MCGILL UNIVERSITY & GENOME QUEBEC INNOVATION CENTRE INVITES YOU TO THE GUEST SPEAKER SEMINAR MATHIEU LUPIEN, Ph.D. Senior Scientist, The Princess Margaret Cancer Centre Investigator, Ontario Institute for Cancer Research Associate Professor, Department of Medical Biophysics University of Toronto WEDNESDAY, DECEMBER 20 TH , 2017 11:00 am – 12:00 pm Strathcona Anatomy & Dentistry Building, Room M/48 Coffee and little pastries will be served TITLE: Metabolomics and cell of origin underlie cancer epigenomes SUMMARY: Cancer development is commonly ascribed to the genetic alterations, whether inherited or acquired. These commonly promote epigenetic reprogramming to induce transcriptional programs favorable to dedifferentiation and long-term self- renewal. However, cancer can also arise independently of genetic alterations. For instance, pediatric ependymomas are free of recurrent genetic alterations. Yet, they harbor epigenetic alterations that drive tumor growth. In this presentation, we will explore the intricate relationship between genetics, epigenetics and metabolomics in cancer.

Poster Invited speaker Mathieu Lupien - McGill …publications.mcgill.ca/humangenetics/files/2017/05/...INVITES YOU TO THE GUEST SPEAKER SEMINAR MATHIEU LUPIEN, Ph.D. Senior Scientist,

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Page 1: Poster Invited speaker Mathieu Lupien - McGill …publications.mcgill.ca/humangenetics/files/2017/05/...INVITES YOU TO THE GUEST SPEAKER SEMINAR MATHIEU LUPIEN, Ph.D. Senior Scientist,

MCGILLUNIVERSITY&GENOMEQUEBECINNOVATIONCENTREINVITESYOUTOTHEGUESTSPEAKERSEMINAR

MATHIEULUPIEN,Ph.D.

SeniorScientist,ThePrincessMargaretCancerCentreInvestigator,OntarioInstituteforCancerResearch

AssociateProfessor,DepartmentofMedicalBiophysicsUniversityofToronto

WEDNESDAY,DECEMBER20TH,201711:00am–12:00pm

StrathconaAnatomy&DentistryBuilding,RoomM/48Coffeeandlittlepastrieswillbeserved

TITLE: Metabolomics and cell of origin underlie cancer epigenomes SUMMARY:Cancer development is commonly ascribed to the genetic alterations, whetherinherited or acquired. These commonly promote epigenetic reprogramming toinducetranscriptionalprogramsfavorabletodedifferentiationandlong-termself-renewal.However,cancercanalsoariseindependentlyofgeneticalterations.Forinstance,pediatricependymomasarefreeofrecurrentgeneticalterations.Yet,theyharborepigeneticalterationsthatdrivetumorgrowth.Inthispresentation,wewillexploretheintricaterelationshipbetweengenetics,epigeneticsandmetabolomicsincancer.