hydrochloride and 4-44 µg /µL for Rabeprazole sodium, with mean recoveries 99.69 ± 0.391, 99.86 ± 0.440 for Itopride hydrochloride using CC and RD; respectively and 100.39 ± 0.537, 100.25 ± 0.458 for Rabeprazole sodium using CC and RD methods; respectively. The proposed methods are applied to pharmaceutical formulation without preliminary separation steps. To assess the speceficity of the methods, analysis of synthetic mixtures containing different ratios of the two studied drugs and their capsules dosage form is done. The statistical comparison shows that there is no significant difference between the results obtained by the proposed methods and the reported HPLC method with regard to both accuracy and precision.The applied methods are validated according to ICH guidelines and can be used for quality control laboratories for the studied mixture. The proposed methods have lower cost and more environmental friendly than the HPLC ones. The methods are also appropriate to be used in laboratories which have deficiency in liquid chromatographic instruments.

BiographyHeba Moustafa has completed her MSc and PhD degrees in pharamceutical analysis from faculty of Pharmacy, Cairo University-Egypt. She has extensive experiance in different analytical techniques and lately she focuses the horizoin on implementing green analytical chemistry principles in pharmaceuticals analysis. She has published more than 20 papers in highly reputed international journals and has been serving as reviewer for many highly esteemed journals.

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Accepted Abstracts

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressIn vivo and in vitro analysis of cancer by Raman-IR-SNOM-AFM imaging and femtosecond spec-troscopy – From single cells to humansHalina AbramczykLodz University of Technology, Poland

This contribution will explore cutting edge molecular (Raman, IR, fluorescence, SNOM, AFM, TERS, femtosecond spectroscopy) mapping and time resolved dynamics of cellular structures of cancers, localization of drugs and nanoparticles

in cells and tissues. The multidisciplinary nature of the studies span the a diverse range of biological, chemical, and physical sciences related to cancer biology. This contribution will provide insight regarding the new molecular mapping and their ability to monitor biochemistry of biomolecules in the cells and tissues, distribution of drugs, and nanomaterials as they interact with cells and tissues. The main focus will be on the presentation of integrated picture of cancer by near field microscopy SNOM, AFM and hyperspectral Raman imaging to look inside human breast ducts. We will demonstrate how this approach gives important answer about location and distribution of biochemical components in human cells and tissue during cancer development. The lecture shows new look inside human breast duct using Raman imaging, an emerging technology of molecular imaging, that may bring revolution in understanding of cancer biology. Our contribution is a first report in the literature demonstrating such a detailed analysis of normal and cancerous ducts in human breast tissue. The main advantage of Raman imaging is that it gives spatial information about various chemical constituents in defined cellular organelles in contrast to conventional methods (LC/MS, NMR, HPLC) that rely on bulk or fractionated analyses of extracted components.

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Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.003

Anticonvulsant activity of newly synthesized benzoylhydrazones with 2H-chromene and coumarin moieties in ICR miceY Voinikov1, Violina T Angelova1, Pavlina A Andreeva- Gateva1, Nikolay G Vassilev2, Slavina Surcheva1 and Jana Tchekalarova3

1Medical University, Bulgaria2BAS-Institute of Organic Chemistry with Centre of Phytochemistry, Bulgaria3BAS-Institute of Neurobiology, Bulgaria

Several 2H-chromene and coumarin based benzoylhydrazones were synthesized and evaluated for their anticonvulsant activity and neurotoxicity. The structures of the newly synthesized compounds were confirmed by 1H and 13C NMR, FTIR

and HRMS (ESI) spectroscopy. The initial anticonvulsant screening was performed using the maximal electroshock induced seizure tests (MES) and the subcutaneous pentylenetetrazol (scPTZ) test in ICR mice. As phenytoin was used as a standard drug, compounds 3a and 3c exhibited 50% and 100% protection, respectively, against tonic-clonic seizures and tendency to alleviate the mortality in the MES test at the highest dose of 300 mg/kg. Unlike diazepam (2.5 mg/kg), the compounds were unable to exhibit 100% suppression of clonic seizures in the scPTZ test, at the experimental doses. However, 3b demonstrated 50% while 3a - 37% protection against clonic seizures at a dose of 300 mg/kg in the scPTZ test. The mortality was also significantly diminished to 0 % and 13 %, respectively. Motor impairment, evaluated with the rotarod test, was minimal at 300 mg/kg. Taken together, the results suggest that the newly synthesized 2H-chromene- and coumarin based benzoylhydrazones could be efficient as adjuvants against secondarily generalized tonic-clonic seizures and primarily generalized seizures in humans.

