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Copyright copy 2011 Pure Health Group trade
About Pure Health Grouptrade
Copyright copy 2011 Pure Health Group trade
Pure Health Grouptrade is a science-based nutraceutical development company
founded in 2008 by John D Vox
With an alarming rise in painkiller addiction among teenagers and adults in the
United States John felt it was time offer those addicted to these powerful opioid
drugs a natural solution to help them break the bonds of drug dependency
After three years of focused research and development work the PHGtrade team is
set to launch a NEW GROUND BREAKING system of Nutraceutical and Lifestyle
support products called The Withdrawal Relief System
The Withdrawal Relief System
Copyright copy 2011 Pure Health Group trade
The Withdrawal Relief System is the most highly advanced scientific
system ever developed to help people overcome opioid dependence
without having to rely on other habit forming drugs
This system considers the whole person as they enter the withdrawal
process
The Withdrawal Relief System is a powerful all-natural system that
supports management of ALL of the most common and discomforting
mental and physical side-effects of opioid withdrawal by focusing
directly on their biological causes The system also provides
individuals with written and recorded support materials helping
to address the mental emotional and lifestyle issues that go
hand-in-hand with opioid dependence
The System Components
Copyright copy 2011 Pure Health Group trade
Withdrawal Relief Complex Nutraceuticals The system contains 3 powerful
nutraceuticals
Daytime Relief This formula is taken first thing in the morning during
acute withdrawal It has been designed to address the most disturbing
daytime withdrawal symptoms including fatigue lethargy depression GI
upset headache and more
Nighttime Relief This formula is taken before bed during acute
withdrawal It has been designed to calm the mind relax restless legs
reduce sleep latency and increase the duration of deep REM sleep
Craving Control Relapse Relief This formula is to be
taken after acute withdrawal has been successfully
negotiated This nutraceutical has been designed to
keep cravings at bay helping individuals avoid relapse
while safely supporting the recovery of vital biological
systems
The System Components (cont)
Copyright copy 2011 Pure Health Group trade
Conquering Opiate Withdrawal amp Addiction Volume 1 (eBook
download) A comprehensive book packed with information not
found in any other book on addiction and recovery This book
includes valuable insights from ex-addicts dietary advice from
leading nutritional scientists psychological support tools and much
more
CHILL Music Compilation (audio download) Prepared by a
professional DJ this one-of-a-kind mellow musical mix has been
designed to help soothe the body and mind
RELAX Audio Compilation (Free audio download) This free audio
download contains powerful guided meditations affirmations and
brain-balancing meta-music selections to support the individual‟s
successful withdrawal from opioid dependence
Pure Health Group‟strade RampD
Copyright copy 2011 Pure Health Group trade
The nutraceuticals in this breakthrough system were developed from years of
research about how opioids work within the body and brain to alter one‟s
physical emotional and mental state specifically how the withdrawal of
opioids acts to create the discomforting symptoms of acute opioid withdrawal
Understanding these causes we spent the next 24 months scouring the
scientific literature for research showing which natural nutrients could
effectively address these biological causes and alleviate withdrawal symptoms
Once the perfect nutrient blend was assessed we
focused on sourcing the purest most potent forms
of each nutrient for our formulas
Pure Health Group‟strade RampD (cont)
Copyright copy 2011 Pure Health Group trade
We understand there is a very wide range of nutrient quality in the
nutraceutical market place Therefore we enlisted the help of our
pharmaceutical manufacturing facility to source and obtain the best
standardized pharmaceutical-grade nutrients available
We then included these nutrients in the formulas in doses shown to be
efficacious in the scientific literature
Based upon the science supporting the symptom-specific efficacy of the
nutrients in our formulas and the empirical evidence we have garnered we
are highly confident that our products offer a safe and effective natural option
to assist with successful withdrawal from opioid dependence
Pure Health Group‟strade RampD (cont)
Copyright copy 2011 Pure Health Group trade
Empirical evidence suggests that those using the complete Withdrawal
Relief System are at least 50 more likely to successfully negotiate their
acute withdrawal period without relapse then those going cold turkey
We are currently in discussions with a Florida based research center
about implementing our first double-blinded placebo-controlled pilot trial
We hope to begin the study in the 4th quarter of 2011
Pure Health Group Inctrade is committed to remaining
on the forefront of opiate dependence research and
translating new discoveries into the best possible
answers and relief for those suffering from opiate
addiction Pure Health Group Inctrade supports
continuous research and development of new
nutraceutical products that will make the journey
towards freedom from opiate dependency as easy and
pain free as possible
How Does The System Work
Copyright copy 2011 Pure Health Group trade
The Withdraw Relief Complex Nutraceuticals aid in the withdrawal and
recovery process by supplying specific nutrients that naturally counter symptoms
reduce pain and send messages that calm opioid receptors in the brain
The Withdraw Relief System gives patients a distinct advantage in the battle to
be opioid free
By dramatically reducing their discomfort patients will
bullBe empowered to maintain a more normal lifestyle through the
withdrawal process
bullBe able to maintain some level of appetite and ingest
supportive foods
bullStay hydrated
bullMaintain some level of physical activity to stimulate natural
endorphins
bullFocus on the opioid-free future that is waiting for them just
around the corner
PHGtrade and Healthcare Providers
Copyright copy 2011 Pure Health Group trade
Pure Health Group Inctrade is committed to partnering with healthcare providers
to eradicate opioid dependence by using innovative science and research to
create extraordinary nutraceutical products that help minimize the pain of
withdrawal
For more information about Pure Health
Grouptrade or about how to become a licensed
distributor of our products please visit
WWWPUREHEALTHGROUPCOM
Or contact John D Vox at
jvoxpurehealthgroupcom
3039555899 ext 701
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
The following information explains exactly how the nutrients in our formulas
create relief by working with your patients body to alleviate withdrawal
symptoms
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Depression Anxiety
One of the most debilitating withdrawal symptoms patients experience is a
deep feeling of depression spiked with intermittent anxiety This depressive
state is caused in great part by a severe depletion of vital neurotransmitters
and naturally occurring opioids combined with desensitization of opioid
receptors in the brain Withdrawal Relief Complex nutraceuticals help support
the rapid return of these vital biological chemicals to healthy levels thus
decreasing the depth and length of the depressive state
Research supporting the efficacy of the natural
nutrients in Withdrawal Relief Complex Nutraceuticals
to combat depression and anxiety symptoms are as
follows
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-
blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine
showed use of this herb significantly decreased depression and anxiety associated with
withdrawal as well as if not better than Clonidine1
bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety
WITHOUT the adverse side effects of the drug2
5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP
dramatically alleviates depression3-9
bullIt does so by bolstering serotonin levels in the brain
Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10
bullSignificantly increases the biosynthesis of natural opioid peptides in the body11
bullDecrease the symptoms of depression in patients by up over 3512
L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital
neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which
indicates that it relaxes the mind without inducing drowsinessrdquo14
bullL-theanine reduces anxiety and calms nerves during stressful events15
Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the
B-vitamins or vitamin C16
bullCorrection of these deficiencies through supplementation with the proper forms and
amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in
complete resolution of mental symptoms in some individualsrdquo16
Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas
bullThis herb standardized for L-Dopa content has been found in research to have potent
anti-depressant actions17
bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Insomnia
Sleepless nights are a very common symptom of opiate withdrawal Long-
term use of opiates tends to disrupt the sleep wake cycle by disturbing
the proper production of melatonin and other sleep-inducing chemicals in
the body In order to re-establish healthy sleep cycles allowing patients to
fall asleep faster and stay asleep longer it is necessary to support the
production of natural sleep chemicals
The Withdrawal Relief Complex contains a
healthy dose of pure Melatonin and other all-
natural sleep support ingredients to help
patients sleep through the night allowing them
to obtain the rest needed to recover quickly
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall
asleep much faster and to significantly increase the amount of sleep achieved throughout the
night19 20
5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with
one study showing a 53 increase in REM sleep during the night21
ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small
doses of barbiturates or benzodiazepansrdquo22
bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23
American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects
take place within 30 minutes of ingestion and have been shown in research to help people fall
asleep faster and stay asleep longer24
Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in
prolonged sleep tests25
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Nausea amp Gastrointestinal Distress
Nausea and GI distress (including intestinal cramping and diarrhea) is one of the
most uncomfortable and disruptive physical symptoms of opiate withdrawal This
symptom generally presents 2 or 3 days after abstaining from opiates and can last
for up to a week
Opiates have a very strong sedative effect on the stomach and intestinal tract
Once opiate use is discontinued these organs become over stimulated Nerves
that have been suppressed for a long time begin to come back to life This
enhanced neural input to the smooth muscles of the stomach and GI tract can be
shocking to the system thus causing cramping and hyper-motility
which can lead to diarrhea nausea and vomiting
To treat these symptoms the Withdrawal Relief Complex
formulas include powerful ingredients that not only help to
provide natural moderate sedation to overactive GI nerves but
also help soothe the stomach
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows
gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the
prescription drug Papaverinerdquo for these uses
Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth
muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27
bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a
spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it
as a natural medicine for GI distress28
Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many
antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-
33
Vitamin B6
bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin
B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated
that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our
combined formulashellipover twice the dose of the studyhellipto ensure best results
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Extreme Fatigue amp Lethargy
The fatigue most people experience during withdrawal is profound It can be severe
enough that patients will literally not be able to get out of bed This is particularly
damaging for those needing to maintain a consistent work schedule and or care for
their family
The fatigue that comes from opiate withdrawal is both physical and mental Many
recovering opiate addicts feel a complete lack of motivation and desire to engage in
life This leads to reclusive behavior poor diet and a host of other actions that tend
to prolong withdrawal and lead to relapse
Therefore it is imperative that patients are supported
in staying energized and motivated as they negotiate
the acute phase of withdrawal
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased
energy focus attention and task performance throughout the day Researchers stated ldquoThese results
provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the
psychoactive properties of ginsengrdquo35
5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to
ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36
L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers
found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37
bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing
neurotransmitters such as epinephrine and norepinephrine
Vitamin B12
bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38
bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase
in energy stamina and well being helliprdquo38
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Restless Leg Syndrome (RLS)
RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced
by nearly everyone going through opiate withdrawal This symptom is not so much
painful as it is disruptive and highly irritating RLS causes agitation during the day
and disrupts sleep during the night This exacerbates the symptoms of insomnia and
creates further daytime agitation locking patients into a vicious cycle
RLS is thought to be caused by the depletion of the neurotransmitter dopamine in
the system Research has shown that providing nutrients to help stimulate
dopamine production can quickly and effectively decrease or eliminate the severity
of this syndrome
The following demonstrates how the nutrients in Withdrawal Relief
Complex support dopamine production in two ways by providing a
direct source of natural dopamine (through the L-dopa content of
Mucuna pruriens) and by supporting dopamine metabolism in the
body with the B-vitamin Folate
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances
levels of dopamine in the brain39
bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a
medical treatment for Parkinsons Disease40
bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly
decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41
Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid
(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and
fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid
levelsrdquo42 43
Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people
with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS
symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in
the Withdrawal Relief Complex Nighttime formula
MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for
treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal
Relief Complex System This formula has been designed to help keep cravings at
bay after acute withdraw has passed allowing the chemical balance in the patient‟s
brain to quickly and safely return to pre-drug use level
CCRR is a four part compound nutraceutical that addresses cravings by
bullSupplying your adrenal system with nutrients you need to feel good The
ingredients in CCRR work hard to heal your body and restore your
organs and mind
bullGiving your brain a natural boost to stave off depression and anxiety
until the chemical balance of your pre-drug healthy brain is restored
bullFlooding your body with nourishing vitamins and antioxidants that
support physical recovery as you continue to gain strength
bullEnsuring that cravings stay manageable while you create more and more
distance from the desire for more drugs
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
About Pure Health Grouptrade
Copyright copy 2011 Pure Health Group trade
Pure Health Grouptrade is a science-based nutraceutical development company
founded in 2008 by John D Vox
With an alarming rise in painkiller addiction among teenagers and adults in the
United States John felt it was time offer those addicted to these powerful opioid
drugs a natural solution to help them break the bonds of drug dependency
After three years of focused research and development work the PHGtrade team is
set to launch a NEW GROUND BREAKING system of Nutraceutical and Lifestyle
support products called The Withdrawal Relief System
The Withdrawal Relief System
Copyright copy 2011 Pure Health Group trade
The Withdrawal Relief System is the most highly advanced scientific
system ever developed to help people overcome opioid dependence
without having to rely on other habit forming drugs
This system considers the whole person as they enter the withdrawal
process
The Withdrawal Relief System is a powerful all-natural system that
supports management of ALL of the most common and discomforting
mental and physical side-effects of opioid withdrawal by focusing
directly on their biological causes The system also provides
individuals with written and recorded support materials helping
to address the mental emotional and lifestyle issues that go
hand-in-hand with opioid dependence
The System Components
Copyright copy 2011 Pure Health Group trade
Withdrawal Relief Complex Nutraceuticals The system contains 3 powerful
nutraceuticals
Daytime Relief This formula is taken first thing in the morning during
acute withdrawal It has been designed to address the most disturbing
daytime withdrawal symptoms including fatigue lethargy depression GI
upset headache and more
Nighttime Relief This formula is taken before bed during acute
withdrawal It has been designed to calm the mind relax restless legs
reduce sleep latency and increase the duration of deep REM sleep
Craving Control Relapse Relief This formula is to be
taken after acute withdrawal has been successfully
negotiated This nutraceutical has been designed to
keep cravings at bay helping individuals avoid relapse
while safely supporting the recovery of vital biological
systems
The System Components (cont)
Copyright copy 2011 Pure Health Group trade
Conquering Opiate Withdrawal amp Addiction Volume 1 (eBook
download) A comprehensive book packed with information not
found in any other book on addiction and recovery This book
includes valuable insights from ex-addicts dietary advice from
leading nutritional scientists psychological support tools and much
more
CHILL Music Compilation (audio download) Prepared by a
professional DJ this one-of-a-kind mellow musical mix has been
designed to help soothe the body and mind
RELAX Audio Compilation (Free audio download) This free audio
download contains powerful guided meditations affirmations and
brain-balancing meta-music selections to support the individual‟s
successful withdrawal from opioid dependence
Pure Health Group‟strade RampD
Copyright copy 2011 Pure Health Group trade
The nutraceuticals in this breakthrough system were developed from years of
research about how opioids work within the body and brain to alter one‟s
physical emotional and mental state specifically how the withdrawal of
opioids acts to create the discomforting symptoms of acute opioid withdrawal
Understanding these causes we spent the next 24 months scouring the
scientific literature for research showing which natural nutrients could
effectively address these biological causes and alleviate withdrawal symptoms
Once the perfect nutrient blend was assessed we
focused on sourcing the purest most potent forms
of each nutrient for our formulas
Pure Health Group‟strade RampD (cont)
Copyright copy 2011 Pure Health Group trade
We understand there is a very wide range of nutrient quality in the
nutraceutical market place Therefore we enlisted the help of our
pharmaceutical manufacturing facility to source and obtain the best
standardized pharmaceutical-grade nutrients available
We then included these nutrients in the formulas in doses shown to be
efficacious in the scientific literature
Based upon the science supporting the symptom-specific efficacy of the
nutrients in our formulas and the empirical evidence we have garnered we
are highly confident that our products offer a safe and effective natural option
to assist with successful withdrawal from opioid dependence
Pure Health Group‟strade RampD (cont)
Copyright copy 2011 Pure Health Group trade
Empirical evidence suggests that those using the complete Withdrawal
Relief System are at least 50 more likely to successfully negotiate their
acute withdrawal period without relapse then those going cold turkey
We are currently in discussions with a Florida based research center
about implementing our first double-blinded placebo-controlled pilot trial
We hope to begin the study in the 4th quarter of 2011
Pure Health Group Inctrade is committed to remaining
on the forefront of opiate dependence research and
translating new discoveries into the best possible
answers and relief for those suffering from opiate
addiction Pure Health Group Inctrade supports
continuous research and development of new
nutraceutical products that will make the journey
towards freedom from opiate dependency as easy and
pain free as possible
How Does The System Work
Copyright copy 2011 Pure Health Group trade
The Withdraw Relief Complex Nutraceuticals aid in the withdrawal and
recovery process by supplying specific nutrients that naturally counter symptoms
reduce pain and send messages that calm opioid receptors in the brain
The Withdraw Relief System gives patients a distinct advantage in the battle to
be opioid free
By dramatically reducing their discomfort patients will
bullBe empowered to maintain a more normal lifestyle through the
withdrawal process
bullBe able to maintain some level of appetite and ingest
supportive foods
bullStay hydrated
bullMaintain some level of physical activity to stimulate natural
endorphins
bullFocus on the opioid-free future that is waiting for them just
around the corner
PHGtrade and Healthcare Providers
Copyright copy 2011 Pure Health Group trade
Pure Health Group Inctrade is committed to partnering with healthcare providers
to eradicate opioid dependence by using innovative science and research to
create extraordinary nutraceutical products that help minimize the pain of
withdrawal
For more information about Pure Health
Grouptrade or about how to become a licensed
distributor of our products please visit
WWWPUREHEALTHGROUPCOM
Or contact John D Vox at
jvoxpurehealthgroupcom
3039555899 ext 701
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
The following information explains exactly how the nutrients in our formulas
create relief by working with your patients body to alleviate withdrawal
symptoms
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Depression Anxiety
One of the most debilitating withdrawal symptoms patients experience is a
deep feeling of depression spiked with intermittent anxiety This depressive
state is caused in great part by a severe depletion of vital neurotransmitters
and naturally occurring opioids combined with desensitization of opioid
receptors in the brain Withdrawal Relief Complex nutraceuticals help support
the rapid return of these vital biological chemicals to healthy levels thus
decreasing the depth and length of the depressive state
Research supporting the efficacy of the natural
nutrients in Withdrawal Relief Complex Nutraceuticals
to combat depression and anxiety symptoms are as
follows
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-
blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine
showed use of this herb significantly decreased depression and anxiety associated with
withdrawal as well as if not better than Clonidine1
bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety
WITHOUT the adverse side effects of the drug2
5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP
dramatically alleviates depression3-9
bullIt does so by bolstering serotonin levels in the brain
Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10
bullSignificantly increases the biosynthesis of natural opioid peptides in the body11
bullDecrease the symptoms of depression in patients by up over 3512
L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital
neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which
indicates that it relaxes the mind without inducing drowsinessrdquo14
bullL-theanine reduces anxiety and calms nerves during stressful events15
Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the
B-vitamins or vitamin C16
bullCorrection of these deficiencies through supplementation with the proper forms and
amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in
complete resolution of mental symptoms in some individualsrdquo16
Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas
bullThis herb standardized for L-Dopa content has been found in research to have potent
anti-depressant actions17
bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Insomnia
Sleepless nights are a very common symptom of opiate withdrawal Long-
term use of opiates tends to disrupt the sleep wake cycle by disturbing
the proper production of melatonin and other sleep-inducing chemicals in
the body In order to re-establish healthy sleep cycles allowing patients to
fall asleep faster and stay asleep longer it is necessary to support the
production of natural sleep chemicals
The Withdrawal Relief Complex contains a
healthy dose of pure Melatonin and other all-
natural sleep support ingredients to help
patients sleep through the night allowing them
to obtain the rest needed to recover quickly
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall
asleep much faster and to significantly increase the amount of sleep achieved throughout the
night19 20
5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with
one study showing a 53 increase in REM sleep during the night21
ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small
doses of barbiturates or benzodiazepansrdquo22
bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23
American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects
take place within 30 minutes of ingestion and have been shown in research to help people fall
asleep faster and stay asleep longer24
Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in
prolonged sleep tests25
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Nausea amp Gastrointestinal Distress
Nausea and GI distress (including intestinal cramping and diarrhea) is one of the
most uncomfortable and disruptive physical symptoms of opiate withdrawal This
symptom generally presents 2 or 3 days after abstaining from opiates and can last
for up to a week
Opiates have a very strong sedative effect on the stomach and intestinal tract
Once opiate use is discontinued these organs become over stimulated Nerves
that have been suppressed for a long time begin to come back to life This
enhanced neural input to the smooth muscles of the stomach and GI tract can be
shocking to the system thus causing cramping and hyper-motility
which can lead to diarrhea nausea and vomiting
To treat these symptoms the Withdrawal Relief Complex
formulas include powerful ingredients that not only help to
provide natural moderate sedation to overactive GI nerves but
also help soothe the stomach
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows
gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the
prescription drug Papaverinerdquo for these uses
Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth
muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27
bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a
spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it
as a natural medicine for GI distress28
Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many
antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-
33
Vitamin B6
bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin
B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated
that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our
combined formulashellipover twice the dose of the studyhellipto ensure best results
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Extreme Fatigue amp Lethargy
The fatigue most people experience during withdrawal is profound It can be severe
enough that patients will literally not be able to get out of bed This is particularly
damaging for those needing to maintain a consistent work schedule and or care for
their family
The fatigue that comes from opiate withdrawal is both physical and mental Many
recovering opiate addicts feel a complete lack of motivation and desire to engage in
life This leads to reclusive behavior poor diet and a host of other actions that tend
to prolong withdrawal and lead to relapse
Therefore it is imperative that patients are supported
in staying energized and motivated as they negotiate
the acute phase of withdrawal
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased
energy focus attention and task performance throughout the day Researchers stated ldquoThese results
provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the
psychoactive properties of ginsengrdquo35
5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to
ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36
L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers
found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37
bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing
neurotransmitters such as epinephrine and norepinephrine
Vitamin B12
bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38
bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase
in energy stamina and well being helliprdquo38
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Restless Leg Syndrome (RLS)
RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced
by nearly everyone going through opiate withdrawal This symptom is not so much
painful as it is disruptive and highly irritating RLS causes agitation during the day
and disrupts sleep during the night This exacerbates the symptoms of insomnia and
creates further daytime agitation locking patients into a vicious cycle
RLS is thought to be caused by the depletion of the neurotransmitter dopamine in
the system Research has shown that providing nutrients to help stimulate
dopamine production can quickly and effectively decrease or eliminate the severity
of this syndrome
The following demonstrates how the nutrients in Withdrawal Relief
Complex support dopamine production in two ways by providing a
direct source of natural dopamine (through the L-dopa content of
Mucuna pruriens) and by supporting dopamine metabolism in the
body with the B-vitamin Folate
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances
levels of dopamine in the brain39
bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a
medical treatment for Parkinsons Disease40
bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly
decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41
Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid
(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and
fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid
levelsrdquo42 43
Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people
with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS
symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in
the Withdrawal Relief Complex Nighttime formula
MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for
treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal
Relief Complex System This formula has been designed to help keep cravings at
bay after acute withdraw has passed allowing the chemical balance in the patient‟s
brain to quickly and safely return to pre-drug use level
CCRR is a four part compound nutraceutical that addresses cravings by
bullSupplying your adrenal system with nutrients you need to feel good The
ingredients in CCRR work hard to heal your body and restore your
organs and mind
bullGiving your brain a natural boost to stave off depression and anxiety
until the chemical balance of your pre-drug healthy brain is restored
bullFlooding your body with nourishing vitamins and antioxidants that
support physical recovery as you continue to gain strength
bullEnsuring that cravings stay manageable while you create more and more
distance from the desire for more drugs
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
The Withdrawal Relief System
Copyright copy 2011 Pure Health Group trade
The Withdrawal Relief System is the most highly advanced scientific
system ever developed to help people overcome opioid dependence
without having to rely on other habit forming drugs
This system considers the whole person as they enter the withdrawal
process
The Withdrawal Relief System is a powerful all-natural system that
supports management of ALL of the most common and discomforting
mental and physical side-effects of opioid withdrawal by focusing
directly on their biological causes The system also provides
individuals with written and recorded support materials helping
to address the mental emotional and lifestyle issues that go
hand-in-hand with opioid dependence
The System Components
Copyright copy 2011 Pure Health Group trade
Withdrawal Relief Complex Nutraceuticals The system contains 3 powerful
nutraceuticals
Daytime Relief This formula is taken first thing in the morning during
acute withdrawal It has been designed to address the most disturbing
daytime withdrawal symptoms including fatigue lethargy depression GI
upset headache and more
Nighttime Relief This formula is taken before bed during acute
withdrawal It has been designed to calm the mind relax restless legs
reduce sleep latency and increase the duration of deep REM sleep
Craving Control Relapse Relief This formula is to be
taken after acute withdrawal has been successfully
negotiated This nutraceutical has been designed to
keep cravings at bay helping individuals avoid relapse
while safely supporting the recovery of vital biological
systems
The System Components (cont)
Copyright copy 2011 Pure Health Group trade
Conquering Opiate Withdrawal amp Addiction Volume 1 (eBook
download) A comprehensive book packed with information not
found in any other book on addiction and recovery This book
includes valuable insights from ex-addicts dietary advice from
leading nutritional scientists psychological support tools and much
more
CHILL Music Compilation (audio download) Prepared by a
professional DJ this one-of-a-kind mellow musical mix has been
designed to help soothe the body and mind
RELAX Audio Compilation (Free audio download) This free audio
download contains powerful guided meditations affirmations and
brain-balancing meta-music selections to support the individual‟s
successful withdrawal from opioid dependence
Pure Health Group‟strade RampD
Copyright copy 2011 Pure Health Group trade
The nutraceuticals in this breakthrough system were developed from years of
research about how opioids work within the body and brain to alter one‟s
physical emotional and mental state specifically how the withdrawal of
opioids acts to create the discomforting symptoms of acute opioid withdrawal
Understanding these causes we spent the next 24 months scouring the
scientific literature for research showing which natural nutrients could
effectively address these biological causes and alleviate withdrawal symptoms
Once the perfect nutrient blend was assessed we
focused on sourcing the purest most potent forms
of each nutrient for our formulas
Pure Health Group‟strade RampD (cont)
Copyright copy 2011 Pure Health Group trade
We understand there is a very wide range of nutrient quality in the
nutraceutical market place Therefore we enlisted the help of our
pharmaceutical manufacturing facility to source and obtain the best
standardized pharmaceutical-grade nutrients available
We then included these nutrients in the formulas in doses shown to be
efficacious in the scientific literature
Based upon the science supporting the symptom-specific efficacy of the
nutrients in our formulas and the empirical evidence we have garnered we
are highly confident that our products offer a safe and effective natural option
to assist with successful withdrawal from opioid dependence
Pure Health Group‟strade RampD (cont)
Copyright copy 2011 Pure Health Group trade
Empirical evidence suggests that those using the complete Withdrawal
Relief System are at least 50 more likely to successfully negotiate their
acute withdrawal period without relapse then those going cold turkey
We are currently in discussions with a Florida based research center
about implementing our first double-blinded placebo-controlled pilot trial
We hope to begin the study in the 4th quarter of 2011
Pure Health Group Inctrade is committed to remaining
on the forefront of opiate dependence research and
translating new discoveries into the best possible
answers and relief for those suffering from opiate
addiction Pure Health Group Inctrade supports
continuous research and development of new
nutraceutical products that will make the journey
towards freedom from opiate dependency as easy and
pain free as possible
How Does The System Work
Copyright copy 2011 Pure Health Group trade
The Withdraw Relief Complex Nutraceuticals aid in the withdrawal and
recovery process by supplying specific nutrients that naturally counter symptoms
reduce pain and send messages that calm opioid receptors in the brain
The Withdraw Relief System gives patients a distinct advantage in the battle to
be opioid free
By dramatically reducing their discomfort patients will
bullBe empowered to maintain a more normal lifestyle through the
withdrawal process
bullBe able to maintain some level of appetite and ingest
supportive foods
bullStay hydrated
bullMaintain some level of physical activity to stimulate natural
endorphins
bullFocus on the opioid-free future that is waiting for them just
around the corner
PHGtrade and Healthcare Providers
Copyright copy 2011 Pure Health Group trade
Pure Health Group Inctrade is committed to partnering with healthcare providers
to eradicate opioid dependence by using innovative science and research to
create extraordinary nutraceutical products that help minimize the pain of
withdrawal
For more information about Pure Health
Grouptrade or about how to become a licensed
distributor of our products please visit
WWWPUREHEALTHGROUPCOM
Or contact John D Vox at
jvoxpurehealthgroupcom
3039555899 ext 701
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
The following information explains exactly how the nutrients in our formulas
create relief by working with your patients body to alleviate withdrawal
symptoms
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Depression Anxiety
One of the most debilitating withdrawal symptoms patients experience is a
deep feeling of depression spiked with intermittent anxiety This depressive
state is caused in great part by a severe depletion of vital neurotransmitters
and naturally occurring opioids combined with desensitization of opioid
receptors in the brain Withdrawal Relief Complex nutraceuticals help support
the rapid return of these vital biological chemicals to healthy levels thus
decreasing the depth and length of the depressive state
Research supporting the efficacy of the natural
nutrients in Withdrawal Relief Complex Nutraceuticals
to combat depression and anxiety symptoms are as
follows
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-
blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine
showed use of this herb significantly decreased depression and anxiety associated with
withdrawal as well as if not better than Clonidine1
bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety
WITHOUT the adverse side effects of the drug2
5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP
dramatically alleviates depression3-9
bullIt does so by bolstering serotonin levels in the brain
Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10
bullSignificantly increases the biosynthesis of natural opioid peptides in the body11
bullDecrease the symptoms of depression in patients by up over 3512
L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital
neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which
indicates that it relaxes the mind without inducing drowsinessrdquo14
bullL-theanine reduces anxiety and calms nerves during stressful events15
Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the
B-vitamins or vitamin C16
bullCorrection of these deficiencies through supplementation with the proper forms and
amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in
complete resolution of mental symptoms in some individualsrdquo16
Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas
bullThis herb standardized for L-Dopa content has been found in research to have potent
anti-depressant actions17
bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Insomnia
Sleepless nights are a very common symptom of opiate withdrawal Long-
term use of opiates tends to disrupt the sleep wake cycle by disturbing
the proper production of melatonin and other sleep-inducing chemicals in
the body In order to re-establish healthy sleep cycles allowing patients to
fall asleep faster and stay asleep longer it is necessary to support the
production of natural sleep chemicals
The Withdrawal Relief Complex contains a
healthy dose of pure Melatonin and other all-
natural sleep support ingredients to help
patients sleep through the night allowing them
to obtain the rest needed to recover quickly
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall
asleep much faster and to significantly increase the amount of sleep achieved throughout the
night19 20
5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with
one study showing a 53 increase in REM sleep during the night21
ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small
doses of barbiturates or benzodiazepansrdquo22
bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23
American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects
take place within 30 minutes of ingestion and have been shown in research to help people fall
asleep faster and stay asleep longer24
Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in
prolonged sleep tests25
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Nausea amp Gastrointestinal Distress
Nausea and GI distress (including intestinal cramping and diarrhea) is one of the
most uncomfortable and disruptive physical symptoms of opiate withdrawal This
symptom generally presents 2 or 3 days after abstaining from opiates and can last
for up to a week
Opiates have a very strong sedative effect on the stomach and intestinal tract
Once opiate use is discontinued these organs become over stimulated Nerves
that have been suppressed for a long time begin to come back to life This
enhanced neural input to the smooth muscles of the stomach and GI tract can be
shocking to the system thus causing cramping and hyper-motility
which can lead to diarrhea nausea and vomiting
To treat these symptoms the Withdrawal Relief Complex
formulas include powerful ingredients that not only help to
provide natural moderate sedation to overactive GI nerves but
also help soothe the stomach
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows
gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the
prescription drug Papaverinerdquo for these uses
Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth
muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27
bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a
spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it
as a natural medicine for GI distress28
Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many
antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-
33
Vitamin B6
bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin
B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated
that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our
combined formulashellipover twice the dose of the studyhellipto ensure best results
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Extreme Fatigue amp Lethargy
The fatigue most people experience during withdrawal is profound It can be severe
enough that patients will literally not be able to get out of bed This is particularly
damaging for those needing to maintain a consistent work schedule and or care for
their family
The fatigue that comes from opiate withdrawal is both physical and mental Many
recovering opiate addicts feel a complete lack of motivation and desire to engage in
life This leads to reclusive behavior poor diet and a host of other actions that tend
to prolong withdrawal and lead to relapse
Therefore it is imperative that patients are supported
in staying energized and motivated as they negotiate
the acute phase of withdrawal
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased
energy focus attention and task performance throughout the day Researchers stated ldquoThese results
provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the
psychoactive properties of ginsengrdquo35
5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to
ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36
L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers
found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37
bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing
neurotransmitters such as epinephrine and norepinephrine
Vitamin B12
bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38
bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase
in energy stamina and well being helliprdquo38
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Restless Leg Syndrome (RLS)
RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced
by nearly everyone going through opiate withdrawal This symptom is not so much
painful as it is disruptive and highly irritating RLS causes agitation during the day
and disrupts sleep during the night This exacerbates the symptoms of insomnia and
creates further daytime agitation locking patients into a vicious cycle
RLS is thought to be caused by the depletion of the neurotransmitter dopamine in
the system Research has shown that providing nutrients to help stimulate
dopamine production can quickly and effectively decrease or eliminate the severity
of this syndrome
The following demonstrates how the nutrients in Withdrawal Relief
Complex support dopamine production in two ways by providing a
direct source of natural dopamine (through the L-dopa content of
Mucuna pruriens) and by supporting dopamine metabolism in the
body with the B-vitamin Folate
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances
levels of dopamine in the brain39
bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a
medical treatment for Parkinsons Disease40
bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly
decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41
Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid
(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and
fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid
levelsrdquo42 43
Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people
with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS
symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in
the Withdrawal Relief Complex Nighttime formula
MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for
treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal
Relief Complex System This formula has been designed to help keep cravings at
bay after acute withdraw has passed allowing the chemical balance in the patient‟s
brain to quickly and safely return to pre-drug use level
CCRR is a four part compound nutraceutical that addresses cravings by
bullSupplying your adrenal system with nutrients you need to feel good The
ingredients in CCRR work hard to heal your body and restore your
organs and mind
bullGiving your brain a natural boost to stave off depression and anxiety
until the chemical balance of your pre-drug healthy brain is restored
bullFlooding your body with nourishing vitamins and antioxidants that
support physical recovery as you continue to gain strength
bullEnsuring that cravings stay manageable while you create more and more
distance from the desire for more drugs
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
The System Components
Copyright copy 2011 Pure Health Group trade
Withdrawal Relief Complex Nutraceuticals The system contains 3 powerful
nutraceuticals
Daytime Relief This formula is taken first thing in the morning during
acute withdrawal It has been designed to address the most disturbing
daytime withdrawal symptoms including fatigue lethargy depression GI
upset headache and more
Nighttime Relief This formula is taken before bed during acute
withdrawal It has been designed to calm the mind relax restless legs
reduce sleep latency and increase the duration of deep REM sleep
Craving Control Relapse Relief This formula is to be
taken after acute withdrawal has been successfully
negotiated This nutraceutical has been designed to
keep cravings at bay helping individuals avoid relapse
while safely supporting the recovery of vital biological
systems
The System Components (cont)
Copyright copy 2011 Pure Health Group trade
Conquering Opiate Withdrawal amp Addiction Volume 1 (eBook
download) A comprehensive book packed with information not
found in any other book on addiction and recovery This book
includes valuable insights from ex-addicts dietary advice from
leading nutritional scientists psychological support tools and much
more
CHILL Music Compilation (audio download) Prepared by a
professional DJ this one-of-a-kind mellow musical mix has been
designed to help soothe the body and mind
RELAX Audio Compilation (Free audio download) This free audio
download contains powerful guided meditations affirmations and
brain-balancing meta-music selections to support the individual‟s
successful withdrawal from opioid dependence
Pure Health Group‟strade RampD
Copyright copy 2011 Pure Health Group trade
The nutraceuticals in this breakthrough system were developed from years of
research about how opioids work within the body and brain to alter one‟s
physical emotional and mental state specifically how the withdrawal of
opioids acts to create the discomforting symptoms of acute opioid withdrawal
Understanding these causes we spent the next 24 months scouring the
scientific literature for research showing which natural nutrients could
effectively address these biological causes and alleviate withdrawal symptoms
Once the perfect nutrient blend was assessed we
focused on sourcing the purest most potent forms
of each nutrient for our formulas
Pure Health Group‟strade RampD (cont)
Copyright copy 2011 Pure Health Group trade
We understand there is a very wide range of nutrient quality in the
nutraceutical market place Therefore we enlisted the help of our
pharmaceutical manufacturing facility to source and obtain the best
standardized pharmaceutical-grade nutrients available
We then included these nutrients in the formulas in doses shown to be
efficacious in the scientific literature
Based upon the science supporting the symptom-specific efficacy of the
nutrients in our formulas and the empirical evidence we have garnered we
are highly confident that our products offer a safe and effective natural option
to assist with successful withdrawal from opioid dependence
Pure Health Group‟strade RampD (cont)
Copyright copy 2011 Pure Health Group trade
Empirical evidence suggests that those using the complete Withdrawal
Relief System are at least 50 more likely to successfully negotiate their
acute withdrawal period without relapse then those going cold turkey
We are currently in discussions with a Florida based research center
about implementing our first double-blinded placebo-controlled pilot trial
We hope to begin the study in the 4th quarter of 2011
Pure Health Group Inctrade is committed to remaining
on the forefront of opiate dependence research and
translating new discoveries into the best possible
answers and relief for those suffering from opiate
addiction Pure Health Group Inctrade supports
continuous research and development of new
nutraceutical products that will make the journey
towards freedom from opiate dependency as easy and
pain free as possible
How Does The System Work
Copyright copy 2011 Pure Health Group trade
The Withdraw Relief Complex Nutraceuticals aid in the withdrawal and
recovery process by supplying specific nutrients that naturally counter symptoms
reduce pain and send messages that calm opioid receptors in the brain
The Withdraw Relief System gives patients a distinct advantage in the battle to
be opioid free
By dramatically reducing their discomfort patients will
bullBe empowered to maintain a more normal lifestyle through the
withdrawal process
bullBe able to maintain some level of appetite and ingest
supportive foods
bullStay hydrated
bullMaintain some level of physical activity to stimulate natural
endorphins
bullFocus on the opioid-free future that is waiting for them just
around the corner
PHGtrade and Healthcare Providers
Copyright copy 2011 Pure Health Group trade
Pure Health Group Inctrade is committed to partnering with healthcare providers
to eradicate opioid dependence by using innovative science and research to
