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Across

type of drug effect that is dose related

and may be just too much of therapeutic

effect of drug

2.

pH of tissue can alter absorption of drug

across membranes

4.

a measure used to compare drugs given

by the same route of administration or

the percent of the dose given that is

measurable in the plasma after different

routes of administration vs. that which is

measured after IV administration

7.

assuming first order kinetics, the time it

takes to reach steady state

concentration or the time it takes to

eliminate >90% of the drug once

administration is stopped.

10.

LD50/ED50, measure of safety of a drug

in a population

12.

how much of an effect is a drug capable

of producing

16.

defined as the body's ability to rid itself

of drug from plasma

20.

binds to receptors with high affinity but

produces only partial activation

21.

type of drug effect that is unexpected,

most likely due to genetic abnormality

24.

can be a measure of potency of a drug -

dose that produces 50% of maximum

possible effect

27.

most common route of drug

administration - subject to 1st pass

effect, slow absorption

28.

the step in drug metabolism whereby a

group is removed to make the compound

more water soluble - example,

hydroxylation

29.

under the tongue route of drug

administration that reduces 1st pass

effect

31.

a dose that is given to rapidly reach

steady state concnetration, usually when

33.

Down

example of a drug that induces liver

enzymes

1.

process important to drug effect least

affected by aging

2.

the decrease in drug available to the

systemic circulation due to metabolism

in the liver

3.

induces 2E1 to increase formation of

toxic metabolites of tylenol

5.

drug class that when used with elderly,

dose should be reduced by half

6.

ttitratable route of drug administration -

no 1st pass effect since drug is delivered

directly into drug stream

8.

the concentration in the plasma that is

eventually reached where drug entering

the bloodstream equals the amount of

drug being eliminated

9.

when one drug increases the amount of

enzymes in the liver so as to speed up

the metabolism of other drugs

11.

binding to these sites retains drug in

plasma in bound state and keeps it from

distributing to active sites where it can

produce its effect - source of drug:drug

interactions

13.

binds to receptor but has zeo efficacy14.

a drug that reduces the potency but not

efficacy of an agonist by competing with

the agonist at the receptor

15.

binds to a receptor and fully activates it17.

atypical form leads to prolonged action

of succinylcholine - may be fatal

18.

metabolizes acetaminophen to

hepatotoxic metabolites

19.

step in drug metabolism where drug is

conjugated - glucuronidation, sulfation -

so as to increase its solubility - usually

leads to inactive metabolites

22.

drug removed per unit time is a fixed

amount rather than fixed percentage

23.

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a quick effect is needed and/o when the

drug has a long half-life

measure of the effective dosage range in

an individual

34.

example: thiopental - when a drug's

duration of action is due to it's

redistribution away from it's active sites

to other regions of the body - thiopental

goes first to brain, patient falls asleep

but then wakes up as brain

concentrations fall below sedative

concentration

35.

how much drug does it take to produce a

measurable effect

36.

when one drug inhibits the metabolism

of another drug by blocking a liver

enzyme

37.

type of drug effect seen in elderly and

young patients that is opposite to

expected effect

39.

a drug that reduces the effect of another

dug by stimulating different receptors to

produce responses that oppose those of

the first drug

41.

generalized inhbitor of liver enzymes25.

when the elimination of the drug from

the body is a constant % of the

concentration in the body removed per

unit time

26.

inhibits 3A4 enzyme30.

must be metabolized by 2D6 to

morphine in order to provide pain relief

32.

route of administration that reduces 1st

pass metabolism by 50%

38.

metabolizes theophylline and induced by

cigarette smoke

40.

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