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressOral delivery of gemcitabine loaded CSKSSDYQC peptide conjugated N-trimethyl chitosan nanoparticles to treat cancer: Synthesis, characterization and animal studiesGuanyu Chen1, Darren Svirskis1, Weiyue Lu2, Man Ying2, Yuan Huang3 and Jingyuan Wen1

1University of Auckland, New Zealand2Fudan University, China3Sichuan University, China

The oral delivery of anticancer drugs represents a significant challenge for global scientist. N-trimethyl chitosan (TMC) is a polymer with the potential to facilitate effective oral drug delivery. Recently, the peptide CSKSSDYQC (CSK) has been

conjugated to TMC as a means of active goblet cell targeting for gastrointestinal uptake. The aim of the study is to develop and optimize a TMC-CSK modified nanoparticules for oral delivery of gemcitabine. TMC was synthesised from deacetylated chitosan using a novel two-step synthesis, then conjugated with CSK to actively target goblet cells. Gemcitabine-loaded TMC-CSK nanoparticles were prepared via ionic gelation. Characterisation studies including particle size, zeta potential, entrapment efficiency and in vitro drug release were then carried out. Cytotoxicity of drug solution and drug loaded formulation was tested on 4T1 breast cancer cell. Lastly, in-vivo pharmacokinetic and pharmacodynamics studies were conducted. The results showed the optimal delivery system showed particle size of 173.6±7.7 nm and zeta potential of 18.5±0.2 mV. Entrapment efficiency of 66.44±0.02%, and a sustained drug release profile was obtained. LD50 of 0.23 µg/mL was determined in cytotoxicity studies. Gemcitabine loaded TMC-CSK nanoparticles significantly improved the oral bioavailability, raised the plasma half-life, and AUC0-∞ of 4.5 fold higher than for gemcitabine solution in pharmacokinetic studies. Obvious tumour size reduction of 2.6 fold was observed for TMC-CSK nanoparticles compared to drug solution in pharmacodynamics studies. In conclusion, gemcitabine can be delivered using this TMC-CSK modified nanoparticulate delivery systems via oral route to elevate its oral bioavailability and therapeutic anticancer effect.

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New systems for organocatalytic asymmetric epoxidationPhilip C Bulman Page University of East Anglia, UK

The development of methods for the introduction of asymmetry into organic molecules remains a topic of great importance. Catalytic systems are particularly desirable, and the combination of a catalytic asymmetric process with an environmentally

friendly reaction system and an inexpensive oxidant offers an especially attractive goal. Non-racemic chiral epoxides are important intermediates for enantioselective carbon-carbon bond formation. We are developing organocatalytic systems in which asymmetric oxidants are formed by reaction of iminium salts with simple oxidants under mild conditions. We currently formulate the reactive intermediates as oxaziridinium ions, from which the iminium salt mediators are regenerated following oxygen transfer to alkene substrates. We can accomplish epoxidation of simple alkenes with up to ca 99% ee. Catalyst loading may be as low as 0.1 mol%. The epoxidation reactions may be carried out under aqueous or non-aqueous conditions. The iminium salt mediators can be easily prepared without chromatography in many cases, and the procedures used are simple to carry out, and require no preparation of unstable reagents. This lecture will discuss the recent developments including new generations of catalyst, the first examples of kinetic resolution, the use of non-aqueous as well as the usual aqueous conditions, and alternative oxidants in place of Oxone, including hydrogen peroxide, bleach, and even electrochemical conditions by oxidant generation at boron-doped diamond electrodes.

