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Copyright © 2011 Pure Health Group ™

PHG Presentation 07112011

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Citation preview

Page 1: PHG Presentation 07112011

Copyright copy 2011 Pure Health Group trade

About Pure Health Grouptrade

Copyright copy 2011 Pure Health Group trade

Pure Health Grouptrade is a science-based nutraceutical development company

founded in 2008 by John D Vox

With an alarming rise in painkiller addiction among teenagers and adults in the

United States John felt it was time offer those addicted to these powerful opioid

drugs a natural solution to help them break the bonds of drug dependency

After three years of focused research and development work the PHGtrade team is

set to launch a NEW GROUND BREAKING system of Nutraceutical and Lifestyle

support products called The Withdrawal Relief System

The Withdrawal Relief System

Copyright copy 2011 Pure Health Group trade

The Withdrawal Relief System is the most highly advanced scientific

system ever developed to help people overcome opioid dependence

without having to rely on other habit forming drugs

This system considers the whole person as they enter the withdrawal

process

The Withdrawal Relief System is a powerful all-natural system that

supports management of ALL of the most common and discomforting

mental and physical side-effects of opioid withdrawal by focusing

directly on their biological causes The system also provides

individuals with written and recorded support materials helping

to address the mental emotional and lifestyle issues that go

hand-in-hand with opioid dependence

The System Components

Copyright copy 2011 Pure Health Group trade

Withdrawal Relief Complex Nutraceuticals The system contains 3 powerful

nutraceuticals

Daytime Relief This formula is taken first thing in the morning during

acute withdrawal It has been designed to address the most disturbing

daytime withdrawal symptoms including fatigue lethargy depression GI

upset headache and more

Nighttime Relief This formula is taken before bed during acute

withdrawal It has been designed to calm the mind relax restless legs

reduce sleep latency and increase the duration of deep REM sleep

Craving Control Relapse Relief This formula is to be

taken after acute withdrawal has been successfully

negotiated This nutraceutical has been designed to

keep cravings at bay helping individuals avoid relapse

while safely supporting the recovery of vital biological

systems

The System Components (cont)

Copyright copy 2011 Pure Health Group trade

Conquering Opiate Withdrawal amp Addiction Volume 1 (eBook

download) A comprehensive book packed with information not

found in any other book on addiction and recovery This book

includes valuable insights from ex-addicts dietary advice from

leading nutritional scientists psychological support tools and much

more

CHILL Music Compilation (audio download) Prepared by a

professional DJ this one-of-a-kind mellow musical mix has been

designed to help soothe the body and mind

RELAX Audio Compilation (Free audio download) This free audio

download contains powerful guided meditations affirmations and

brain-balancing meta-music selections to support the individual‟s

successful withdrawal from opioid dependence

Pure Health Group‟strade RampD

Copyright copy 2011 Pure Health Group trade

The nutraceuticals in this breakthrough system were developed from years of

research about how opioids work within the body and brain to alter one‟s

physical emotional and mental state specifically how the withdrawal of

opioids acts to create the discomforting symptoms of acute opioid withdrawal

Understanding these causes we spent the next 24 months scouring the

scientific literature for research showing which natural nutrients could

effectively address these biological causes and alleviate withdrawal symptoms

Once the perfect nutrient blend was assessed we

focused on sourcing the purest most potent forms

of each nutrient for our formulas

Pure Health Group‟strade RampD (cont)

Copyright copy 2011 Pure Health Group trade

We understand there is a very wide range of nutrient quality in the

nutraceutical market place Therefore we enlisted the help of our

pharmaceutical manufacturing facility to source and obtain the best

standardized pharmaceutical-grade nutrients available

We then included these nutrients in the formulas in doses shown to be

efficacious in the scientific literature

Based upon the science supporting the symptom-specific efficacy of the

nutrients in our formulas and the empirical evidence we have garnered we

are highly confident that our products offer a safe and effective natural option

to assist with successful withdrawal from opioid dependence

Pure Health Group‟strade RampD (cont)

Copyright copy 2011 Pure Health Group trade

Empirical evidence suggests that those using the complete Withdrawal

Relief System are at least 50 more likely to successfully negotiate their

acute withdrawal period without relapse then those going cold turkey

We are currently in discussions with a Florida based research center

about implementing our first double-blinded placebo-controlled pilot trial

We hope to begin the study in the 4th quarter of 2011

Pure Health Group Inctrade is committed to remaining

on the forefront of opiate dependence research and

translating new discoveries into the best possible

answers and relief for those suffering from opiate

addiction Pure Health Group Inctrade supports

continuous research and development of new

nutraceutical products that will make the journey

towards freedom from opiate dependency as easy and

pain free as possible

How Does The System Work

Copyright copy 2011 Pure Health Group trade

The Withdraw Relief Complex Nutraceuticals aid in the withdrawal and

recovery process by supplying specific nutrients that naturally counter symptoms

reduce pain and send messages that calm opioid receptors in the brain

The Withdraw Relief System gives patients a distinct advantage in the battle to

be opioid free

By dramatically reducing their discomfort patients will

bullBe empowered to maintain a more normal lifestyle through the

withdrawal process

bullBe able to maintain some level of appetite and ingest

supportive foods

bullStay hydrated

bullMaintain some level of physical activity to stimulate natural

endorphins

bullFocus on the opioid-free future that is waiting for them just

around the corner

PHGtrade and Healthcare Providers

Copyright copy 2011 Pure Health Group trade

Pure Health Group Inctrade is committed to partnering with healthcare providers

to eradicate opioid dependence by using innovative science and research to

create extraordinary nutraceutical products that help minimize the pain of

withdrawal

For more information about Pure Health

Grouptrade or about how to become a licensed

distributor of our products please visit

WWWPUREHEALTHGROUPCOM

Or contact John D Vox at

jvoxpurehealthgroupcom

3039555899 ext 701

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

The following information explains exactly how the nutrients in our formulas

create relief by working with your patients body to alleviate withdrawal

symptoms

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Depression Anxiety

One of the most debilitating withdrawal symptoms patients experience is a

deep feeling of depression spiked with intermittent anxiety This depressive

state is caused in great part by a severe depletion of vital neurotransmitters

and naturally occurring opioids combined with desensitization of opioid

receptors in the brain Withdrawal Relief Complex nutraceuticals help support

the rapid return of these vital biological chemicals to healthy levels thus

decreasing the depth and length of the depressive state

Research supporting the efficacy of the natural

nutrients in Withdrawal Relief Complex Nutraceuticals

to combat depression and anxiety symptoms are as

follows

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-

blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine

showed use of this herb significantly decreased depression and anxiety associated with

withdrawal as well as if not better than Clonidine1

bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety

WITHOUT the adverse side effects of the drug2

5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP

dramatically alleviates depression3-9

bullIt does so by bolstering serotonin levels in the brain

Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10

bullSignificantly increases the biosynthesis of natural opioid peptides in the body11

bullDecrease the symptoms of depression in patients by up over 3512

L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital

neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which

indicates that it relaxes the mind without inducing drowsinessrdquo14

bullL-theanine reduces anxiety and calms nerves during stressful events15

Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the

B-vitamins or vitamin C16

bullCorrection of these deficiencies through supplementation with the proper forms and

amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in

complete resolution of mental symptoms in some individualsrdquo16

Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas

bullThis herb standardized for L-Dopa content has been found in research to have potent

anti-depressant actions17

bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Insomnia

Sleepless nights are a very common symptom of opiate withdrawal Long-

term use of opiates tends to disrupt the sleep wake cycle by disturbing

the proper production of melatonin and other sleep-inducing chemicals in

the body In order to re-establish healthy sleep cycles allowing patients to

fall asleep faster and stay asleep longer it is necessary to support the

production of natural sleep chemicals

The Withdrawal Relief Complex contains a

healthy dose of pure Melatonin and other all-

natural sleep support ingredients to help

patients sleep through the night allowing them

to obtain the rest needed to recover quickly

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall

asleep much faster and to significantly increase the amount of sleep achieved throughout the

night19 20

5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with

one study showing a 53 increase in REM sleep during the night21

ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small

doses of barbiturates or benzodiazepansrdquo22

bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23

American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects

take place within 30 minutes of ingestion and have been shown in research to help people fall

asleep faster and stay asleep longer24

Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in

prolonged sleep tests25

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Nausea amp Gastrointestinal Distress

Nausea and GI distress (including intestinal cramping and diarrhea) is one of the

most uncomfortable and disruptive physical symptoms of opiate withdrawal This

symptom generally presents 2 or 3 days after abstaining from opiates and can last

for up to a week

Opiates have a very strong sedative effect on the stomach and intestinal tract

Once opiate use is discontinued these organs become over stimulated Nerves

that have been suppressed for a long time begin to come back to life This

enhanced neural input to the smooth muscles of the stomach and GI tract can be

shocking to the system thus causing cramping and hyper-motility

which can lead to diarrhea nausea and vomiting

To treat these symptoms the Withdrawal Relief Complex

formulas include powerful ingredients that not only help to

provide natural moderate sedation to overactive GI nerves but

also help soothe the stomach

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows

gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the

prescription drug Papaverinerdquo for these uses

Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth

muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27

bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a

spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it

as a natural medicine for GI distress28

Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many

antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-

33

Vitamin B6

bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin

B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated

that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our

combined formulashellipover twice the dose of the studyhellipto ensure best results

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Extreme Fatigue amp Lethargy

The fatigue most people experience during withdrawal is profound It can be severe

enough that patients will literally not be able to get out of bed This is particularly

damaging for those needing to maintain a consistent work schedule and or care for

their family

The fatigue that comes from opiate withdrawal is both physical and mental Many

recovering opiate addicts feel a complete lack of motivation and desire to engage in

life This leads to reclusive behavior poor diet and a host of other actions that tend

to prolong withdrawal and lead to relapse

Therefore it is imperative that patients are supported

in staying energized and motivated as they negotiate

the acute phase of withdrawal

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased

energy focus attention and task performance throughout the day Researchers stated ldquoThese results

provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the

psychoactive properties of ginsengrdquo35

5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to

ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36

L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers

found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37

bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing

neurotransmitters such as epinephrine and norepinephrine

Vitamin B12

bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38

bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase

in energy stamina and well being helliprdquo38

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Restless Leg Syndrome (RLS)

RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced

by nearly everyone going through opiate withdrawal This symptom is not so much

painful as it is disruptive and highly irritating RLS causes agitation during the day

and disrupts sleep during the night This exacerbates the symptoms of insomnia and

creates further daytime agitation locking patients into a vicious cycle

RLS is thought to be caused by the depletion of the neurotransmitter dopamine in

the system Research has shown that providing nutrients to help stimulate

dopamine production can quickly and effectively decrease or eliminate the severity

of this syndrome

The following demonstrates how the nutrients in Withdrawal Relief

Complex support dopamine production in two ways by providing a

direct source of natural dopamine (through the L-dopa content of

Mucuna pruriens) and by supporting dopamine metabolism in the

body with the B-vitamin Folate

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances

levels of dopamine in the brain39

bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a

medical treatment for Parkinsons Disease40

bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly

decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41

Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid

(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and

fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid

levelsrdquo42 43

Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people

with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS

symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in

the Withdrawal Relief Complex Nighttime formula

MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for

treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal

Relief Complex System This formula has been designed to help keep cravings at

bay after acute withdraw has passed allowing the chemical balance in the patient‟s

brain to quickly and safely return to pre-drug use level

CCRR is a four part compound nutraceutical that addresses cravings by

bullSupplying your adrenal system with nutrients you need to feel good The

ingredients in CCRR work hard to heal your body and restore your

organs and mind

bullGiving your brain a natural boost to stave off depression and anxiety

until the chemical balance of your pre-drug healthy brain is restored

bullFlooding your body with nourishing vitamins and antioxidants that

support physical recovery as you continue to gain strength

bullEnsuring that cravings stay manageable while you create more and more

distance from the desire for more drugs

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 2: PHG Presentation 07112011

About Pure Health Grouptrade

Copyright copy 2011 Pure Health Group trade

Pure Health Grouptrade is a science-based nutraceutical development company

founded in 2008 by John D Vox

With an alarming rise in painkiller addiction among teenagers and adults in the

United States John felt it was time offer those addicted to these powerful opioid

drugs a natural solution to help them break the bonds of drug dependency

After three years of focused research and development work the PHGtrade team is

set to launch a NEW GROUND BREAKING system of Nutraceutical and Lifestyle

support products called The Withdrawal Relief System

The Withdrawal Relief System

Copyright copy 2011 Pure Health Group trade

The Withdrawal Relief System is the most highly advanced scientific

system ever developed to help people overcome opioid dependence

without having to rely on other habit forming drugs

This system considers the whole person as they enter the withdrawal

process

The Withdrawal Relief System is a powerful all-natural system that

supports management of ALL of the most common and discomforting

mental and physical side-effects of opioid withdrawal by focusing

directly on their biological causes The system also provides

individuals with written and recorded support materials helping

to address the mental emotional and lifestyle issues that go

hand-in-hand with opioid dependence

The System Components

Copyright copy 2011 Pure Health Group trade

Withdrawal Relief Complex Nutraceuticals The system contains 3 powerful

nutraceuticals

Daytime Relief This formula is taken first thing in the morning during

acute withdrawal It has been designed to address the most disturbing

daytime withdrawal symptoms including fatigue lethargy depression GI

upset headache and more

Nighttime Relief This formula is taken before bed during acute

withdrawal It has been designed to calm the mind relax restless legs

reduce sleep latency and increase the duration of deep REM sleep

Craving Control Relapse Relief This formula is to be

taken after acute withdrawal has been successfully

negotiated This nutraceutical has been designed to

keep cravings at bay helping individuals avoid relapse

while safely supporting the recovery of vital biological

systems

The System Components (cont)

Copyright copy 2011 Pure Health Group trade

Conquering Opiate Withdrawal amp Addiction Volume 1 (eBook

download) A comprehensive book packed with information not

found in any other book on addiction and recovery This book

includes valuable insights from ex-addicts dietary advice from

leading nutritional scientists psychological support tools and much

more

CHILL Music Compilation (audio download) Prepared by a

professional DJ this one-of-a-kind mellow musical mix has been

designed to help soothe the body and mind

RELAX Audio Compilation (Free audio download) This free audio

download contains powerful guided meditations affirmations and

brain-balancing meta-music selections to support the individual‟s

successful withdrawal from opioid dependence

Pure Health Group‟strade RampD

Copyright copy 2011 Pure Health Group trade

The nutraceuticals in this breakthrough system were developed from years of

research about how opioids work within the body and brain to alter one‟s

physical emotional and mental state specifically how the withdrawal of

opioids acts to create the discomforting symptoms of acute opioid withdrawal

Understanding these causes we spent the next 24 months scouring the

scientific literature for research showing which natural nutrients could

effectively address these biological causes and alleviate withdrawal symptoms

Once the perfect nutrient blend was assessed we

focused on sourcing the purest most potent forms

of each nutrient for our formulas

Pure Health Group‟strade RampD (cont)

Copyright copy 2011 Pure Health Group trade

We understand there is a very wide range of nutrient quality in the

nutraceutical market place Therefore we enlisted the help of our

pharmaceutical manufacturing facility to source and obtain the best

standardized pharmaceutical-grade nutrients available

We then included these nutrients in the formulas in doses shown to be

efficacious in the scientific literature

Based upon the science supporting the symptom-specific efficacy of the

nutrients in our formulas and the empirical evidence we have garnered we

are highly confident that our products offer a safe and effective natural option

to assist with successful withdrawal from opioid dependence

Pure Health Group‟strade RampD (cont)

Copyright copy 2011 Pure Health Group trade

Empirical evidence suggests that those using the complete Withdrawal

Relief System are at least 50 more likely to successfully negotiate their

acute withdrawal period without relapse then those going cold turkey

We are currently in discussions with a Florida based research center

about implementing our first double-blinded placebo-controlled pilot trial

We hope to begin the study in the 4th quarter of 2011

Pure Health Group Inctrade is committed to remaining

on the forefront of opiate dependence research and

translating new discoveries into the best possible

answers and relief for those suffering from opiate

addiction Pure Health Group Inctrade supports

continuous research and development of new

nutraceutical products that will make the journey

towards freedom from opiate dependency as easy and

pain free as possible

How Does The System Work

Copyright copy 2011 Pure Health Group trade

The Withdraw Relief Complex Nutraceuticals aid in the withdrawal and

recovery process by supplying specific nutrients that naturally counter symptoms

reduce pain and send messages that calm opioid receptors in the brain

The Withdraw Relief System gives patients a distinct advantage in the battle to

be opioid free

By dramatically reducing their discomfort patients will

bullBe empowered to maintain a more normal lifestyle through the

withdrawal process

bullBe able to maintain some level of appetite and ingest

supportive foods

bullStay hydrated

bullMaintain some level of physical activity to stimulate natural

endorphins

bullFocus on the opioid-free future that is waiting for them just

around the corner

PHGtrade and Healthcare Providers

Copyright copy 2011 Pure Health Group trade

Pure Health Group Inctrade is committed to partnering with healthcare providers

to eradicate opioid dependence by using innovative science and research to

create extraordinary nutraceutical products that help minimize the pain of

withdrawal

For more information about Pure Health

Grouptrade or about how to become a licensed

distributor of our products please visit

WWWPUREHEALTHGROUPCOM

Or contact John D Vox at

jvoxpurehealthgroupcom

3039555899 ext 701

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

The following information explains exactly how the nutrients in our formulas

create relief by working with your patients body to alleviate withdrawal

symptoms

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Depression Anxiety

One of the most debilitating withdrawal symptoms patients experience is a

deep feeling of depression spiked with intermittent anxiety This depressive

state is caused in great part by a severe depletion of vital neurotransmitters

and naturally occurring opioids combined with desensitization of opioid

receptors in the brain Withdrawal Relief Complex nutraceuticals help support

the rapid return of these vital biological chemicals to healthy levels thus

decreasing the depth and length of the depressive state

Research supporting the efficacy of the natural

nutrients in Withdrawal Relief Complex Nutraceuticals

to combat depression and anxiety symptoms are as

follows

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-

blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine

showed use of this herb significantly decreased depression and anxiety associated with

withdrawal as well as if not better than Clonidine1

bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety

WITHOUT the adverse side effects of the drug2

5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP

dramatically alleviates depression3-9

bullIt does so by bolstering serotonin levels in the brain

Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10

bullSignificantly increases the biosynthesis of natural opioid peptides in the body11

bullDecrease the symptoms of depression in patients by up over 3512

L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital

neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which

indicates that it relaxes the mind without inducing drowsinessrdquo14

bullL-theanine reduces anxiety and calms nerves during stressful events15

Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the

B-vitamins or vitamin C16

bullCorrection of these deficiencies through supplementation with the proper forms and

amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in

complete resolution of mental symptoms in some individualsrdquo16

Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas

bullThis herb standardized for L-Dopa content has been found in research to have potent

anti-depressant actions17

bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Insomnia

Sleepless nights are a very common symptom of opiate withdrawal Long-

term use of opiates tends to disrupt the sleep wake cycle by disturbing

the proper production of melatonin and other sleep-inducing chemicals in

the body In order to re-establish healthy sleep cycles allowing patients to

fall asleep faster and stay asleep longer it is necessary to support the

production of natural sleep chemicals

The Withdrawal Relief Complex contains a

healthy dose of pure Melatonin and other all-

natural sleep support ingredients to help

patients sleep through the night allowing them

to obtain the rest needed to recover quickly

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall

asleep much faster and to significantly increase the amount of sleep achieved throughout the

night19 20

5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with

one study showing a 53 increase in REM sleep during the night21

ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small

doses of barbiturates or benzodiazepansrdquo22

bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23

American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects

take place within 30 minutes of ingestion and have been shown in research to help people fall

asleep faster and stay asleep longer24

Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in

prolonged sleep tests25

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Nausea amp Gastrointestinal Distress

