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ACUTE PNEUMONIA IN CHILDREN Department of pediatrics
ACUTE PNEUMONIA IN CHILDREN Pneumonia is an inflammation of the parenchyma of the lung,Incidence 0.026 episodes per child/year in USA,0.28 episodes per child/year in developed countries
SYMPTOMS AND SIGNS Raised respiratory rate - 50 per minute or more if child 2mo up to 12mo;- 40 per minute or more if child 12 mo up to 5 yr- 30 per minute or more if child above 5 yrStridor in calm child or wheezingFever >37.5oDry cough or production of sputumWorse signs:the child is not able to drink or feeding wall, vomit everything, is lethargic or had convulsionsFocal chest signs- chest indrawing- decreased expansion- dullness on percussion- bronchial breathing- pleural chest pain in older children
ETIOLOGY Viruses: influenza A and B, RS, adenovirus, parainfluenzaGram + bacteria: Str.pneumoniae, Str.pyogenes, Staph.aureusGram- bacteria: H.influenzae, Kl.pneumoniae, Ps.aeruginosa, Morax. catarrhalis, Neis. meningitides, E.coli, Proteus, Enterobacter.Atypical nonbacterial bacilli: Mycoplasma or Chlamydia pneumoniae,Legionella (acquired by breathing droplets or contaminated water)Specific pneumonia in infants: aspiration (diminished gag reflex), gastroesophagal reflux, heart defects, genetic disorders, asthma, impaired immune system.
CLINICAL MANIFESTATIONS History- recent respiratory infection, exposure to people with pneumonia, fever, acute or persistent cough, dry/productive, related to feeding (aspiration), choking/ staccato/paroxysmal (foreign body aspiration, pertussis).Worse signs: not able to drink or feeding, vomit everything, is lethargic or had convulsions Physical examination-confusions, abnormally sleepy, cyanosis, fast breathing, nasal flaring, respiratory distress, grunting, stridor, wheezing;- vomiting, diarrhea, abdominal pain in paralytic ileus; - dullness on percussion: -consolidation or pleural effusion, empyema;- auscultation- rales, crackles, crepitations, rhonchi (rumblings).- clinical signs that predict death in children:worse signs, prolonged illness, severe X-ray changes, cyanosis, leukocytosis, hepatomegaly.
PNEUMONIA- DIAGNOSIS Chest X-ray confirms pneumonia and pleural effusion or empyema - Confluent lobar consolidation is typically in pneumococcal causes - Viral pneumonia- hyperinflation with bilateral interstitial infiltratesBronchoscopy, USG, CT scan in malformation or tumorsWBC in viral pneumonia are normal or 20,000/ml, granulocyte risesAtypical pneumonia: a higher WBC, ESR and C-reactive proteinDNA, RNA, antibodies tests for the rapid detection of virusesPCR test or seroconversion in an IgG assaySerologic evidence of the ASL-OSerum IgE in recurrent wheezingIsolation of the bacteria from the blood, pleural fluid or lungCulture of sputum and susceptibility of the antibioticsUrinary antigen test positive
PNEUMONIA -TREATMENTANTIBIOTIS:1.Penicillins and betalactams: Amoxycillin, Amoxi/Clav, Sulbactam2.Cephalosporines- Cefazolin, Cefuroxim, Ceftriaxon, Ceftazidizime3.Penems- Imipenem/Cilastatin, Meropenem, Ertapenem4.Quinolones-Ciprofloxacin, Levofloxacin, Moxifloxacin, Gatifloxacin- more effective in Gram- bacteria5.In atypical pneumonia macrolides: Clarithromycin, Roxithromycin, Azithromycin (7.5-15mg/kg/day)6.Aminoglycosides- dosage according to age, weight and kidney function (Gentamicin, Tobramycin, Amikacin)7.In viral pneumonia treatment withhold antibiotics
RESPONSE TO TREATMENTThe factors then patients leads to Slowly resolving pneumonia: 1. complications such as empyema2 .bacterial resistance 3.viral causes, foreign bodies or food aspiration4. bronchial obstruction 5.pre-existing immunodeficiencies6. cyliary dyskinesia, cystic fibrosis, other noninfectious causes. The first step- repeat chest X-ray
COMPLICATIONS The result of direct spread in the thoracic cavity: pleural effusion, empyema, pneumothorax, pericarditis Hematologic spread:sepsis, meningitis, arthritis, osteomyelitis
PREVENTION OF PNEUMONIA Immunization against H. influenzae type b Influenza vaccine Heptavalent pneumococcal conjugate vaccine Health education of the community Messages for mothers to recognize the signs of pneumonia
REFERENCES1.Nelson textbook of pediatrics, 18-th edition, 2007, p.1795-18002.Dr Herman Laferi-Community acquired pneumonia, diagnosis, treatment, Satellite Symposium Update in Infectious Pathology, 2006, Chisinau3.Technical bases for WHO recommendations on the management of pneumonia in children at first-level health facilities, Geneva, 2001