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressHighly switchable and shape-controlled photocatalysis within dye-based metal-organic frame-worksTiexin ZhangDalian University of Technology, China

Photocatalysis could promote challenging chemical reactions via green energy, however, controlling the chemo-/stereoselectivity of photocatalysis has long been hindered due to the dearth of effective binding strategy for substrates

and the in situ generated radical species. Imposing additional interactions on substrates or radical species is beneficial to orienting the conformation of substrates or intermediates, favouring the chemo- or stereocontrol of photocatalysis especially when there are no covalent binding sites on the substrates. The other strategy is to “fix” the reactive radical species via inner sphere modes of complexation with transition metal ions. By merging photoactive organic dyes and transition metals within metal-organic frameworks, the synergy of photocatalytic and transition metal catalytic cycles would be carried out, and the abundant non-covalent interactions sites within MOF channels are capable of imposing conformational orientation on substrates, resulting in perfect stereocontrol. When the MOF photocatalyst is comprised of Zn4O nodes and triarylamine-based ligand, aryltrifluoromethylation of unsaturated olefins could be conducted with enhanced diastereoselectivity. While the combination of Cu2(O2CR)4 paddle-wheel nodes and triarylamine-based ligand within MOFs switches to suppress the radical cyclization process, favouring the atom transfer radical addition (ATRA). The non-covalent interaction induced shape-control has been confirmed by X-ray single crystal diffraction experiments on the MOFs crystals encapsulating substrates. And the asymmetrically catalyzed ATRA is primarily examined after introducing chiral auxiliaries into the MOFs.

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Diagnostic value of tumor markers in lung adenocarcinoma-associated cytologically negative pleural effusionsCheng-Chuan SuTzu Chi University, Taiwan

Cytology fails to detect neoplastic cells in 40–50% of malignant pleural effusions (PEs), which commonly accompany lung adenocarcinomas. Diagnostic accuracy of various tumor markers in lung adenocarcinoma-associated cytologically

negative pleural effusions (LAC-CNPEs) has been poor. This study aimed to maximize diagnostic efforts in distinguishing LAC-CNPEs from benign PEs. Pleural effusion samples were collected from 74 lung adenocarcinoma patients with associated cytologically positive (41) and negative (33) effusions, and from 99 patients with benign conditions including tuberculosis (26), pneumonia (28), congestive heart failure (25), and liver cirrhosis (20). We evaluated the diagnostic sensitivity and optimal cutoff points for tumor markers Her-2/neu, Cyfra 21-1, and carcinoembryonic antigen (CEA) to distinguish LAC-CNPEs from benign PEs. Mean levels of Her-2/neu, Cyfra 21-1, and CEA were significantly higher in LAC-CNPEs than in benign pleural effusions (P= 0.0050, =0.0039, and <0.0001, respectively). The cutoff points for Her-2/neu, Cyfra 21-1, and CEA were optimally set at 3.6 ng/mL, 60 ng/mL, and 6.0 ng/mL. Their sensitivities ranged from 12.1%, to 30.3%, to 63.6%, respectively. CEA combined with Cyfra 21-1 increased diagnostic sensitivity to 66.7%. False-positive rates of these markers in benign PEs were 6.1%, 2.0% and 0%, respectively. Combining CEA with Cyfra 21-1 will provide the best differentiation between LAC-CNPEs and benign PEs with two tumor markers to date, and allows early diagnosis and early treatment for two-thirds of affected patients.

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressExtending axial chirality in supramolecular coordination complex of nucleotideHui LiBeijing Institute of Technology, China

The research about chirality of coordination complexes and supramolecular assembly of nucleotide is significant for understanding the origin of life. In addition to the function of chirality delivery, the nucleotide ligands can also serve

as a chiral inducer to generate new chiral sources. We have designed Co(II)-nucleotide-4,4’-bipy coordination system. Several kinds of coordinatuon complexes have been obtained and studied. Different kinds of chirality have been investigated comprehensively, including chiral coordination environment of metal center and supramolecular helix. Importantly, the axial chirality of the twisted 4, 4’-bipy has been captured and delivered along infinite one dimensional coordination chain by two effective strategies, which are coordination bonding and chiral inducing based on the nucleotide ligands for the first time. We defined this new kind of chirality is an Extended Axial Chirality (EAC). The absolute configuration of EAC has been analysized by X-ray single crystal diffraction method and solution- and solid-state circular dichroism (CD) spectroscopy. The relationship between structure and chirality properties were reationalized. This work will contribute to the nucleotide coordination chemistry and chiral materials design, and provides a facile method to construct an integrated chirality system.

