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Possible origins of yeast prion domains from polyQ/n tracts. Alexander Alexandrov , Michael Ter-Avanesyan. Amyloids and prions in yeast. Glutamine/Asparagine rich amyloidogenic sequences. Homogenous. Heterogenous. natural. NQGNNQQNYQ (50+). QQQQQQQQQ (35+). QQQYQQQQYQ (50+). - PowerPoint PPT Presentation
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POSSIBLE ORIGINS OF YEAST PRION DOMAINS FROM POLYQ/N TRACTS
Alexander Alexandrov, Michael Ter-Avanesyan
Glutamine/Asparagine rich amyloidogenic sequences
Homogenous Heterogenous
QQQQQQQQQ (35+)NNNNNNNN
NQGNNQQNYQ (50+)
Amyloids and prions in yeast
Accumulation of mutations in polyQ
QQQYQQQQYQ (50+)naturalartificial
Importance
Emergence of prionogenic proteins may be a inevitable consequence of the existence of numerous proteins with polyQ and polyN in the proteome.
Prions – blessing or disease?
Was there positive selection for prion properties?