Nausea and GI distress (including intestinal cramping and diarrhea) is one of the

most uncomfortable and disruptive physical symptoms of opiate withdrawal This

symptom generally presents 2 or 3 days after abstaining from opiates and can last

for up to a week

Opiates have a very strong sedative effect on the stomach and intestinal tract

Once opiate use is discontinued these organs become over stimulated Nerves

that have been suppressed for a long time begin to come back to life This

enhanced neural input to the smooth muscles of the stomach and GI tract can be

shocking to the system thus causing cramping and hyper-motility

which can lead to diarrhea nausea and vomiting

To treat these symptoms the Withdrawal Relief Complex

formulas include powerful ingredients that not only help to

provide natural moderate sedation to overactive GI nerves but

also help soothe the stomach

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows

gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the

prescription drug Papaverinerdquo for these uses

Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth

muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27

bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a

spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it

as a natural medicine for GI distress28

Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many

antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-

33

Vitamin B6

bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin

B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated

that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our

combined formulashellipover twice the dose of the studyhellipto ensure best results

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Extreme Fatigue amp Lethargy

The fatigue most people experience during withdrawal is profound It can be severe

enough that patients will literally not be able to get out of bed This is particularly

damaging for those needing to maintain a consistent work schedule and or care for

their family

The fatigue that comes from opiate withdrawal is both physical and mental Many

recovering opiate addicts feel a complete lack of motivation and desire to engage in

life This leads to reclusive behavior poor diet and a host of other actions that tend

to prolong withdrawal and lead to relapse

Therefore it is imperative that patients are supported

in staying energized and motivated as they negotiate

the acute phase of withdrawal

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased

energy focus attention and task performance throughout the day Researchers stated ldquoThese results

provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the

psychoactive properties of ginsengrdquo35

5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to

ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36

L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers

found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37

bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing

neurotransmitters such as epinephrine and norepinephrine

Vitamin B12

bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38

bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase

in energy stamina and well being helliprdquo38

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Restless Leg Syndrome (RLS)

RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced

by nearly everyone going through opiate withdrawal This symptom is not so much

painful as it is disruptive and highly irritating RLS causes agitation during the day

and disrupts sleep during the night This exacerbates the symptoms of insomnia and

creates further daytime agitation locking patients into a vicious cycle

RLS is thought to be caused by the depletion of the neurotransmitter dopamine in

the system Research has shown that providing nutrients to help stimulate

dopamine production can quickly and effectively decrease or eliminate the severity

of this syndrome

The following demonstrates how the nutrients in Withdrawal Relief

Complex support dopamine production in two ways by providing a

direct source of natural dopamine (through the L-dopa content of

Mucuna pruriens) and by supporting dopamine metabolism in the

body with the B-vitamin Folate

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances

levels of dopamine in the brain39

bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a

medical treatment for Parkinsons Disease40

bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly

decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41

Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid

(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and

fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid

levelsrdquo42 43

Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people

with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS

symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in

the Withdrawal Relief Complex Nighttime formula

MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for

treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal

Relief Complex System This formula has been designed to help keep cravings at

bay after acute withdraw has passed allowing the chemical balance in the patient‟s

brain to quickly and safely return to pre-drug use level

CCRR is a four part compound nutraceutical that addresses cravings by

bullSupplying your adrenal system with nutrients you need to feel good The

ingredients in CCRR work hard to heal your body and restore your

organs and mind

bullGiving your brain a natural boost to stave off depression and anxiety

until the chemical balance of your pre-drug healthy brain is restored

bullFlooding your body with nourishing vitamins and antioxidants that

support physical recovery as you continue to gain strength

bullEnsuring that cravings stay manageable while you create more and more

distance from the desire for more drugs

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 3: PHG Presentation 07112011

The Withdrawal Relief System

Copyright copy 2011 Pure Health Group trade

The Withdrawal Relief System is the most highly advanced scientific

system ever developed to help people overcome opioid dependence

without having to rely on other habit forming drugs

This system considers the whole person as they enter the withdrawal

process

The Withdrawal Relief System is a powerful all-natural system that

supports management of ALL of the most common and discomforting

mental and physical side-effects of opioid withdrawal by focusing

directly on their biological causes The system also provides

individuals with written and recorded support materials helping

to address the mental emotional and lifestyle issues that go

hand-in-hand with opioid dependence

The System Components

Copyright copy 2011 Pure Health Group trade

Withdrawal Relief Complex Nutraceuticals The system contains 3 powerful

nutraceuticals

Daytime Relief This formula is taken first thing in the morning during

acute withdrawal It has been designed to address the most disturbing

daytime withdrawal symptoms including fatigue lethargy depression GI

upset headache and more

Nighttime Relief This formula is taken before bed during acute

withdrawal It has been designed to calm the mind relax restless legs

reduce sleep latency and increase the duration of deep REM sleep

Craving Control Relapse Relief This formula is to be

taken after acute withdrawal has been successfully

negotiated This nutraceutical has been designed to

keep cravings at bay helping individuals avoid relapse

while safely supporting the recovery of vital biological

systems

The System Components (cont)

Copyright copy 2011 Pure Health Group trade

Conquering Opiate Withdrawal amp Addiction Volume 1 (eBook

download) A comprehensive book packed with information not

found in any other book on addiction and recovery This book

includes valuable insights from ex-addicts dietary advice from

leading nutritional scientists psychological support tools and much

more

CHILL Music Compilation (audio download) Prepared by a

professional DJ this one-of-a-kind mellow musical mix has been

designed to help soothe the body and mind

RELAX Audio Compilation (Free audio download) This free audio

download contains powerful guided meditations affirmations and

brain-balancing meta-music selections to support the individual‟s

successful withdrawal from opioid dependence

Pure Health Group‟strade RampD

Copyright copy 2011 Pure Health Group trade

The nutraceuticals in this breakthrough system were developed from years of

research about how opioids work within the body and brain to alter one‟s

physical emotional and mental state specifically how the withdrawal of

opioids acts to create the discomforting symptoms of acute opioid withdrawal

Understanding these causes we spent the next 24 months scouring the

scientific literature for research showing which natural nutrients could

effectively address these biological causes and alleviate withdrawal symptoms

Once the perfect nutrient blend was assessed we

focused on sourcing the purest most potent forms

of each nutrient for our formulas

Pure Health Group‟strade RampD (cont)

Copyright copy 2011 Pure Health Group trade

We understand there is a very wide range of nutrient quality in the

nutraceutical market place Therefore we enlisted the help of our

pharmaceutical manufacturing facility to source and obtain the best

standardized pharmaceutical-grade nutrients available

We then included these nutrients in the formulas in doses shown to be

efficacious in the scientific literature

Based upon the science supporting the symptom-specific efficacy of the

nutrients in our formulas and the empirical evidence we have garnered we

are highly confident that our products offer a safe and effective natural option

to assist with successful withdrawal from opioid dependence

Pure Health Group‟strade RampD (cont)

Copyright copy 2011 Pure Health Group trade

Empirical evidence suggests that those using the complete Withdrawal

Relief System are at least 50 more likely to successfully negotiate their

acute withdrawal period without relapse then those going cold turkey

We are currently in discussions with a Florida based research center

about implementing our first double-blinded placebo-controlled pilot trial

We hope to begin the study in the 4th quarter of 2011

Pure Health Group Inctrade is committed to remaining

on the forefront of opiate dependence research and

translating new discoveries into the best possible

answers and relief for those suffering from opiate

addiction Pure Health Group Inctrade supports

continuous research and development of new

nutraceutical products that will make the journey

towards freedom from opiate dependency as easy and

pain free as possible

How Does The System Work

Copyright copy 2011 Pure Health Group trade

The Withdraw Relief Complex Nutraceuticals aid in the withdrawal and

recovery process by supplying specific nutrients that naturally counter symptoms

reduce pain and send messages that calm opioid receptors in the brain

The Withdraw Relief System gives patients a distinct advantage in the battle to

be opioid free

By dramatically reducing their discomfort patients will

bullBe empowered to maintain a more normal lifestyle through the

withdrawal process

bullBe able to maintain some level of appetite and ingest

supportive foods

bullStay hydrated

bullMaintain some level of physical activity to stimulate natural

endorphins

bullFocus on the opioid-free future that is waiting for them just

around the corner

PHGtrade and Healthcare Providers

Copyright copy 2011 Pure Health Group trade

Pure Health Group Inctrade is committed to partnering with healthcare providers

to eradicate opioid dependence by using innovative science and research to

create extraordinary nutraceutical products that help minimize the pain of

withdrawal

For more information about Pure Health

Grouptrade or about how to become a licensed

distributor of our products please visit

WWWPUREHEALTHGROUPCOM

Or contact John D Vox at

jvoxpurehealthgroupcom

3039555899 ext 701

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

The following information explains exactly how the nutrients in our formulas

create relief by working with your patients body to alleviate withdrawal

symptoms

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Depression Anxiety

One of the most debilitating withdrawal symptoms patients experience is a

deep feeling of depression spiked with intermittent anxiety This depressive

state is caused in great part by a severe depletion of vital neurotransmitters

and naturally occurring opioids combined with desensitization of opioid

receptors in the brain Withdrawal Relief Complex nutraceuticals help support

the rapid return of these vital biological chemicals to healthy levels thus

decreasing the depth and length of the depressive state

Research supporting the efficacy of the natural

nutrients in Withdrawal Relief Complex Nutraceuticals

to combat depression and anxiety symptoms are as

follows

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-

blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine

showed use of this herb significantly decreased depression and anxiety associated with

withdrawal as well as if not better than Clonidine1

bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety

WITHOUT the adverse side effects of the drug2

5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP

dramatically alleviates depression3-9

bullIt does so by bolstering serotonin levels in the brain

Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10

bullSignificantly increases the biosynthesis of natural opioid peptides in the body11

bullDecrease the symptoms of depression in patients by up over 3512

L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital

neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which

indicates that it relaxes the mind without inducing drowsinessrdquo14

bullL-theanine reduces anxiety and calms nerves during stressful events15

Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the

B-vitamins or vitamin C16

bullCorrection of these deficiencies through supplementation with the proper forms and

amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in

complete resolution of mental symptoms in some individualsrdquo16

Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas

bullThis herb standardized for L-Dopa content has been found in research to have potent

anti-depressant actions17

bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Insomnia

Sleepless nights are a very common symptom of opiate withdrawal Long-

term use of opiates tends to disrupt the sleep wake cycle by disturbing

the proper production of melatonin and other sleep-inducing chemicals in

the body In order to re-establish healthy sleep cycles allowing patients to

fall asleep faster and stay asleep longer it is necessary to support the

production of natural sleep chemicals

The Withdrawal Relief Complex contains a

healthy dose of pure Melatonin and other all-

natural sleep support ingredients to help

patients sleep through the night allowing them

to obtain the rest needed to recover quickly

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall

asleep much faster and to significantly increase the amount of sleep achieved throughout the

night19 20

5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with

one study showing a 53 increase in REM sleep during the night21

ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small

doses of barbiturates or benzodiazepansrdquo22

bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23

American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects

take place within 30 minutes of ingestion and have been shown in research to help people fall

asleep faster and stay asleep longer24

Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in

prolonged sleep tests25

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Nausea amp Gastrointestinal Distress

Nausea and GI distress (including intestinal cramping and diarrhea) is one of the

most uncomfortable and disruptive physical symptoms of opiate withdrawal This

symptom generally presents 2 or 3 days after abstaining from opiates and can last

for up to a week

Opiates have a very strong sedative effect on the stomach and intestinal tract

Once opiate use is discontinued these organs become over stimulated Nerves

that have been suppressed for a long time begin to come back to life This

enhanced neural input to the smooth muscles of the stomach and GI tract can be

shocking to the system thus causing cramping and hyper-motility

which can lead to diarrhea nausea and vomiting

To treat these symptoms the Withdrawal Relief Complex

formulas include powerful ingredients that not only help to

provide natural moderate sedation to overactive GI nerves but

also help soothe the stomach

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows

gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the

prescription drug Papaverinerdquo for these uses

Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth

muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27

bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a

spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it

as a natural medicine for GI distress28

Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many

antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-

33

Vitamin B6

bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin

B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated

that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our

combined formulashellipover twice the dose of the studyhellipto ensure best results

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Extreme Fatigue amp Lethargy

The fatigue most people experience during withdrawal is profound It can be severe

enough that patients will literally not be able to get out of bed This is particularly

damaging for those needing to maintain a consistent work schedule and or care for

their family

The fatigue that comes from opiate withdrawal is both physical and mental Many

recovering opiate addicts feel a complete lack of motivation and desire to engage in

life This leads to reclusive behavior poor diet and a host of other actions that tend

to prolong withdrawal and lead to relapse

Therefore it is imperative that patients are supported

in staying energized and motivated as they negotiate

the acute phase of withdrawal

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased

energy focus attention and task performance throughout the day Researchers stated ldquoThese results

provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the

psychoactive properties of ginsengrdquo35

5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to

ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36

L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers

found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37

bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing

neurotransmitters such as epinephrine and norepinephrine

Vitamin B12

bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38

bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase

in energy stamina and well being helliprdquo38

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Restless Leg Syndrome (RLS)

RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced

by nearly everyone going through opiate withdrawal This symptom is not so much

painful as it is disruptive and highly irritating RLS causes agitation during the day

and disrupts sleep during the night This exacerbates the symptoms of insomnia and

creates further daytime agitation locking patients into a vicious cycle

RLS is thought to be caused by the depletion of the neurotransmitter dopamine in

the system Research has shown that providing nutrients to help stimulate

dopamine production can quickly and effectively decrease or eliminate the severity

of this syndrome

The following demonstrates how the nutrients in Withdrawal Relief

Complex support dopamine production in two ways by providing a

direct source of natural dopamine (through the L-dopa content of

Mucuna pruriens) and by supporting dopamine metabolism in the

body with the B-vitamin Folate

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances

levels of dopamine in the brain39

bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a

medical treatment for Parkinsons Disease40

bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly

decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41

Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid

(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and

fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid

levelsrdquo42 43

Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people

with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS

symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in

the Withdrawal Relief Complex Nighttime formula

MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for

treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal

Relief Complex System This formula has been designed to help keep cravings at

bay after acute withdraw has passed allowing the chemical balance in the patient‟s

brain to quickly and safely return to pre-drug use level

CCRR is a four part compound nutraceutical that addresses cravings by

bullSupplying your adrenal system with nutrients you need to feel good The

ingredients in CCRR work hard to heal your body and restore your

organs and mind

bullGiving your brain a natural boost to stave off depression and anxiety

until the chemical balance of your pre-drug healthy brain is restored

bullFlooding your body with nourishing vitamins and antioxidants that

support physical recovery as you continue to gain strength

bullEnsuring that cravings stay manageable while you create more and more

distance from the desire for more drugs

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 4: PHG Presentation 07112011

The System Components

Copyright copy 2011 Pure Health Group trade

Withdrawal Relief Complex Nutraceuticals The system contains 3 powerful

nutraceuticals

Daytime Relief This formula is taken first thing in the morning during

acute withdrawal It has been designed to address the most disturbing

daytime withdrawal symptoms including fatigue lethargy depression GI

upset headache and more

Nighttime Relief This formula is taken before bed during acute

withdrawal It has been designed to calm the mind relax restless legs

reduce sleep latency and increase the duration of deep REM sleep

Craving Control Relapse Relief This formula is to be

taken after acute withdrawal has been successfully

negotiated This nutraceutical has been designed to

keep cravings at bay helping individuals avoid relapse

while safely supporting the recovery of vital biological

systems

The System Components (cont)

Copyright copy 2011 Pure Health Group trade

Conquering Opiate Withdrawal amp Addiction Volume 1 (eBook

download) A comprehensive book packed with information not

found in any other book on addiction and recovery This book

includes valuable insights from ex-addicts dietary advice from

leading nutritional scientists psychological support tools and much

more

CHILL Music Compilation (audio download) Prepared by a

professional DJ this one-of-a-kind mellow musical mix has been

designed to help soothe the body and mind

RELAX Audio Compilation (Free audio download) This free audio

download contains powerful guided meditations affirmations and

brain-balancing meta-music selections to support the individual‟s

successful withdrawal from opioid dependence

Pure Health Group‟strade RampD

Copyright copy 2011 Pure Health Group trade

The nutraceuticals in this breakthrough system were developed from years of

research about how opioids work within the body and brain to alter one‟s

physical emotional and mental state specifically how the withdrawal of

opioids acts to create the discomforting symptoms of acute opioid withdrawal

Understanding these causes we spent the next 24 months scouring the

scientific literature for research showing which natural nutrients could

effectively address these biological causes and alleviate withdrawal symptoms

Once the perfect nutrient blend was assessed we

focused on sourcing the purest most potent forms

of each nutrient for our formulas

Pure Health Group‟strade RampD (cont)

Copyright copy 2011 Pure Health Group trade

We understand there is a very wide range of nutrient quality in the

nutraceutical market place Therefore we enlisted the help of our

pharmaceutical manufacturing facility to source and obtain the best

standardized pharmaceutical-grade nutrients available

We then included these nutrients in the formulas in doses shown to be

efficacious in the scientific literature

Based upon the science supporting the symptom-specific efficacy of the

nutrients in our formulas and the empirical evidence we have garnered we

are highly confident that our products offer a safe and effective natural option

to assist with successful withdrawal from opioid dependence

Pure Health Group‟strade RampD (cont)