create extraordinary nutraceutical products that help minimize the pain of
withdrawal
For more information about Pure Health
Grouptrade or about how to become a licensed
distributor of our products please visit
WWWPUREHEALTHGROUPCOM
Or contact John D Vox at
jvoxpurehealthgroupcom
3039555899 ext 701
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
The following information explains exactly how the nutrients in our formulas
create relief by working with your patients body to alleviate withdrawal
symptoms
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Depression Anxiety
One of the most debilitating withdrawal symptoms patients experience is a
deep feeling of depression spiked with intermittent anxiety This depressive
state is caused in great part by a severe depletion of vital neurotransmitters
and naturally occurring opioids combined with desensitization of opioid
receptors in the brain Withdrawal Relief Complex nutraceuticals help support
the rapid return of these vital biological chemicals to healthy levels thus
decreasing the depth and length of the depressive state
Research supporting the efficacy of the natural
nutrients in Withdrawal Relief Complex Nutraceuticals
to combat depression and anxiety symptoms are as
follows
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-
blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine
showed use of this herb significantly decreased depression and anxiety associated with
withdrawal as well as if not better than Clonidine1
bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety
WITHOUT the adverse side effects of the drug2
5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP
dramatically alleviates depression3-9
bullIt does so by bolstering serotonin levels in the brain
Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10
bullSignificantly increases the biosynthesis of natural opioid peptides in the body11
bullDecrease the symptoms of depression in patients by up over 3512
L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital
neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which
indicates that it relaxes the mind without inducing drowsinessrdquo14
bullL-theanine reduces anxiety and calms nerves during stressful events15
Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the
B-vitamins or vitamin C16
bullCorrection of these deficiencies through supplementation with the proper forms and
amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in
complete resolution of mental symptoms in some individualsrdquo16
Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas
bullThis herb standardized for L-Dopa content has been found in research to have potent
anti-depressant actions17
bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Insomnia
Sleepless nights are a very common symptom of opiate withdrawal Long-
term use of opiates tends to disrupt the sleep wake cycle by disturbing
the proper production of melatonin and other sleep-inducing chemicals in
the body In order to re-establish healthy sleep cycles allowing patients to
fall asleep faster and stay asleep longer it is necessary to support the
production of natural sleep chemicals
The Withdrawal Relief Complex contains a
healthy dose of pure Melatonin and other all-
natural sleep support ingredients to help
patients sleep through the night allowing them
to obtain the rest needed to recover quickly
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall
asleep much faster and to significantly increase the amount of sleep achieved throughout the
night19 20
5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with
one study showing a 53 increase in REM sleep during the night21
ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small
doses of barbiturates or benzodiazepansrdquo22
bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23
American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects
take place within 30 minutes of ingestion and have been shown in research to help people fall
asleep faster and stay asleep longer24
Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in
prolonged sleep tests25
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Nausea amp Gastrointestinal Distress
Nausea and GI distress (including intestinal cramping and diarrhea) is one of the
most uncomfortable and disruptive physical symptoms of opiate withdrawal This
symptom generally presents 2 or 3 days after abstaining from opiates and can last
for up to a week
Opiates have a very strong sedative effect on the stomach and intestinal tract
Once opiate use is discontinued these organs become over stimulated Nerves
that have been suppressed for a long time begin to come back to life This
enhanced neural input to the smooth muscles of the stomach and GI tract can be
shocking to the system thus causing cramping and hyper-motility
which can lead to diarrhea nausea and vomiting
To treat these symptoms the Withdrawal Relief Complex
formulas include powerful ingredients that not only help to
provide natural moderate sedation to overactive GI nerves but
also help soothe the stomach
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows
gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the
prescription drug Papaverinerdquo for these uses
Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth
muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27
bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a
spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it
as a natural medicine for GI distress28
Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many
antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-
33
Vitamin B6
bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin
B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated
that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our
combined formulashellipover twice the dose of the studyhellipto ensure best results
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Extreme Fatigue amp Lethargy
The fatigue most people experience during withdrawal is profound It can be severe
enough that patients will literally not be able to get out of bed This is particularly
damaging for those needing to maintain a consistent work schedule and or care for
their family
The fatigue that comes from opiate withdrawal is both physical and mental Many
recovering opiate addicts feel a complete lack of motivation and desire to engage in
life This leads to reclusive behavior poor diet and a host of other actions that tend
to prolong withdrawal and lead to relapse
Therefore it is imperative that patients are supported
in staying energized and motivated as they negotiate
the acute phase of withdrawal
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased
energy focus attention and task performance throughout the day Researchers stated ldquoThese results
provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the
psychoactive properties of ginsengrdquo35
5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to
ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36
L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers
found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37
bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing
neurotransmitters such as epinephrine and norepinephrine
Vitamin B12
bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38
bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase
in energy stamina and well being helliprdquo38
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Restless Leg Syndrome (RLS)
RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced
by nearly everyone going through opiate withdrawal This symptom is not so much
painful as it is disruptive and highly irritating RLS causes agitation during the day
and disrupts sleep during the night This exacerbates the symptoms of insomnia and
creates further daytime agitation locking patients into a vicious cycle
RLS is thought to be caused by the depletion of the neurotransmitter dopamine in
the system Research has shown that providing nutrients to help stimulate
dopamine production can quickly and effectively decrease or eliminate the severity
of this syndrome
The following demonstrates how the nutrients in Withdrawal Relief
Complex support dopamine production in two ways by providing a
direct source of natural dopamine (through the L-dopa content of
Mucuna pruriens) and by supporting dopamine metabolism in the
body with the B-vitamin Folate
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances
levels of dopamine in the brain39
bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a
medical treatment for Parkinsons Disease40
bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly
decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41
Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid
(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and
fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid
levelsrdquo42 43
Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people
with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS
symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in
the Withdrawal Relief Complex Nighttime formula
MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for
treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal
Relief Complex System This formula has been designed to help keep cravings at
bay after acute withdraw has passed allowing the chemical balance in the patient‟s
brain to quickly and safely return to pre-drug use level
CCRR is a four part compound nutraceutical that addresses cravings by
bullSupplying your adrenal system with nutrients you need to feel good The
ingredients in CCRR work hard to heal your body and restore your
organs and mind
bullGiving your brain a natural boost to stave off depression and anxiety
until the chemical balance of your pre-drug healthy brain is restored
bullFlooding your body with nourishing vitamins and antioxidants that
support physical recovery as you continue to gain strength
bullEnsuring that cravings stay manageable while you create more and more
distance from the desire for more drugs
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
The System Components (cont)
Copyright copy 2011 Pure Health Group trade
Conquering Opiate Withdrawal amp Addiction Volume 1 (eBook
download) A comprehensive book packed with information not
found in any other book on addiction and recovery This book
includes valuable insights from ex-addicts dietary advice from
leading nutritional scientists psychological support tools and much
more
CHILL Music Compilation (audio download) Prepared by a
professional DJ this one-of-a-kind mellow musical mix has been
designed to help soothe the body and mind
RELAX Audio Compilation (Free audio download) This free audio
download contains powerful guided meditations affirmations and
brain-balancing meta-music selections to support the individual‟s
successful withdrawal from opioid dependence
Pure Health Group‟strade RampD
Copyright copy 2011 Pure Health Group trade
The nutraceuticals in this breakthrough system were developed from years of
research about how opioids work within the body and brain to alter one‟s
physical emotional and mental state specifically how the withdrawal of
opioids acts to create the discomforting symptoms of acute opioid withdrawal
Understanding these causes we spent the next 24 months scouring the
scientific literature for research showing which natural nutrients could
effectively address these biological causes and alleviate withdrawal symptoms
Once the perfect nutrient blend was assessed we
focused on sourcing the purest most potent forms
of each nutrient for our formulas
Pure Health Group‟strade RampD (cont)
Copyright copy 2011 Pure Health Group trade
We understand there is a very wide range of nutrient quality in the
nutraceutical market place Therefore we enlisted the help of our
pharmaceutical manufacturing facility to source and obtain the best
standardized pharmaceutical-grade nutrients available
We then included these nutrients in the formulas in doses shown to be
efficacious in the scientific literature
Based upon the science supporting the symptom-specific efficacy of the
nutrients in our formulas and the empirical evidence we have garnered we
are highly confident that our products offer a safe and effective natural option
to assist with successful withdrawal from opioid dependence
Pure Health Group‟strade RampD (cont)
Copyright copy 2011 Pure Health Group trade
Empirical evidence suggests that those using the complete Withdrawal
Relief System are at least 50 more likely to successfully negotiate their
acute withdrawal period without relapse then those going cold turkey
We are currently in discussions with a Florida based research center
about implementing our first double-blinded placebo-controlled pilot trial
We hope to begin the study in the 4th quarter of 2011
Pure Health Group Inctrade is committed to remaining
on the forefront of opiate dependence research and
translating new discoveries into the best possible
answers and relief for those suffering from opiate
addiction Pure Health Group Inctrade supports
continuous research and development of new
nutraceutical products that will make the journey
towards freedom from opiate dependency as easy and
pain free as possible
How Does The System Work
Copyright copy 2011 Pure Health Group trade
The Withdraw Relief Complex Nutraceuticals aid in the withdrawal and
recovery process by supplying specific nutrients that naturally counter symptoms
reduce pain and send messages that calm opioid receptors in the brain
The Withdraw Relief System gives patients a distinct advantage in the battle to
be opioid free
By dramatically reducing their discomfort patients will
bullBe empowered to maintain a more normal lifestyle through the
withdrawal process
bullBe able to maintain some level of appetite and ingest
supportive foods
bullStay hydrated
bullMaintain some level of physical activity to stimulate natural
endorphins
bullFocus on the opioid-free future that is waiting for them just
around the corner
PHGtrade and Healthcare Providers
Copyright copy 2011 Pure Health Group trade
Pure Health Group Inctrade is committed to partnering with healthcare providers
to eradicate opioid dependence by using innovative science and research to
create extraordinary nutraceutical products that help minimize the pain of
withdrawal
For more information about Pure Health
Grouptrade or about how to become a licensed
distributor of our products please visit
WWWPUREHEALTHGROUPCOM
Or contact John D Vox at
jvoxpurehealthgroupcom
3039555899 ext 701
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
The following information explains exactly how the nutrients in our formulas
create relief by working with your patients body to alleviate withdrawal
symptoms
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Depression Anxiety
One of the most debilitating withdrawal symptoms patients experience is a
deep feeling of depression spiked with intermittent anxiety This depressive
state is caused in great part by a severe depletion of vital neurotransmitters
and naturally occurring opioids combined with desensitization of opioid
receptors in the brain Withdrawal Relief Complex nutraceuticals help support
the rapid return of these vital biological chemicals to healthy levels thus
decreasing the depth and length of the depressive state
Research supporting the efficacy of the natural
nutrients in Withdrawal Relief Complex Nutraceuticals
to combat depression and anxiety symptoms are as
follows
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-
blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine
showed use of this herb significantly decreased depression and anxiety associated with
withdrawal as well as if not better than Clonidine1
bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety
WITHOUT the adverse side effects of the drug2
5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP
dramatically alleviates depression3-9
bullIt does so by bolstering serotonin levels in the brain
Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10
bullSignificantly increases the biosynthesis of natural opioid peptides in the body11
bullDecrease the symptoms of depression in patients by up over 3512
L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital
neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which
indicates that it relaxes the mind without inducing drowsinessrdquo14
bullL-theanine reduces anxiety and calms nerves during stressful events15
Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the
B-vitamins or vitamin C16
bullCorrection of these deficiencies through supplementation with the proper forms and
amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in
complete resolution of mental symptoms in some individualsrdquo16
Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas
bullThis herb standardized for L-Dopa content has been found in research to have potent
anti-depressant actions17
bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Insomnia
Sleepless nights are a very common symptom of opiate withdrawal Long-
term use of opiates tends to disrupt the sleep wake cycle by disturbing
the proper production of melatonin and other sleep-inducing chemicals in
the body In order to re-establish healthy sleep cycles allowing patients to
fall asleep faster and stay asleep longer it is necessary to support the
production of natural sleep chemicals
The Withdrawal Relief Complex contains a
healthy dose of pure Melatonin and other all-
natural sleep support ingredients to help
patients sleep through the night allowing them
to obtain the rest needed to recover quickly
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall
asleep much faster and to significantly increase the amount of sleep achieved throughout the
night19 20
5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with
one study showing a 53 increase in REM sleep during the night21
ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small
doses of barbiturates or benzodiazepansrdquo22
bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23
American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects
take place within 30 minutes of ingestion and have been shown in research to help people fall
asleep faster and stay asleep longer24
Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in
prolonged sleep tests25
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Nausea amp Gastrointestinal Distress
Nausea and GI distress (including intestinal cramping and diarrhea) is one of the
most uncomfortable and disruptive physical symptoms of opiate withdrawal This
symptom generally presents 2 or 3 days after abstaining from opiates and can last
for up to a week
Opiates have a very strong sedative effect on the stomach and intestinal tract
Once opiate use is discontinued these organs become over stimulated Nerves
that have been suppressed for a long time begin to come back to life This
enhanced neural input to the smooth muscles of the stomach and GI tract can be
shocking to the system thus causing cramping and hyper-motility
which can lead to diarrhea nausea and vomiting
To treat these symptoms the Withdrawal Relief Complex
formulas include powerful ingredients that not only help to
provide natural moderate sedation to overactive GI nerves but
also help soothe the stomach
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows
gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the
prescription drug Papaverinerdquo for these uses
Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth
muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27
bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a
spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it
as a natural medicine for GI distress28
Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many
antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-
33
Vitamin B6
bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin
B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated
that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our
combined formulashellipover twice the dose of the studyhellipto ensure best results
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Extreme Fatigue amp Lethargy
The fatigue most people experience during withdrawal is profound It can be severe
enough that patients will literally not be able to get out of bed This is particularly
damaging for those needing to maintain a consistent work schedule and or care for
their family
The fatigue that comes from opiate withdrawal is both physical and mental Many
recovering opiate addicts feel a complete lack of motivation and desire to engage in
life This leads to reclusive behavior poor diet and a host of other actions that tend
to prolong withdrawal and lead to relapse
Therefore it is imperative that patients are supported
in staying energized and motivated as they negotiate
the acute phase of withdrawal
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased
energy focus attention and task performance throughout the day Researchers stated ldquoThese results
provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the
psychoactive properties of ginsengrdquo35
5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to
ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36
L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers
found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37
bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing
neurotransmitters such as epinephrine and norepinephrine
Vitamin B12
bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38
bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase
in energy stamina and well being helliprdquo38
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Restless Leg Syndrome (RLS)
RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced
by nearly everyone going through opiate withdrawal This symptom is not so much
painful as it is disruptive and highly irritating RLS causes agitation during the day
and disrupts sleep during the night This exacerbates the symptoms of insomnia and
creates further daytime agitation locking patients into a vicious cycle
RLS is thought to be caused by the depletion of the neurotransmitter dopamine in
the system Research has shown that providing nutrients to help stimulate
dopamine production can quickly and effectively decrease or eliminate the severity
of this syndrome
The following demonstrates how the nutrients in Withdrawal Relief
Complex support dopamine production in two ways by providing a
direct source of natural dopamine (through the L-dopa content of
Mucuna pruriens) and by supporting dopamine metabolism in the
body with the B-vitamin Folate
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances
levels of dopamine in the brain39
bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a
medical treatment for Parkinsons Disease40
bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly
decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41
Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid
(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and
fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid
levelsrdquo42 43
Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people
with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS
symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in
the Withdrawal Relief Complex Nighttime formula
MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for
treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal
Relief Complex System This formula has been designed to help keep cravings at
bay after acute withdraw has passed allowing the chemical balance in the patient‟s
brain to quickly and safely return to pre-drug use level
CCRR is a four part compound nutraceutical that addresses cravings by
bullSupplying your adrenal system with nutrients you need to feel good The
ingredients in CCRR work hard to heal your body and restore your
organs and mind
bullGiving your brain a natural boost to stave off depression and anxiety
until the chemical balance of your pre-drug healthy brain is restored
bullFlooding your body with nourishing vitamins and antioxidants that
support physical recovery as you continue to gain strength
bullEnsuring that cravings stay manageable while you create more and more
distance from the desire for more drugs
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
Pure Health Group‟strade RampD
Copyright copy 2011 Pure Health Group trade
The nutraceuticals in this breakthrough system were developed from years of
research about how opioids work within the body and brain to alter one‟s
physical emotional and mental state specifically how the withdrawal of
opioids acts to create the discomforting symptoms of acute opioid withdrawal
Understanding these causes we spent the next 24 months scouring the
scientific literature for research showing which natural nutrients could
effectively address these biological causes and alleviate withdrawal symptoms
Once the perfect nutrient blend was assessed we
focused on sourcing the purest most potent forms
of each nutrient for our formulas
Pure Health Group‟strade RampD (cont)
Copyright copy 2011 Pure Health Group trade
We understand there is a very wide range of nutrient quality in the
nutraceutical market place Therefore we enlisted the help of our
pharmaceutical manufacturing facility to source and obtain the best
standardized pharmaceutical-grade nutrients available
We then included these nutrients in the formulas in doses shown to be
efficacious in the scientific literature
Based upon the science supporting the symptom-specific efficacy of the
nutrients in our formulas and the empirical evidence we have garnered we
are highly confident that our products offer a safe and effective natural option
to assist with successful withdrawal from opioid dependence
Pure Health Group‟strade RampD (cont)
Copyright copy 2011 Pure Health Group trade
Empirical evidence suggests that those using the complete Withdrawal
Relief System are at least 50 more likely to successfully negotiate their
acute withdrawal period without relapse then those going cold turkey
We are currently in discussions with a Florida based research center
about implementing our first double-blinded placebo-controlled pilot trial
We hope to begin the study in the 4th quarter of 2011
Pure Health Group Inctrade is committed to remaining
on the forefront of opiate dependence research and
translating new discoveries into the best possible
answers and relief for those suffering from opiate
addiction Pure Health Group Inctrade supports
continuous research and development of new
nutraceutical products that will make the journey
towards freedom from opiate dependency as easy and
pain free as possible
How Does The System Work
Copyright copy 2011 Pure Health Group trade
The Withdraw Relief Complex Nutraceuticals aid in the withdrawal and
recovery process by supplying specific nutrients that naturally counter symptoms