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New developments in the Castagnoli-Cushman reaction toward drug disoceovery and lead generationMikhail KrasavinSaint Petersburg State University, Russia

The Castagoli-Cushman reaction is firmly establishing itself as the mainstream in multi-component chemistry. More recent contributions from our group not only advanced the heterocyclic product space accessible by this reaction to a completely

new level but also gained some mechanistic insight into this important reactions. This, in turn, has allowed us making this reaction a far for amenable to plant setting and green chemisty standards. A number of drug leads have also emerged from these efforts which will be of interest to a wider durg discovery-minded audience.

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressSpatio-temporal variation in heavy metal concentration near mining sites using Enhalus acoroides as biomonitorJonalyn C Madriaga and Rene N RollonUniversity of the Philippines Diliman, Philippines

In this study, Enhalus acoroides was used as a proxy in determining the spatial and temporal variations of heavy metal concentrations in Hinadkaban Bay, Claver Surigao del Norte (an area near mining activities). Heavy metal concentration

in the leaves and rhizomes of the seagrass and the sediments of the area are quantified. Furthermore, the capability of E. acoroides as biomonitor was evaluated. More importantly, an attempt to reconstruct the levels of heavy metal for the past 10 years using lepidochronology technique was done. Given such, temporal trends can be elucidated. All heavy metal analysis will be performed using Agilent 7500 Inductively Coupled Plasma Mass Spectroscopy. Results showed that Enhalus acoroides is a good biomonitor. It was found that the levels of heavy metals in tissues of seagrass species in areas near mining discharge points are significantly higher than those that are away from it. The result of this study will give us an information on the condition of the area which could be used to assess whether the efforts of LGU towards Marine and Coastal Protection has been effective. In the given context, it might give an idea whether there is a need to review and/or amend some policy and guidelines with respect to Marine and Coastal Protection and Environmental Monitoring Strategies. The ability to reconstruct past heavy metal concentrations may serve as a quicker and cheaper tool in developing baseline and monitoring information, which serves to be significant in Environmental Impact Assessment (EIA).

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Novel tools for highly efficient detection of nucleic acids - Going beyond amplificationKira AstakhovaUniversity of Southern Denmark, Denmark

Detection and studies of nucleic acids (DNA and RNA) are highly desirable in modern research, biotechnology and clinical assays. Owing to improved biological activity and stability artificial nucleic acids have much to offer as diagnostic and

research tools. However, so far the detection of nucleic acids has been fully relied on enzymatic amplification of targets. In our research we aim at enzyme-free detection and studies of DNA and RNA. To do this, we develop novel design tools and synthesis of efficient fluorescent probes with improved properties for detection of nucleic acids. In my talk I will present our recent findings in the development of oligonucleotide probes and assays that allows to detect long natural DNA and RNA molecules at ultra-low concentrations. In particular, enzyme-free detection of EBOLA RNA using our new approach will be described. Naturally occurring nucleic acids are typically present as super-coiled molecules in complex biological media and often at very low concentrations. This makes them challenging objects for detection which require ultra-sensitive and specific oligonucleotide probes. The novel probes and assays which we develop could become a new approach to rapid, reliable and enzyme-free detection of viral and other nucleic acids. Importantly, stoichiometry of detected targets will be conserved in the enzyme-free assay, which allows for an accurate studies and estimation of e.g. mutation abundance when the detection limit requirement is met. Using fluorescence microscopy, this could become a new approach to detect and investigate DNA at single-molecule resolution and directly in the biological sample of choice.

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressWaste plastic to liquid hydrocarbon fuelMoinuddin SarkerWaste Technologies LLC, USA

Waste Plastic Waste is huge problem in USA and around the Global. This is global problem. Inventions of the twentieth century, plastics are everywhere. Society has found ample ways to use plastics. But users are less adept at managing the