Copyright copy 2011 Pure Health Group trade

Empirical evidence suggests that those using the complete Withdrawal

Relief System are at least 50 more likely to successfully negotiate their

acute withdrawal period without relapse then those going cold turkey

We are currently in discussions with a Florida based research center

about implementing our first double-blinded placebo-controlled pilot trial

We hope to begin the study in the 4th quarter of 2011

Pure Health Group Inctrade is committed to remaining

on the forefront of opiate dependence research and

translating new discoveries into the best possible

answers and relief for those suffering from opiate

addiction Pure Health Group Inctrade supports

continuous research and development of new

nutraceutical products that will make the journey

towards freedom from opiate dependency as easy and

pain free as possible

How Does The System Work

Copyright copy 2011 Pure Health Group trade

The Withdraw Relief Complex Nutraceuticals aid in the withdrawal and

recovery process by supplying specific nutrients that naturally counter symptoms

reduce pain and send messages that calm opioid receptors in the brain

The Withdraw Relief System gives patients a distinct advantage in the battle to

be opioid free

By dramatically reducing their discomfort patients will

bullBe empowered to maintain a more normal lifestyle through the

withdrawal process

bullBe able to maintain some level of appetite and ingest

supportive foods

bullStay hydrated

bullMaintain some level of physical activity to stimulate natural

endorphins

bullFocus on the opioid-free future that is waiting for them just

around the corner

PHGtrade and Healthcare Providers

Copyright copy 2011 Pure Health Group trade

Pure Health Group Inctrade is committed to partnering with healthcare providers

to eradicate opioid dependence by using innovative science and research to

create extraordinary nutraceutical products that help minimize the pain of

withdrawal

For more information about Pure Health

Grouptrade or about how to become a licensed

distributor of our products please visit

WWWPUREHEALTHGROUPCOM

Or contact John D Vox at

jvoxpurehealthgroupcom

3039555899 ext 701

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

The following information explains exactly how the nutrients in our formulas

create relief by working with your patients body to alleviate withdrawal

symptoms

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Depression Anxiety

One of the most debilitating withdrawal symptoms patients experience is a

deep feeling of depression spiked with intermittent anxiety This depressive

state is caused in great part by a severe depletion of vital neurotransmitters

and naturally occurring opioids combined with desensitization of opioid

receptors in the brain Withdrawal Relief Complex nutraceuticals help support

the rapid return of these vital biological chemicals to healthy levels thus

decreasing the depth and length of the depressive state

Research supporting the efficacy of the natural

nutrients in Withdrawal Relief Complex Nutraceuticals

to combat depression and anxiety symptoms are as

follows

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-

blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine

showed use of this herb significantly decreased depression and anxiety associated with

withdrawal as well as if not better than Clonidine1

bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety

WITHOUT the adverse side effects of the drug2

5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP

dramatically alleviates depression3-9

bullIt does so by bolstering serotonin levels in the brain

Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10

bullSignificantly increases the biosynthesis of natural opioid peptides in the body11

bullDecrease the symptoms of depression in patients by up over 3512

L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital

neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which

indicates that it relaxes the mind without inducing drowsinessrdquo14

bullL-theanine reduces anxiety and calms nerves during stressful events15

Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the

B-vitamins or vitamin C16

bullCorrection of these deficiencies through supplementation with the proper forms and

amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in

complete resolution of mental symptoms in some individualsrdquo16

Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas

bullThis herb standardized for L-Dopa content has been found in research to have potent

anti-depressant actions17

bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Insomnia

Sleepless nights are a very common symptom of opiate withdrawal Long-

term use of opiates tends to disrupt the sleep wake cycle by disturbing

the proper production of melatonin and other sleep-inducing chemicals in

the body In order to re-establish healthy sleep cycles allowing patients to

fall asleep faster and stay asleep longer it is necessary to support the

production of natural sleep chemicals

The Withdrawal Relief Complex contains a

healthy dose of pure Melatonin and other all-

natural sleep support ingredients to help

patients sleep through the night allowing them

to obtain the rest needed to recover quickly

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall

asleep much faster and to significantly increase the amount of sleep achieved throughout the

night19 20

5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with

one study showing a 53 increase in REM sleep during the night21

ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small

doses of barbiturates or benzodiazepansrdquo22

bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23

American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects

take place within 30 minutes of ingestion and have been shown in research to help people fall

asleep faster and stay asleep longer24

Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in

prolonged sleep tests25

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Nausea amp Gastrointestinal Distress

Nausea and GI distress (including intestinal cramping and diarrhea) is one of the

most uncomfortable and disruptive physical symptoms of opiate withdrawal This

symptom generally presents 2 or 3 days after abstaining from opiates and can last

for up to a week

Opiates have a very strong sedative effect on the stomach and intestinal tract

Once opiate use is discontinued these organs become over stimulated Nerves

that have been suppressed for a long time begin to come back to life This

enhanced neural input to the smooth muscles of the stomach and GI tract can be

shocking to the system thus causing cramping and hyper-motility

which can lead to diarrhea nausea and vomiting

To treat these symptoms the Withdrawal Relief Complex

formulas include powerful ingredients that not only help to

provide natural moderate sedation to overactive GI nerves but

also help soothe the stomach

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows

gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the

prescription drug Papaverinerdquo for these uses

Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth

muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27

bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a

spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it

as a natural medicine for GI distress28

Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many

antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-

33

Vitamin B6

bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin

B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated

that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our

combined formulashellipover twice the dose of the studyhellipto ensure best results

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Extreme Fatigue amp Lethargy

The fatigue most people experience during withdrawal is profound It can be severe

enough that patients will literally not be able to get out of bed This is particularly

damaging for those needing to maintain a consistent work schedule and or care for

their family

The fatigue that comes from opiate withdrawal is both physical and mental Many

recovering opiate addicts feel a complete lack of motivation and desire to engage in

life This leads to reclusive behavior poor diet and a host of other actions that tend

to prolong withdrawal and lead to relapse

Therefore it is imperative that patients are supported

in staying energized and motivated as they negotiate

the acute phase of withdrawal

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased

energy focus attention and task performance throughout the day Researchers stated ldquoThese results

provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the

psychoactive properties of ginsengrdquo35

5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to

ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36

L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers

found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37

bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing

neurotransmitters such as epinephrine and norepinephrine

Vitamin B12

bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38

bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase

in energy stamina and well being helliprdquo38

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Restless Leg Syndrome (RLS)

RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced

by nearly everyone going through opiate withdrawal This symptom is not so much

painful as it is disruptive and highly irritating RLS causes agitation during the day

and disrupts sleep during the night This exacerbates the symptoms of insomnia and

creates further daytime agitation locking patients into a vicious cycle

RLS is thought to be caused by the depletion of the neurotransmitter dopamine in

the system Research has shown that providing nutrients to help stimulate

dopamine production can quickly and effectively decrease or eliminate the severity

of this syndrome

The following demonstrates how the nutrients in Withdrawal Relief

Complex support dopamine production in two ways by providing a

direct source of natural dopamine (through the L-dopa content of

Mucuna pruriens) and by supporting dopamine metabolism in the

body with the B-vitamin Folate

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances

levels of dopamine in the brain39

bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a

medical treatment for Parkinsons Disease40

bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly

decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41

Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid

(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and

fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid

levelsrdquo42 43

Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people

with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS

symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in

the Withdrawal Relief Complex Nighttime formula

MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for

treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal

Relief Complex System This formula has been designed to help keep cravings at

bay after acute withdraw has passed allowing the chemical balance in the patient‟s

brain to quickly and safely return to pre-drug use level

CCRR is a four part compound nutraceutical that addresses cravings by

bullSupplying your adrenal system with nutrients you need to feel good The

ingredients in CCRR work hard to heal your body and restore your

organs and mind

bullGiving your brain a natural boost to stave off depression and anxiety

until the chemical balance of your pre-drug healthy brain is restored

bullFlooding your body with nourishing vitamins and antioxidants that

support physical recovery as you continue to gain strength

bullEnsuring that cravings stay manageable while you create more and more

distance from the desire for more drugs

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 5: PHG Presentation 07112011

The System Components (cont)

Copyright copy 2011 Pure Health Group trade

Conquering Opiate Withdrawal amp Addiction Volume 1 (eBook

download) A comprehensive book packed with information not

found in any other book on addiction and recovery This book

includes valuable insights from ex-addicts dietary advice from

leading nutritional scientists psychological support tools and much

more

CHILL Music Compilation (audio download) Prepared by a

professional DJ this one-of-a-kind mellow musical mix has been

designed to help soothe the body and mind

RELAX Audio Compilation (Free audio download) This free audio

download contains powerful guided meditations affirmations and

brain-balancing meta-music selections to support the individual‟s

successful withdrawal from opioid dependence

Pure Health Group‟strade RampD

Copyright copy 2011 Pure Health Group trade

The nutraceuticals in this breakthrough system were developed from years of

research about how opioids work within the body and brain to alter one‟s

physical emotional and mental state specifically how the withdrawal of

opioids acts to create the discomforting symptoms of acute opioid withdrawal

Understanding these causes we spent the next 24 months scouring the

scientific literature for research showing which natural nutrients could

effectively address these biological causes and alleviate withdrawal symptoms

Once the perfect nutrient blend was assessed we

focused on sourcing the purest most potent forms

of each nutrient for our formulas

Pure Health Group‟strade RampD (cont)

Copyright copy 2011 Pure Health Group trade

We understand there is a very wide range of nutrient quality in the

nutraceutical market place Therefore we enlisted the help of our

pharmaceutical manufacturing facility to source and obtain the best

standardized pharmaceutical-grade nutrients available

We then included these nutrients in the formulas in doses shown to be

efficacious in the scientific literature

Based upon the science supporting the symptom-specific efficacy of the

nutrients in our formulas and the empirical evidence we have garnered we

are highly confident that our products offer a safe and effective natural option

to assist with successful withdrawal from opioid dependence

Pure Health Group‟strade RampD (cont)

Copyright copy 2011 Pure Health Group trade

Empirical evidence suggests that those using the complete Withdrawal

Relief System are at least 50 more likely to successfully negotiate their

acute withdrawal period without relapse then those going cold turkey

We are currently in discussions with a Florida based research center

about implementing our first double-blinded placebo-controlled pilot trial

We hope to begin the study in the 4th quarter of 2011

Pure Health Group Inctrade is committed to remaining

on the forefront of opiate dependence research and

translating new discoveries into the best possible

answers and relief for those suffering from opiate

addiction Pure Health Group Inctrade supports

continuous research and development of new

nutraceutical products that will make the journey

towards freedom from opiate dependency as easy and

pain free as possible

How Does The System Work

Copyright copy 2011 Pure Health Group trade

The Withdraw Relief Complex Nutraceuticals aid in the withdrawal and

recovery process by supplying specific nutrients that naturally counter symptoms

reduce pain and send messages that calm opioid receptors in the brain

The Withdraw Relief System gives patients a distinct advantage in the battle to

be opioid free

By dramatically reducing their discomfort patients will

bullBe empowered to maintain a more normal lifestyle through the

withdrawal process

bullBe able to maintain some level of appetite and ingest

supportive foods

bullStay hydrated

bullMaintain some level of physical activity to stimulate natural

endorphins

bullFocus on the opioid-free future that is waiting for them just

around the corner

PHGtrade and Healthcare Providers

Copyright copy 2011 Pure Health Group trade

Pure Health Group Inctrade is committed to partnering with healthcare providers

to eradicate opioid dependence by using innovative science and research to

create extraordinary nutraceutical products that help minimize the pain of

withdrawal

For more information about Pure Health

Grouptrade or about how to become a licensed

distributor of our products please visit

WWWPUREHEALTHGROUPCOM

Or contact John D Vox at

jvoxpurehealthgroupcom

3039555899 ext 701

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

The following information explains exactly how the nutrients in our formulas

create relief by working with your patients body to alleviate withdrawal

symptoms

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Depression Anxiety

One of the most debilitating withdrawal symptoms patients experience is a

deep feeling of depression spiked with intermittent anxiety This depressive

state is caused in great part by a severe depletion of vital neurotransmitters

and naturally occurring opioids combined with desensitization of opioid

receptors in the brain Withdrawal Relief Complex nutraceuticals help support

the rapid return of these vital biological chemicals to healthy levels thus

decreasing the depth and length of the depressive state

Research supporting the efficacy of the natural

nutrients in Withdrawal Relief Complex Nutraceuticals

to combat depression and anxiety symptoms are as

follows

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-

blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine

showed use of this herb significantly decreased depression and anxiety associated with

withdrawal as well as if not better than Clonidine1

bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety

WITHOUT the adverse side effects of the drug2

5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP

dramatically alleviates depression3-9

bullIt does so by bolstering serotonin levels in the brain

Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10

bullSignificantly increases the biosynthesis of natural opioid peptides in the body11

bullDecrease the symptoms of depression in patients by up over 3512

L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital

neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which

indicates that it relaxes the mind without inducing drowsinessrdquo14

bullL-theanine reduces anxiety and calms nerves during stressful events15

Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the

B-vitamins or vitamin C16

bullCorrection of these deficiencies through supplementation with the proper forms and

amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in

complete resolution of mental symptoms in some individualsrdquo16

Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas

bullThis herb standardized for L-Dopa content has been found in research to have potent

anti-depressant actions17

bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Insomnia

Sleepless nights are a very common symptom of opiate withdrawal Long-

term use of opiates tends to disrupt the sleep wake cycle by disturbing

the proper production of melatonin and other sleep-inducing chemicals in

the body In order to re-establish healthy sleep cycles allowing patients to

fall asleep faster and stay asleep longer it is necessary to support the

production of natural sleep chemicals

The Withdrawal Relief Complex contains a

healthy dose of pure Melatonin and other all-

natural sleep support ingredients to help

patients sleep through the night allowing them

to obtain the rest needed to recover quickly

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall

asleep much faster and to significantly increase the amount of sleep achieved throughout the

night19 20

5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with

one study showing a 53 increase in REM sleep during the night21

ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small

doses of barbiturates or benzodiazepansrdquo22

bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23

American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects

take place within 30 minutes of ingestion and have been shown in research to help people fall

asleep faster and stay asleep longer24

Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in

prolonged sleep tests25

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Nausea amp Gastrointestinal Distress

Nausea and GI distress (including intestinal cramping and diarrhea) is one of the

most uncomfortable and disruptive physical symptoms of opiate withdrawal This

symptom generally presents 2 or 3 days after abstaining from opiates and can last

for up to a week

Opiates have a very strong sedative effect on the stomach and intestinal tract

Once opiate use is discontinued these organs become over stimulated Nerves

that have been suppressed for a long time begin to come back to life This

enhanced neural input to the smooth muscles of the stomach and GI tract can be

shocking to the system thus causing cramping and hyper-motility

which can lead to diarrhea nausea and vomiting

To treat these symptoms the Withdrawal Relief Complex

formulas include powerful ingredients that not only help to

provide natural moderate sedation to overactive GI nerves but

also help soothe the stomach

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows

gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the

prescription drug Papaverinerdquo for these uses

Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth

muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27

bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a

spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it

as a natural medicine for GI distress28

Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many

antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-

33

Vitamin B6

bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin

B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated

that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our

combined formulashellipover twice the dose of the studyhellipto ensure best results

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Extreme Fatigue amp Lethargy

The fatigue most people experience during withdrawal is profound It can be severe

enough that patients will literally not be able to get out of bed This is particularly

damaging for those needing to maintain a consistent work schedule and or care for

their family

The fatigue that comes from opiate withdrawal is both physical and mental Many

recovering opiate addicts feel a complete lack of motivation and desire to engage in

life This leads to reclusive behavior poor diet and a host of other actions that tend

to prolong withdrawal and lead to relapse

Therefore it is imperative that patients are supported

in staying energized and motivated as they negotiate

the acute phase of withdrawal

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased

energy focus attention and task performance throughout the day Researchers stated ldquoThese results

provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the

psychoactive properties of ginsengrdquo35

5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to

ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36

L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers

found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37

bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing

neurotransmitters such as epinephrine and norepinephrine

Vitamin B12

bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38

bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase

in energy stamina and well being helliprdquo38

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Restless Leg Syndrome (RLS)

RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced

by nearly everyone going through opiate withdrawal This symptom is not so much

painful as it is disruptive and highly irritating RLS causes agitation during the day

and disrupts sleep during the night This exacerbates the symptoms of insomnia and

creates further daytime agitation locking patients into a vicious cycle

RLS is thought to be caused by the depletion of the neurotransmitter dopamine in

the system Research has shown that providing nutrients to help stimulate

dopamine production can quickly and effectively decrease or eliminate the severity

of this syndrome

The following demonstrates how the nutrients in Withdrawal Relief

Complex support dopamine production in two ways by providing a

direct source of natural dopamine (through the L-dopa content of

Mucuna pruriens) and by supporting dopamine metabolism in the

body with the B-vitamin Folate

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances

levels of dopamine in the brain39

bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a

medical treatment for Parkinsons Disease40

bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly

decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41

Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid

(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and

fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid

levelsrdquo42 43

Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people

with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS

symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in

the Withdrawal Relief Complex Nighttime formula

MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for

treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal

Relief Complex System This formula has been designed to help keep cravings at

bay after acute withdraw has passed allowing the chemical balance in the patient‟s

brain to quickly and safely return to pre-drug use level

CCRR is a four part compound nutraceutical that addresses cravings by

bullSupplying your adrenal system with nutrients you need to feel good The

ingredients in CCRR work hard to heal your body and restore your

organs and mind

bullGiving your brain a natural boost to stave off depression and anxiety

until the chemical balance of your pre-drug healthy brain is restored

bullFlooding your body with nourishing vitamins and antioxidants that

support physical recovery as you continue to gain strength

bullEnsuring that cravings stay manageable while you create more and more

distance from the desire for more drugs

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 6: PHG Presentation 07112011

Pure Health Group‟strade RampD

Copyright copy 2011 Pure Health Group trade

The nutraceuticals in this breakthrough system were developed from years of

research about how opioids work within the body and brain to alter one‟s

physical emotional and mental state specifically how the withdrawal of

opioids acts to create the discomforting symptoms of acute opioid withdrawal

Understanding these causes we spent the next 24 months scouring the

scientific literature for research showing which natural nutrients could

effectively address these biological causes and alleviate withdrawal symptoms

Once the perfect nutrient blend was assessed we

focused on sourcing the purest most potent forms

of each nutrient for our formulas

Pure Health Group‟strade RampD (cont)

Copyright copy 2011 Pure Health Group trade

We understand there is a very wide range of nutrient quality in the

nutraceutical market place Therefore we enlisted the help of our

pharmaceutical manufacturing facility to source and obtain the best

standardized pharmaceutical-grade nutrients available

We then included these nutrients in the formulas in doses shown to be

efficacious in the scientific literature

Based upon the science supporting the symptom-specific efficacy of the

nutrients in our formulas and the empirical evidence we have garnered we

are highly confident that our products offer a safe and effective natural option

to assist with successful withdrawal from opioid dependence

Pure Health Group‟strade RampD (cont)