reduce pain and send messages that calm opioid receptors in the brain
The Withdraw Relief System gives patients a distinct advantage in the battle to
be opioid free
By dramatically reducing their discomfort patients will
bullBe empowered to maintain a more normal lifestyle through the
withdrawal process
bullBe able to maintain some level of appetite and ingest
supportive foods
bullStay hydrated
bullMaintain some level of physical activity to stimulate natural
endorphins
bullFocus on the opioid-free future that is waiting for them just
around the corner
PHGtrade and Healthcare Providers
Copyright copy 2011 Pure Health Group trade
Pure Health Group Inctrade is committed to partnering with healthcare providers
to eradicate opioid dependence by using innovative science and research to
create extraordinary nutraceutical products that help minimize the pain of
withdrawal
For more information about Pure Health
Grouptrade or about how to become a licensed
distributor of our products please visit
WWWPUREHEALTHGROUPCOM
Or contact John D Vox at
jvoxpurehealthgroupcom
3039555899 ext 701
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
The following information explains exactly how the nutrients in our formulas
create relief by working with your patients body to alleviate withdrawal
symptoms
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Depression Anxiety
One of the most debilitating withdrawal symptoms patients experience is a
deep feeling of depression spiked with intermittent anxiety This depressive
state is caused in great part by a severe depletion of vital neurotransmitters
and naturally occurring opioids combined with desensitization of opioid
receptors in the brain Withdrawal Relief Complex nutraceuticals help support
the rapid return of these vital biological chemicals to healthy levels thus
decreasing the depth and length of the depressive state
Research supporting the efficacy of the natural
nutrients in Withdrawal Relief Complex Nutraceuticals
to combat depression and anxiety symptoms are as
follows
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-
blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine
showed use of this herb significantly decreased depression and anxiety associated with
withdrawal as well as if not better than Clonidine1
bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety
WITHOUT the adverse side effects of the drug2
5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP
dramatically alleviates depression3-9
bullIt does so by bolstering serotonin levels in the brain
Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10
bullSignificantly increases the biosynthesis of natural opioid peptides in the body11
bullDecrease the symptoms of depression in patients by up over 3512
L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital
neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which
indicates that it relaxes the mind without inducing drowsinessrdquo14
bullL-theanine reduces anxiety and calms nerves during stressful events15
Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the
B-vitamins or vitamin C16
bullCorrection of these deficiencies through supplementation with the proper forms and
amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in
complete resolution of mental symptoms in some individualsrdquo16
Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas
bullThis herb standardized for L-Dopa content has been found in research to have potent
anti-depressant actions17
bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Insomnia
Sleepless nights are a very common symptom of opiate withdrawal Long-
term use of opiates tends to disrupt the sleep wake cycle by disturbing
the proper production of melatonin and other sleep-inducing chemicals in
the body In order to re-establish healthy sleep cycles allowing patients to
fall asleep faster and stay asleep longer it is necessary to support the
production of natural sleep chemicals
The Withdrawal Relief Complex contains a
healthy dose of pure Melatonin and other all-
natural sleep support ingredients to help
patients sleep through the night allowing them
to obtain the rest needed to recover quickly
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall
asleep much faster and to significantly increase the amount of sleep achieved throughout the
night19 20
5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with
one study showing a 53 increase in REM sleep during the night21
ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small
doses of barbiturates or benzodiazepansrdquo22
bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23
American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects
take place within 30 minutes of ingestion and have been shown in research to help people fall
asleep faster and stay asleep longer24
Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in
prolonged sleep tests25
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Nausea amp Gastrointestinal Distress
Nausea and GI distress (including intestinal cramping and diarrhea) is one of the
most uncomfortable and disruptive physical symptoms of opiate withdrawal This
symptom generally presents 2 or 3 days after abstaining from opiates and can last
for up to a week
Opiates have a very strong sedative effect on the stomach and intestinal tract
Once opiate use is discontinued these organs become over stimulated Nerves
that have been suppressed for a long time begin to come back to life This
enhanced neural input to the smooth muscles of the stomach and GI tract can be
shocking to the system thus causing cramping and hyper-motility
which can lead to diarrhea nausea and vomiting
To treat these symptoms the Withdrawal Relief Complex
formulas include powerful ingredients that not only help to
provide natural moderate sedation to overactive GI nerves but
also help soothe the stomach
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows
gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the
prescription drug Papaverinerdquo for these uses
Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth
muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27
bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a
spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it
as a natural medicine for GI distress28
Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many
antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-
33
Vitamin B6
bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin
B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated
that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our
combined formulashellipover twice the dose of the studyhellipto ensure best results
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Extreme Fatigue amp Lethargy
The fatigue most people experience during withdrawal is profound It can be severe
enough that patients will literally not be able to get out of bed This is particularly
damaging for those needing to maintain a consistent work schedule and or care for
their family
The fatigue that comes from opiate withdrawal is both physical and mental Many
recovering opiate addicts feel a complete lack of motivation and desire to engage in
life This leads to reclusive behavior poor diet and a host of other actions that tend
to prolong withdrawal and lead to relapse
Therefore it is imperative that patients are supported
in staying energized and motivated as they negotiate
the acute phase of withdrawal
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased
energy focus attention and task performance throughout the day Researchers stated ldquoThese results
provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the
psychoactive properties of ginsengrdquo35
5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to
ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36
L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers
found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37
bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing
neurotransmitters such as epinephrine and norepinephrine
Vitamin B12
bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38
bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase
in energy stamina and well being helliprdquo38
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Restless Leg Syndrome (RLS)
RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced
by nearly everyone going through opiate withdrawal This symptom is not so much
painful as it is disruptive and highly irritating RLS causes agitation during the day
and disrupts sleep during the night This exacerbates the symptoms of insomnia and
creates further daytime agitation locking patients into a vicious cycle
RLS is thought to be caused by the depletion of the neurotransmitter dopamine in
the system Research has shown that providing nutrients to help stimulate
dopamine production can quickly and effectively decrease or eliminate the severity
of this syndrome
The following demonstrates how the nutrients in Withdrawal Relief
Complex support dopamine production in two ways by providing a
direct source of natural dopamine (through the L-dopa content of
Mucuna pruriens) and by supporting dopamine metabolism in the
body with the B-vitamin Folate
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances
levels of dopamine in the brain39
bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a
medical treatment for Parkinsons Disease40
bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly
decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41
Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid
(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and
fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid
levelsrdquo42 43
Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people
with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS
symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in
the Withdrawal Relief Complex Nighttime formula
MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for
treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal
Relief Complex System This formula has been designed to help keep cravings at
bay after acute withdraw has passed allowing the chemical balance in the patient‟s
brain to quickly and safely return to pre-drug use level
CCRR is a four part compound nutraceutical that addresses cravings by
bullSupplying your adrenal system with nutrients you need to feel good The
ingredients in CCRR work hard to heal your body and restore your
organs and mind
bullGiving your brain a natural boost to stave off depression and anxiety
until the chemical balance of your pre-drug healthy brain is restored
bullFlooding your body with nourishing vitamins and antioxidants that
support physical recovery as you continue to gain strength
bullEnsuring that cravings stay manageable while you create more and more
distance from the desire for more drugs
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
Pure Health Group‟strade RampD (cont)
Copyright copy 2011 Pure Health Group trade
We understand there is a very wide range of nutrient quality in the
nutraceutical market place Therefore we enlisted the help of our
pharmaceutical manufacturing facility to source and obtain the best
standardized pharmaceutical-grade nutrients available
We then included these nutrients in the formulas in doses shown to be
efficacious in the scientific literature
Based upon the science supporting the symptom-specific efficacy of the
nutrients in our formulas and the empirical evidence we have garnered we
are highly confident that our products offer a safe and effective natural option
to assist with successful withdrawal from opioid dependence
Pure Health Group‟strade RampD (cont)
Copyright copy 2011 Pure Health Group trade
Empirical evidence suggests that those using the complete Withdrawal
Relief System are at least 50 more likely to successfully negotiate their
acute withdrawal period without relapse then those going cold turkey
We are currently in discussions with a Florida based research center
about implementing our first double-blinded placebo-controlled pilot trial
We hope to begin the study in the 4th quarter of 2011
Pure Health Group Inctrade is committed to remaining
on the forefront of opiate dependence research and
translating new discoveries into the best possible
answers and relief for those suffering from opiate
addiction Pure Health Group Inctrade supports
continuous research and development of new
nutraceutical products that will make the journey
towards freedom from opiate dependency as easy and
pain free as possible
How Does The System Work
Copyright copy 2011 Pure Health Group trade
The Withdraw Relief Complex Nutraceuticals aid in the withdrawal and
recovery process by supplying specific nutrients that naturally counter symptoms
reduce pain and send messages that calm opioid receptors in the brain
The Withdraw Relief System gives patients a distinct advantage in the battle to
be opioid free
By dramatically reducing their discomfort patients will
bullBe empowered to maintain a more normal lifestyle through the
withdrawal process
bullBe able to maintain some level of appetite and ingest
supportive foods
bullStay hydrated
bullMaintain some level of physical activity to stimulate natural
endorphins
bullFocus on the opioid-free future that is waiting for them just
around the corner
PHGtrade and Healthcare Providers
Copyright copy 2011 Pure Health Group trade
Pure Health Group Inctrade is committed to partnering with healthcare providers
to eradicate opioid dependence by using innovative science and research to
create extraordinary nutraceutical products that help minimize the pain of
withdrawal
For more information about Pure Health
Grouptrade or about how to become a licensed
distributor of our products please visit
WWWPUREHEALTHGROUPCOM
Or contact John D Vox at
jvoxpurehealthgroupcom
3039555899 ext 701
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
The following information explains exactly how the nutrients in our formulas
create relief by working with your patients body to alleviate withdrawal
symptoms
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Depression Anxiety
One of the most debilitating withdrawal symptoms patients experience is a
deep feeling of depression spiked with intermittent anxiety This depressive
state is caused in great part by a severe depletion of vital neurotransmitters
and naturally occurring opioids combined with desensitization of opioid
receptors in the brain Withdrawal Relief Complex nutraceuticals help support
the rapid return of these vital biological chemicals to healthy levels thus
decreasing the depth and length of the depressive state
Research supporting the efficacy of the natural
nutrients in Withdrawal Relief Complex Nutraceuticals
to combat depression and anxiety symptoms are as
follows
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-
blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine
showed use of this herb significantly decreased depression and anxiety associated with
withdrawal as well as if not better than Clonidine1
bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety
WITHOUT the adverse side effects of the drug2
5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP
dramatically alleviates depression3-9
bullIt does so by bolstering serotonin levels in the brain
Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10
bullSignificantly increases the biosynthesis of natural opioid peptides in the body11
bullDecrease the symptoms of depression in patients by up over 3512
L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital
neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which
indicates that it relaxes the mind without inducing drowsinessrdquo14
bullL-theanine reduces anxiety and calms nerves during stressful events15
Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the
B-vitamins or vitamin C16
bullCorrection of these deficiencies through supplementation with the proper forms and
amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in
complete resolution of mental symptoms in some individualsrdquo16
Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas
bullThis herb standardized for L-Dopa content has been found in research to have potent
anti-depressant actions17
bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Insomnia
Sleepless nights are a very common symptom of opiate withdrawal Long-
term use of opiates tends to disrupt the sleep wake cycle by disturbing
the proper production of melatonin and other sleep-inducing chemicals in
the body In order to re-establish healthy sleep cycles allowing patients to
fall asleep faster and stay asleep longer it is necessary to support the
production of natural sleep chemicals
The Withdrawal Relief Complex contains a
healthy dose of pure Melatonin and other all-
natural sleep support ingredients to help
patients sleep through the night allowing them
to obtain the rest needed to recover quickly
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall
asleep much faster and to significantly increase the amount of sleep achieved throughout the
night19 20
5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with
one study showing a 53 increase in REM sleep during the night21
ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small
doses of barbiturates or benzodiazepansrdquo22
bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23
American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects
take place within 30 minutes of ingestion and have been shown in research to help people fall
asleep faster and stay asleep longer24
Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in
prolonged sleep tests25
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Nausea amp Gastrointestinal Distress
Nausea and GI distress (including intestinal cramping and diarrhea) is one of the
most uncomfortable and disruptive physical symptoms of opiate withdrawal This
symptom generally presents 2 or 3 days after abstaining from opiates and can last
for up to a week
Opiates have a very strong sedative effect on the stomach and intestinal tract
Once opiate use is discontinued these organs become over stimulated Nerves
that have been suppressed for a long time begin to come back to life This
enhanced neural input to the smooth muscles of the stomach and GI tract can be
shocking to the system thus causing cramping and hyper-motility
which can lead to diarrhea nausea and vomiting
To treat these symptoms the Withdrawal Relief Complex
formulas include powerful ingredients that not only help to
provide natural moderate sedation to overactive GI nerves but
also help soothe the stomach
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows
gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the
prescription drug Papaverinerdquo for these uses
Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth
muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27
bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a
spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it
as a natural medicine for GI distress28
Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many
antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-
33
Vitamin B6
bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin
B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated
that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our
combined formulashellipover twice the dose of the studyhellipto ensure best results
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Extreme Fatigue amp Lethargy
The fatigue most people experience during withdrawal is profound It can be severe
enough that patients will literally not be able to get out of bed This is particularly
damaging for those needing to maintain a consistent work schedule and or care for
their family
The fatigue that comes from opiate withdrawal is both physical and mental Many
recovering opiate addicts feel a complete lack of motivation and desire to engage in
life This leads to reclusive behavior poor diet and a host of other actions that tend
to prolong withdrawal and lead to relapse
Therefore it is imperative that patients are supported
in staying energized and motivated as they negotiate
the acute phase of withdrawal
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased
energy focus attention and task performance throughout the day Researchers stated ldquoThese results
provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the
psychoactive properties of ginsengrdquo35
5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to
ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36
L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers
found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37
bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing
neurotransmitters such as epinephrine and norepinephrine
Vitamin B12
bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38
bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase
in energy stamina and well being helliprdquo38
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Restless Leg Syndrome (RLS)
RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced
by nearly everyone going through opiate withdrawal This symptom is not so much
painful as it is disruptive and highly irritating RLS causes agitation during the day
and disrupts sleep during the night This exacerbates the symptoms of insomnia and
creates further daytime agitation locking patients into a vicious cycle
RLS is thought to be caused by the depletion of the neurotransmitter dopamine in
the system Research has shown that providing nutrients to help stimulate
dopamine production can quickly and effectively decrease or eliminate the severity
of this syndrome
The following demonstrates how the nutrients in Withdrawal Relief
Complex support dopamine production in two ways by providing a
direct source of natural dopamine (through the L-dopa content of
Mucuna pruriens) and by supporting dopamine metabolism in the
body with the B-vitamin Folate
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances
levels of dopamine in the brain39
bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a
medical treatment for Parkinsons Disease40
bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly
decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41
Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid
(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and
fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid
levelsrdquo42 43
Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people
with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS
symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in
the Withdrawal Relief Complex Nighttime formula
MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for
treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal
Relief Complex System This formula has been designed to help keep cravings at
bay after acute withdraw has passed allowing the chemical balance in the patient‟s
brain to quickly and safely return to pre-drug use level
CCRR is a four part compound nutraceutical that addresses cravings by
bullSupplying your adrenal system with nutrients you need to feel good The
ingredients in CCRR work hard to heal your body and restore your
organs and mind
bullGiving your brain a natural boost to stave off depression and anxiety
until the chemical balance of your pre-drug healthy brain is restored
bullFlooding your body with nourishing vitamins and antioxidants that
support physical recovery as you continue to gain strength
bullEnsuring that cravings stay manageable while you create more and more
distance from the desire for more drugs
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
Pure Health Group‟strade RampD (cont)
Copyright copy 2011 Pure Health Group trade
Empirical evidence suggests that those using the complete Withdrawal
Relief System are at least 50 more likely to successfully negotiate their
acute withdrawal period without relapse then those going cold turkey
We are currently in discussions with a Florida based research center
about implementing our first double-blinded placebo-controlled pilot trial
We hope to begin the study in the 4th quarter of 2011
Pure Health Group Inctrade is committed to remaining
on the forefront of opiate dependence research and
translating new discoveries into the best possible
answers and relief for those suffering from opiate
addiction Pure Health Group Inctrade supports
continuous research and development of new
nutraceutical products that will make the journey
towards freedom from opiate dependency as easy and
pain free as possible
How Does The System Work
Copyright copy 2011 Pure Health Group trade
The Withdraw Relief Complex Nutraceuticals aid in the withdrawal and
recovery process by supplying specific nutrients that naturally counter symptoms
reduce pain and send messages that calm opioid receptors in the brain
The Withdraw Relief System gives patients a distinct advantage in the battle to
be opioid free
By dramatically reducing their discomfort patients will
bullBe empowered to maintain a more normal lifestyle through the
withdrawal process
bullBe able to maintain some level of appetite and ingest
supportive foods
bullStay hydrated
bullMaintain some level of physical activity to stimulate natural
endorphins
bullFocus on the opioid-free future that is waiting for them just
around the corner
PHGtrade and Healthcare Providers
Copyright copy 2011 Pure Health Group trade
Pure Health Group Inctrade is committed to partnering with healthcare providers
to eradicate opioid dependence by using innovative science and research to
create extraordinary nutraceutical products that help minimize the pain of
withdrawal
For more information about Pure Health
Grouptrade or about how to become a licensed
distributor of our products please visit
WWWPUREHEALTHGROUPCOM
Or contact John D Vox at
jvoxpurehealthgroupcom
3039555899 ext 701
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
The following information explains exactly how the nutrients in our formulas
create relief by working with your patients body to alleviate withdrawal
symptoms
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Depression Anxiety
One of the most debilitating withdrawal symptoms patients experience is a
deep feeling of depression spiked with intermittent anxiety This depressive
state is caused in great part by a severe depletion of vital neurotransmitters
and naturally occurring opioids combined with desensitization of opioid
receptors in the brain Withdrawal Relief Complex nutraceuticals help support
the rapid return of these vital biological chemicals to healthy levels thus
decreasing the depth and length of the depressive state
Research supporting the efficacy of the natural
nutrients in Withdrawal Relief Complex Nutraceuticals
to combat depression and anxiety symptoms are as
follows
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-
blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine
showed use of this herb significantly decreased depression and anxiety associated with
withdrawal as well as if not better than Clonidine1
bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety
WITHOUT the adverse side effects of the drug2
5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP
dramatically alleviates depression3-9
bullIt does so by bolstering serotonin levels in the brain
Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10
bullSignificantly increases the biosynthesis of natural opioid peptides in the body11
bullDecrease the symptoms of depression in patients by up over 3512
L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital
neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which
indicates that it relaxes the mind without inducing drowsinessrdquo14
bullL-theanine reduces anxiety and calms nerves during stressful events15
Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the
B-vitamins or vitamin C16
bullCorrection of these deficiencies through supplementation with the proper forms and
amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in
complete resolution of mental symptoms in some individualsrdquo16
Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas
bullThis herb standardized for L-Dopa content has been found in research to have potent
anti-depressant actions17
bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Insomnia
Sleepless nights are a very common symptom of opiate withdrawal Long-
term use of opiates tends to disrupt the sleep wake cycle by disturbing
the proper production of melatonin and other sleep-inducing chemicals in
the body In order to re-establish healthy sleep cycles allowing patients to
fall asleep faster and stay asleep longer it is necessary to support the
production of natural sleep chemicals
The Withdrawal Relief Complex contains a
healthy dose of pure Melatonin and other all-
natural sleep support ingredients to help
patients sleep through the night allowing them
to obtain the rest needed to recover quickly
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall
asleep much faster and to significantly increase the amount of sleep achieved throughout the
night19 20
5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with
one study showing a 53 increase in REM sleep during the night21
ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small
doses of barbiturates or benzodiazepansrdquo22
bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23
American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects
take place within 30 minutes of ingestion and have been shown in research to help people fall
asleep faster and stay asleep longer24
Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in
prolonged sleep tests25
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Nausea amp Gastrointestinal Distress
Nausea and GI distress (including intestinal cramping and diarrhea) is one of the
most uncomfortable and disruptive physical symptoms of opiate withdrawal This
symptom generally presents 2 or 3 days after abstaining from opiates and can last
for up to a week
Opiates have a very strong sedative effect on the stomach and intestinal tract
Once opiate use is discontinued these organs become over stimulated Nerves
that have been suppressed for a long time begin to come back to life This
enhanced neural input to the smooth muscles of the stomach and GI tract can be
shocking to the system thus causing cramping and hyper-motility
which can lead to diarrhea nausea and vomiting
To treat these symptoms the Withdrawal Relief Complex
formulas include powerful ingredients that not only help to
provide natural moderate sedation to overactive GI nerves but
also help soothe the stomach
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows
gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the
prescription drug Papaverinerdquo for these uses
Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth
muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27
bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a
spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it
as a natural medicine for GI distress28
Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many
antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-
33
Vitamin B6
bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin
B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated
that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our
combined formulashellipover twice the dose of the studyhellipto ensure best results
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Extreme Fatigue amp Lethargy
The fatigue most people experience during withdrawal is profound It can be severe
enough that patients will literally not be able to get out of bed This is particularly
damaging for those needing to maintain a consistent work schedule and or care for
their family
The fatigue that comes from opiate withdrawal is both physical and mental Many
recovering opiate addicts feel a complete lack of motivation and desire to engage in
life This leads to reclusive behavior poor diet and a host of other actions that tend
to prolong withdrawal and lead to relapse
Therefore it is imperative that patients are supported
in staying energized and motivated as they negotiate
the acute phase of withdrawal
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased
energy focus attention and task performance throughout the day Researchers stated ldquoThese results
provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the
psychoactive properties of ginsengrdquo35
5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to
ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36
L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers
found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37
bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing
neurotransmitters such as epinephrine and norepinephrine
Vitamin B12
bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38
bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase
in energy stamina and well being helliprdquo38
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Restless Leg Syndrome (RLS)
RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced
by nearly everyone going through opiate withdrawal This symptom is not so much
painful as it is disruptive and highly irritating RLS causes agitation during the day
and disrupts sleep during the night This exacerbates the symptoms of insomnia and
creates further daytime agitation locking patients into a vicious cycle
RLS is thought to be caused by the depletion of the neurotransmitter dopamine in
the system Research has shown that providing nutrients to help stimulate
dopamine production can quickly and effectively decrease or eliminate the severity
of this syndrome
The following demonstrates how the nutrients in Withdrawal Relief
Complex support dopamine production in two ways by providing a
direct source of natural dopamine (through the L-dopa content of
Mucuna pruriens) and by supporting dopamine metabolism in the
body with the B-vitamin Folate
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances
levels of dopamine in the brain39
bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a
medical treatment for Parkinsons Disease40
bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly
decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41
Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid
(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and
fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid
levelsrdquo42 43
Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people
with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS
symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in
the Withdrawal Relief Complex Nighttime formula
MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for
treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal
Relief Complex System This formula has been designed to help keep cravings at
bay after acute withdraw has passed allowing the chemical balance in the patient‟s
brain to quickly and safely return to pre-drug use level
CCRR is a four part compound nutraceutical that addresses cravings by
bullSupplying your adrenal system with nutrients you need to feel good The
ingredients in CCRR work hard to heal your body and restore your
organs and mind
bullGiving your brain a natural boost to stave off depression and anxiety
until the chemical balance of your pre-drug healthy brain is restored
bullFlooding your body with nourishing vitamins and antioxidants that
support physical recovery as you continue to gain strength
bullEnsuring that cravings stay manageable while you create more and more
distance from the desire for more drugs
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
How Does The System Work
Copyright copy 2011 Pure Health Group trade
The Withdraw Relief Complex Nutraceuticals aid in the withdrawal and
recovery process by supplying specific nutrients that naturally counter symptoms
reduce pain and send messages that calm opioid receptors in the brain
The Withdraw Relief System gives patients a distinct advantage in the battle to
be opioid free
By dramatically reducing their discomfort patients will
bullBe empowered to maintain a more normal lifestyle through the
withdrawal process
bullBe able to maintain some level of appetite and ingest
supportive foods
bullStay hydrated
bullMaintain some level of physical activity to stimulate natural
endorphins
bullFocus on the opioid-free future that is waiting for them just
around the corner
PHGtrade and Healthcare Providers
Copyright copy 2011 Pure Health Group trade
Pure Health Group Inctrade is committed to partnering with healthcare providers
to eradicate opioid dependence by using innovative science and research to
create extraordinary nutraceutical products that help minimize the pain of
withdrawal
For more information about Pure Health
Grouptrade or about how to become a licensed
distributor of our products please visit
WWWPUREHEALTHGROUPCOM
Or contact John D Vox at
jvoxpurehealthgroupcom
3039555899 ext 701
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
The following information explains exactly how the nutrients in our formulas
create relief by working with your patients body to alleviate withdrawal
symptoms
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Depression Anxiety
One of the most debilitating withdrawal symptoms patients experience is a
deep feeling of depression spiked with intermittent anxiety This depressive
state is caused in great part by a severe depletion of vital neurotransmitters
and naturally occurring opioids combined with desensitization of opioid
receptors in the brain Withdrawal Relief Complex nutraceuticals help support
the rapid return of these vital biological chemicals to healthy levels thus
decreasing the depth and length of the depressive state
Research supporting the efficacy of the natural
nutrients in Withdrawal Relief Complex Nutraceuticals
to combat depression and anxiety symptoms are as
follows
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-
blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine
showed use of this herb significantly decreased depression and anxiety associated with
withdrawal as well as if not better than Clonidine1
bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety
WITHOUT the adverse side effects of the drug2
5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP
dramatically alleviates depression3-9
bullIt does so by bolstering serotonin levels in the brain
Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10
bullSignificantly increases the biosynthesis of natural opioid peptides in the body11
bullDecrease the symptoms of depression in patients by up over 3512
L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital
neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which
indicates that it relaxes the mind without inducing drowsinessrdquo14
bullL-theanine reduces anxiety and calms nerves during stressful events15
Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the
B-vitamins or vitamin C16
bullCorrection of these deficiencies through supplementation with the proper forms and
amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in
complete resolution of mental symptoms in some individualsrdquo16
Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas
bullThis herb standardized for L-Dopa content has been found in research to have potent
anti-depressant actions17
bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Insomnia
Sleepless nights are a very common symptom of opiate withdrawal Long-
term use of opiates tends to disrupt the sleep wake cycle by disturbing
the proper production of melatonin and other sleep-inducing chemicals in
the body In order to re-establish healthy sleep cycles allowing patients to
fall asleep faster and stay asleep longer it is necessary to support the
production of natural sleep chemicals
The Withdrawal Relief Complex contains a
healthy dose of pure Melatonin and other all-
natural sleep support ingredients to help
patients sleep through the night allowing them
to obtain the rest needed to recover quickly
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall
asleep much faster and to significantly increase the amount of sleep achieved throughout the
night19 20
5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with
one study showing a 53 increase in REM sleep during the night21
ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small
doses of barbiturates or benzodiazepansrdquo22
bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23
American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects
take place within 30 minutes of ingestion and have been shown in research to help people fall
asleep faster and stay asleep longer24
Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in
prolonged sleep tests25
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Nausea amp Gastrointestinal Distress
Nausea and GI distress (including intestinal cramping and diarrhea) is one of the
most uncomfortable and disruptive physical symptoms of opiate withdrawal This
symptom generally presents 2 or 3 days after abstaining from opiates and can last
for up to a week
Opiates have a very strong sedative effect on the stomach and intestinal tract
Once opiate use is discontinued these organs become over stimulated Nerves
that have been suppressed for a long time begin to come back to life This
enhanced neural input to the smooth muscles of the stomach and GI tract can be
shocking to the system thus causing cramping and hyper-motility
which can lead to diarrhea nausea and vomiting
To treat these symptoms the Withdrawal Relief Complex
formulas include powerful ingredients that not only help to
provide natural moderate sedation to overactive GI nerves but
also help soothe the stomach
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows
gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the
prescription drug Papaverinerdquo for these uses
Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth
muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27
bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a
spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it
as a natural medicine for GI distress28
Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many
antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-
33
Vitamin B6
bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin
B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated
that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our
combined formulashellipover twice the dose of the studyhellipto ensure best results
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Extreme Fatigue amp Lethargy
The fatigue most people experience during withdrawal is profound It can be severe
enough that patients will literally not be able to get out of bed This is particularly
damaging for those needing to maintain a consistent work schedule and or care for
their family
The fatigue that comes from opiate withdrawal is both physical and mental Many
recovering opiate addicts feel a complete lack of motivation and desire to engage in
life This leads to reclusive behavior poor diet and a host of other actions that tend
to prolong withdrawal and lead to relapse
Therefore it is imperative that patients are supported
in staying energized and motivated as they negotiate
the acute phase of withdrawal
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased
energy focus attention and task performance throughout the day Researchers stated ldquoThese results
provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the
psychoactive properties of ginsengrdquo35
5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to
ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36
L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers
found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37
bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing
neurotransmitters such as epinephrine and norepinephrine
Vitamin B12
bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38
bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase
in energy stamina and well being helliprdquo38
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Restless Leg Syndrome (RLS)
RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced
by nearly everyone going through opiate withdrawal This symptom is not so much
painful as it is disruptive and highly irritating RLS causes agitation during the day
and disrupts sleep during the night This exacerbates the symptoms of insomnia and
creates further daytime agitation locking patients into a vicious cycle
RLS is thought to be caused by the depletion of the neurotransmitter dopamine in
the system Research has shown that providing nutrients to help stimulate
dopamine production can quickly and effectively decrease or eliminate the severity
of this syndrome
The following demonstrates how the nutrients in Withdrawal Relief
Complex support dopamine production in two ways by providing a
direct source of natural dopamine (through the L-dopa content of
Mucuna pruriens) and by supporting dopamine metabolism in the
body with the B-vitamin Folate
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances
levels of dopamine in the brain39
bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a
medical treatment for Parkinsons Disease40
bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly
decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41
Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid
(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and
fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid
levelsrdquo42 43
Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people
with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS
symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in
the Withdrawal Relief Complex Nighttime formula
MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for
treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal
Relief Complex System This formula has been designed to help keep cravings at
bay after acute withdraw has passed allowing the chemical balance in the patient‟s
brain to quickly and safely return to pre-drug use level
CCRR is a four part compound nutraceutical that addresses cravings by
bullSupplying your adrenal system with nutrients you need to feel good The
ingredients in CCRR work hard to heal your body and restore your
organs and mind
bullGiving your brain a natural boost to stave off depression and anxiety
until the chemical balance of your pre-drug healthy brain is restored
bullFlooding your body with nourishing vitamins and antioxidants that
support physical recovery as you continue to gain strength
bullEnsuring that cravings stay manageable while you create more and more
distance from the desire for more drugs
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
PHGtrade and Healthcare Providers
Copyright copy 2011 Pure Health Group trade
Pure Health Group Inctrade is committed to partnering with healthcare providers
to eradicate opioid dependence by using innovative science and research to
create extraordinary nutraceutical products that help minimize the pain of
withdrawal
For more information about Pure Health
Grouptrade or about how to become a licensed
distributor of our products please visit
WWWPUREHEALTHGROUPCOM
Or contact John D Vox at
jvoxpurehealthgroupcom
3039555899 ext 701
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
The following information explains exactly how the nutrients in our formulas
create relief by working with your patients body to alleviate withdrawal
symptoms
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Depression Anxiety
One of the most debilitating withdrawal symptoms patients experience is a
deep feeling of depression spiked with intermittent anxiety This depressive
state is caused in great part by a severe depletion of vital neurotransmitters
and naturally occurring opioids combined with desensitization of opioid
receptors in the brain Withdrawal Relief Complex nutraceuticals help support
the rapid return of these vital biological chemicals to healthy levels thus
decreasing the depth and length of the depressive state
Research supporting the efficacy of the natural
nutrients in Withdrawal Relief Complex Nutraceuticals
to combat depression and anxiety symptoms are as
follows
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-
blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine
showed use of this herb significantly decreased depression and anxiety associated with
withdrawal as well as if not better than Clonidine1
bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety
WITHOUT the adverse side effects of the drug2
5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP
dramatically alleviates depression3-9
bullIt does so by bolstering serotonin levels in the brain
Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10
bullSignificantly increases the biosynthesis of natural opioid peptides in the body11
bullDecrease the symptoms of depression in patients by up over 3512
L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital
neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which
indicates that it relaxes the mind without inducing drowsinessrdquo14
bullL-theanine reduces anxiety and calms nerves during stressful events15
Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the
B-vitamins or vitamin C16
bullCorrection of these deficiencies through supplementation with the proper forms and
amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in
complete resolution of mental symptoms in some individualsrdquo16
Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas
bullThis herb standardized for L-Dopa content has been found in research to have potent
anti-depressant actions17
bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Insomnia
Sleepless nights are a very common symptom of opiate withdrawal Long-
term use of opiates tends to disrupt the sleep wake cycle by disturbing
the proper production of melatonin and other sleep-inducing chemicals in
the body In order to re-establish healthy sleep cycles allowing patients to
fall asleep faster and stay asleep longer it is necessary to support the
production of natural sleep chemicals
The Withdrawal Relief Complex contains a
healthy dose of pure Melatonin and other all-
natural sleep support ingredients to help
patients sleep through the night allowing them
to obtain the rest needed to recover quickly
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall
asleep much faster and to significantly increase the amount of sleep achieved throughout the
night19 20
5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with
one study showing a 53 increase in REM sleep during the night21
ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small
doses of barbiturates or benzodiazepansrdquo22
bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23
American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects
take place within 30 minutes of ingestion and have been shown in research to help people fall
asleep faster and stay asleep longer24
Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in
prolonged sleep tests25
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Nausea amp Gastrointestinal Distress
Nausea and GI distress (including intestinal cramping and diarrhea) is one of the
most uncomfortable and disruptive physical symptoms of opiate withdrawal This
symptom generally presents 2 or 3 days after abstaining from opiates and can last
for up to a week
Opiates have a very strong sedative effect on the stomach and intestinal tract
Once opiate use is discontinued these organs become over stimulated Nerves
that have been suppressed for a long time begin to come back to life This
enhanced neural input to the smooth muscles of the stomach and GI tract can be
shocking to the system thus causing cramping and hyper-motility
which can lead to diarrhea nausea and vomiting
To treat these symptoms the Withdrawal Relief Complex
formulas include powerful ingredients that not only help to
provide natural moderate sedation to overactive GI nerves but
also help soothe the stomach
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows
gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the
prescription drug Papaverinerdquo for these uses
Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth
muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27
bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a
spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it
as a natural medicine for GI distress28
Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many
antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-
33
Vitamin B6
bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin
B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated
that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our
combined formulashellipover twice the dose of the studyhellipto ensure best results
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Extreme Fatigue amp Lethargy
The fatigue most people experience during withdrawal is profound It can be severe
enough that patients will literally not be able to get out of bed This is particularly
damaging for those needing to maintain a consistent work schedule and or care for
their family
The fatigue that comes from opiate withdrawal is both physical and mental Many
recovering opiate addicts feel a complete lack of motivation and desire to engage in
life This leads to reclusive behavior poor diet and a host of other actions that tend
to prolong withdrawal and lead to relapse
Therefore it is imperative that patients are supported
in staying energized and motivated as they negotiate
the acute phase of withdrawal
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased
energy focus attention and task performance throughout the day Researchers stated ldquoThese results
provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the
psychoactive properties of ginsengrdquo35
5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to
ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36
L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers
found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37
bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing
neurotransmitters such as epinephrine and norepinephrine
Vitamin B12
bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38
bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase
in energy stamina and well being helliprdquo38
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Restless Leg Syndrome (RLS)
RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced
by nearly everyone going through opiate withdrawal This symptom is not so much
painful as it is disruptive and highly irritating RLS causes agitation during the day
and disrupts sleep during the night This exacerbates the symptoms of insomnia and
creates further daytime agitation locking patients into a vicious cycle
RLS is thought to be caused by the depletion of the neurotransmitter dopamine in
the system Research has shown that providing nutrients to help stimulate
dopamine production can quickly and effectively decrease or eliminate the severity
of this syndrome
The following demonstrates how the nutrients in Withdrawal Relief
Complex support dopamine production in two ways by providing a
direct source of natural dopamine (through the L-dopa content of
Mucuna pruriens) and by supporting dopamine metabolism in the
body with the B-vitamin Folate
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances
levels of dopamine in the brain39
bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a
medical treatment for Parkinsons Disease40
bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly
decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41
Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid
(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and
fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid
levelsrdquo42 43
Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people
with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS
symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in
the Withdrawal Relief Complex Nighttime formula
MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for
treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal
Relief Complex System This formula has been designed to help keep cravings at
bay after acute withdraw has passed allowing the chemical balance in the patient‟s
brain to quickly and safely return to pre-drug use level
CCRR is a four part compound nutraceutical that addresses cravings by
bullSupplying your adrenal system with nutrients you need to feel good The
ingredients in CCRR work hard to heal your body and restore your
organs and mind
bullGiving your brain a natural boost to stave off depression and anxiety
until the chemical balance of your pre-drug healthy brain is restored
bullFlooding your body with nourishing vitamins and antioxidants that
support physical recovery as you continue to gain strength
bullEnsuring that cravings stay manageable while you create more and more
distance from the desire for more drugs
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
The following information explains exactly how the nutrients in our formulas
create relief by working with your patients body to alleviate withdrawal
symptoms
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Depression Anxiety
One of the most debilitating withdrawal symptoms patients experience is a
deep feeling of depression spiked with intermittent anxiety This depressive
state is caused in great part by a severe depletion of vital neurotransmitters
and naturally occurring opioids combined with desensitization of opioid
receptors in the brain Withdrawal Relief Complex nutraceuticals help support
the rapid return of these vital biological chemicals to healthy levels thus
decreasing the depth and length of the depressive state
Research supporting the efficacy of the natural
nutrients in Withdrawal Relief Complex Nutraceuticals
to combat depression and anxiety symptoms are as
follows
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-
blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine
showed use of this herb significantly decreased depression and anxiety associated with
withdrawal as well as if not better than Clonidine1
bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety
WITHOUT the adverse side effects of the drug2
5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP
dramatically alleviates depression3-9
bullIt does so by bolstering serotonin levels in the brain
Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10
bullSignificantly increases the biosynthesis of natural opioid peptides in the body11
bullDecrease the symptoms of depression in patients by up over 3512
L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital
neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which
indicates that it relaxes the mind without inducing drowsinessrdquo14
bullL-theanine reduces anxiety and calms nerves during stressful events15
Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the
B-vitamins or vitamin C16
bullCorrection of these deficiencies through supplementation with the proper forms and
amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in
complete resolution of mental symptoms in some individualsrdquo16
Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas
bullThis herb standardized for L-Dopa content has been found in research to have potent
anti-depressant actions17
bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Insomnia
Sleepless nights are a very common symptom of opiate withdrawal Long-
term use of opiates tends to disrupt the sleep wake cycle by disturbing
the proper production of melatonin and other sleep-inducing chemicals in
the body In order to re-establish healthy sleep cycles allowing patients to
fall asleep faster and stay asleep longer it is necessary to support the
production of natural sleep chemicals
The Withdrawal Relief Complex contains a
healthy dose of pure Melatonin and other all-
natural sleep support ingredients to help
patients sleep through the night allowing them
to obtain the rest needed to recover quickly
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall
asleep much faster and to significantly increase the amount of sleep achieved throughout the
night19 20
5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with
one study showing a 53 increase in REM sleep during the night21
ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small
doses of barbiturates or benzodiazepansrdquo22
bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23
American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects
take place within 30 minutes of ingestion and have been shown in research to help people fall
asleep faster and stay asleep longer24
Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in
prolonged sleep tests25
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Nausea amp Gastrointestinal Distress
Nausea and GI distress (including intestinal cramping and diarrhea) is one of the
most uncomfortable and disruptive physical symptoms of opiate withdrawal This
symptom generally presents 2 or 3 days after abstaining from opiates and can last
for up to a week
Opiates have a very strong sedative effect on the stomach and intestinal tract
Once opiate use is discontinued these organs become over stimulated Nerves
that have been suppressed for a long time begin to come back to life This
enhanced neural input to the smooth muscles of the stomach and GI tract can be
shocking to the system thus causing cramping and hyper-motility
which can lead to diarrhea nausea and vomiting
To treat these symptoms the Withdrawal Relief Complex
formulas include powerful ingredients that not only help to
provide natural moderate sedation to overactive GI nerves but
also help soothe the stomach
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows
gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the
prescription drug Papaverinerdquo for these uses
Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth
muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27
bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a
spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it
as a natural medicine for GI distress28
Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many
antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-
33
Vitamin B6
bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin
B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated
that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our
combined formulashellipover twice the dose of the studyhellipto ensure best results
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Extreme Fatigue amp Lethargy
The fatigue most people experience during withdrawal is profound It can be severe
enough that patients will literally not be able to get out of bed This is particularly
damaging for those needing to maintain a consistent work schedule and or care for
their family
The fatigue that comes from opiate withdrawal is both physical and mental Many
recovering opiate addicts feel a complete lack of motivation and desire to engage in
life This leads to reclusive behavior poor diet and a host of other actions that tend
to prolong withdrawal and lead to relapse
Therefore it is imperative that patients are supported
in staying energized and motivated as they negotiate
the acute phase of withdrawal
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased
energy focus attention and task performance throughout the day Researchers stated ldquoThese results
provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the
psychoactive properties of ginsengrdquo35
5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to
ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36
L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers
found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37
bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing
neurotransmitters such as epinephrine and norepinephrine
Vitamin B12
bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38
bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase
in energy stamina and well being helliprdquo38
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Restless Leg Syndrome (RLS)
RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced
by nearly everyone going through opiate withdrawal This symptom is not so much
painful as it is disruptive and highly irritating RLS causes agitation during the day
and disrupts sleep during the night This exacerbates the symptoms of insomnia and
creates further daytime agitation locking patients into a vicious cycle
RLS is thought to be caused by the depletion of the neurotransmitter dopamine in
the system Research has shown that providing nutrients to help stimulate
dopamine production can quickly and effectively decrease or eliminate the severity
of this syndrome
The following demonstrates how the nutrients in Withdrawal Relief
Complex support dopamine production in two ways by providing a
direct source of natural dopamine (through the L-dopa content of
Mucuna pruriens) and by supporting dopamine metabolism in the
body with the B-vitamin Folate
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances
levels of dopamine in the brain39
bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a
medical treatment for Parkinsons Disease40
bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly
decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41
Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid
(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and
fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid
levelsrdquo42 43
Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people
with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS
symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in
the Withdrawal Relief Complex Nighttime formula
MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for
treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal
Relief Complex System This formula has been designed to help keep cravings at
bay after acute withdraw has passed allowing the chemical balance in the patient‟s
brain to quickly and safely return to pre-drug use level
CCRR is a four part compound nutraceutical that addresses cravings by
bullSupplying your adrenal system with nutrients you need to feel good The
ingredients in CCRR work hard to heal your body and restore your
organs and mind
bullGiving your brain a natural boost to stave off depression and anxiety
until the chemical balance of your pre-drug healthy brain is restored
bullFlooding your body with nourishing vitamins and antioxidants that
support physical recovery as you continue to gain strength
bullEnsuring that cravings stay manageable while you create more and more
distance from the desire for more drugs
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Depression Anxiety
One of the most debilitating withdrawal symptoms patients experience is a
deep feeling of depression spiked with intermittent anxiety This depressive
state is caused in great part by a severe depletion of vital neurotransmitters
and naturally occurring opioids combined with desensitization of opioid
receptors in the brain Withdrawal Relief Complex nutraceuticals help support
the rapid return of these vital biological chemicals to healthy levels thus
decreasing the depth and length of the depressive state
Research supporting the efficacy of the natural
nutrients in Withdrawal Relief Complex Nutraceuticals
to combat depression and anxiety symptoms are as
follows
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-
blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine
showed use of this herb significantly decreased depression and anxiety associated with
withdrawal as well as if not better than Clonidine1
bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety
WITHOUT the adverse side effects of the drug2
5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP
dramatically alleviates depression3-9
bullIt does so by bolstering serotonin levels in the brain
Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10
bullSignificantly increases the biosynthesis of natural opioid peptides in the body11
bullDecrease the symptoms of depression in patients by up over 3512
L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital
neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which
indicates that it relaxes the mind without inducing drowsinessrdquo14
bullL-theanine reduces anxiety and calms nerves during stressful events15
Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the
B-vitamins or vitamin C16
bullCorrection of these deficiencies through supplementation with the proper forms and
amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in
complete resolution of mental symptoms in some individualsrdquo16
Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas
bullThis herb standardized for L-Dopa content has been found in research to have potent
anti-depressant actions17
bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Insomnia
Sleepless nights are a very common symptom of opiate withdrawal Long-
term use of opiates tends to disrupt the sleep wake cycle by disturbing
the proper production of melatonin and other sleep-inducing chemicals in
the body In order to re-establish healthy sleep cycles allowing patients to
fall asleep faster and stay asleep longer it is necessary to support the
production of natural sleep chemicals
The Withdrawal Relief Complex contains a
healthy dose of pure Melatonin and other all-
natural sleep support ingredients to help
patients sleep through the night allowing them
to obtain the rest needed to recover quickly
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall
asleep much faster and to significantly increase the amount of sleep achieved throughout the
night19 20
5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with
one study showing a 53 increase in REM sleep during the night21
ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small
doses of barbiturates or benzodiazepansrdquo22
bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23
American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects
take place within 30 minutes of ingestion and have been shown in research to help people fall
asleep faster and stay asleep longer24
Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in
prolonged sleep tests25
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Nausea amp Gastrointestinal Distress
Nausea and GI distress (including intestinal cramping and diarrhea) is one of the
most uncomfortable and disruptive physical symptoms of opiate withdrawal This
symptom generally presents 2 or 3 days after abstaining from opiates and can last
for up to a week
Opiates have a very strong sedative effect on the stomach and intestinal tract
Once opiate use is discontinued these organs become over stimulated Nerves
that have been suppressed for a long time begin to come back to life This
enhanced neural input to the smooth muscles of the stomach and GI tract can be
shocking to the system thus causing cramping and hyper-motility
which can lead to diarrhea nausea and vomiting
To treat these symptoms the Withdrawal Relief Complex
formulas include powerful ingredients that not only help to
provide natural moderate sedation to overactive GI nerves but
also help soothe the stomach
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows
gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the
prescription drug Papaverinerdquo for these uses
Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth
muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27
bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a
spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it
as a natural medicine for GI distress28
Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many
antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-
33
Vitamin B6
bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin
B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated
that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our
combined formulashellipover twice the dose of the studyhellipto ensure best results
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Extreme Fatigue amp Lethargy
The fatigue most people experience during withdrawal is profound It can be severe
enough that patients will literally not be able to get out of bed This is particularly
damaging for those needing to maintain a consistent work schedule and or care for
their family
The fatigue that comes from opiate withdrawal is both physical and mental Many
recovering opiate addicts feel a complete lack of motivation and desire to engage in
life This leads to reclusive behavior poor diet and a host of other actions that tend
to prolong withdrawal and lead to relapse
Therefore it is imperative that patients are supported
in staying energized and motivated as they negotiate
the acute phase of withdrawal
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased
energy focus attention and task performance throughout the day Researchers stated ldquoThese results
provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the
psychoactive properties of ginsengrdquo35
5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to
ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36
L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers
found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37
bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing
neurotransmitters such as epinephrine and norepinephrine
Vitamin B12
bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38
bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase
in energy stamina and well being helliprdquo38
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Restless Leg Syndrome (RLS)
RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced
by nearly everyone going through opiate withdrawal This symptom is not so much
painful as it is disruptive and highly irritating RLS causes agitation during the day
and disrupts sleep during the night This exacerbates the symptoms of insomnia and
creates further daytime agitation locking patients into a vicious cycle
RLS is thought to be caused by the depletion of the neurotransmitter dopamine in
the system Research has shown that providing nutrients to help stimulate
dopamine production can quickly and effectively decrease or eliminate the severity
of this syndrome
The following demonstrates how the nutrients in Withdrawal Relief
Complex support dopamine production in two ways by providing a
direct source of natural dopamine (through the L-dopa content of
Mucuna pruriens) and by supporting dopamine metabolism in the
body with the B-vitamin Folate
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances
levels of dopamine in the brain39
bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a
medical treatment for Parkinsons Disease40
bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly
decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41
Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid
(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and
fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid
levelsrdquo42 43
Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people
with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS
symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in
the Withdrawal Relief Complex Nighttime formula
MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for
treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal
Relief Complex System This formula has been designed to help keep cravings at
bay after acute withdraw has passed allowing the chemical balance in the patient‟s
brain to quickly and safely return to pre-drug use level
CCRR is a four part compound nutraceutical that addresses cravings by
bullSupplying your adrenal system with nutrients you need to feel good The
ingredients in CCRR work hard to heal your body and restore your
organs and mind
bullGiving your brain a natural boost to stave off depression and anxiety
until the chemical balance of your pre-drug healthy brain is restored
bullFlooding your body with nourishing vitamins and antioxidants that
support physical recovery as you continue to gain strength
bullEnsuring that cravings stay manageable while you create more and more
distance from the desire for more drugs
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-
blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine
showed use of this herb significantly decreased depression and anxiety associated with
withdrawal as well as if not better than Clonidine1
bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety
WITHOUT the adverse side effects of the drug2
5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP
dramatically alleviates depression3-9
bullIt does so by bolstering serotonin levels in the brain
Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10
bullSignificantly increases the biosynthesis of natural opioid peptides in the body11
bullDecrease the symptoms of depression in patients by up over 3512
L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital
neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which
indicates that it relaxes the mind without inducing drowsinessrdquo14
bullL-theanine reduces anxiety and calms nerves during stressful events15
Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the
B-vitamins or vitamin C16
bullCorrection of these deficiencies through supplementation with the proper forms and
amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in
complete resolution of mental symptoms in some individualsrdquo16
Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas
bullThis herb standardized for L-Dopa content has been found in research to have potent
anti-depressant actions17
bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Insomnia
Sleepless nights are a very common symptom of opiate withdrawal Long-
term use of opiates tends to disrupt the sleep wake cycle by disturbing
the proper production of melatonin and other sleep-inducing chemicals in
the body In order to re-establish healthy sleep cycles allowing patients to
fall asleep faster and stay asleep longer it is necessary to support the
production of natural sleep chemicals
The Withdrawal Relief Complex contains a
healthy dose of pure Melatonin and other all-
natural sleep support ingredients to help
patients sleep through the night allowing them
to obtain the rest needed to recover quickly
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall
asleep much faster and to significantly increase the amount of sleep achieved throughout the
night19 20
5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with
one study showing a 53 increase in REM sleep during the night21
ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small
doses of barbiturates or benzodiazepansrdquo22
bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23
American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects
take place within 30 minutes of ingestion and have been shown in research to help people fall
asleep faster and stay asleep longer24
Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in
prolonged sleep tests25
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Nausea amp Gastrointestinal Distress
Nausea and GI distress (including intestinal cramping and diarrhea) is one of the
most uncomfortable and disruptive physical symptoms of opiate withdrawal This
symptom generally presents 2 or 3 days after abstaining from opiates and can last
for up to a week
Opiates have a very strong sedative effect on the stomach and intestinal tract
Once opiate use is discontinued these organs become over stimulated Nerves
that have been suppressed for a long time begin to come back to life This
enhanced neural input to the smooth muscles of the stomach and GI tract can be
shocking to the system thus causing cramping and hyper-motility
which can lead to diarrhea nausea and vomiting
To treat these symptoms the Withdrawal Relief Complex
formulas include powerful ingredients that not only help to
provide natural moderate sedation to overactive GI nerves but
also help soothe the stomach
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows
gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the
prescription drug Papaverinerdquo for these uses
Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth
muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27
bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a
spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it
as a natural medicine for GI distress28
Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many
antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-
33
Vitamin B6
bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin
B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated
that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our
combined formulashellipover twice the dose of the studyhellipto ensure best results
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Extreme Fatigue amp Lethargy
The fatigue most people experience during withdrawal is profound It can be severe
enough that patients will literally not be able to get out of bed This is particularly
damaging for those needing to maintain a consistent work schedule and or care for
their family
The fatigue that comes from opiate withdrawal is both physical and mental Many
recovering opiate addicts feel a complete lack of motivation and desire to engage in
life This leads to reclusive behavior poor diet and a host of other actions that tend
to prolong withdrawal and lead to relapse
Therefore it is imperative that patients are supported
in staying energized and motivated as they negotiate
the acute phase of withdrawal
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased
energy focus attention and task performance throughout the day Researchers stated ldquoThese results
provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the
psychoactive properties of ginsengrdquo35
5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to
ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36
L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers
found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37
bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing
neurotransmitters such as epinephrine and norepinephrine
Vitamin B12
bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38
bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase
in energy stamina and well being helliprdquo38
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Restless Leg Syndrome (RLS)
RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced
by nearly everyone going through opiate withdrawal This symptom is not so much
painful as it is disruptive and highly irritating RLS causes agitation during the day
and disrupts sleep during the night This exacerbates the symptoms of insomnia and
creates further daytime agitation locking patients into a vicious cycle
RLS is thought to be caused by the depletion of the neurotransmitter dopamine in
the system Research has shown that providing nutrients to help stimulate
dopamine production can quickly and effectively decrease or eliminate the severity
of this syndrome
The following demonstrates how the nutrients in Withdrawal Relief
Complex support dopamine production in two ways by providing a
direct source of natural dopamine (through the L-dopa content of
Mucuna pruriens) and by supporting dopamine metabolism in the
body with the B-vitamin Folate
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances
levels of dopamine in the brain39
bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a
medical treatment for Parkinsons Disease40
bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly
decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41
Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid
(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and
fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid
levelsrdquo42 43
Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people
with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS
symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in
the Withdrawal Relief Complex Nighttime formula
MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for
treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal
Relief Complex System This formula has been designed to help keep cravings at
bay after acute withdraw has passed allowing the chemical balance in the patient‟s
brain to quickly and safely return to pre-drug use level
CCRR is a four part compound nutraceutical that addresses cravings by
bullSupplying your adrenal system with nutrients you need to feel good The
ingredients in CCRR work hard to heal your body and restore your
organs and mind
bullGiving your brain a natural boost to stave off depression and anxiety
until the chemical balance of your pre-drug healthy brain is restored
bullFlooding your body with nourishing vitamins and antioxidants that
support physical recovery as you continue to gain strength
bullEnsuring that cravings stay manageable while you create more and more
distance from the desire for more drugs
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which
indicates that it relaxes the mind without inducing drowsinessrdquo14
bullL-theanine reduces anxiety and calms nerves during stressful events15
Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the
B-vitamins or vitamin C16
bullCorrection of these deficiencies through supplementation with the proper forms and
amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in
complete resolution of mental symptoms in some individualsrdquo16
Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas
bullThis herb standardized for L-Dopa content has been found in research to have potent
anti-depressant actions17
bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Insomnia
Sleepless nights are a very common symptom of opiate withdrawal Long-
term use of opiates tends to disrupt the sleep wake cycle by disturbing
the proper production of melatonin and other sleep-inducing chemicals in
the body In order to re-establish healthy sleep cycles allowing patients to
fall asleep faster and stay asleep longer it is necessary to support the
production of natural sleep chemicals
The Withdrawal Relief Complex contains a
healthy dose of pure Melatonin and other all-
natural sleep support ingredients to help
patients sleep through the night allowing them
to obtain the rest needed to recover quickly
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall
asleep much faster and to significantly increase the amount of sleep achieved throughout the
night19 20
5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with
one study showing a 53 increase in REM sleep during the night21
ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small
doses of barbiturates or benzodiazepansrdquo22
bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23
American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects
take place within 30 minutes of ingestion and have been shown in research to help people fall
asleep faster and stay asleep longer24
Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in
prolonged sleep tests25
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Nausea amp Gastrointestinal Distress
Nausea and GI distress (including intestinal cramping and diarrhea) is one of the
most uncomfortable and disruptive physical symptoms of opiate withdrawal This
symptom generally presents 2 or 3 days after abstaining from opiates and can last
for up to a week
Opiates have a very strong sedative effect on the stomach and intestinal tract
Once opiate use is discontinued these organs become over stimulated Nerves
that have been suppressed for a long time begin to come back to life This
enhanced neural input to the smooth muscles of the stomach and GI tract can be
shocking to the system thus causing cramping and hyper-motility
which can lead to diarrhea nausea and vomiting
To treat these symptoms the Withdrawal Relief Complex
formulas include powerful ingredients that not only help to
provide natural moderate sedation to overactive GI nerves but
also help soothe the stomach
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows
gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the
prescription drug Papaverinerdquo for these uses
Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth
muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27
bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a
spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it
as a natural medicine for GI distress28
Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many
antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-
33
Vitamin B6
bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin
B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated
that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our
combined formulashellipover twice the dose of the studyhellipto ensure best results
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Extreme Fatigue amp Lethargy
The fatigue most people experience during withdrawal is profound It can be severe
enough that patients will literally not be able to get out of bed This is particularly
damaging for those needing to maintain a consistent work schedule and or care for
their family
The fatigue that comes from opiate withdrawal is both physical and mental Many
recovering opiate addicts feel a complete lack of motivation and desire to engage in
life This leads to reclusive behavior poor diet and a host of other actions that tend
to prolong withdrawal and lead to relapse
Therefore it is imperative that patients are supported
in staying energized and motivated as they negotiate
the acute phase of withdrawal
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased
energy focus attention and task performance throughout the day Researchers stated ldquoThese results
provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the
psychoactive properties of ginsengrdquo35
5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to
ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36
L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers
found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37
bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing
neurotransmitters such as epinephrine and norepinephrine
Vitamin B12
bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38
bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase
in energy stamina and well being helliprdquo38
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Restless Leg Syndrome (RLS)
RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced
by nearly everyone going through opiate withdrawal This symptom is not so much
painful as it is disruptive and highly irritating RLS causes agitation during the day
and disrupts sleep during the night This exacerbates the symptoms of insomnia and
creates further daytime agitation locking patients into a vicious cycle
RLS is thought to be caused by the depletion of the neurotransmitter dopamine in
the system Research has shown that providing nutrients to help stimulate
dopamine production can quickly and effectively decrease or eliminate the severity
of this syndrome
The following demonstrates how the nutrients in Withdrawal Relief
Complex support dopamine production in two ways by providing a
direct source of natural dopamine (through the L-dopa content of
Mucuna pruriens) and by supporting dopamine metabolism in the
body with the B-vitamin Folate
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances
levels of dopamine in the brain39
bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a
medical treatment for Parkinsons Disease40
bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly
decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41
Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid
(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and
fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid
levelsrdquo42 43
Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people
with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS
symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in
the Withdrawal Relief Complex Nighttime formula
MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for
treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal
Relief Complex System This formula has been designed to help keep cravings at
bay after acute withdraw has passed allowing the chemical balance in the patient‟s
brain to quickly and safely return to pre-drug use level
CCRR is a four part compound nutraceutical that addresses cravings by
bullSupplying your adrenal system with nutrients you need to feel good The
ingredients in CCRR work hard to heal your body and restore your
organs and mind
bullGiving your brain a natural boost to stave off depression and anxiety
until the chemical balance of your pre-drug healthy brain is restored
bullFlooding your body with nourishing vitamins and antioxidants that
support physical recovery as you continue to gain strength
bullEnsuring that cravings stay manageable while you create more and more
distance from the desire for more drugs
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Insomnia
Sleepless nights are a very common symptom of opiate withdrawal Long-
term use of opiates tends to disrupt the sleep wake cycle by disturbing
the proper production of melatonin and other sleep-inducing chemicals in
the body In order to re-establish healthy sleep cycles allowing patients to
fall asleep faster and stay asleep longer it is necessary to support the
production of natural sleep chemicals
The Withdrawal Relief Complex contains a
healthy dose of pure Melatonin and other all-
natural sleep support ingredients to help
patients sleep through the night allowing them
to obtain the rest needed to recover quickly
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall
asleep much faster and to significantly increase the amount of sleep achieved throughout the
night19 20
5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with
one study showing a 53 increase in REM sleep during the night21
ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small
doses of barbiturates or benzodiazepansrdquo22
bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23
American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects
take place within 30 minutes of ingestion and have been shown in research to help people fall
asleep faster and stay asleep longer24
Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in
prolonged sleep tests25
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Nausea amp Gastrointestinal Distress
Nausea and GI distress (including intestinal cramping and diarrhea) is one of the
most uncomfortable and disruptive physical symptoms of opiate withdrawal This
symptom generally presents 2 or 3 days after abstaining from opiates and can last
for up to a week
Opiates have a very strong sedative effect on the stomach and intestinal tract
Once opiate use is discontinued these organs become over stimulated Nerves
that have been suppressed for a long time begin to come back to life This
enhanced neural input to the smooth muscles of the stomach and GI tract can be
shocking to the system thus causing cramping and hyper-motility
which can lead to diarrhea nausea and vomiting
To treat these symptoms the Withdrawal Relief Complex
formulas include powerful ingredients that not only help to
provide natural moderate sedation to overactive GI nerves but
also help soothe the stomach
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows
gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the
prescription drug Papaverinerdquo for these uses
Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth
muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27
bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a
spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it
as a natural medicine for GI distress28
Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many
antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-
33
Vitamin B6
bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin
B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated
that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our
combined formulashellipover twice the dose of the studyhellipto ensure best results
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Extreme Fatigue amp Lethargy
The fatigue most people experience during withdrawal is profound It can be severe
enough that patients will literally not be able to get out of bed This is particularly
damaging for those needing to maintain a consistent work schedule and or care for
their family
The fatigue that comes from opiate withdrawal is both physical and mental Many
recovering opiate addicts feel a complete lack of motivation and desire to engage in
life This leads to reclusive behavior poor diet and a host of other actions that tend
to prolong withdrawal and lead to relapse
Therefore it is imperative that patients are supported
in staying energized and motivated as they negotiate
the acute phase of withdrawal
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased
energy focus attention and task performance throughout the day Researchers stated ldquoThese results
provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the
psychoactive properties of ginsengrdquo35
5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to
ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36
L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers
found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37
bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing
neurotransmitters such as epinephrine and norepinephrine
Vitamin B12
bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38
bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase
in energy stamina and well being helliprdquo38
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Restless Leg Syndrome (RLS)
RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced
by nearly everyone going through opiate withdrawal This symptom is not so much
painful as it is disruptive and highly irritating RLS causes agitation during the day
and disrupts sleep during the night This exacerbates the symptoms of insomnia and
creates further daytime agitation locking patients into a vicious cycle
RLS is thought to be caused by the depletion of the neurotransmitter dopamine in
the system Research has shown that providing nutrients to help stimulate
dopamine production can quickly and effectively decrease or eliminate the severity
of this syndrome
The following demonstrates how the nutrients in Withdrawal Relief
Complex support dopamine production in two ways by providing a
direct source of natural dopamine (through the L-dopa content of
Mucuna pruriens) and by supporting dopamine metabolism in the
body with the B-vitamin Folate
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances
levels of dopamine in the brain39
bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a
medical treatment for Parkinsons Disease40
bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly
decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41
Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid
(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and
fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid
levelsrdquo42 43
Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people
with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS
symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in
the Withdrawal Relief Complex Nighttime formula
MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for
treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal
Relief Complex System This formula has been designed to help keep cravings at
bay after acute withdraw has passed allowing the chemical balance in the patient‟s
brain to quickly and safely return to pre-drug use level
CCRR is a four part compound nutraceutical that addresses cravings by
bullSupplying your adrenal system with nutrients you need to feel good The
ingredients in CCRR work hard to heal your body and restore your
organs and mind
bullGiving your brain a natural boost to stave off depression and anxiety
until the chemical balance of your pre-drug healthy brain is restored
bullFlooding your body with nourishing vitamins and antioxidants that
support physical recovery as you continue to gain strength
bullEnsuring that cravings stay manageable while you create more and more
distance from the desire for more drugs
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall
asleep much faster and to significantly increase the amount of sleep achieved throughout the
night19 20
5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with
one study showing a 53 increase in REM sleep during the night21
ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small
doses of barbiturates or benzodiazepansrdquo22
bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23
American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects
take place within 30 minutes of ingestion and have been shown in research to help people fall
asleep faster and stay asleep longer24
Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in
prolonged sleep tests25
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Nausea amp Gastrointestinal Distress
Nausea and GI distress (including intestinal cramping and diarrhea) is one of the
most uncomfortable and disruptive physical symptoms of opiate withdrawal This
symptom generally presents 2 or 3 days after abstaining from opiates and can last
for up to a week
Opiates have a very strong sedative effect on the stomach and intestinal tract
Once opiate use is discontinued these organs become over stimulated Nerves
that have been suppressed for a long time begin to come back to life This
enhanced neural input to the smooth muscles of the stomach and GI tract can be
shocking to the system thus causing cramping and hyper-motility
which can lead to diarrhea nausea and vomiting
To treat these symptoms the Withdrawal Relief Complex
formulas include powerful ingredients that not only help to
provide natural moderate sedation to overactive GI nerves but
also help soothe the stomach
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows
gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the
prescription drug Papaverinerdquo for these uses
Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth
muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27
bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a
spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it
as a natural medicine for GI distress28
Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many
antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-
33
Vitamin B6
bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin
B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated
that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our
combined formulashellipover twice the dose of the studyhellipto ensure best results
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Extreme Fatigue amp Lethargy
The fatigue most people experience during withdrawal is profound It can be severe
enough that patients will literally not be able to get out of bed This is particularly
damaging for those needing to maintain a consistent work schedule and or care for
their family
The fatigue that comes from opiate withdrawal is both physical and mental Many
recovering opiate addicts feel a complete lack of motivation and desire to engage in
life This leads to reclusive behavior poor diet and a host of other actions that tend
to prolong withdrawal and lead to relapse
Therefore it is imperative that patients are supported
in staying energized and motivated as they negotiate
the acute phase of withdrawal
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased
energy focus attention and task performance throughout the day Researchers stated ldquoThese results
provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the
psychoactive properties of ginsengrdquo35
5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to
ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36
L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers
found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37
bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing
neurotransmitters such as epinephrine and norepinephrine
Vitamin B12
bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38
bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase
in energy stamina and well being helliprdquo38
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Restless Leg Syndrome (RLS)
RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced
by nearly everyone going through opiate withdrawal This symptom is not so much
painful as it is disruptive and highly irritating RLS causes agitation during the day
and disrupts sleep during the night This exacerbates the symptoms of insomnia and
creates further daytime agitation locking patients into a vicious cycle
RLS is thought to be caused by the depletion of the neurotransmitter dopamine in
the system Research has shown that providing nutrients to help stimulate
dopamine production can quickly and effectively decrease or eliminate the severity
of this syndrome
The following demonstrates how the nutrients in Withdrawal Relief
Complex support dopamine production in two ways by providing a
direct source of natural dopamine (through the L-dopa content of
Mucuna pruriens) and by supporting dopamine metabolism in the
body with the B-vitamin Folate
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances
levels of dopamine in the brain39
bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a
medical treatment for Parkinsons Disease40
bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly
decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41
Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid
(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and
fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid
levelsrdquo42 43
Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people
with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS
symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in
the Withdrawal Relief Complex Nighttime formula
MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for
treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal
Relief Complex System This formula has been designed to help keep cravings at
bay after acute withdraw has passed allowing the chemical balance in the patient‟s
brain to quickly and safely return to pre-drug use level
CCRR is a four part compound nutraceutical that addresses cravings by
bullSupplying your adrenal system with nutrients you need to feel good The
ingredients in CCRR work hard to heal your body and restore your
organs and mind
bullGiving your brain a natural boost to stave off depression and anxiety
until the chemical balance of your pre-drug healthy brain is restored
bullFlooding your body with nourishing vitamins and antioxidants that
support physical recovery as you continue to gain strength
bullEnsuring that cravings stay manageable while you create more and more
distance from the desire for more drugs
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Nausea amp Gastrointestinal Distress
Nausea and GI distress (including intestinal cramping and diarrhea) is one of the
most uncomfortable and disruptive physical symptoms of opiate withdrawal This