material when they are finished with it—often after only one use. The volume of plastics being produced, used, generated, and discarded is greater than ever before. Plastics therefore require increasing effort and ingenuity to properly manage. Annually, of the 120 billion pounds of plastics produced in the United States only about 6% or 4.8 billion pounds are recycled. For all the talk of plastic ban, plastic production is increasing. Waste Technologies LLC (WTL) has the solution at its disposal. This technology can produce approximately 1.3 liter of “WTL fuel” from one kilogram of plastic waste. The exact yield depends on the type of plastic, and the grade of WTL fuel desired. Typically, the process produces a residue of less than 5% of the weight of the plastic waste. This residue is rich in carbon and may be an environmentally superior substitute for coal with a higher BTU value. The WTL technology is able to cater to a wide range of diverse applications, including but not limited to fuel, gas and electrical generation. NSR’s / WTL patented technology, in conjunction with WTL technology and know-how, is a simple and economically viable process to decompose the hydrocarbon polymers of waste plastic into the shorter chain hydrocarbons of liquid fuel. WTL believes that it can convert approximately one tonne of plastic into about 300 gallons of fuel at a cost of about $0.75-$1.00 per gallon and produces 4,205 ft3 (CFT) of light gas (C1-C4) byproduct when developed to commercial size. WTL’s refining process is uncomplicated and promises to be very competitive with large crude oil installations. In financial projections WTL uses $30/bbl. ($0.71 per gallon) for preprocessing and refining costs. Other plastic recycling technologies generally have a very narrow band of plastics they can use. Nearly all recycling is done with plastic designations 1 or 2 while designations 3 through 7 are virtually untapped (over 70% of all plastic fall within these categories). A combination of economic and technological factors, account for this situation. The advantage of WTL technology is that it can produce a profitable product from material that society generally pays to thrown away. It is this no or low cost feedstock that is the key advantage.

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Scale storage mechanism studies of the advanced anode materials for energy storageXi Wang and Yoshio BandoInternational Center for Young Scientists (ICYS), Japan

Lithium-ion batteries (LIBs) can deliver high levels of energy storage density and offer long operating lifetimes, but their power density is too low for many important applications. Therefore, we developed some new strategies and fabricated

novel electrodes for fast Li transport and its facile synthesis including N-doped graphene-SnO2 sandwich papers bicontinuous nanoporous Cu/Li4Ti5O12 electrode, and binder-free N-doped graphene papers. In addition, by using advanced in-TEM, STEM techniques and the theoretical simulations, we systematically studied and understood their storage mechanisms at the atomic scale, which shed a new light on the reasons of the ultrafast lithium storage property and high capacity for these advanced anodes. For example, by using advanced in-situ TEM, we directly investigated these processes using an individual CuO nanowire anode and constructed a LIB prototype within a TEM. Being promising candidates for anodes in lithium-ion batteries (LIBs), transition metal oxide anodes utilizing the so-called conversion mechanism principle typically suffer from the severe capacity fading during the 1st cycle of lithiation–delithiation. Also we report on the atomistic insights of the GN energy storage as revealed by in situ TEM. The lithiation process on edges and basal planes is directly visualized, the pyrrolic N "hole" defect and the perturbed solid-electrolyte-interface (SEI) configurations are observed, and charge transfer states for three N-existing forms are also investigated. In situ HRTEM experiments together with theoretical calculations provide a solid evidence that enlarged edge {0001} spacings and surface "hole" defects result in improved surface capacitive effects and thus high rate capability and the high capacity is owing to short-distance orderings at the edges during discharging and numerous surface defects; the phenomena cannot be understood previously by standard electron or X-ray diffraction analyses.

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressEvaluation of nickel and chromium in legumes consumed in TurkeyMehmet YamanFirat University, Turkey

The determination of minerals and trace elements in foodstuffs is an important part of nutritional and toxicological analyses. Although copper, chromium, iron and zinc play an important role in human metabolism and so, they are

essential micronutrients for human health. Their higher intake as well as the prolonged intake of even low concentration (Ni) can cause serious toxic effects. The interest in these elements is increasing together with reports of relationships between trace element status and oxidative diseases. Environmental pollution is the main cause of heavy metal contamination in the food chain. Of all foods, legumes most adequately meet the recommended dietary guidelines for healthful eating because they are high in carbohydrate and dietary fiber, mostly low in fat, supply adequate protein while being a good source of vitamins and minerals. In this study, nickel and chromium concentrations were determined in legumes taken from Turkish markets. Further, sulfur concentrations of the samples were also determined and the relationship between metals and sulfur were examined. The element concentrations were measured by using ICP-MS after digestion by microwave digestion system. It was found that the highest Ni concentration is 2.5 mg/kg for beans. To check the reliability, the SRM was examined for the studied elements.