Copyright copy 2011 Pure Health Group trade

Empirical evidence suggests that those using the complete Withdrawal

Relief System are at least 50 more likely to successfully negotiate their

acute withdrawal period without relapse then those going cold turkey

We are currently in discussions with a Florida based research center

about implementing our first double-blinded placebo-controlled pilot trial

We hope to begin the study in the 4th quarter of 2011

Pure Health Group Inctrade is committed to remaining

on the forefront of opiate dependence research and

translating new discoveries into the best possible

answers and relief for those suffering from opiate

addiction Pure Health Group Inctrade supports

continuous research and development of new

nutraceutical products that will make the journey

towards freedom from opiate dependency as easy and

pain free as possible

How Does The System Work

Copyright copy 2011 Pure Health Group trade

The Withdraw Relief Complex Nutraceuticals aid in the withdrawal and

recovery process by supplying specific nutrients that naturally counter symptoms

reduce pain and send messages that calm opioid receptors in the brain

The Withdraw Relief System gives patients a distinct advantage in the battle to

be opioid free

By dramatically reducing their discomfort patients will

bullBe empowered to maintain a more normal lifestyle through the

withdrawal process

bullBe able to maintain some level of appetite and ingest

supportive foods

bullStay hydrated

bullMaintain some level of physical activity to stimulate natural

endorphins

bullFocus on the opioid-free future that is waiting for them just

around the corner

PHGtrade and Healthcare Providers

Copyright copy 2011 Pure Health Group trade

Pure Health Group Inctrade is committed to partnering with healthcare providers

to eradicate opioid dependence by using innovative science and research to

create extraordinary nutraceutical products that help minimize the pain of

withdrawal

For more information about Pure Health

Grouptrade or about how to become a licensed

distributor of our products please visit

WWWPUREHEALTHGROUPCOM

Or contact John D Vox at

jvoxpurehealthgroupcom

3039555899 ext 701

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

The following information explains exactly how the nutrients in our formulas

create relief by working with your patients body to alleviate withdrawal

symptoms

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Depression Anxiety

One of the most debilitating withdrawal symptoms patients experience is a

deep feeling of depression spiked with intermittent anxiety This depressive

state is caused in great part by a severe depletion of vital neurotransmitters

and naturally occurring opioids combined with desensitization of opioid

receptors in the brain Withdrawal Relief Complex nutraceuticals help support

the rapid return of these vital biological chemicals to healthy levels thus

decreasing the depth and length of the depressive state

Research supporting the efficacy of the natural

nutrients in Withdrawal Relief Complex Nutraceuticals

to combat depression and anxiety symptoms are as

follows

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-

blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine

showed use of this herb significantly decreased depression and anxiety associated with

withdrawal as well as if not better than Clonidine1

bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety

WITHOUT the adverse side effects of the drug2

5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP

dramatically alleviates depression3-9

bullIt does so by bolstering serotonin levels in the brain

Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10

bullSignificantly increases the biosynthesis of natural opioid peptides in the body11

bullDecrease the symptoms of depression in patients by up over 3512

L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital

neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which

indicates that it relaxes the mind without inducing drowsinessrdquo14

bullL-theanine reduces anxiety and calms nerves during stressful events15

Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the

B-vitamins or vitamin C16

bullCorrection of these deficiencies through supplementation with the proper forms and

amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in

complete resolution of mental symptoms in some individualsrdquo16

Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas

bullThis herb standardized for L-Dopa content has been found in research to have potent

anti-depressant actions17

bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Insomnia

Sleepless nights are a very common symptom of opiate withdrawal Long-

term use of opiates tends to disrupt the sleep wake cycle by disturbing

the proper production of melatonin and other sleep-inducing chemicals in

the body In order to re-establish healthy sleep cycles allowing patients to

fall asleep faster and stay asleep longer it is necessary to support the

production of natural sleep chemicals

The Withdrawal Relief Complex contains a

healthy dose of pure Melatonin and other all-

natural sleep support ingredients to help

patients sleep through the night allowing them

to obtain the rest needed to recover quickly

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall

asleep much faster and to significantly increase the amount of sleep achieved throughout the

night19 20

5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with

one study showing a 53 increase in REM sleep during the night21

ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small

doses of barbiturates or benzodiazepansrdquo22

bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23

American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects

take place within 30 minutes of ingestion and have been shown in research to help people fall

asleep faster and stay asleep longer24

Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in

prolonged sleep tests25

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Nausea amp Gastrointestinal Distress

Nausea and GI distress (including intestinal cramping and diarrhea) is one of the

most uncomfortable and disruptive physical symptoms of opiate withdrawal This

symptom generally presents 2 or 3 days after abstaining from opiates and can last

for up to a week

Opiates have a very strong sedative effect on the stomach and intestinal tract

Once opiate use is discontinued these organs become over stimulated Nerves

that have been suppressed for a long time begin to come back to life This

enhanced neural input to the smooth muscles of the stomach and GI tract can be

shocking to the system thus causing cramping and hyper-motility

which can lead to diarrhea nausea and vomiting

To treat these symptoms the Withdrawal Relief Complex

formulas include powerful ingredients that not only help to

provide natural moderate sedation to overactive GI nerves but

also help soothe the stomach

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows

gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the

prescription drug Papaverinerdquo for these uses

Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth

muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27

bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a

spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it

as a natural medicine for GI distress28

Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many

antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-

33

Vitamin B6

bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin

B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated

that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our

combined formulashellipover twice the dose of the studyhellipto ensure best results

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Extreme Fatigue amp Lethargy

The fatigue most people experience during withdrawal is profound It can be severe

enough that patients will literally not be able to get out of bed This is particularly

damaging for those needing to maintain a consistent work schedule and or care for

their family

The fatigue that comes from opiate withdrawal is both physical and mental Many

recovering opiate addicts feel a complete lack of motivation and desire to engage in

life This leads to reclusive behavior poor diet and a host of other actions that tend

to prolong withdrawal and lead to relapse

Therefore it is imperative that patients are supported

in staying energized and motivated as they negotiate

the acute phase of withdrawal

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased

energy focus attention and task performance throughout the day Researchers stated ldquoThese results

provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the

psychoactive properties of ginsengrdquo35

5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to

ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36

L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers

found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37

bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing

neurotransmitters such as epinephrine and norepinephrine

Vitamin B12

bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38

bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase

in energy stamina and well being helliprdquo38

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Restless Leg Syndrome (RLS)

RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced

by nearly everyone going through opiate withdrawal This symptom is not so much

painful as it is disruptive and highly irritating RLS causes agitation during the day

and disrupts sleep during the night This exacerbates the symptoms of insomnia and

creates further daytime agitation locking patients into a vicious cycle

RLS is thought to be caused by the depletion of the neurotransmitter dopamine in

the system Research has shown that providing nutrients to help stimulate

dopamine production can quickly and effectively decrease or eliminate the severity

of this syndrome

The following demonstrates how the nutrients in Withdrawal Relief

Complex support dopamine production in two ways by providing a

direct source of natural dopamine (through the L-dopa content of

Mucuna pruriens) and by supporting dopamine metabolism in the

body with the B-vitamin Folate

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances

levels of dopamine in the brain39

bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a

medical treatment for Parkinsons Disease40

bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly

decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41

Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid

(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and

fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid

levelsrdquo42 43

Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people

with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS

symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in

the Withdrawal Relief Complex Nighttime formula

MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for

treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal

Relief Complex System This formula has been designed to help keep cravings at

bay after acute withdraw has passed allowing the chemical balance in the patient‟s

brain to quickly and safely return to pre-drug use level

CCRR is a four part compound nutraceutical that addresses cravings by

bullSupplying your adrenal system with nutrients you need to feel good The

ingredients in CCRR work hard to heal your body and restore your

organs and mind

bullGiving your brain a natural boost to stave off depression and anxiety

until the chemical balance of your pre-drug healthy brain is restored

bullFlooding your body with nourishing vitamins and antioxidants that

support physical recovery as you continue to gain strength

bullEnsuring that cravings stay manageable while you create more and more

distance from the desire for more drugs

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 7: PHG Presentation 07112011

Pure Health Group‟strade RampD (cont)

Copyright copy 2011 Pure Health Group trade

We understand there is a very wide range of nutrient quality in the

nutraceutical market place Therefore we enlisted the help of our

pharmaceutical manufacturing facility to source and obtain the best

standardized pharmaceutical-grade nutrients available

We then included these nutrients in the formulas in doses shown to be

efficacious in the scientific literature

Based upon the science supporting the symptom-specific efficacy of the

nutrients in our formulas and the empirical evidence we have garnered we

are highly confident that our products offer a safe and effective natural option

to assist with successful withdrawal from opioid dependence

Pure Health Group‟strade RampD (cont)

Copyright copy 2011 Pure Health Group trade

Empirical evidence suggests that those using the complete Withdrawal

Relief System are at least 50 more likely to successfully negotiate their

acute withdrawal period without relapse then those going cold turkey

We are currently in discussions with a Florida based research center

about implementing our first double-blinded placebo-controlled pilot trial

We hope to begin the study in the 4th quarter of 2011

Pure Health Group Inctrade is committed to remaining

on the forefront of opiate dependence research and

translating new discoveries into the best possible

answers and relief for those suffering from opiate

addiction Pure Health Group Inctrade supports

continuous research and development of new

nutraceutical products that will make the journey

towards freedom from opiate dependency as easy and

pain free as possible

How Does The System Work

Copyright copy 2011 Pure Health Group trade

The Withdraw Relief Complex Nutraceuticals aid in the withdrawal and

recovery process by supplying specific nutrients that naturally counter symptoms

reduce pain and send messages that calm opioid receptors in the brain

The Withdraw Relief System gives patients a distinct advantage in the battle to

be opioid free

By dramatically reducing their discomfort patients will

bullBe empowered to maintain a more normal lifestyle through the

withdrawal process

bullBe able to maintain some level of appetite and ingest

supportive foods

bullStay hydrated

bullMaintain some level of physical activity to stimulate natural

endorphins

bullFocus on the opioid-free future that is waiting for them just

around the corner

PHGtrade and Healthcare Providers

Copyright copy 2011 Pure Health Group trade

Pure Health Group Inctrade is committed to partnering with healthcare providers

to eradicate opioid dependence by using innovative science and research to

create extraordinary nutraceutical products that help minimize the pain of

withdrawal

For more information about Pure Health

Grouptrade or about how to become a licensed

distributor of our products please visit

WWWPUREHEALTHGROUPCOM

Or contact John D Vox at

jvoxpurehealthgroupcom

3039555899 ext 701

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

The following information explains exactly how the nutrients in our formulas

create relief by working with your patients body to alleviate withdrawal

symptoms

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Depression Anxiety

One of the most debilitating withdrawal symptoms patients experience is a

deep feeling of depression spiked with intermittent anxiety This depressive

state is caused in great part by a severe depletion of vital neurotransmitters

and naturally occurring opioids combined with desensitization of opioid

receptors in the brain Withdrawal Relief Complex nutraceuticals help support

the rapid return of these vital biological chemicals to healthy levels thus

decreasing the depth and length of the depressive state

Research supporting the efficacy of the natural

nutrients in Withdrawal Relief Complex Nutraceuticals

to combat depression and anxiety symptoms are as

follows

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-

blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine

showed use of this herb significantly decreased depression and anxiety associated with

withdrawal as well as if not better than Clonidine1

bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety

WITHOUT the adverse side effects of the drug2

5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP

dramatically alleviates depression3-9

bullIt does so by bolstering serotonin levels in the brain

Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10

bullSignificantly increases the biosynthesis of natural opioid peptides in the body11

bullDecrease the symptoms of depression in patients by up over 3512

L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital

neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which

indicates that it relaxes the mind without inducing drowsinessrdquo14

bullL-theanine reduces anxiety and calms nerves during stressful events15

Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the

B-vitamins or vitamin C16

bullCorrection of these deficiencies through supplementation with the proper forms and

amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in

complete resolution of mental symptoms in some individualsrdquo16

Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas

bullThis herb standardized for L-Dopa content has been found in research to have potent

anti-depressant actions17

bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Insomnia

Sleepless nights are a very common symptom of opiate withdrawal Long-

term use of opiates tends to disrupt the sleep wake cycle by disturbing

the proper production of melatonin and other sleep-inducing chemicals in

the body In order to re-establish healthy sleep cycles allowing patients to

fall asleep faster and stay asleep longer it is necessary to support the

production of natural sleep chemicals

The Withdrawal Relief Complex contains a

healthy dose of pure Melatonin and other all-

natural sleep support ingredients to help

patients sleep through the night allowing them

to obtain the rest needed to recover quickly

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall

asleep much faster and to significantly increase the amount of sleep achieved throughout the

night19 20

5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with

one study showing a 53 increase in REM sleep during the night21

ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small

doses of barbiturates or benzodiazepansrdquo22

bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23

American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects

take place within 30 minutes of ingestion and have been shown in research to help people fall

asleep faster and stay asleep longer24

Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in

prolonged sleep tests25

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Nausea amp Gastrointestinal Distress

Nausea and GI distress (including intestinal cramping and diarrhea) is one of the

most uncomfortable and disruptive physical symptoms of opiate withdrawal This

symptom generally presents 2 or 3 days after abstaining from opiates and can last

for up to a week

Opiates have a very strong sedative effect on the stomach and intestinal tract

Once opiate use is discontinued these organs become over stimulated Nerves

that have been suppressed for a long time begin to come back to life This

enhanced neural input to the smooth muscles of the stomach and GI tract can be

shocking to the system thus causing cramping and hyper-motility

which can lead to diarrhea nausea and vomiting

To treat these symptoms the Withdrawal Relief Complex

formulas include powerful ingredients that not only help to

provide natural moderate sedation to overactive GI nerves but

also help soothe the stomach

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows

gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the

prescription drug Papaverinerdquo for these uses

Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth

muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27

bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a

spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it

as a natural medicine for GI distress28

Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many

antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-

33

Vitamin B6

bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin

B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated

that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our

combined formulashellipover twice the dose of the studyhellipto ensure best results

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Extreme Fatigue amp Lethargy

The fatigue most people experience during withdrawal is profound It can be severe

enough that patients will literally not be able to get out of bed This is particularly

damaging for those needing to maintain a consistent work schedule and or care for

their family

The fatigue that comes from opiate withdrawal is both physical and mental Many

recovering opiate addicts feel a complete lack of motivation and desire to engage in

life This leads to reclusive behavior poor diet and a host of other actions that tend

to prolong withdrawal and lead to relapse

Therefore it is imperative that patients are supported

in staying energized and motivated as they negotiate

the acute phase of withdrawal

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased

energy focus attention and task performance throughout the day Researchers stated ldquoThese results

provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the

psychoactive properties of ginsengrdquo35

5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to

ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36

L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers

found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37

bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing

neurotransmitters such as epinephrine and norepinephrine

Vitamin B12

bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38

bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase

in energy stamina and well being helliprdquo38

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Restless Leg Syndrome (RLS)

RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced

by nearly everyone going through opiate withdrawal This symptom is not so much

painful as it is disruptive and highly irritating RLS causes agitation during the day

and disrupts sleep during the night This exacerbates the symptoms of insomnia and

creates further daytime agitation locking patients into a vicious cycle

RLS is thought to be caused by the depletion of the neurotransmitter dopamine in

the system Research has shown that providing nutrients to help stimulate

dopamine production can quickly and effectively decrease or eliminate the severity

of this syndrome

The following demonstrates how the nutrients in Withdrawal Relief

Complex support dopamine production in two ways by providing a

direct source of natural dopamine (through the L-dopa content of

Mucuna pruriens) and by supporting dopamine metabolism in the

body with the B-vitamin Folate

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances

levels of dopamine in the brain39

bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a

medical treatment for Parkinsons Disease40

bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly

decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41

Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid

(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and

fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid

levelsrdquo42 43

Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people

with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS

symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in

the Withdrawal Relief Complex Nighttime formula

MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for

treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal

Relief Complex System This formula has been designed to help keep cravings at

bay after acute withdraw has passed allowing the chemical balance in the patient‟s

brain to quickly and safely return to pre-drug use level

CCRR is a four part compound nutraceutical that addresses cravings by

bullSupplying your adrenal system with nutrients you need to feel good The

ingredients in CCRR work hard to heal your body and restore your

organs and mind

bullGiving your brain a natural boost to stave off depression and anxiety

until the chemical balance of your pre-drug healthy brain is restored

bullFlooding your body with nourishing vitamins and antioxidants that

support physical recovery as you continue to gain strength

bullEnsuring that cravings stay manageable while you create more and more

distance from the desire for more drugs

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 8: PHG Presentation 07112011

Pure Health Group‟strade RampD (cont)

Copyright copy 2011 Pure Health Group trade

Empirical evidence suggests that those using the complete Withdrawal

Relief System are at least 50 more likely to successfully negotiate their

acute withdrawal period without relapse then those going cold turkey

We are currently in discussions with a Florida based research center

about implementing our first double-blinded placebo-controlled pilot trial

We hope to begin the study in the 4th quarter of 2011

Pure Health Group Inctrade is committed to remaining

on the forefront of opiate dependence research and

translating new discoveries into the best possible

answers and relief for those suffering from opiate

addiction Pure Health Group Inctrade supports

continuous research and development of new

nutraceutical products that will make the journey

towards freedom from opiate dependency as easy and

pain free as possible

How Does The System Work

Copyright copy 2011 Pure Health Group trade

The Withdraw Relief Complex Nutraceuticals aid in the withdrawal and

recovery process by supplying specific nutrients that naturally counter symptoms

reduce pain and send messages that calm opioid receptors in the brain

The Withdraw Relief System gives patients a distinct advantage in the battle to

be opioid free

By dramatically reducing their discomfort patients will

bullBe empowered to maintain a more normal lifestyle through the

withdrawal process

bullBe able to maintain some level of appetite and ingest

supportive foods

bullStay hydrated

bullMaintain some level of physical activity to stimulate natural

endorphins

bullFocus on the opioid-free future that is waiting for them just

around the corner

PHGtrade and Healthcare Providers

Copyright copy 2011 Pure Health Group trade

Pure Health Group Inctrade is committed to partnering with healthcare providers

to eradicate opioid dependence by using innovative science and research to

create extraordinary nutraceutical products that help minimize the pain of

withdrawal

For more information about Pure Health

Grouptrade or about how to become a licensed

distributor of our products please visit

WWWPUREHEALTHGROUPCOM

Or contact John D Vox at

jvoxpurehealthgroupcom

3039555899 ext 701

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

The following information explains exactly how the nutrients in our formulas

create relief by working with your patients body to alleviate withdrawal

symptoms

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Depression Anxiety

One of the most debilitating withdrawal symptoms patients experience is a

deep feeling of depression spiked with intermittent anxiety This depressive

state is caused in great part by a severe depletion of vital neurotransmitters

and naturally occurring opioids combined with desensitization of opioid

receptors in the brain Withdrawal Relief Complex nutraceuticals help support

the rapid return of these vital biological chemicals to healthy levels thus

decreasing the depth and length of the depressive state

Research supporting the efficacy of the natural

nutrients in Withdrawal Relief Complex Nutraceuticals

to combat depression and anxiety symptoms are as

follows

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-

blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine

showed use of this herb significantly decreased depression and anxiety associated with

withdrawal as well as if not better than Clonidine1

bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety

WITHOUT the adverse side effects of the drug2

5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP

dramatically alleviates depression3-9

bullIt does so by bolstering serotonin levels in the brain

Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10

bullSignificantly increases the biosynthesis of natural opioid peptides in the body11

bullDecrease the symptoms of depression in patients by up over 3512

L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital

neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which

indicates that it relaxes the mind without inducing drowsinessrdquo14

bullL-theanine reduces anxiety and calms nerves during stressful events15

Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the

B-vitamins or vitamin C16

bullCorrection of these deficiencies through supplementation with the proper forms and

amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in

complete resolution of mental symptoms in some individualsrdquo16

Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas

bullThis herb standardized for L-Dopa content has been found in research to have potent

anti-depressant actions17

bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Insomnia

Sleepless nights are a very common symptom of opiate withdrawal Long-

term use of opiates tends to disrupt the sleep wake cycle by disturbing

the proper production of melatonin and other sleep-inducing chemicals in

the body In order to re-establish healthy sleep cycles allowing patients to

fall asleep faster and stay asleep longer it is necessary to support the

production of natural sleep chemicals

The Withdrawal Relief Complex contains a

healthy dose of pure Melatonin and other all-

natural sleep support ingredients to help

patients sleep through the night allowing them

to obtain the rest needed to recover quickly

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall

asleep much faster and to significantly increase the amount of sleep achieved throughout the

night19 20

5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with

one study showing a 53 increase in REM sleep during the night21

ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small

doses of barbiturates or benzodiazepansrdquo22

bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23

American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects

take place within 30 minutes of ingestion and have been shown in research to help people fall

asleep faster and stay asleep longer24

Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in

prolonged sleep tests25

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Nausea amp Gastrointestinal Distress

