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PLASTICITY OF FIBER TYPE PLASTICITY OF FIBER TYPE EXPRESSIONEXPRESSION
OBJECTIVES (I and II)OBJECTIVES (I and II)•Methodology:Methodology:
• Electrophysiology: resting Em and action Electrophysiology: resting Em and action potential potential
• Measurement of ion channel activityMeasurement of ion channel activity• Source of informationSource of information
•Role of Role of ::• CalcineurinCalcineurin• nFATnFAT• Nitric oxide (NO)Nitric oxide (NO)• NOR-1NOR-1
INTRODUCTIONINTRODUCTION
CALCINEURIN
CATALYTIC DOMAIN
CaM-Bindingdomain
Auto-InhibitoryDomain
Calcineurin A (CNA)
CALCINEURIN AND NFAT PATHWAY IN B-LYMPHOCYTES
CALCINEURIN-NFAT Pathway
CALCINEURIN INCREASES mRNA LEVELS FOR MYOGLOBIN, SLOW TnI AND SARCOMERIC MITOCHONDRIAL CREATINE
KINASE IN GASTROCNEMIUS MUSCLE
CALCINEURIN DECREASES mRNA LEVELS FOR PARVALBUMIN AND MUSCLE CREATINE KINASE
IN GASTROCNEMIUS MUSCLE
FIRING PATTERNS IN MUSCLE
FIRING PATTERNS IN MUSCLE
FIRING PATTERNS vs. FORCE-FREQUENCY CURVE IN MUSCLE
Ca2+ TRANSIENT IN SLOW AND FAST FIBERS
DISCUSSIONDISCUSSION
ACTIVATION OF NF-ЌB, JNK1 AND NFAT IN B-LYMPHOCYTES
ACTIVATION OF NF-ЌB, JNK1 AND NFAT IN Ca2+ spike vs. prolonged
elevation
ACTIVATION OF NF-ЌB, JNK1 AND NFAT IN small prolonged elevation of
Ca2+
ACTIVATION OF NF-ЌB, JNK1 AND NFAT IN Ca2+ dose-response curve
MUSCLE OVERLAOD CAUSES A CALCINEURIN DEPENDENT
HYPERTROPHY
MUSCLE OVERLAOD CAUSES A CALCINEURIN DEPENDENT INCREASE
IN TYPE I FIBERS
MUSCLE OVERLAOD CAUSES A CALCINEURIN DEPENDENT CHANGE IN mRNA OF MHC AND
TnI
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