Pharmacology Department Student Study Guide 3rd year MBBS

Pharmacology Department Student Study Guide

3rd year MBBS (session 2018-2023) Year 2020-2021

CMH Multan Institute of Medical Sciences Year 2020 - 2021

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Disclaimer:

This student study guidebook is subject to further amendments.


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Table of Contents

Sr. No Contents Page No

a. Introduction to subject 3

2. Introduction to Pharmacology Department i. Faculty

ii. Technical and Supporting Staff iii. Facilities and Infrastructure

3 - 6

3. Curricular Map 7

4. Teaching and Learning Strategies 8

5. Learning Resources i. Text and References book List

ii. Audio/Visual Resources

9-10

6. Course content i. Block – I

ii. Block – II iii. Block – III

11 - 23

7. Assessment methods and Strategies 24

8. Table of Specification i. Theory

ii. Practical

25 – 26

9. Student Internal Assessment Card / Log Book 27-32


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Introduction to Subject:

Pharmacology, the subject of basic & clinical & sciences is taught to the medical

students in 3rd year MBBS. It is an allied subject of surgery and medical specialties

and sub specialties.

It deals with classification, preparation, dosages, usage and adverse effects etc. of

the drugs for the purpose of diagnosis or prevention or treatment of various

ailments. The subject is taught throughout in 3rd academic year and has 300 credit

hours, as per curriculum of Pakistan Medical Council (PMC) and National University

of Medical Sciences (NUMS).

Introduction to Pharmacology Department:

Department of Pharmacology was established in 2015 at CIMS Multan. The

department is fully functional and active. All the academic and extra-curricular

activities have been carried out under the guidelines of CIMS and NUMS

administration since then.


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Department of Pharmacology

i. Faculty

Professor

Dr. Afshan Kamran (HOD)

MBBS, M.Phil, PhD

Dr. Arshad Qureshi

MBBS, M.Phil

Assistant Professor

Dr. Saba Batool

MBBS, M.Phil

Demonstrator

Dr. Aish Khan

Senior Demonstrator

MBBS

Dr. Sadaf Akhtar

MBBS

Dr. Tahira Rafique

MBBS

Dr. Urwa Tul Woosqa

MBBS

Dr. Maria

MBBS

Dr. Aqsa Rehman

MBBS

Pharmacist

Dr. Huma Mehtab

Pharm-D


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ii. Technical and Supporting Staff

Computer Operator

Miss Dania Ali

B.A

Lab Technician

Mumtaz Hussain

Matric

Lab Attendant

Imran Zulfiqar

Matric (Science)

Animal House Attendant

Rana M. Imran

Matric


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iii. Facilities and Infrastructure:

Sr. No Facility Available Remarks

1. Pharmacology laboratory * 01 Functional

2. Pharmacology museum 01 Functional

3. Offices

02 Furnished

4. Demonstrator room 01 Furnished

5. Lecture Hall (no.4)* 01 Functional with all facilities

6. Tutorial Room (no. 5)* 01 Functional with all facilities

7. Animal house 01 Functional with all facilities

* Audio/Visual facilities available


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1. Curricular Map:

Months Curricular and Non- curricular Activities

December Block-I

Winter Vacations Year 2021

January

Block-I February

March

Block - II April

May

June

Block-III July

August

September

Pre-Annual

October

Annual

Note:

• Curricular map will be updated accordingly.

• The non-academic/extracurricular activities will be carried out under the direction of

CIMS administration.

• The gazetted/ local holidays, summer/winter break will be granted as per CIMS and

NUMS directives.


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2. Teaching and Learning Strategies:

Sr. No Strategies

1. Large group discussion (Lectures)

2. Small group discussion

3. Practical demonstration

4. Case base learning (CBL)

5. Tutorials

6. E-teaching (Google classrooms, Zoom cloud meetings)

7. Presentations

8. Flipped classroom

9. Seminars

10. Peer assisted learning (PAL)

11. Self-directed learning (SDL)

12. Group study


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3. Learning Resources:

Sr. No Title of Book Edition Author’s Name

a. Text and reference books

1. Basic & Clinical Pharmacology (LANGE) 14th Katzung. G Masters. B Trevor. J

2. Goodman & Gillman’s The Pharmacological Basis of Therapeutics

13th Bjorn C. Knollmann Laurence L. Brunton Randa Hilal - Dandan

3. Pharmacology Examination Board Review

11th Trevor. J Katzung. G

4. Lippincott Illustrated Reviews Pharmacology

6th Karen Whalen Richard Finkel Thomas A. Panavelil

b. Practical notebook

1. AHMED’s practical note book of Pharmacology & Therapeutics

3rd Prof Dr. Ahmed Danyal


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a. Audio/ Visual Resources

Sr. No Title

DVD- 1 • Mounting of rabbit’s ileum

• Effects of drugs on ileum of rabbit

DVD- 2 • Frog heart (pithing, dissection, effects of drugs, kymmographical presentation of effects)

• Mounting of frog’s heart

DVD- 3 • Effects of epinephrine on frog’s heart

• Autonomic effects on rabbit eye

DVD- 4 • To study the site of action of CNS stimulant in frog (Reflex time)

DVD- 5 • Respiratory depressants effect on rabbit

• Effects of drugs on rabbit eye


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Block – I

Code: Y3B1

Duration: 12 weeks


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BLOCK -I

1. Theme: General Pharmacology Weightage: 25%

Course Content Learning Outcomes

• Pharmacology: Introduction, Historical overview

• Branches/division of Pharmacology • Sources & active principles of drugs • Routes of administration of drugs • Pharmacokinetics: • Absorption of drugs: processes • Factors modifying drug absorption • Distribution &plasma protein binding of

drugs • Biotransformation of drugs • Factors modifying biotransformation • Bioavailability: clinical significance &

factors affecting • Half-life of drugs: factors affecting

&clinical significance • Excretion of drugs: Drug clearance • Pharmacodynamics: Mechanism of

drug action • Factors modifying actions & doses of

drugs • Pharmacogenetics • Design and optimization of dosage

regimen

By the end of Block-I, the students will be able to: • Interpret the different

pharmacokinetic patterns, their clinical significance and factors affecting these parameters.

• Correlate the concept of molecular mechanistic to the therapeutics.

• Identify the genetic principles in drug disposition


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2. Theme: Drugs acting on Autonomic Nervous System (ANS) Weightage: 25%


• Autonomic Nervous System: Introduction • Parasympathomimetics or cholinergic

Drugs • Anticholinesterases, Myasthenia gravis • Organophosphate poisoning & Oximes • Cholinergic blockers: Natural alkaloids,

Comparison between Hyoscine & Atropine

• Catecholamines: Adrenaline. Nor adrenaline, Dopamine & Dobutamine

• Non Catecholamines: Ephedrine, Amphetamines α/β2 receptor agonists etc.

• Adrenergic Blockers: Alpha-receptor Blockers, Beta receptor Blockers

• Central Sympathoplegics • Skeletal Muscle Relaxants • Drug treatment of glaucoma

Correlate the physiology of autonomic receptors with the therapeutic application

3. Theme: Drugs acting on Cardio Vascular System Weightage: 20%


• Revisiting physiology of Cardiovascular System

• Cardiotonic drugs: Management of cardiotoxicity of cardiac glycosides

• Antihypertensive drugs • Drug treatment of Ischemic Heart Disease • Anti-arrhythmic drugs

Relate the pathophysiology of heart and vessels to its treatment modalities


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4. Theme: Blood Weightage: 15%


• Haematinics • Anticoagulants • Thrombolytic • Anti-platelets • Anti-Hyperlipidemics

Justify the management plan of anemia, coagulation disorders and dyslipidemias by correlating it to the patho-physiological basis of disease

5. Theme: Diuretics Weightage: 15%


Thiazide, loop, potassium sparing, osmotic , Carbonic Anhydrase inhibitors

•Recollect the anatomical physiological basis of renal system.

•Differentiate therapeutic application of different diuretics

Total Weightage: 100%


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List of Practicals

Sr. No Topics Name

1. Introduction to pharmacy basic terminologies

2. Apparatus and equipment used in pharmacy

3. Metrology

4. Biostatistics

5. Wrapping and labeling of pharmaceutical preparations

6. Powders

7. Interpret and report the effects of drugs in rabbit’s eye

8. Interpret and report the effects of drugs on isolated rabbit’s ileum

9. Ointments

10. Mixtures


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Block – II

Code: Y3B2

Duration: 10 weeks


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Block - II

1. Theme: Central Nervous System Weightage 50%

Course Content Learning Outcomes • Central Neurotransmission • General Anesthetics • Local Anesthetics • Aliphatic Alcohols • Sedatives/ Anxiolytics & Hypnotics • Anti-epilepsy drugs • Anti-psychotic drugs • Anti-depressants • Drugs used in Parkinsonism • Drug treatment of Migraine • Non-Narcotic Analgesics