Nausea and GI distress (including intestinal cramping and diarrhea) is one of the

most uncomfortable and disruptive physical symptoms of opiate withdrawal This

symptom generally presents 2 or 3 days after abstaining from opiates and can last

for up to a week

Opiates have a very strong sedative effect on the stomach and intestinal tract

Once opiate use is discontinued these organs become over stimulated Nerves

that have been suppressed for a long time begin to come back to life This

enhanced neural input to the smooth muscles of the stomach and GI tract can be

shocking to the system thus causing cramping and hyper-motility

which can lead to diarrhea nausea and vomiting

To treat these symptoms the Withdrawal Relief Complex

formulas include powerful ingredients that not only help to

provide natural moderate sedation to overactive GI nerves but

also help soothe the stomach

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows

gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the

prescription drug Papaverinerdquo for these uses

Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth

muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27

bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a

spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it

as a natural medicine for GI distress28

Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many

antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-

33

Vitamin B6

bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin

B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated

that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our

combined formulashellipover twice the dose of the studyhellipto ensure best results

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Extreme Fatigue amp Lethargy

The fatigue most people experience during withdrawal is profound It can be severe

enough that patients will literally not be able to get out of bed This is particularly

damaging for those needing to maintain a consistent work schedule and or care for

their family

The fatigue that comes from opiate withdrawal is both physical and mental Many

recovering opiate addicts feel a complete lack of motivation and desire to engage in

life This leads to reclusive behavior poor diet and a host of other actions that tend

to prolong withdrawal and lead to relapse

Therefore it is imperative that patients are supported

in staying energized and motivated as they negotiate

the acute phase of withdrawal

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased

energy focus attention and task performance throughout the day Researchers stated ldquoThese results

provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the

psychoactive properties of ginsengrdquo35

5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to

ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36

L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers

found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37

bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing

neurotransmitters such as epinephrine and norepinephrine

Vitamin B12

bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38

bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase

in energy stamina and well being helliprdquo38

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Restless Leg Syndrome (RLS)

RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced

by nearly everyone going through opiate withdrawal This symptom is not so much

painful as it is disruptive and highly irritating RLS causes agitation during the day

and disrupts sleep during the night This exacerbates the symptoms of insomnia and

creates further daytime agitation locking patients into a vicious cycle

RLS is thought to be caused by the depletion of the neurotransmitter dopamine in

the system Research has shown that providing nutrients to help stimulate

dopamine production can quickly and effectively decrease or eliminate the severity

of this syndrome

The following demonstrates how the nutrients in Withdrawal Relief

Complex support dopamine production in two ways by providing a

direct source of natural dopamine (through the L-dopa content of

Mucuna pruriens) and by supporting dopamine metabolism in the

body with the B-vitamin Folate

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances

levels of dopamine in the brain39

bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a

medical treatment for Parkinsons Disease40

bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly

decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41

Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid

(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and

fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid

levelsrdquo42 43

Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people

with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS

symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in

the Withdrawal Relief Complex Nighttime formula

MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for

treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal

Relief Complex System This formula has been designed to help keep cravings at

bay after acute withdraw has passed allowing the chemical balance in the patient‟s

brain to quickly and safely return to pre-drug use level

CCRR is a four part compound nutraceutical that addresses cravings by

bullSupplying your adrenal system with nutrients you need to feel good The

ingredients in CCRR work hard to heal your body and restore your

organs and mind

bullGiving your brain a natural boost to stave off depression and anxiety

until the chemical balance of your pre-drug healthy brain is restored

bullFlooding your body with nourishing vitamins and antioxidants that

support physical recovery as you continue to gain strength

bullEnsuring that cravings stay manageable while you create more and more

distance from the desire for more drugs

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 9: PHG Presentation 07112011

How Does The System Work

Copyright copy 2011 Pure Health Group trade

The Withdraw Relief Complex Nutraceuticals aid in the withdrawal and

recovery process by supplying specific nutrients that naturally counter symptoms

reduce pain and send messages that calm opioid receptors in the brain

The Withdraw Relief System gives patients a distinct advantage in the battle to

be opioid free

By dramatically reducing their discomfort patients will

bullBe empowered to maintain a more normal lifestyle through the

withdrawal process

bullBe able to maintain some level of appetite and ingest

supportive foods

bullStay hydrated

bullMaintain some level of physical activity to stimulate natural

endorphins

bullFocus on the opioid-free future that is waiting for them just

around the corner

PHGtrade and Healthcare Providers

Copyright copy 2011 Pure Health Group trade

Pure Health Group Inctrade is committed to partnering with healthcare providers

to eradicate opioid dependence by using innovative science and research to

create extraordinary nutraceutical products that help minimize the pain of

withdrawal

For more information about Pure Health

Grouptrade or about how to become a licensed

distributor of our products please visit

WWWPUREHEALTHGROUPCOM

Or contact John D Vox at

jvoxpurehealthgroupcom

3039555899 ext 701

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

The following information explains exactly how the nutrients in our formulas

create relief by working with your patients body to alleviate withdrawal

symptoms

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Depression Anxiety

One of the most debilitating withdrawal symptoms patients experience is a

deep feeling of depression spiked with intermittent anxiety This depressive

state is caused in great part by a severe depletion of vital neurotransmitters

and naturally occurring opioids combined with desensitization of opioid

receptors in the brain Withdrawal Relief Complex nutraceuticals help support

the rapid return of these vital biological chemicals to healthy levels thus

decreasing the depth and length of the depressive state

Research supporting the efficacy of the natural

nutrients in Withdrawal Relief Complex Nutraceuticals

to combat depression and anxiety symptoms are as

follows

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-

blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine

showed use of this herb significantly decreased depression and anxiety associated with

withdrawal as well as if not better than Clonidine1

bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety

WITHOUT the adverse side effects of the drug2

5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP

dramatically alleviates depression3-9

bullIt does so by bolstering serotonin levels in the brain

Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10

bullSignificantly increases the biosynthesis of natural opioid peptides in the body11

bullDecrease the symptoms of depression in patients by up over 3512

L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital

neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which

indicates that it relaxes the mind without inducing drowsinessrdquo14

bullL-theanine reduces anxiety and calms nerves during stressful events15

Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the

B-vitamins or vitamin C16

bullCorrection of these deficiencies through supplementation with the proper forms and

amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in

complete resolution of mental symptoms in some individualsrdquo16

Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas

bullThis herb standardized for L-Dopa content has been found in research to have potent

anti-depressant actions17

bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Insomnia

Sleepless nights are a very common symptom of opiate withdrawal Long-

term use of opiates tends to disrupt the sleep wake cycle by disturbing

the proper production of melatonin and other sleep-inducing chemicals in

the body In order to re-establish healthy sleep cycles allowing patients to

fall asleep faster and stay asleep longer it is necessary to support the

production of natural sleep chemicals

The Withdrawal Relief Complex contains a

healthy dose of pure Melatonin and other all-

natural sleep support ingredients to help

patients sleep through the night allowing them

to obtain the rest needed to recover quickly

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall

asleep much faster and to significantly increase the amount of sleep achieved throughout the

night19 20

5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with

one study showing a 53 increase in REM sleep during the night21

ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small

doses of barbiturates or benzodiazepansrdquo22

bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23

American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects

take place within 30 minutes of ingestion and have been shown in research to help people fall

asleep faster and stay asleep longer24

Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in

prolonged sleep tests25

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Nausea amp Gastrointestinal Distress

Nausea and GI distress (including intestinal cramping and diarrhea) is one of the

most uncomfortable and disruptive physical symptoms of opiate withdrawal This

symptom generally presents 2 or 3 days after abstaining from opiates and can last

for up to a week

Opiates have a very strong sedative effect on the stomach and intestinal tract

Once opiate use is discontinued these organs become over stimulated Nerves

that have been suppressed for a long time begin to come back to life This

enhanced neural input to the smooth muscles of the stomach and GI tract can be

shocking to the system thus causing cramping and hyper-motility

which can lead to diarrhea nausea and vomiting

To treat these symptoms the Withdrawal Relief Complex

formulas include powerful ingredients that not only help to

provide natural moderate sedation to overactive GI nerves but

also help soothe the stomach

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows

gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the

prescription drug Papaverinerdquo for these uses

Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth

muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27

bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a

spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it

as a natural medicine for GI distress28

Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many

antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-

33

Vitamin B6

bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin

B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated

that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our

combined formulashellipover twice the dose of the studyhellipto ensure best results

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Extreme Fatigue amp Lethargy

The fatigue most people experience during withdrawal is profound It can be severe

enough that patients will literally not be able to get out of bed This is particularly

damaging for those needing to maintain a consistent work schedule and or care for

their family

The fatigue that comes from opiate withdrawal is both physical and mental Many

recovering opiate addicts feel a complete lack of motivation and desire to engage in

life This leads to reclusive behavior poor diet and a host of other actions that tend

to prolong withdrawal and lead to relapse

Therefore it is imperative that patients are supported

in staying energized and motivated as they negotiate

the acute phase of withdrawal

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased

energy focus attention and task performance throughout the day Researchers stated ldquoThese results

provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the

psychoactive properties of ginsengrdquo35

5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to

ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36

L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers

found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37

bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing

neurotransmitters such as epinephrine and norepinephrine

Vitamin B12

bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38

bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase

in energy stamina and well being helliprdquo38

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Restless Leg Syndrome (RLS)

RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced

by nearly everyone going through opiate withdrawal This symptom is not so much

painful as it is disruptive and highly irritating RLS causes agitation during the day

and disrupts sleep during the night This exacerbates the symptoms of insomnia and

creates further daytime agitation locking patients into a vicious cycle

RLS is thought to be caused by the depletion of the neurotransmitter dopamine in

the system Research has shown that providing nutrients to help stimulate

dopamine production can quickly and effectively decrease or eliminate the severity

of this syndrome

The following demonstrates how the nutrients in Withdrawal Relief

Complex support dopamine production in two ways by providing a

direct source of natural dopamine (through the L-dopa content of

Mucuna pruriens) and by supporting dopamine metabolism in the

body with the B-vitamin Folate

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances

levels of dopamine in the brain39

bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a

medical treatment for Parkinsons Disease40

bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly

decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41

Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid

(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and

fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid

levelsrdquo42 43

Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people

with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS

symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in

the Withdrawal Relief Complex Nighttime formula

MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for

treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal

Relief Complex System This formula has been designed to help keep cravings at

bay after acute withdraw has passed allowing the chemical balance in the patient‟s

brain to quickly and safely return to pre-drug use level

CCRR is a four part compound nutraceutical that addresses cravings by

bullSupplying your adrenal system with nutrients you need to feel good The

ingredients in CCRR work hard to heal your body and restore your

organs and mind

bullGiving your brain a natural boost to stave off depression and anxiety

until the chemical balance of your pre-drug healthy brain is restored

bullFlooding your body with nourishing vitamins and antioxidants that

support physical recovery as you continue to gain strength

bullEnsuring that cravings stay manageable while you create more and more

distance from the desire for more drugs

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 10: PHG Presentation 07112011

PHGtrade and Healthcare Providers

Copyright copy 2011 Pure Health Group trade

Pure Health Group Inctrade is committed to partnering with healthcare providers

to eradicate opioid dependence by using innovative science and research to

create extraordinary nutraceutical products that help minimize the pain of

withdrawal

For more information about Pure Health

Grouptrade or about how to become a licensed

distributor of our products please visit

WWWPUREHEALTHGROUPCOM

Or contact John D Vox at

jvoxpurehealthgroupcom

3039555899 ext 701

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

The following information explains exactly how the nutrients in our formulas

create relief by working with your patients body to alleviate withdrawal

symptoms

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Depression Anxiety

One of the most debilitating withdrawal symptoms patients experience is a

deep feeling of depression spiked with intermittent anxiety This depressive

state is caused in great part by a severe depletion of vital neurotransmitters

and naturally occurring opioids combined with desensitization of opioid

receptors in the brain Withdrawal Relief Complex nutraceuticals help support

the rapid return of these vital biological chemicals to healthy levels thus

decreasing the depth and length of the depressive state

Research supporting the efficacy of the natural

nutrients in Withdrawal Relief Complex Nutraceuticals

to combat depression and anxiety symptoms are as

follows

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-

blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine

showed use of this herb significantly decreased depression and anxiety associated with

withdrawal as well as if not better than Clonidine1

bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety

WITHOUT the adverse side effects of the drug2

5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP

dramatically alleviates depression3-9

bullIt does so by bolstering serotonin levels in the brain

Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10

bullSignificantly increases the biosynthesis of natural opioid peptides in the body11

bullDecrease the symptoms of depression in patients by up over 3512

L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital

neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which

indicates that it relaxes the mind without inducing drowsinessrdquo14

bullL-theanine reduces anxiety and calms nerves during stressful events15

Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the

B-vitamins or vitamin C16

bullCorrection of these deficiencies through supplementation with the proper forms and

amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in

complete resolution of mental symptoms in some individualsrdquo16

Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas

bullThis herb standardized for L-Dopa content has been found in research to have potent

anti-depressant actions17

bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Insomnia

Sleepless nights are a very common symptom of opiate withdrawal Long-

term use of opiates tends to disrupt the sleep wake cycle by disturbing

the proper production of melatonin and other sleep-inducing chemicals in

the body In order to re-establish healthy sleep cycles allowing patients to

fall asleep faster and stay asleep longer it is necessary to support the

production of natural sleep chemicals

The Withdrawal Relief Complex contains a

healthy dose of pure Melatonin and other all-

natural sleep support ingredients to help

patients sleep through the night allowing them

to obtain the rest needed to recover quickly

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall

asleep much faster and to significantly increase the amount of sleep achieved throughout the

night19 20

5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with

one study showing a 53 increase in REM sleep during the night21

ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small

doses of barbiturates or benzodiazepansrdquo22

bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23

American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects

take place within 30 minutes of ingestion and have been shown in research to help people fall

asleep faster and stay asleep longer24

Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in

prolonged sleep tests25

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Nausea amp Gastrointestinal Distress

Nausea and GI distress (including intestinal cramping and diarrhea) is one of the

most uncomfortable and disruptive physical symptoms of opiate withdrawal This

symptom generally presents 2 or 3 days after abstaining from opiates and can last

for up to a week

Opiates have a very strong sedative effect on the stomach and intestinal tract

Once opiate use is discontinued these organs become over stimulated Nerves

that have been suppressed for a long time begin to come back to life This

enhanced neural input to the smooth muscles of the stomach and GI tract can be

shocking to the system thus causing cramping and hyper-motility

which can lead to diarrhea nausea and vomiting

To treat these symptoms the Withdrawal Relief Complex

formulas include powerful ingredients that not only help to

provide natural moderate sedation to overactive GI nerves but

also help soothe the stomach

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows

gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the

prescription drug Papaverinerdquo for these uses

Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth

muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27

bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a

spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it

as a natural medicine for GI distress28

Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many

antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-

33

Vitamin B6

bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin

B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated

that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our

combined formulashellipover twice the dose of the studyhellipto ensure best results

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Extreme Fatigue amp Lethargy

The fatigue most people experience during withdrawal is profound It can be severe

enough that patients will literally not be able to get out of bed This is particularly

damaging for those needing to maintain a consistent work schedule and or care for

their family

The fatigue that comes from opiate withdrawal is both physical and mental Many

recovering opiate addicts feel a complete lack of motivation and desire to engage in

life This leads to reclusive behavior poor diet and a host of other actions that tend

to prolong withdrawal and lead to relapse

Therefore it is imperative that patients are supported

in staying energized and motivated as they negotiate

the acute phase of withdrawal

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased

energy focus attention and task performance throughout the day Researchers stated ldquoThese results

provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the

psychoactive properties of ginsengrdquo35

5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to

ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36

L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers

found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37

bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing

neurotransmitters such as epinephrine and norepinephrine

Vitamin B12

bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38

bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase

in energy stamina and well being helliprdquo38

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Restless Leg Syndrome (RLS)

RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced

by nearly everyone going through opiate withdrawal This symptom is not so much

painful as it is disruptive and highly irritating RLS causes agitation during the day

and disrupts sleep during the night This exacerbates the symptoms of insomnia and

creates further daytime agitation locking patients into a vicious cycle

RLS is thought to be caused by the depletion of the neurotransmitter dopamine in

the system Research has shown that providing nutrients to help stimulate

dopamine production can quickly and effectively decrease or eliminate the severity

of this syndrome

The following demonstrates how the nutrients in Withdrawal Relief

Complex support dopamine production in two ways by providing a

direct source of natural dopamine (through the L-dopa content of

Mucuna pruriens) and by supporting dopamine metabolism in the

body with the B-vitamin Folate

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances

levels of dopamine in the brain39

bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a

medical treatment for Parkinsons Disease40

bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly

decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41

Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid

(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and

fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid

levelsrdquo42 43

Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people

with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS

symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in

the Withdrawal Relief Complex Nighttime formula

MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for

treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal

Relief Complex System This formula has been designed to help keep cravings at

bay after acute withdraw has passed allowing the chemical balance in the patient‟s

brain to quickly and safely return to pre-drug use level

CCRR is a four part compound nutraceutical that addresses cravings by

bullSupplying your adrenal system with nutrients you need to feel good The

ingredients in CCRR work hard to heal your body and restore your

organs and mind

bullGiving your brain a natural boost to stave off depression and anxiety

until the chemical balance of your pre-drug healthy brain is restored

bullFlooding your body with nourishing vitamins and antioxidants that

support physical recovery as you continue to gain strength

bullEnsuring that cravings stay manageable while you create more and more

distance from the desire for more drugs

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 11: PHG Presentation 07112011