symptom generally presents 2 or 3 days after abstaining from opiates and can last
for up to a week
Opiates have a very strong sedative effect on the stomach and intestinal tract
Once opiate use is discontinued these organs become over stimulated Nerves
that have been suppressed for a long time begin to come back to life This
enhanced neural input to the smooth muscles of the stomach and GI tract can be
shocking to the system thus causing cramping and hyper-motility
which can lead to diarrhea nausea and vomiting
To treat these symptoms the Withdrawal Relief Complex
formulas include powerful ingredients that not only help to
provide natural moderate sedation to overactive GI nerves but
also help soothe the stomach
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows
gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the
prescription drug Papaverinerdquo for these uses
Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth
muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27
bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a
spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it
as a natural medicine for GI distress28
Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many
antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-
33
Vitamin B6
bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin
B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated
that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our
combined formulashellipover twice the dose of the studyhellipto ensure best results
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Extreme Fatigue amp Lethargy
The fatigue most people experience during withdrawal is profound It can be severe
enough that patients will literally not be able to get out of bed This is particularly
damaging for those needing to maintain a consistent work schedule and or care for
their family
The fatigue that comes from opiate withdrawal is both physical and mental Many
recovering opiate addicts feel a complete lack of motivation and desire to engage in
life This leads to reclusive behavior poor diet and a host of other actions that tend
to prolong withdrawal and lead to relapse
Therefore it is imperative that patients are supported
in staying energized and motivated as they negotiate
the acute phase of withdrawal
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased
energy focus attention and task performance throughout the day Researchers stated ldquoThese results
provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the
psychoactive properties of ginsengrdquo35
5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to
ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36
L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers
found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37
bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing
neurotransmitters such as epinephrine and norepinephrine
Vitamin B12
bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38
bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase
in energy stamina and well being helliprdquo38
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Restless Leg Syndrome (RLS)
RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced
by nearly everyone going through opiate withdrawal This symptom is not so much
painful as it is disruptive and highly irritating RLS causes agitation during the day
and disrupts sleep during the night This exacerbates the symptoms of insomnia and
creates further daytime agitation locking patients into a vicious cycle
RLS is thought to be caused by the depletion of the neurotransmitter dopamine in
the system Research has shown that providing nutrients to help stimulate
dopamine production can quickly and effectively decrease or eliminate the severity
of this syndrome
The following demonstrates how the nutrients in Withdrawal Relief
Complex support dopamine production in two ways by providing a
direct source of natural dopamine (through the L-dopa content of
Mucuna pruriens) and by supporting dopamine metabolism in the
body with the B-vitamin Folate
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances
levels of dopamine in the brain39
bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a
medical treatment for Parkinsons Disease40
bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly
decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41
Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid
(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and
fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid
levelsrdquo42 43
Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people
with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS
symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in
the Withdrawal Relief Complex Nighttime formula
MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for
treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal
Relief Complex System This formula has been designed to help keep cravings at
bay after acute withdraw has passed allowing the chemical balance in the patient‟s
brain to quickly and safely return to pre-drug use level
CCRR is a four part compound nutraceutical that addresses cravings by
bullSupplying your adrenal system with nutrients you need to feel good The
ingredients in CCRR work hard to heal your body and restore your
organs and mind
bullGiving your brain a natural boost to stave off depression and anxiety
until the chemical balance of your pre-drug healthy brain is restored
bullFlooding your body with nourishing vitamins and antioxidants that
support physical recovery as you continue to gain strength
bullEnsuring that cravings stay manageable while you create more and more
distance from the desire for more drugs
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows
gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the
prescription drug Papaverinerdquo for these uses
Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth
muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27
bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a
spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it
as a natural medicine for GI distress28
Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many
antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-
33
Vitamin B6
bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin
B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated
that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our
combined formulashellipover twice the dose of the studyhellipto ensure best results
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Extreme Fatigue amp Lethargy
The fatigue most people experience during withdrawal is profound It can be severe
enough that patients will literally not be able to get out of bed This is particularly
damaging for those needing to maintain a consistent work schedule and or care for
their family
The fatigue that comes from opiate withdrawal is both physical and mental Many
recovering opiate addicts feel a complete lack of motivation and desire to engage in
life This leads to reclusive behavior poor diet and a host of other actions that tend
to prolong withdrawal and lead to relapse
Therefore it is imperative that patients are supported
in staying energized and motivated as they negotiate
the acute phase of withdrawal
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased
energy focus attention and task performance throughout the day Researchers stated ldquoThese results
provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the
psychoactive properties of ginsengrdquo35
5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to
ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36
L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers
found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37
bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing
neurotransmitters such as epinephrine and norepinephrine
Vitamin B12
bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38
bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase
in energy stamina and well being helliprdquo38
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Restless Leg Syndrome (RLS)
RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced
by nearly everyone going through opiate withdrawal This symptom is not so much
painful as it is disruptive and highly irritating RLS causes agitation during the day
and disrupts sleep during the night This exacerbates the symptoms of insomnia and
creates further daytime agitation locking patients into a vicious cycle
RLS is thought to be caused by the depletion of the neurotransmitter dopamine in
the system Research has shown that providing nutrients to help stimulate
dopamine production can quickly and effectively decrease or eliminate the severity
of this syndrome
The following demonstrates how the nutrients in Withdrawal Relief
Complex support dopamine production in two ways by providing a
direct source of natural dopamine (through the L-dopa content of
Mucuna pruriens) and by supporting dopamine metabolism in the
body with the B-vitamin Folate
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances
levels of dopamine in the brain39
bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a
medical treatment for Parkinsons Disease40
bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly
decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41
Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid
(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and
fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid
levelsrdquo42 43
Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people
with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS
symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in
the Withdrawal Relief Complex Nighttime formula
MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for
treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal
Relief Complex System This formula has been designed to help keep cravings at
bay after acute withdraw has passed allowing the chemical balance in the patient‟s
brain to quickly and safely return to pre-drug use level
CCRR is a four part compound nutraceutical that addresses cravings by
bullSupplying your adrenal system with nutrients you need to feel good The
ingredients in CCRR work hard to heal your body and restore your
organs and mind
bullGiving your brain a natural boost to stave off depression and anxiety
until the chemical balance of your pre-drug healthy brain is restored
bullFlooding your body with nourishing vitamins and antioxidants that
support physical recovery as you continue to gain strength
bullEnsuring that cravings stay manageable while you create more and more
distance from the desire for more drugs
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Extreme Fatigue amp Lethargy
The fatigue most people experience during withdrawal is profound It can be severe
enough that patients will literally not be able to get out of bed This is particularly
damaging for those needing to maintain a consistent work schedule and or care for
their family
The fatigue that comes from opiate withdrawal is both physical and mental Many
recovering opiate addicts feel a complete lack of motivation and desire to engage in
life This leads to reclusive behavior poor diet and a host of other actions that tend
to prolong withdrawal and lead to relapse
Therefore it is imperative that patients are supported
in staying energized and motivated as they negotiate
the acute phase of withdrawal
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased
energy focus attention and task performance throughout the day Researchers stated ldquoThese results
provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the
psychoactive properties of ginsengrdquo35
5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to
ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36
L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers
found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37
bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing
neurotransmitters such as epinephrine and norepinephrine
Vitamin B12
bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38
bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase
in energy stamina and well being helliprdquo38
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Restless Leg Syndrome (RLS)
RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced
by nearly everyone going through opiate withdrawal This symptom is not so much
painful as it is disruptive and highly irritating RLS causes agitation during the day
and disrupts sleep during the night This exacerbates the symptoms of insomnia and
creates further daytime agitation locking patients into a vicious cycle
RLS is thought to be caused by the depletion of the neurotransmitter dopamine in
the system Research has shown that providing nutrients to help stimulate
dopamine production can quickly and effectively decrease or eliminate the severity
of this syndrome
The following demonstrates how the nutrients in Withdrawal Relief
Complex support dopamine production in two ways by providing a
direct source of natural dopamine (through the L-dopa content of
Mucuna pruriens) and by supporting dopamine metabolism in the
body with the B-vitamin Folate
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances
levels of dopamine in the brain39
bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a
medical treatment for Parkinsons Disease40
bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly
decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41
Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid
(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and
fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid
levelsrdquo42 43
Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people
with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS
symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in
the Withdrawal Relief Complex Nighttime formula
MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for
treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal
Relief Complex System This formula has been designed to help keep cravings at
bay after acute withdraw has passed allowing the chemical balance in the patient‟s
brain to quickly and safely return to pre-drug use level
CCRR is a four part compound nutraceutical that addresses cravings by
bullSupplying your adrenal system with nutrients you need to feel good The
ingredients in CCRR work hard to heal your body and restore your
organs and mind
bullGiving your brain a natural boost to stave off depression and anxiety
until the chemical balance of your pre-drug healthy brain is restored
bullFlooding your body with nourishing vitamins and antioxidants that
support physical recovery as you continue to gain strength
bullEnsuring that cravings stay manageable while you create more and more
distance from the desire for more drugs
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased
energy focus attention and task performance throughout the day Researchers stated ldquoThese results
provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the
psychoactive properties of ginsengrdquo35
5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to
ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36
L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers
found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37
bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing
neurotransmitters such as epinephrine and norepinephrine
Vitamin B12
bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38
bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase
in energy stamina and well being helliprdquo38
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Restless Leg Syndrome (RLS)
RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced
by nearly everyone going through opiate withdrawal This symptom is not so much
painful as it is disruptive and highly irritating RLS causes agitation during the day
and disrupts sleep during the night This exacerbates the symptoms of insomnia and
creates further daytime agitation locking patients into a vicious cycle
RLS is thought to be caused by the depletion of the neurotransmitter dopamine in
the system Research has shown that providing nutrients to help stimulate
dopamine production can quickly and effectively decrease or eliminate the severity
of this syndrome
The following demonstrates how the nutrients in Withdrawal Relief
Complex support dopamine production in two ways by providing a
direct source of natural dopamine (through the L-dopa content of
Mucuna pruriens) and by supporting dopamine metabolism in the
body with the B-vitamin Folate
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances
levels of dopamine in the brain39
bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a
medical treatment for Parkinsons Disease40
bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly
decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41
Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid
(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and
fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid
levelsrdquo42 43
Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people
with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS
symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in
the Withdrawal Relief Complex Nighttime formula
MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for
treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal
Relief Complex System This formula has been designed to help keep cravings at
bay after acute withdraw has passed allowing the chemical balance in the patient‟s
brain to quickly and safely return to pre-drug use level
CCRR is a four part compound nutraceutical that addresses cravings by
bullSupplying your adrenal system with nutrients you need to feel good The
ingredients in CCRR work hard to heal your body and restore your
organs and mind
bullGiving your brain a natural boost to stave off depression and anxiety
until the chemical balance of your pre-drug healthy brain is restored
bullFlooding your body with nourishing vitamins and antioxidants that
support physical recovery as you continue to gain strength
bullEnsuring that cravings stay manageable while you create more and more
distance from the desire for more drugs
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Restless Leg Syndrome (RLS)
RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced
by nearly everyone going through opiate withdrawal This symptom is not so much
painful as it is disruptive and highly irritating RLS causes agitation during the day
and disrupts sleep during the night This exacerbates the symptoms of insomnia and
creates further daytime agitation locking patients into a vicious cycle
RLS is thought to be caused by the depletion of the neurotransmitter dopamine in
the system Research has shown that providing nutrients to help stimulate
dopamine production can quickly and effectively decrease or eliminate the severity
of this syndrome
The following demonstrates how the nutrients in Withdrawal Relief
Complex support dopamine production in two ways by providing a
direct source of natural dopamine (through the L-dopa content of
Mucuna pruriens) and by supporting dopamine metabolism in the
body with the B-vitamin Folate
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances
levels of dopamine in the brain39
bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a
medical treatment for Parkinsons Disease40
bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly
decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41
Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid
(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and
fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid
levelsrdquo42 43
Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people
with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS
symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in
the Withdrawal Relief Complex Nighttime formula
MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for
treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal
Relief Complex System This formula has been designed to help keep cravings at
bay after acute withdraw has passed allowing the chemical balance in the patient‟s
brain to quickly and safely return to pre-drug use level
CCRR is a four part compound nutraceutical that addresses cravings by
bullSupplying your adrenal system with nutrients you need to feel good The
ingredients in CCRR work hard to heal your body and restore your
organs and mind
bullGiving your brain a natural boost to stave off depression and anxiety
until the chemical balance of your pre-drug healthy brain is restored
bullFlooding your body with nourishing vitamins and antioxidants that
support physical recovery as you continue to gain strength
bullEnsuring that cravings stay manageable while you create more and more
distance from the desire for more drugs
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances
levels of dopamine in the brain39
bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a
medical treatment for Parkinsons Disease40
bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly
decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41
Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid
(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and
fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid
levelsrdquo42 43
Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people
with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS
symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in
the Withdrawal Relief Complex Nighttime formula
MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for
treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal
Relief Complex System This formula has been designed to help keep cravings at
bay after acute withdraw has passed allowing the chemical balance in the patient‟s
brain to quickly and safely return to pre-drug use level
CCRR is a four part compound nutraceutical that addresses cravings by
bullSupplying your adrenal system with nutrients you need to feel good The
ingredients in CCRR work hard to heal your body and restore your
organs and mind
bullGiving your brain a natural boost to stave off depression and anxiety
until the chemical balance of your pre-drug healthy brain is restored
bullFlooding your body with nourishing vitamins and antioxidants that
support physical recovery as you continue to gain strength
bullEnsuring that cravings stay manageable while you create more and more
distance from the desire for more drugs
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
Active Ingredients ndash Explanation amp Scientific Substantiation
Copyright copy 2011 Pure Health Group trade
Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal
Relief Complex System This formula has been designed to help keep cravings at
bay after acute withdraw has passed allowing the chemical balance in the patient‟s
brain to quickly and safely return to pre-drug use level
CCRR is a four part compound nutraceutical that addresses cravings by
bullSupplying your adrenal system with nutrients you need to feel good The
ingredients in CCRR work hard to heal your body and restore your
organs and mind
bullGiving your brain a natural boost to stave off depression and anxiety
until the chemical balance of your pre-drug healthy brain is restored
bullFlooding your body with nourishing vitamins and antioxidants that
support physical recovery as you continue to gain strength
bullEnsuring that cravings stay manageable while you create more and more
distance from the desire for more drugs
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment
of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001
Oct26(5)369-73
2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized
controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7
3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res
1980375-83
4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over
50 years of age Encephale 19806241-246
5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The
treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240
6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine
Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186
7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment
of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15
8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and
evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187
9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic
monamines Med Physiol 19874085-87
11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424
12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348
13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73
14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8
15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45
16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264
17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna
pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58
19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558
20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376
21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798
22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8
23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71
24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata
after oral administration Phytotherapy Research 1996 10 S92-S94
24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45
25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993
26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986
27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49
28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101
29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107
30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657
31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206
32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med
1994 1 203-206
34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884
35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11
36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189
37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459
38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20
39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101
40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade
References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs
syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009
42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223
43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246
44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8
45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5
Copyright copy 2011 Pure Health Group trade