a. Non-steroidal Anti- inflammatory drugs

b. Drugs used in gout. c. Disease Modifying Anti Rheumatic

Drugs/ Biological Agents • Opioids • Drug Dependence

By the end of Block-II, the students will be able to: • Correlate the patho-physiology of

psychiatric illnesses to their management • Differentiate between different

pharmacological agents (Local Anesthetic, General Anesthetic, opioids, Non-Steroidal Anti-inflammatory Drugs) used in the pain management

• Justify the use of anti-Parkinson drugs correlating it to the underlying pathophysiology of the disease

• Analyze the effects of anti-epileptic drugs in relation to neuro-excitatory illnesses

• Strategize the management of migraine in accordance with the underlying disease mechanism

• Correlate the effects of substances of abuse (alcohol, opioids, heroin) on body to its plan for aversion therapy

• Critique on the pharmacological effects of sedative /hypnotics

2. Theme: Chemotherapy-I Weightage 50%


* Introduction & General Principles of Chemotherapy

• Mechanism of Resistance • Penicillins • Cephalosporin • Sulfonamides

• Justify the treatment modalities for various microbes (bacteria, viruses) according to mode of action, resistance patterns and regional current practices


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• Macrolides • Tetracyclines • Chloramphenicol • Aminoglycosides • Quinolones • Anti- tuberculosis drugs • Miscellaneous Drugs: Clindamycin, Fusidic

acids, vancomycin, Nitrofurantoin, Linezolid



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List of Practicals

Sr. No Topics Name

1. Emulsions

2. Solutions

3. Lotions

4. Suspension

5. Throat paint

6. Expectorants

7. Prescription writing

8. Prescription for various illnesses


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Block – III

Code: Y3B3

Duration: 10 weeks


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Block - III

1. Theme: Chemotherapy-II Weightage 30%


• Anti-fungal drugs • Anti-viral drugs • Anti-Malarial • Anti Amoebics • Anthelmintics • Anti-Cancer drugs

By the end of Block-III, the students will be able to:

• Justify the treatment modalities for various microbes (helminths, parasites) according to mode of action, resistance patterns and regional current practices-II

• Appraise the principles of cancer chemotherapy in relation to its current therapeutic modalities

2. Theme: Endocrinology Weightage 43%


• Anti-diabetic drugs • Thyroid/Anti-thyroid drugs • Adrenal Hormones • Sex Hormones: Estrogens

& Progestins, Anabolic steroids

• Drug used in treatment of Infertility

• Hormonal contraceptives • Oxytocic drugs &Uterine

Relaxants • Drug treatment of osteoporosis

• Correlate the pathophysiological basis of pituitary, thyroid and adrenal hormones with their therapeutics.

• Correlate types of diabetes mellitus to their different treatment modalities

• Justify the clinical use of sex hormones in relation to reproductive physiology

• Correlate the patho-physiological basis of osteoporosis to its pharmacological management.


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3. Theme: Respiratory System Weightage 10%


• Expectorants & Antitussives • Drugs used in Bronchial Asthma • Antihistamines (H1

antagonists) Prostaglandins

Develop and justify the management plan of obstructive pulmonary disorders (Asthma)

4. Theme: Drugs acting on Gastrointestinal tract (GIT) Weightage 15%


• Anti-emetics • Anti-diarrhoeals • Purgatives/laxatives Drugs

used in Peptic Ulcer

Develop and justify the management plan of common disorders of gastrointestinal tract (peptic ulcer, vomiting, constipation, gastropathies, and diarrhea).

5. Theme: Miscellaneous Topics Weightage 02%


• Heavy Metal Poisoning & Antidotes (Chelating Agents)

• Drug – Drug interactions

Outline the essential pharmacological principles of toxicology.