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

The following information explains exactly how the nutrients in our formulas

create relief by working with your patients body to alleviate withdrawal

symptoms

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Depression Anxiety

One of the most debilitating withdrawal symptoms patients experience is a

deep feeling of depression spiked with intermittent anxiety This depressive

state is caused in great part by a severe depletion of vital neurotransmitters

and naturally occurring opioids combined with desensitization of opioid

receptors in the brain Withdrawal Relief Complex nutraceuticals help support

the rapid return of these vital biological chemicals to healthy levels thus

decreasing the depth and length of the depressive state

Research supporting the efficacy of the natural

nutrients in Withdrawal Relief Complex Nutraceuticals

to combat depression and anxiety symptoms are as

follows

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-

blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine

showed use of this herb significantly decreased depression and anxiety associated with

withdrawal as well as if not better than Clonidine1

bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety

WITHOUT the adverse side effects of the drug2

5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP

dramatically alleviates depression3-9

bullIt does so by bolstering serotonin levels in the brain

Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10

bullSignificantly increases the biosynthesis of natural opioid peptides in the body11

bullDecrease the symptoms of depression in patients by up over 3512

L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital

neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which

indicates that it relaxes the mind without inducing drowsinessrdquo14

bullL-theanine reduces anxiety and calms nerves during stressful events15

Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the

B-vitamins or vitamin C16

bullCorrection of these deficiencies through supplementation with the proper forms and

amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in

complete resolution of mental symptoms in some individualsrdquo16

Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas

bullThis herb standardized for L-Dopa content has been found in research to have potent

anti-depressant actions17

bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Insomnia

Sleepless nights are a very common symptom of opiate withdrawal Long-

term use of opiates tends to disrupt the sleep wake cycle by disturbing

the proper production of melatonin and other sleep-inducing chemicals in

the body In order to re-establish healthy sleep cycles allowing patients to

fall asleep faster and stay asleep longer it is necessary to support the

production of natural sleep chemicals

The Withdrawal Relief Complex contains a

healthy dose of pure Melatonin and other all-

natural sleep support ingredients to help

patients sleep through the night allowing them

to obtain the rest needed to recover quickly

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall

asleep much faster and to significantly increase the amount of sleep achieved throughout the

night19 20

5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with

one study showing a 53 increase in REM sleep during the night21

ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small

doses of barbiturates or benzodiazepansrdquo22

bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23

American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects

take place within 30 minutes of ingestion and have been shown in research to help people fall

asleep faster and stay asleep longer24

Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in

prolonged sleep tests25

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Nausea amp Gastrointestinal Distress

Nausea and GI distress (including intestinal cramping and diarrhea) is one of the

most uncomfortable and disruptive physical symptoms of opiate withdrawal This

symptom generally presents 2 or 3 days after abstaining from opiates and can last

for up to a week

Opiates have a very strong sedative effect on the stomach and intestinal tract

Once opiate use is discontinued these organs become over stimulated Nerves

that have been suppressed for a long time begin to come back to life This

enhanced neural input to the smooth muscles of the stomach and GI tract can be

shocking to the system thus causing cramping and hyper-motility

which can lead to diarrhea nausea and vomiting

To treat these symptoms the Withdrawal Relief Complex

formulas include powerful ingredients that not only help to

provide natural moderate sedation to overactive GI nerves but

also help soothe the stomach

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows

gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the

prescription drug Papaverinerdquo for these uses

Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth

muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27

bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a

spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it

as a natural medicine for GI distress28

Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many

antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-

33

Vitamin B6

bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin

B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated

that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our

combined formulashellipover twice the dose of the studyhellipto ensure best results

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Extreme Fatigue amp Lethargy

The fatigue most people experience during withdrawal is profound It can be severe

enough that patients will literally not be able to get out of bed This is particularly

damaging for those needing to maintain a consistent work schedule and or care for

their family

The fatigue that comes from opiate withdrawal is both physical and mental Many

recovering opiate addicts feel a complete lack of motivation and desire to engage in

life This leads to reclusive behavior poor diet and a host of other actions that tend

to prolong withdrawal and lead to relapse

Therefore it is imperative that patients are supported

in staying energized and motivated as they negotiate

the acute phase of withdrawal

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased

energy focus attention and task performance throughout the day Researchers stated ldquoThese results

provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the

psychoactive properties of ginsengrdquo35

5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to

ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36

L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers

found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37

bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing

neurotransmitters such as epinephrine and norepinephrine

Vitamin B12

bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38

bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase

in energy stamina and well being helliprdquo38

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Restless Leg Syndrome (RLS)

RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced

by nearly everyone going through opiate withdrawal This symptom is not so much

painful as it is disruptive and highly irritating RLS causes agitation during the day

and disrupts sleep during the night This exacerbates the symptoms of insomnia and

creates further daytime agitation locking patients into a vicious cycle

RLS is thought to be caused by the depletion of the neurotransmitter dopamine in

the system Research has shown that providing nutrients to help stimulate

dopamine production can quickly and effectively decrease or eliminate the severity

of this syndrome

The following demonstrates how the nutrients in Withdrawal Relief

Complex support dopamine production in two ways by providing a

direct source of natural dopamine (through the L-dopa content of

Mucuna pruriens) and by supporting dopamine metabolism in the

body with the B-vitamin Folate

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances

levels of dopamine in the brain39

bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a

medical treatment for Parkinsons Disease40

bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly

decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41

Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid

(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and

fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid

levelsrdquo42 43

Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people

with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS

symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in

the Withdrawal Relief Complex Nighttime formula

MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for

treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal

Relief Complex System This formula has been designed to help keep cravings at

bay after acute withdraw has passed allowing the chemical balance in the patient‟s

brain to quickly and safely return to pre-drug use level

CCRR is a four part compound nutraceutical that addresses cravings by

bullSupplying your adrenal system with nutrients you need to feel good The

ingredients in CCRR work hard to heal your body and restore your

organs and mind

bullGiving your brain a natural boost to stave off depression and anxiety

until the chemical balance of your pre-drug healthy brain is restored

bullFlooding your body with nourishing vitamins and antioxidants that

support physical recovery as you continue to gain strength

bullEnsuring that cravings stay manageable while you create more and more

distance from the desire for more drugs

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 12: PHG Presentation 07112011

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Depression Anxiety

One of the most debilitating withdrawal symptoms patients experience is a

deep feeling of depression spiked with intermittent anxiety This depressive

state is caused in great part by a severe depletion of vital neurotransmitters

and naturally occurring opioids combined with desensitization of opioid

receptors in the brain Withdrawal Relief Complex nutraceuticals help support

the rapid return of these vital biological chemicals to healthy levels thus

decreasing the depth and length of the depressive state

Research supporting the efficacy of the natural

nutrients in Withdrawal Relief Complex Nutraceuticals

to combat depression and anxiety symptoms are as

follows

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-

blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine

showed use of this herb significantly decreased depression and anxiety associated with

withdrawal as well as if not better than Clonidine1

bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety

WITHOUT the adverse side effects of the drug2

5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP

dramatically alleviates depression3-9

bullIt does so by bolstering serotonin levels in the brain

Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10

bullSignificantly increases the biosynthesis of natural opioid peptides in the body11

bullDecrease the symptoms of depression in patients by up over 3512

L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital

neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which

indicates that it relaxes the mind without inducing drowsinessrdquo14

bullL-theanine reduces anxiety and calms nerves during stressful events15

Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the

B-vitamins or vitamin C16

bullCorrection of these deficiencies through supplementation with the proper forms and

amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in

complete resolution of mental symptoms in some individualsrdquo16

Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas

bullThis herb standardized for L-Dopa content has been found in research to have potent

anti-depressant actions17

bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Insomnia

Sleepless nights are a very common symptom of opiate withdrawal Long-

term use of opiates tends to disrupt the sleep wake cycle by disturbing

the proper production of melatonin and other sleep-inducing chemicals in

the body In order to re-establish healthy sleep cycles allowing patients to

fall asleep faster and stay asleep longer it is necessary to support the

production of natural sleep chemicals

The Withdrawal Relief Complex contains a

healthy dose of pure Melatonin and other all-

natural sleep support ingredients to help

patients sleep through the night allowing them

to obtain the rest needed to recover quickly

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall

asleep much faster and to significantly increase the amount of sleep achieved throughout the

night19 20

5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with

one study showing a 53 increase in REM sleep during the night21

ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small

doses of barbiturates or benzodiazepansrdquo22

bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23

American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects

take place within 30 minutes of ingestion and have been shown in research to help people fall

asleep faster and stay asleep longer24

Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in

prolonged sleep tests25

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Nausea amp Gastrointestinal Distress

Nausea and GI distress (including intestinal cramping and diarrhea) is one of the

most uncomfortable and disruptive physical symptoms of opiate withdrawal This

symptom generally presents 2 or 3 days after abstaining from opiates and can last

for up to a week

Opiates have a very strong sedative effect on the stomach and intestinal tract

Once opiate use is discontinued these organs become over stimulated Nerves

that have been suppressed for a long time begin to come back to life This

enhanced neural input to the smooth muscles of the stomach and GI tract can be

shocking to the system thus causing cramping and hyper-motility

which can lead to diarrhea nausea and vomiting

To treat these symptoms the Withdrawal Relief Complex

formulas include powerful ingredients that not only help to

provide natural moderate sedation to overactive GI nerves but

also help soothe the stomach

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows

gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the

prescription drug Papaverinerdquo for these uses

Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth

muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27

bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a

spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it

as a natural medicine for GI distress28

Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many

antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-

33

Vitamin B6

bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin

B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated

that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our

combined formulashellipover twice the dose of the studyhellipto ensure best results

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Extreme Fatigue amp Lethargy

The fatigue most people experience during withdrawal is profound It can be severe

enough that patients will literally not be able to get out of bed This is particularly

damaging for those needing to maintain a consistent work schedule and or care for

their family

The fatigue that comes from opiate withdrawal is both physical and mental Many

recovering opiate addicts feel a complete lack of motivation and desire to engage in

life This leads to reclusive behavior poor diet and a host of other actions that tend

to prolong withdrawal and lead to relapse

Therefore it is imperative that patients are supported

in staying energized and motivated as they negotiate

the acute phase of withdrawal

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased

energy focus attention and task performance throughout the day Researchers stated ldquoThese results

provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the

psychoactive properties of ginsengrdquo35

5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to

ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36

L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers

found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37

bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing

neurotransmitters such as epinephrine and norepinephrine

Vitamin B12

bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38

bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase

in energy stamina and well being helliprdquo38

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Restless Leg Syndrome (RLS)

RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced

by nearly everyone going through opiate withdrawal This symptom is not so much

painful as it is disruptive and highly irritating RLS causes agitation during the day

and disrupts sleep during the night This exacerbates the symptoms of insomnia and

creates further daytime agitation locking patients into a vicious cycle

RLS is thought to be caused by the depletion of the neurotransmitter dopamine in

the system Research has shown that providing nutrients to help stimulate

dopamine production can quickly and effectively decrease or eliminate the severity

of this syndrome

The following demonstrates how the nutrients in Withdrawal Relief

Complex support dopamine production in two ways by providing a

direct source of natural dopamine (through the L-dopa content of

Mucuna pruriens) and by supporting dopamine metabolism in the

body with the B-vitamin Folate

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances

levels of dopamine in the brain39

bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a

medical treatment for Parkinsons Disease40

bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly

decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41

Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid

(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and

fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid

levelsrdquo42 43

Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people

with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS

symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in

the Withdrawal Relief Complex Nighttime formula

MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for

treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal

Relief Complex System This formula has been designed to help keep cravings at

bay after acute withdraw has passed allowing the chemical balance in the patient‟s

brain to quickly and safely return to pre-drug use level

CCRR is a four part compound nutraceutical that addresses cravings by

bullSupplying your adrenal system with nutrients you need to feel good The

ingredients in CCRR work hard to heal your body and restore your

organs and mind

bullGiving your brain a natural boost to stave off depression and anxiety

until the chemical balance of your pre-drug healthy brain is restored

bullFlooding your body with nourishing vitamins and antioxidants that

support physical recovery as you continue to gain strength

bullEnsuring that cravings stay manageable while you create more and more

distance from the desire for more drugs

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 13: PHG Presentation 07112011

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullA recent study entitled ldquoPassionflower in the treatment of opiate withdrawal a double-

blind randomized controlled trialrdquo comparing the effects of passion flower with Clonidine

showed use of this herb significantly decreased depression and anxiety associated with

withdrawal as well as if not better than Clonidine1

bullPassion flower shown to be as effective as ldquoOxazepamrdquo in the treatment of anxiety

WITHOUT the adverse side effects of the drug2

5-Hydroxytryptophan (5-HTP)bullMultiple scientific studies have shown that short-term supplementation with 5-HTP

dramatically alleviates depression3-9

bullIt does so by bolstering serotonin levels in the brain

Rhodiola roseabull300 increase is neurotransmitter levels in the brain with Rhodiola supplementation10

bullSignificantly increases the biosynthesis of natural opioid peptides in the body11

bullDecrease the symptoms of depression in patients by up over 3512

L-tyrosinebullHas been stated in a comprehensive review study to ldquohellipsignificantly enhance levels of vital

neurotransmittershelliprdquo in the brain thus acting as a powerful anti-depressant13

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which

indicates that it relaxes the mind without inducing drowsinessrdquo14

bullL-theanine reduces anxiety and calms nerves during stressful events15

Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the

B-vitamins or vitamin C16

bullCorrection of these deficiencies through supplementation with the proper forms and

amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in

complete resolution of mental symptoms in some individualsrdquo16

Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas

bullThis herb standardized for L-Dopa content has been found in research to have potent

anti-depressant actions17

bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Insomnia

Sleepless nights are a very common symptom of opiate withdrawal Long-

term use of opiates tends to disrupt the sleep wake cycle by disturbing

the proper production of melatonin and other sleep-inducing chemicals in

the body In order to re-establish healthy sleep cycles allowing patients to

fall asleep faster and stay asleep longer it is necessary to support the

production of natural sleep chemicals

The Withdrawal Relief Complex contains a

healthy dose of pure Melatonin and other all-

natural sleep support ingredients to help

patients sleep through the night allowing them

to obtain the rest needed to recover quickly

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall

asleep much faster and to significantly increase the amount of sleep achieved throughout the

night19 20

5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with

one study showing a 53 increase in REM sleep during the night21

ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small

doses of barbiturates or benzodiazepansrdquo22

bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23

American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects

take place within 30 minutes of ingestion and have been shown in research to help people fall

asleep faster and stay asleep longer24

Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in

prolonged sleep tests25

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Nausea amp Gastrointestinal Distress

Nausea and GI distress (including intestinal cramping and diarrhea) is one of the

most uncomfortable and disruptive physical symptoms of opiate withdrawal This

symptom generally presents 2 or 3 days after abstaining from opiates and can last

for up to a week

Opiates have a very strong sedative effect on the stomach and intestinal tract

Once opiate use is discontinued these organs become over stimulated Nerves

that have been suppressed for a long time begin to come back to life This

enhanced neural input to the smooth muscles of the stomach and GI tract can be

shocking to the system thus causing cramping and hyper-motility

which can lead to diarrhea nausea and vomiting

To treat these symptoms the Withdrawal Relief Complex

formulas include powerful ingredients that not only help to

provide natural moderate sedation to overactive GI nerves but

also help soothe the stomach

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows

gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the

prescription drug Papaverinerdquo for these uses

Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth

muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27

bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a

spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it

as a natural medicine for GI distress28

Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many

antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-

33

Vitamin B6

bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin

B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated

that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our

combined formulashellipover twice the dose of the studyhellipto ensure best results

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Extreme Fatigue amp Lethargy

The fatigue most people experience during withdrawal is profound It can be severe

enough that patients will literally not be able to get out of bed This is particularly

damaging for those needing to maintain a consistent work schedule and or care for

their family

The fatigue that comes from opiate withdrawal is both physical and mental Many

recovering opiate addicts feel a complete lack of motivation and desire to engage in

life This leads to reclusive behavior poor diet and a host of other actions that tend

to prolong withdrawal and lead to relapse

Therefore it is imperative that patients are supported

in staying energized and motivated as they negotiate

the acute phase of withdrawal

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased

energy focus attention and task performance throughout the day Researchers stated ldquoThese results

provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the

psychoactive properties of ginsengrdquo35

5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to

ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36

L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers

found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37

bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing

neurotransmitters such as epinephrine and norepinephrine

Vitamin B12

bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38

bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase

in energy stamina and well being helliprdquo38

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Restless Leg Syndrome (RLS)

RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced

by nearly everyone going through opiate withdrawal This symptom is not so much

painful as it is disruptive and highly irritating RLS causes agitation during the day

and disrupts sleep during the night This exacerbates the symptoms of insomnia and

creates further daytime agitation locking patients into a vicious cycle

RLS is thought to be caused by the depletion of the neurotransmitter dopamine in

the system Research has shown that providing nutrients to help stimulate

dopamine production can quickly and effectively decrease or eliminate the severity

of this syndrome

The following demonstrates how the nutrients in Withdrawal Relief

Complex support dopamine production in two ways by providing a

direct source of natural dopamine (through the L-dopa content of

Mucuna pruriens) and by supporting dopamine metabolism in the

body with the B-vitamin Folate

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances

levels of dopamine in the brain39

bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a

medical treatment for Parkinsons Disease40

bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly

decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41

Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid

(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and

fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid

levelsrdquo42 43

Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people

with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS

symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in

the Withdrawal Relief Complex Nighttime formula

MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for

treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal

Relief Complex System This formula has been designed to help keep cravings at

bay after acute withdraw has passed allowing the chemical balance in the patient‟s

brain to quickly and safely return to pre-drug use level

CCRR is a four part compound nutraceutical that addresses cravings by

bullSupplying your adrenal system with nutrients you need to feel good The

ingredients in CCRR work hard to heal your body and restore your

organs and mind

bullGiving your brain a natural boost to stave off depression and anxiety

until the chemical balance of your pre-drug healthy brain is restored

bullFlooding your body with nourishing vitamins and antioxidants that

support physical recovery as you continue to gain strength

bullEnsuring that cravings stay manageable while you create more and more

distance from the desire for more drugs

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 14: PHG Presentation 07112011

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

L-TheaninebullldquoL-theanine significantly increases activity in the alpha frequency band in the brain which

indicates that it relaxes the mind without inducing drowsinessrdquo14

bullL-theanine reduces anxiety and calms nerves during stressful events15

Vitamin C amp B-VitaminsbullA large number of people suffering from depression are deficient in one or more of the

B-vitamins or vitamin C16

bullCorrection of these deficiencies through supplementation with the proper forms and

amounts of these vitamins (as found in Withdrawal Relief Complete) ldquohellipmay result in

complete resolution of mental symptoms in some individualsrdquo16

Mucuna pruriensbullStandardized for 20 L-Dopa in our formulas

bullThis herb standardized for L-Dopa content has been found in research to have potent

anti-depressant actions17

bullAlso acts as an aphrodisiac and libido enhancer due to its dopamine enhancing actions18

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Insomnia

Sleepless nights are a very common symptom of opiate withdrawal Long-

term use of opiates tends to disrupt the sleep wake cycle by disturbing

the proper production of melatonin and other sleep-inducing chemicals in

the body In order to re-establish healthy sleep cycles allowing patients to

fall asleep faster and stay asleep longer it is necessary to support the

production of natural sleep chemicals

The Withdrawal Relief Complex contains a

healthy dose of pure Melatonin and other all-

natural sleep support ingredients to help

patients sleep through the night allowing them

to obtain the rest needed to recover quickly

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall

asleep much faster and to significantly increase the amount of sleep achieved throughout the

night19 20

5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with

one study showing a 53 increase in REM sleep during the night21

ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small

doses of barbiturates or benzodiazepansrdquo22

bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23

American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects

take place within 30 minutes of ingestion and have been shown in research to help people fall

asleep faster and stay asleep longer24

Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in

prolonged sleep tests25

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Nausea amp Gastrointestinal Distress