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Infrared and computational studies of weakly and strongly hydrogen bonded complexes of atmospheric interestA LoewenschussThe Hebrew University of Jerusalem, Israel

We shall report the FTIR spectra of several H-bonded complexes of atmospheric and environmental interest matrix isolated in frozen rare gases at cryogenic temperatures. The substances between which the interactions are studied

involve water, sulfuric acid, formic acid, ammonia, trimethyl-amine, methyl alcohol, sulfur trioxide, carbon monoxide and dioxide as well as xenon. The hydrogen bonds involved range from almost complete proton transfer to strong to weak and to very weak interactions. We examine the correlation between number and position of new bands not observed for the parent molecules and assigned to be the results of intermolecular complexation, on one hand and the induced hydroxyl stretch frequency shifts and hydrogen bond strengths and lengths, on the other. Our experimental work is accompanied by high-level computational results.

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressBiosensors with nanoscale controlled architecture applicable in glycomics and diagnosticsJan Tkac, Tomáš Bertók, Ľudmila Kluková, András Hushegyi, Dominika Pihíková and Štefan BelickýSlovak Academy of Sciences, Slovakia

Glycomics is a hot research field since analysis of genomic/proteomic profiles cannot be applied to study many pathological processes. Glycans (complex carbohydrates) are attached to 70% of all proteins and with high density to the surface of

the cells. Analysis of protein-linked glycans is crucial for understanding of numerous physiological/pathological processes. Current state-of-the-art tool for glycan analysis is mass spectrometry (MS) combined with chromatographic/electrophoretic instrumentation. MS analysis of some glycan changes associated with cancer is quite challenging due to long analysis time, extensive sample pre-treatment/ derivatization and data interpretation is required by skilled operators. This is why advanced analytical approaches are needed for advancements in the field of glycomics and diagnostics. In this presentation we show that impedimetric biosensors constructed with interfacial layers controlled at nanoscale can detect glycans down to a single molecule level (i.e. aM level). The biosensors were extensively optimised in a way to resist non-specific interactions for analysis of complex samples i.e. serum from patients having various diseases (rheumatoid arthritis, systemic sclerosis, prostate cancer), lysates of isolated human cells (leukaemia) and even with intact leukemic cell lines and flu viruses.

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Green alternative solvents for peptide synthesisAyman El-Faham1, Yahya E Jad2, Gerardo A Acosta3, Sherine N Khattab4, Beatriz G de la Torre5, Thavendran Govender2, Hendrik G Kruger2 and Fernando Albericio1,2,3,61King Saud University, Saudi Arabia 2University of Kwazulu-Natal, South Africa 3Institute for Research in Biomedicine-Barcelona, Spain4Alexandria University, Egypt 5Yachay City of Knowledge, Ecuador6University of Barcelona, Spain

To date, N,N-dimethylformamide (DMF) has been considered the only solvent suitable for peptide synthesis. Here we reported the use of 2-Methyltetrahydrofuran (2-MeTHF), cyclopentylmethyl ether (CPME),) tetrahydrofuran (THF) and

acetonitrile (ACN) as greener alternative solvents in peptide synthesis. The ability of these solvents to dissolve amino acid derivatives and a range of coupling reagents were evaluated as well as the swelling of polystyrene and polyethylene glycol resins. In addition, racemization and coupling efficiencies were evaluated with a model of peptide (stepwise and segment coupling). The combination between 2-MeTHF as a solvent with DIC/OxymaPure as a coupling methodology gave the lowest racemization level during stepwise synthesis and the highest purity during SPPS of pentapeptide (Aib-enkephalin pentapeptide; H-Tyr-Aib-Aib-Phe-Leu-NH2). Moreover, the use of ACN and THF in the solid-phase peptide synthesis of hindered peptides, such as Aib-enkephaline pentapeptide and Aib-ACP decapeptide, in combination with the totally polyethylene glycol ChemMatrixresin, gave a better coupling efficiency than DMF.

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressGold nanoparticles (GNPs) new synthesis method and modification with novel polyethylene glycol (PEG)-N-acetyl cysteine (NAC) conjugate Amal Hwaree Ayoub, Maisa Haj Inebtawi and Seba Jawabry ShadafnyMetallo Therapy ltd., Israel

In this paper, we describe a new method to synthesize small gold nanoparticles (average diameter of ~3.5 nm). Our method is based on the use of micro emulsion to mediate the reduction process; the micro emulsion guarantees soft reduction

process, uniformity of the produced GNPs as well as it controls particles size and shape. In addition, we introduce a novel polyethylene glycol (PEG)-N-acetyl cysteine (NAC) conjugate (PEG-NAC) for surface modification of the GNPs. The new PEG-NAC conjugate attaches the surface of the gold nanoparticles via the thiol group of the NAC and intended to provide GNPs enhanced solubility and improved stability particularly at protein containing solutions.