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List of Practicals

Sr. No Topics Name

1. Selection of priority drugs for various indications

2. Interpretations of dose response curve

3. Calculation of different concentration of drugs or solutions

4. Perform and interpret the effects of cardiac specific drugs on frog’s heart.

5. Evaluate the effect of drugs on blood vessels of frogs.

6. Interpret and report the effects of CNS stimulants/depressants on frog


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Assessment Methods:

i. Formative assessment

• Student/teacher feedback forms (written/verbal feedback)

• Assignments

• Presentation

• In-class activities

ii. Summative assessment

• Written examination

➢ Multiple choice questions (MCQs)

➢ Short essay questions (SEQs)

➢ Short answer questions (SAQs)

• Oral examination / Viva Voice

• Practical examination

➢ Objective structured practical examination (OSPE)

• Presentation

• Assignments


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TABLE OF SPECIFICATIONS (TOS)

Annual 3rd Professional Examination: Theory

Time Allowed = 03 hrs (including MCQs) Marks of theory paper = 135 Internal assessment = 15 Total marks = 150 Pass marks = 75 65 x MCQs = (65 Marks) Time = 1 hr 15 min (6 x SAQs / SEQs (Recall) = 7 marks each 4 x SAQs / SEQs (Application) = 7 marks each Total Marks = (70 Marks) Time = 1 hr 45min

Topic

Number of MCQs (65)

Recall : 50%

Application : 50%

(1 mark each)

Number of SAQs /SEQs (10)

Recall (06) Application (04) (7 marks each)

General Pharmacology 08 01

Drugs acting on Autonomic Nervous System

(ANS)

08 01

Drugs acting on Central Nervous System (CNS) 12 02

Drugs acting on Cardiovascular System (CVS) /

Diuretics

12 01

Chemotherapy 12 02

Endocrinology 05 01

Respiration / Autacoids / Miscellaneous (Heavy

Metal Poisoning & Antidotes (Chelating Agents),

Drugs-Drugs interactions

03 01

Gastrointestinal System (GIT) / Blood 05 01

Total 65 (65 Marks) 10 (70 Marks)


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TABLE OF SPECIFICATIONS (TOS)

Annual 3rd Professional Examination: Practical

Practical = 135

Internal Assessment = 15

Total marks = 150

Pass Marks = 75

Gen Viva Voce Practical

Gen Viva

+

Practical

Internal

Evaluation Total

Internal

Examiner

External

Examiner OSPE/Practical Notebook

135

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150 35 35 60 5

Lab Work:

• 03 Observed stations (Pharmacodynamics) of 10 marks each = 30 Marks

• 05 Unobserved stations of 06 marks each = 30 Marks


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Student Internal Assessment Cards or Log Book:

Sample is attached as ANX ‘A’.


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DEPARTMENT OF PHARMACOLOGY & THERAPEUTICS

CMH MULTAN INSTITUTE OF MEDICAL SCIENCES (CIMS)

DEPARTMENTAL ACADEMIC RECORD

(3rd YEAR MBBS)

Signature of Student NUMS Registration No. Roll No.

Name of Student: ___________________________________________

Father/ Guardian’s Name: ___________________________Phone No: ____________

Occupation: __________________ E mail Address: ____________________________

Permanent Mailing Address: ______________________________________________

Emergency Contact No: i. _______________________________

ii. _______________________________

Previous Academic Record

Exam Total Marks Marks obtained Position/Distinction Annual / Supplementary

1st Prof

2nd Prof

PHOTO

Size (1”x1”)


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PHARMACOLOGY

LARGE GROUP TEACHING SESSIONS (Didactic / interactive lectures)

Sr. Date Description Sign of

facilitator


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PHARMACOLOGY

SMALL GROUP TEACHING SESSIONS (CBL/PBL)

Sr. Date Description Sign of

Facilitator


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PHARMACOLOGY

PRACTICAL / LAB TEACHING SESSIONS

Sr. Date Topic / Description Sign of

Facilitator


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DEPARTMENT OF PHARMACOLOGY

Pre-Annual Exam Held on: _____________ Total Marks: __________________

Theory Viva / Practical I/A (10%)

Total

(% age)

Tutor Sign

MCQ's SEQ's Total Viva Practical Total

Internal Assessment

Break up Total Marks

Marks Obtained

%age Tutor Sign

Attendance (End of year)

Class Tests

End Block Examinations

Pre Annual Exam.

Remarks:

________________________________________________________________________________

_________________________________________________________________________________

_________________________________________________________________________________

_________________________________________________________________________________

Date: _____________ Sign____________

Head of Department

Documents

Pharmacology Department Student Study Guide 3rd year MBBS