Nausea and GI distress (including intestinal cramping and diarrhea) is one of the

most uncomfortable and disruptive physical symptoms of opiate withdrawal This

symptom generally presents 2 or 3 days after abstaining from opiates and can last

for up to a week

Opiates have a very strong sedative effect on the stomach and intestinal tract

Once opiate use is discontinued these organs become over stimulated Nerves

that have been suppressed for a long time begin to come back to life This

enhanced neural input to the smooth muscles of the stomach and GI tract can be

shocking to the system thus causing cramping and hyper-motility

which can lead to diarrhea nausea and vomiting

To treat these symptoms the Withdrawal Relief Complex

formulas include powerful ingredients that not only help to

provide natural moderate sedation to overactive GI nerves but

also help soothe the stomach

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows

gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the

prescription drug Papaverinerdquo for these uses

Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth

muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27

bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a

spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it

as a natural medicine for GI distress28

Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many

antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-

33

Vitamin B6

bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin

B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated

that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our

combined formulashellipover twice the dose of the studyhellipto ensure best results

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Extreme Fatigue amp Lethargy

The fatigue most people experience during withdrawal is profound It can be severe

enough that patients will literally not be able to get out of bed This is particularly

damaging for those needing to maintain a consistent work schedule and or care for

their family

The fatigue that comes from opiate withdrawal is both physical and mental Many

recovering opiate addicts feel a complete lack of motivation and desire to engage in

life This leads to reclusive behavior poor diet and a host of other actions that tend

to prolong withdrawal and lead to relapse

Therefore it is imperative that patients are supported

in staying energized and motivated as they negotiate

the acute phase of withdrawal

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased

energy focus attention and task performance throughout the day Researchers stated ldquoThese results

provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the

psychoactive properties of ginsengrdquo35

5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to

ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36

L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers

found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37

bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing

neurotransmitters such as epinephrine and norepinephrine

Vitamin B12

bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38

bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase

in energy stamina and well being helliprdquo38

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Restless Leg Syndrome (RLS)

RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced

by nearly everyone going through opiate withdrawal This symptom is not so much

painful as it is disruptive and highly irritating RLS causes agitation during the day

and disrupts sleep during the night This exacerbates the symptoms of insomnia and

creates further daytime agitation locking patients into a vicious cycle

RLS is thought to be caused by the depletion of the neurotransmitter dopamine in

the system Research has shown that providing nutrients to help stimulate

dopamine production can quickly and effectively decrease or eliminate the severity

of this syndrome

The following demonstrates how the nutrients in Withdrawal Relief

Complex support dopamine production in two ways by providing a

direct source of natural dopamine (through the L-dopa content of

Mucuna pruriens) and by supporting dopamine metabolism in the

body with the B-vitamin Folate

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances

levels of dopamine in the brain39

bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a

medical treatment for Parkinsons Disease40

bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly

decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41

Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid

(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and

fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid

levelsrdquo42 43

Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people

with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS

symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in

the Withdrawal Relief Complex Nighttime formula

MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for

treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal

Relief Complex System This formula has been designed to help keep cravings at

bay after acute withdraw has passed allowing the chemical balance in the patient‟s

brain to quickly and safely return to pre-drug use level

CCRR is a four part compound nutraceutical that addresses cravings by

bullSupplying your adrenal system with nutrients you need to feel good The

ingredients in CCRR work hard to heal your body and restore your

organs and mind

bullGiving your brain a natural boost to stave off depression and anxiety

until the chemical balance of your pre-drug healthy brain is restored

bullFlooding your body with nourishing vitamins and antioxidants that

support physical recovery as you continue to gain strength

bullEnsuring that cravings stay manageable while you create more and more

distance from the desire for more drugs

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 15: PHG Presentation 07112011

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Insomnia

Sleepless nights are a very common symptom of opiate withdrawal Long-

term use of opiates tends to disrupt the sleep wake cycle by disturbing

the proper production of melatonin and other sleep-inducing chemicals in

the body In order to re-establish healthy sleep cycles allowing patients to

fall asleep faster and stay asleep longer it is necessary to support the

production of natural sleep chemicals

The Withdrawal Relief Complex contains a

healthy dose of pure Melatonin and other all-

natural sleep support ingredients to help

patients sleep through the night allowing them

to obtain the rest needed to recover quickly

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall

asleep much faster and to significantly increase the amount of sleep achieved throughout the

night19 20

5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with

one study showing a 53 increase in REM sleep during the night21

ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small

doses of barbiturates or benzodiazepansrdquo22

bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23

American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects

take place within 30 minutes of ingestion and have been shown in research to help people fall

asleep faster and stay asleep longer24

Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in

prolonged sleep tests25

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Nausea amp Gastrointestinal Distress

Nausea and GI distress (including intestinal cramping and diarrhea) is one of the

most uncomfortable and disruptive physical symptoms of opiate withdrawal This

symptom generally presents 2 or 3 days after abstaining from opiates and can last

for up to a week

Opiates have a very strong sedative effect on the stomach and intestinal tract

Once opiate use is discontinued these organs become over stimulated Nerves

that have been suppressed for a long time begin to come back to life This

enhanced neural input to the smooth muscles of the stomach and GI tract can be

shocking to the system thus causing cramping and hyper-motility

which can lead to diarrhea nausea and vomiting

To treat these symptoms the Withdrawal Relief Complex

formulas include powerful ingredients that not only help to

provide natural moderate sedation to overactive GI nerves but

also help soothe the stomach

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows

gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the

prescription drug Papaverinerdquo for these uses

Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth

muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27

bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a

spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it

as a natural medicine for GI distress28

Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many

antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-

33

Vitamin B6

bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin

B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated

that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our

combined formulashellipover twice the dose of the studyhellipto ensure best results

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Extreme Fatigue amp Lethargy

The fatigue most people experience during withdrawal is profound It can be severe

enough that patients will literally not be able to get out of bed This is particularly

damaging for those needing to maintain a consistent work schedule and or care for

their family

The fatigue that comes from opiate withdrawal is both physical and mental Many

recovering opiate addicts feel a complete lack of motivation and desire to engage in

life This leads to reclusive behavior poor diet and a host of other actions that tend

to prolong withdrawal and lead to relapse

Therefore it is imperative that patients are supported

in staying energized and motivated as they negotiate

the acute phase of withdrawal

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased

energy focus attention and task performance throughout the day Researchers stated ldquoThese results

provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the

psychoactive properties of ginsengrdquo35

5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to

ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36

L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers

found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37

bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing

neurotransmitters such as epinephrine and norepinephrine

Vitamin B12

bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38

bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase

in energy stamina and well being helliprdquo38

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Restless Leg Syndrome (RLS)

RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced

by nearly everyone going through opiate withdrawal This symptom is not so much

painful as it is disruptive and highly irritating RLS causes agitation during the day

and disrupts sleep during the night This exacerbates the symptoms of insomnia and

creates further daytime agitation locking patients into a vicious cycle

RLS is thought to be caused by the depletion of the neurotransmitter dopamine in

the system Research has shown that providing nutrients to help stimulate

dopamine production can quickly and effectively decrease or eliminate the severity

of this syndrome

The following demonstrates how the nutrients in Withdrawal Relief

Complex support dopamine production in two ways by providing a

direct source of natural dopamine (through the L-dopa content of

Mucuna pruriens) and by supporting dopamine metabolism in the

body with the B-vitamin Folate

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances

levels of dopamine in the brain39

bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a

medical treatment for Parkinsons Disease40

bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly

decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41

Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid

(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and

fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid

levelsrdquo42 43

Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people

with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS

symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in

the Withdrawal Relief Complex Nighttime formula

MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for

treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal

Relief Complex System This formula has been designed to help keep cravings at

bay after acute withdraw has passed allowing the chemical balance in the patient‟s

brain to quickly and safely return to pre-drug use level

CCRR is a four part compound nutraceutical that addresses cravings by

bullSupplying your adrenal system with nutrients you need to feel good The

ingredients in CCRR work hard to heal your body and restore your

organs and mind

bullGiving your brain a natural boost to stave off depression and anxiety

until the chemical balance of your pre-drug healthy brain is restored

bullFlooding your body with nourishing vitamins and antioxidants that

support physical recovery as you continue to gain strength

bullEnsuring that cravings stay manageable while you create more and more

distance from the desire for more drugs

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 16: PHG Presentation 07112011

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

MelatoninbullUse of melatonin in the evenings to induce sleep has been shown to help insomniacs fall

asleep much faster and to significantly increase the amount of sleep achieved throughout the

night19 20

5-Hydroxytryptophan (5-HTP)bull5-HTP has been shown to be treat insomnia by increasing serotonin levels in the brain with

one study showing a 53 increase in REM sleep during the night21

ValerianbullStudies show it ldquohellipmay be as effective in reducing sleep latency (time to fall asleep) as small

doses of barbiturates or benzodiazepansrdquo22

bullAlso increases sleep quality and with no ldquohangoverrdquo the next morning23

American SkullcapbullThis powerful herbal sedative helps decrease anxiety restlessness and irritability These effects

take place within 30 minutes of ingestion and have been shown in research to help people fall

asleep faster and stay asleep longer24

Passion FlowerbullPassion flower extracts found to be as effective as some barbiturates at inducing sleep in

prolonged sleep tests25

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Nausea amp Gastrointestinal Distress

Nausea and GI distress (including intestinal cramping and diarrhea) is one of the

most uncomfortable and disruptive physical symptoms of opiate withdrawal This

symptom generally presents 2 or 3 days after abstaining from opiates and can last

for up to a week

Opiates have a very strong sedative effect on the stomach and intestinal tract

Once opiate use is discontinued these organs become over stimulated Nerves

that have been suppressed for a long time begin to come back to life This

enhanced neural input to the smooth muscles of the stomach and GI tract can be

shocking to the system thus causing cramping and hyper-motility

which can lead to diarrhea nausea and vomiting

To treat these symptoms the Withdrawal Relief Complex

formulas include powerful ingredients that not only help to

provide natural moderate sedation to overactive GI nerves but

also help soothe the stomach

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows

gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the

prescription drug Papaverinerdquo for these uses

Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth

muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27

bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a

spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it

as a natural medicine for GI distress28

Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many

antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-

33

Vitamin B6

bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin

B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated

that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our

combined formulashellipover twice the dose of the studyhellipto ensure best results

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Extreme Fatigue amp Lethargy

The fatigue most people experience during withdrawal is profound It can be severe

enough that patients will literally not be able to get out of bed This is particularly

damaging for those needing to maintain a consistent work schedule and or care for

their family

The fatigue that comes from opiate withdrawal is both physical and mental Many

recovering opiate addicts feel a complete lack of motivation and desire to engage in

life This leads to reclusive behavior poor diet and a host of other actions that tend

to prolong withdrawal and lead to relapse

Therefore it is imperative that patients are supported

in staying energized and motivated as they negotiate

the acute phase of withdrawal

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased

energy focus attention and task performance throughout the day Researchers stated ldquoThese results

provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the

psychoactive properties of ginsengrdquo35

5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to

ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36

L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers

found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37

bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing

neurotransmitters such as epinephrine and norepinephrine

Vitamin B12

bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38

bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase

in energy stamina and well being helliprdquo38

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Restless Leg Syndrome (RLS)

RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced

by nearly everyone going through opiate withdrawal This symptom is not so much

painful as it is disruptive and highly irritating RLS causes agitation during the day

and disrupts sleep during the night This exacerbates the symptoms of insomnia and

creates further daytime agitation locking patients into a vicious cycle

RLS is thought to be caused by the depletion of the neurotransmitter dopamine in

the system Research has shown that providing nutrients to help stimulate

dopamine production can quickly and effectively decrease or eliminate the severity

of this syndrome

The following demonstrates how the nutrients in Withdrawal Relief

Complex support dopamine production in two ways by providing a

direct source of natural dopamine (through the L-dopa content of

Mucuna pruriens) and by supporting dopamine metabolism in the

body with the B-vitamin Folate

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances

levels of dopamine in the brain39

bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a

medical treatment for Parkinsons Disease40

bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly

decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41

Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid

(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and

fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid

levelsrdquo42 43

Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people

with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS

symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in

the Withdrawal Relief Complex Nighttime formula

MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for

treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal

Relief Complex System This formula has been designed to help keep cravings at

bay after acute withdraw has passed allowing the chemical balance in the patient‟s

brain to quickly and safely return to pre-drug use level

CCRR is a four part compound nutraceutical that addresses cravings by

bullSupplying your adrenal system with nutrients you need to feel good The

ingredients in CCRR work hard to heal your body and restore your

organs and mind

bullGiving your brain a natural boost to stave off depression and anxiety

until the chemical balance of your pre-drug healthy brain is restored

bullFlooding your body with nourishing vitamins and antioxidants that

support physical recovery as you continue to gain strength

bullEnsuring that cravings stay manageable while you create more and more

distance from the desire for more drugs

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 17: PHG Presentation 07112011

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Nausea amp Gastrointestinal Distress

Nausea and GI distress (including intestinal cramping and diarrhea) is one of the

most uncomfortable and disruptive physical symptoms of opiate withdrawal This

symptom generally presents 2 or 3 days after abstaining from opiates and can last

for up to a week

Opiates have a very strong sedative effect on the stomach and intestinal tract

Once opiate use is discontinued these organs become over stimulated Nerves

that have been suppressed for a long time begin to come back to life This

enhanced neural input to the smooth muscles of the stomach and GI tract can be

shocking to the system thus causing cramping and hyper-motility

which can lead to diarrhea nausea and vomiting

To treat these symptoms the Withdrawal Relief Complex

formulas include powerful ingredients that not only help to

provide natural moderate sedation to overactive GI nerves but

also help soothe the stomach

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows

gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the

prescription drug Papaverinerdquo for these uses

Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth

muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27

bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a

spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it

as a natural medicine for GI distress28

Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many

antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-

33

Vitamin B6

bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin

B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated

that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our

combined formulashellipover twice the dose of the studyhellipto ensure best results

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Extreme Fatigue amp Lethargy

The fatigue most people experience during withdrawal is profound It can be severe

enough that patients will literally not be able to get out of bed This is particularly

damaging for those needing to maintain a consistent work schedule and or care for

their family

The fatigue that comes from opiate withdrawal is both physical and mental Many

recovering opiate addicts feel a complete lack of motivation and desire to engage in

life This leads to reclusive behavior poor diet and a host of other actions that tend

to prolong withdrawal and lead to relapse

Therefore it is imperative that patients are supported

in staying energized and motivated as they negotiate

the acute phase of withdrawal

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased

energy focus attention and task performance throughout the day Researchers stated ldquoThese results

provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the

psychoactive properties of ginsengrdquo35

5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to

ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36

L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers

found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37

bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing

neurotransmitters such as epinephrine and norepinephrine

Vitamin B12

bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38

bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase

in energy stamina and well being helliprdquo38

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Restless Leg Syndrome (RLS)

RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced

by nearly everyone going through opiate withdrawal This symptom is not so much

painful as it is disruptive and highly irritating RLS causes agitation during the day

and disrupts sleep during the night This exacerbates the symptoms of insomnia and

creates further daytime agitation locking patients into a vicious cycle

RLS is thought to be caused by the depletion of the neurotransmitter dopamine in

the system Research has shown that providing nutrients to help stimulate

dopamine production can quickly and effectively decrease or eliminate the severity

of this syndrome

The following demonstrates how the nutrients in Withdrawal Relief

Complex support dopamine production in two ways by providing a

direct source of natural dopamine (through the L-dopa content of

Mucuna pruriens) and by supporting dopamine metabolism in the

body with the B-vitamin Folate

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances

levels of dopamine in the brain39

bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a

medical treatment for Parkinsons Disease40

bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly

decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41

Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid

(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and

fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid

levelsrdquo42 43

Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people

with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS

symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in

the Withdrawal Relief Complex Nighttime formula

MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for

treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal

Relief Complex System This formula has been designed to help keep cravings at

bay after acute withdraw has passed allowing the chemical balance in the patient‟s

brain to quickly and safely return to pre-drug use level

CCRR is a four part compound nutraceutical that addresses cravings by

bullSupplying your adrenal system with nutrients you need to feel good The

ingredients in CCRR work hard to heal your body and restore your

organs and mind

bullGiving your brain a natural boost to stave off depression and anxiety

until the chemical balance of your pre-drug healthy brain is restored

bullFlooding your body with nourishing vitamins and antioxidants that

support physical recovery as you continue to gain strength

bullEnsuring that cravings stay manageable while you create more and more

distance from the desire for more drugs

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 18: PHG Presentation 07112011

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Passion FlowerbullClinical research has shown that Passion Flower decreases spasms in the gastrointestinal tract and slows

gut motility thus helping to alleviate diarrhea and stomach cramps 26 Found to be as effective as the

prescription drug Papaverinerdquo for these uses

Peppermint LeavesbullThe active oils in peppermint leaves have been shown to inhibit the hyper-contractility of smooth

muscles in the upper intestine thereby returning the muscle to its proper tone and relieving discomfort27

bullThe German Commission E (Germany‟s version of the FDA) has found peppermint to be effective as a

spasmolytic (particularly useful for discomfort caused by spasms in the upper digestive tract) scheduling it

as a natural medicine for GI distress28

Ginger RootbullFive double-blind clinical trials have show ginger to be as effective in reducing nausea as many

antiemetic pharmaceuticals such as dimenhydrinate domperidone scopolamine cyclizine and meclizine29-

33

Vitamin B6

bullA recent study using 342 pregnant women with severe morning sickness showed 30 mg day of Vitamin

B6 significantly decrease nausea and vomiting episodes over a 5-day trial period34 Researchers stated

that ldquohelliplarger doses would likely have been even more effectiverdquo That is why we included 70 mg in our

combined formulashellipover twice the dose of the studyhellipto ensure best results

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Extreme Fatigue amp Lethargy

The fatigue most people experience during withdrawal is profound It can be severe

enough that patients will literally not be able to get out of bed This is particularly

damaging for those needing to maintain a consistent work schedule and or care for

their family

The fatigue that comes from opiate withdrawal is both physical and mental Many

recovering opiate addicts feel a complete lack of motivation and desire to engage in

life This leads to reclusive behavior poor diet and a host of other actions that tend

to prolong withdrawal and lead to relapse

Therefore it is imperative that patients are supported

in staying energized and motivated as they negotiate

the acute phase of withdrawal

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased

energy focus attention and task performance throughout the day Researchers stated ldquoThese results

provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the

psychoactive properties of ginsengrdquo35

5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to

ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36

L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers

found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37

bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing

neurotransmitters such as epinephrine and norepinephrine

Vitamin B12

bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38

bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase

in energy stamina and well being helliprdquo38

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Restless Leg Syndrome (RLS)

RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced

by nearly everyone going through opiate withdrawal This symptom is not so much

painful as it is disruptive and highly irritating RLS causes agitation during the day

and disrupts sleep during the night This exacerbates the symptoms of insomnia and

creates further daytime agitation locking patients into a vicious cycle

RLS is thought to be caused by the depletion of the neurotransmitter dopamine in

the system Research has shown that providing nutrients to help stimulate

dopamine production can quickly and effectively decrease or eliminate the severity

of this syndrome

The following demonstrates how the nutrients in Withdrawal Relief

Complex support dopamine production in two ways by providing a

direct source of natural dopamine (through the L-dopa content of

Mucuna pruriens) and by supporting dopamine metabolism in the

body with the B-vitamin Folate

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances

levels of dopamine in the brain39

bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a

medical treatment for Parkinsons Disease40

bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly

decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41

Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid

(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and

fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid

levelsrdquo42 43

Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people

with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS

symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in

the Withdrawal Relief Complex Nighttime formula

MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for

treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal

Relief Complex System This formula has been designed to help keep cravings at

bay after acute withdraw has passed allowing the chemical balance in the patient‟s

brain to quickly and safely return to pre-drug use level

CCRR is a four part compound nutraceutical that addresses cravings by

bullSupplying your adrenal system with nutrients you need to feel good The

ingredients in CCRR work hard to heal your body and restore your

organs and mind

bullGiving your brain a natural boost to stave off depression and anxiety

until the chemical balance of your pre-drug healthy brain is restored

bullFlooding your body with nourishing vitamins and antioxidants that

support physical recovery as you continue to gain strength

bullEnsuring that cravings stay manageable while you create more and more

distance from the desire for more drugs

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 19: PHG Presentation 07112011

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Extreme Fatigue amp Lethargy

The fatigue most people experience during withdrawal is profound It can be severe

enough that patients will literally not be able to get out of bed This is particularly

damaging for those needing to maintain a consistent work schedule and or care for

their family

The fatigue that comes from opiate withdrawal is both physical and mental Many

recovering opiate addicts feel a complete lack of motivation and desire to engage in

life This leads to reclusive behavior poor diet and a host of other actions that tend

to prolong withdrawal and lead to relapse

Therefore it is imperative that patients are supported

in staying energized and motivated as they negotiate

the acute phase of withdrawal

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased

energy focus attention and task performance throughout the day Researchers stated ldquoThese results

provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the

psychoactive properties of ginsengrdquo35

5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to

ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36

L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers

found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37

bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing

neurotransmitters such as epinephrine and norepinephrine

Vitamin B12

bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38

bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase

in energy stamina and well being helliprdquo38

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Restless Leg Syndrome (RLS)

RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced

by nearly everyone going through opiate withdrawal This symptom is not so much

painful as it is disruptive and highly irritating RLS causes agitation during the day

and disrupts sleep during the night This exacerbates the symptoms of insomnia and

creates further daytime agitation locking patients into a vicious cycle

RLS is thought to be caused by the depletion of the neurotransmitter dopamine in

the system Research has shown that providing nutrients to help stimulate

dopamine production can quickly and effectively decrease or eliminate the severity

of this syndrome

The following demonstrates how the nutrients in Withdrawal Relief

Complex support dopamine production in two ways by providing a

direct source of natural dopamine (through the L-dopa content of

Mucuna pruriens) and by supporting dopamine metabolism in the

body with the B-vitamin Folate

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances

levels of dopamine in the brain39

bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a

medical treatment for Parkinsons Disease40

bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly

decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41

Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid

(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and

fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid

levelsrdquo42 43

Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people

with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS

symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in

the Withdrawal Relief Complex Nighttime formula

MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for

treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal

Relief Complex System This formula has been designed to help keep cravings at

bay after acute withdraw has passed allowing the chemical balance in the patient‟s

brain to quickly and safely return to pre-drug use level

CCRR is a four part compound nutraceutical that addresses cravings by

bullSupplying your adrenal system with nutrients you need to feel good The

ingredients in CCRR work hard to heal your body and restore your

organs and mind

bullGiving your brain a natural boost to stave off depression and anxiety

until the chemical balance of your pre-drug healthy brain is restored

bullFlooding your body with nourishing vitamins and antioxidants that

support physical recovery as you continue to gain strength

bullEnsuring that cravings stay manageable while you create more and more

distance from the desire for more drugs

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 20: PHG Presentation 07112011

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Guarana seed + Panax GinsengbullIn a very recent study it was shown that the combination of Guarana seed amp Panax ginseng increased

energy focus attention and task performance throughout the day Researchers stated ldquoThese results

provide the first demonstration in humans of the psychoactive effects of guarana and confirmation of the

psychoactive properties of ginsengrdquo35

5-Hydroxytryptophan (5-HTP)bullA study of 50 Fibromyalgia patients with chronic fatigue showed that 300 mg of 5-HTP per day lead to

ldquohellipsignificant improvements in fatigue number of tender points pain intensity anxiety and sleep qualityrdquo36

L-TyrosinebullIn a 6-month study looking at the effect of L-Tyrosine supplementation in narcoleptic patients researchers

found that L-Tyrosine ldquohellipresulted in complete elimination of daytime sleep attacks and cataplexyrdquo37

bullThis anti-fatigue effect is due to L-Tyrosine‟s ability to stimulate production of energy-enhancing

neurotransmitters such as epinephrine and norepinephrine

Vitamin B12

bullLevels of vitamin B12 are shown to be deficient in those with Chronic Fatigue38

bullSupplementation with B12 in one study found that up to 80 of subjects ldquohellipresponded with and increase

in energy stamina and well being helliprdquo38

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Restless Leg Syndrome (RLS)

RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced

by nearly everyone going through opiate withdrawal This symptom is not so much

painful as it is disruptive and highly irritating RLS causes agitation during the day

and disrupts sleep during the night This exacerbates the symptoms of insomnia and

creates further daytime agitation locking patients into a vicious cycle

RLS is thought to be caused by the depletion of the neurotransmitter dopamine in

the system Research has shown that providing nutrients to help stimulate

dopamine production can quickly and effectively decrease or eliminate the severity

of this syndrome

The following demonstrates how the nutrients in Withdrawal Relief

Complex support dopamine production in two ways by providing a

direct source of natural dopamine (through the L-dopa content of

Mucuna pruriens) and by supporting dopamine metabolism in the

body with the B-vitamin Folate

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances

levels of dopamine in the brain39

bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a

medical treatment for Parkinsons Disease40

bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly

decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41

Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid

(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and

fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid

levelsrdquo42 43

Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people

with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS

symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in

the Withdrawal Relief Complex Nighttime formula

MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for

treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal

Relief Complex System This formula has been designed to help keep cravings at

bay after acute withdraw has passed allowing the chemical balance in the patient‟s

brain to quickly and safely return to pre-drug use level

CCRR is a four part compound nutraceutical that addresses cravings by

bullSupplying your adrenal system with nutrients you need to feel good The

ingredients in CCRR work hard to heal your body and restore your

organs and mind

bullGiving your brain a natural boost to stave off depression and anxiety

until the chemical balance of your pre-drug healthy brain is restored

bullFlooding your body with nourishing vitamins and antioxidants that

support physical recovery as you continue to gain strength

bullEnsuring that cravings stay manageable while you create more and more

distance from the desire for more drugs

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 21: PHG Presentation 07112011

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Restless Leg Syndrome (RLS)

RLS It is characterized by ldquotwitchingrdquo or ldquojumpyrdquo leg muscles and is experienced

by nearly everyone going through opiate withdrawal This symptom is not so much

painful as it is disruptive and highly irritating RLS causes agitation during the day

and disrupts sleep during the night This exacerbates the symptoms of insomnia and

creates further daytime agitation locking patients into a vicious cycle

RLS is thought to be caused by the depletion of the neurotransmitter dopamine in

the system Research has shown that providing nutrients to help stimulate

dopamine production can quickly and effectively decrease or eliminate the severity

of this syndrome

The following demonstrates how the nutrients in Withdrawal Relief

Complex support dopamine production in two ways by providing a

direct source of natural dopamine (through the L-dopa content of

Mucuna pruriens) and by supporting dopamine metabolism in the

body with the B-vitamin Folate

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances

levels of dopamine in the brain39

bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a

medical treatment for Parkinsons Disease40

bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly

decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41

Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid

(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and

fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid

levelsrdquo42 43

Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people

with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS

symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in

the Withdrawal Relief Complex Nighttime formula

MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for

treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal

Relief Complex System This formula has been designed to help keep cravings at

bay after acute withdraw has passed allowing the chemical balance in the patient‟s

brain to quickly and safely return to pre-drug use level

CCRR is a four part compound nutraceutical that addresses cravings by

bullSupplying your adrenal system with nutrients you need to feel good The

ingredients in CCRR work hard to heal your body and restore your

organs and mind

bullGiving your brain a natural boost to stave off depression and anxiety

until the chemical balance of your pre-drug healthy brain is restored

bullFlooding your body with nourishing vitamins and antioxidants that

support physical recovery as you continue to gain strength

bullEnsuring that cravings stay manageable while you create more and more

distance from the desire for more drugs

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 22: PHG Presentation 07112011

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Mucuna Pruriens (20 L-dopa)bullResearch has shown that oral administration of this powerful herbal extract significantly enhances

levels of dopamine in the brain39

bullThis herb is so effective at increasing dopamine levels in humans that it is now being used as a

medical treatment for Parkinsons Disease40

bullOver 35 clinical research studies have shown that increasing dopamine levels in the brain significantly

decreases RLS increases quantity and quality of sleep and decreases daytime drowsiness41

Folic AcidbullTwo separate research studies show that supplementation with pharmacological doses of Folic Acid

(like those found in Withdrawal Relief Complex) in patients experiencing long-term RLS depression and

fatigue was able to ldquohellipimprove all symptoms in all patients even in patients with normal RBC folic acid

levelsrdquo42 43

Valerian Root ExtractbullIn a very recent study entitled ldquoDoes valerian improve sleepiness and symptom severity in people

with restless legs syndromerdquo researchers found that ldquoAll patients reported improvement in RLS

symptom severity and sleeprdquo44 This study used nightly doses of Valerian Root extract like that found in

the Withdrawal Relief Complex Nighttime formula

MagnesiumbullResearchers testing the effects of supplementation with Magnesium in the evening before bed for

treatment of RLS state ldquoSymptoms were decreased by an average of 59 in the magnesium grouprdquo45

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal

Relief Complex System This formula has been designed to help keep cravings at

bay after acute withdraw has passed allowing the chemical balance in the patient‟s

brain to quickly and safely return to pre-drug use level

CCRR is a four part compound nutraceutical that addresses cravings by

bullSupplying your adrenal system with nutrients you need to feel good The

ingredients in CCRR work hard to heal your body and restore your

organs and mind

bullGiving your brain a natural boost to stave off depression and anxiety

until the chemical balance of your pre-drug healthy brain is restored

bullFlooding your body with nourishing vitamins and antioxidants that

support physical recovery as you continue to gain strength

bullEnsuring that cravings stay manageable while you create more and more

distance from the desire for more drugs

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 23: PHG Presentation 07112011

Active Ingredients ndash Explanation amp Scientific Substantiation

Copyright copy 2011 Pure Health Group trade

Craving Control Relapse Relief Nutraceutical is the 3rd prong to our Withdrawal

Relief Complex System This formula has been designed to help keep cravings at

bay after acute withdraw has passed allowing the chemical balance in the patient‟s

brain to quickly and safely return to pre-drug use level

CCRR is a four part compound nutraceutical that addresses cravings by

bullSupplying your adrenal system with nutrients you need to feel good The

ingredients in CCRR work hard to heal your body and restore your

organs and mind

bullGiving your brain a natural boost to stave off depression and anxiety

until the chemical balance of your pre-drug healthy brain is restored

bullFlooding your body with nourishing vitamins and antioxidants that

support physical recovery as you continue to gain strength

bullEnsuring that cravings stay manageable while you create more and more

distance from the desire for more drugs

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 24: PHG Presentation 07112011

References1 Akhondzadeh S Kashani L Mobaseri M Hosseini SH Nikzad S Khani M Passionflower in the treatment

of opiates withdrawal a double-blind randomized controlled trial J Clin Pharm Ther 2001

Oct26(5)369-73

2 Akhondzadeh S Passion flower in the treatment of generalized anxiety a pilot double-blind randomized

controlled trial with oxazepam J Clin Pharm Ther 2001 Oct26(5)363-7

3 Van Praag H de Hann S Depression vulnerability and 5-hydroxytryptophan prophylaxis Psychiatry Res

1980375-83

4 Loo H Zarifian E Wirth JF Deniker P Open study of L-5-HTP in melancholic depressed patients over

50 years of age Encephale 19806241-246

5 van Hiele LJ L-5-Hydroxytryptophan in depression the first substitution therapy in psychiatry The

treatment of 99 out-patients with bdquotherapy-resistant‟ depressions Neuropsychobiology 19806230-240

6 Angst J Woggon B Schoepf J The treatment of depression with L-5-hydroxytryptophan versus imipramine

Results of two open and one double-blind study Arch Psychiatr Nervenkr 1977224175-186

7 Alino JJ Gutierrez JL Iglesias ML 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment

of depressions A double-blind controlled study Int Pharmacopsychiatry 1976118-15

8 Takahashi S Kondo H Kato N Effect of L-5-hydroxytryptophan on brain monoamine metabolism and

evaluation of its clinical effect in depressed patients J Psychiatr Res 197512177-187

9 Persson T Roos BE 5-hydroxytryptophan for depression Lancet 19672987-988

Copyright copy 2011 Pure Health Group trade

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 25: PHG Presentation 07112011

References (cont)10 Stancheva SL Mosharrof A Effect of the extract Rhodiola rosea L on the content of the brain biogenic

monamines Med Physiol 19874085-87

11 Lishmanov IB et al Plasma beta-endorphins and stress hormones in stress and adaptation Biull Eksp BiolMed 1987103422-424

12 Darbinyan V Aslanyan G Amroyan E et al Clinical trial of Rhodiola rosea L extract SHR-5 in the treatment of mild to moderate depression Nord J Psychiatry 200761343-348

13 Gelenberg AJ Gibson CJ Tyrosine for the treatment of depression Nutr Health 19843(3)163-73

14 Nobre AC Rao A Owen GN L-theanine a natural constituent in tea and its effect on mental state Asia Pac J Clin Nutr 200817 Suppl 1167-8

15 Kimura K Ozeki M Juneja LR Ohira H L-Theanine reduces psychological and physiological stress responses Biol Psychol 2007 Jan74(1)39-45

16 Wurtman R et al Nutrition and the Brain Vol 3 Raven Press New York NY 1979 pp 183-264

17 M Daniel Medicinal Plants Chemistry and Properties ISBN 978-1-57808-395-4 2006

Copyright copy 2011 Pure Health Group trade

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 26: PHG Presentation 07112011

References (cont)18 Amin KMY Khan MN Hakim Syed Zillur Rahman et al Sexual function improving effect of Mucuna

pruriens in sexually normal male rats Fitoterapia jrg67 (nr1) pp 53-58

19 Zhadanova IV et al Sleep-inducing effects of low doses of melatonin ingested in the evening ClinPharmacol Ther 199557552-558

20 MacFarlane GJ et al The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs A preliminary study Biol Psychiatry 199130371-376

21 Soulairac A Lambinet H Effect of 5-hydroxytryptophan a serotonin precursor on sleep disorders Ann Med Psychol 19771792-798

22 Leathwood PD Chauffard F Aqueous extract of valerian reduces latency to fall asleep in man Planta Med 1985 Apr(2)144-8

23 Leathwood PD Chauffard F Heck E Munoz-Box R Aqueous extract of valerian root (Valeriana officinalis L) improves sleep quality in man Pharmacol Biochem Behav 1982 Jul17(1)65-71

24 Wolfson P Hoffmann DL An investigation into the efficacy of Scutellaria lateriflora in healthy volunteersAltern Ther Health Med 2003 Mar-Apr9(2)74-8

Copyright copy 2011 Pure Health Group trade

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 27: PHG Presentation 07112011

References (cont)23 Speroni E Billi R Mercati V Boncompagni E Toja E Sedative effects of crude extract of Passiflora incarnata

after oral administration Phytotherapy Research 1996 10 S92-S94

24 Lutomski J Segriet E Szpunar K Grisse K Pharmazie in unserer Zeit 1981 10 45

25 Rainforest Remedies Rosita Arvigo Michael Balick Lotus Press 1993

26 Brundesanzeiger (Cologne Germany) November 30 1985 March 13 1986

27 Grontved A et al Ginger root against sea sickness A controlled trial on the open sea Acta Otoloaryngol1988 105 45-49

28 Riebenfeld D Borzone L Randomized double-blind study comparing ginger (Zintona) and dimenhydrinatein motion sickness Healthnotes Rev 1999 6 98-101

29 Careddu P Motion sickness in children results of a double-blind study with ginger (Zintona) and dimenhydrinate Healthnotes Rev 1999 6 102-107

30 Mowrey DB Clayson DE Motion sickness ginger and psychophysics Lancet 1982 1 655-657

31 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med1994 1 203-206

32 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

Copyright copy 2011 Pure Health Group trade

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 28: PHG Presentation 07112011

References (cont)33 Schmid R et al Comparison of seven commonly used agents for prophylaxis of seasickness J Travel Med

1994 1 203-206

34 Vutananich T et al Pyridoxine for nausea and vomiting of pregnancy A randomized double-blind placebo-controlled trial Am J Obstet Gynecol 1995 173 881-884

35 Kennedy DO Haskell CF Wesnes KA Scholey AB Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract comparison and interaction with Panaxginseng Pharmacol Biochem Behav 2004 Nov79(3)401-11

36 Puttini PS Caruso I Primary Fibromyalgia Syndrome and 5-Hydroxy L-Tryptophan a 90-day open study J Int Med Res 199220182-189

37 Mouret J et al Treatment of Narcolepsy with L-Tyrosine Lancet 198821458-1459

38 Lapp CW Cheney PR The rationale for using high-dose cobalamin (Vitamin B-12) The CFIDS Chronicle Physicians Forum Fall 199319-20

39 Manyam BV Dhanasekaran M Hare TA Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters Phytother Res 2004 Feb18(2)97-101

40 Lieu CA Kunselman AR Manyam BV Venkiteswaran K Subramanian T A water extract of Mucuna pruriensprovides long-term amelioration of parkinsonism with reduced risk for dyskinesias Parkinsonism RelatDisord 2010 Aug16(7)458-65

Copyright copy 2011 Pure Health Group trade

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade

Page 29: PHG Presentation 07112011

References (cont)41 Scholz H Trenkwalder C Kohnen R Riemann D Kriston L Hornyak M Dopamine agonists for restless legs

syndrome Cochrane Database Syst Rev 2011 Mar 163CD006009

42 Botez MI et al Neruologic disorders responsive to folic acid therapy Can Med Assoc J 1976115217-223

43 Botez MI et al Folate-responsive neurological and mental disorders report of 16 cases Eur Neurol197716230-246

44 Cuellar NG Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome Altern Ther Health Med 2009 Mar-Apr15(2)22-8

45 Hornyak M Voderholzer U Hohagen F Berger M Riemann D Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome an open pilot study Sleep 1998 Aug 121(5)501-5

Copyright copy 2011 Pure Health Group trade