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Schrödinger theory of the electronic structure of matter from a ‘Newtonian’ perspectiveViraht SahniCity University of New York, USA

This talk is on a description of the Schrödinger theory of the electronic structure of matter as defined by a system of N electrons in the presence of an arbitrary time-dependent external field Fext(rt) = − nabla v(rt), in terms of a ‘Newtonian’

perspective. The perspective is based on the ‘Quantal Newtonian’ second law of motion for each electron. This is a description in terms of ‘classical’ fields that pervade all space, and whose sources are quantal in that they are expectations of Hermitian operators taken with respect to the system wave function. In analogy to classical physics, there is then in addition to the external field, an internal field, and a field representative of the response of each electron. The internal field is a sum of fields representative of electron correlations due to the Pauli Exclusion Principle and Coulomb repulsion, the density, and kinetic effects. The perspective leads to an understanding of the intrinsic self-consistent nature of the Schrödinger equation. On summing the law over all electrons, each component of the internal field vanishes (as is the case in classical physics), thereby leading to Ehrenfest’s theorem. The ‘Quantal Newtonian’ first law, a special case, is in turn descriptive of stationary state Schrödinger theory. The individual electron perspective will be explicated for both a ground and excited state via an exactly solvable interacting model system. This interpretation of Schrödinger theory constitutes the basis for Quantal Density Functional Theory, and leads to insights into traditional Density Functional Theory and Quantum Fluid Dynamics.

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http://dx.doi.org/10.4172/2150-3494.C1.003


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressSimple, rapid and valid thin layer chromatographic method for determining malachite green resi-dues in fishCécile SoulignacUniversity of Rouen, France

A thin-layer chromatography (TLC) method for determining the sum of MG and LMG residues in fish is described. The total MG on TLC gave a characteristic green color at visible light by naked eyes. This property was used to determine TCs

on silica gel by densitometer. Using a mobile phase of ACN: acidified MeOH: acetic acid 0.1N (8:1:1, v/v/v) and a silica gel thin-layer, total MG were well separated from impurities. The total MG was selectively determined by densitometry at 620 nm. The relative standard deviation for the method at 1µg kg-1 was <3.0%. The detection capability (CCβ) was 1 µg kg-1 and the limit of detection (LOD) was 0.5 µg kg-1. Trueness (recovery) was 73.4%. The variation of results was not significant, as the coefficient of variation (CV%) was 8.71% (<20%).

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Method to probe glass transition temperatures of polymer thin filmsBolin Li1, Fu-Gen Wu1, Xiaofeng Han1, Xiaolin Lu1 and Zhan Chen2

1Southeast University, China2University of Michigan, USA

A new methodology was developed to probe glass transition temperatures (Tgs) of polymer thin films supported on gold substrates and confined between two solid (silica and silver) surfaces based on the surface plasmon polariton (SFPP)

signals generated by sum frequency generation (SFG) spectroscopy. The detected abrupt change of the temperature-dependent SFPP signal demonstrated the viability of this methodology to determine Tgs of polymer thin films. The measured Tgs for polymer (poly(methyl methacrylate), poly(benzyl methacrylate) and poly(ethyl methacrylate)) thin films supported on gold (Au) substrates showed similar thickness-dependent trend compared to those previously measured using other methods, i.e., the Tg decreased as the thin film thickness decreased due to the free surface effect. However, the measured Tg of the polymer (poly(methyl methacrylate)) thin films confined between two solid (silica and silver) surfaces increased significantly with respect to the bulk value, indicating the strong interfacial effect on the dynamic behaviors of polymer thin films when the free surface was replaced by a buried interface. This new method to measure Tg is general and can be applied to study many different polymer thin films supported on metal surfaces or confined between two solid surfaces with different surface chemistries. More importantly, SFG has the unique selectivity and sensitivity to study surfaces and interfaces, which provides the feasibility to develop SFG into a powerful tool to detect surface, interfacial and bulk Tgs of a polymer thin film simultaneously in the future.

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http://dx.doi.org/10.4172/2150-3494.C1.003


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