PHARMACOGNOSY I 241 Ain Shams University Faculty: …s3.amazonaws.com/.../pharm.shams.edu.eg/ContentPages/2464996652… · Pharmacognosy department ... 6.1- Course notes Lecture and

courses description2010/2011 Pharmacognosy department

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PHARMACOGNOSY I 241

University: Ain Shams University Faculty: Faculty of Pharmacy Course specifications Programme(s) on which the course is given: Bachelor Degree in Pharmaceutical Sciences

Major or minor element of programmes: Single Major Department offering the programme: Interdisciplinary Department offering the course: Pharmacognosy Academic year / Level: 1st professional year-1st term / 2010 Date of specification approval: 11/2005 Date of specification revision: 9/2010

A- Basic Information Title: Pharmacognosy Code: 241/8 Credit Hours: 3hr/week Lecture: 2hr/week Tutorial: --------- Practical: 3hr/week Total: 5hr/week B- Professional Information 1 – Overall aim of course

• Upon successful completion of this course, the students should be able to illustrate the morphological and histological structures of different organs of medicinal plants such as seeds, fruits, roots and rhizomes.

• The students should be also able to discuss role of these medicinal plants in the treatment of different disease conditions is also studied.

• The student in this end of this course will be able to identify many medicinal plants microscopically in both their entire and powdered forms.

2 – Intended learning outcomes of course (ILOs) a- Knowledge and understanding: The student should be able to

a 1. Describe the histological structure of the different medicinal plant parts, seeds, fruits, roots and rhizomes. a 2. Give an account on the biologically active principles in each plant part (seeds, fruits, roots and rhizomes) as well as their biological activity. a 3. Define Complementary therapies, including herbal therapies. a 4. Explain the concepts of medicinal drugs from plant kingdom; their identification as well as, their proper collection, storage and marketing according to compendial books.

b- Intellectual skills The student should be capable of:

b 1. Determine unknown drugs seeds, fruits, roots and rhizomes (morphologically and microscopically) b 2.Judge whatever the powdered drug is related to seeds, fruits, roots and rhizomes.

c- Professional and practical skills The student should be capable of:


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c 1. Use the microscope to decide a given unknown plant powder is related to seeds, fruits, roots and rhizomes. c 2. Design and perform experiments for detection of adulteration c 3. Analyze herbal drugs for the purpose of using such skill in determining adulteration of herbal dugs, controlling the quality of produced medicinal agents, and discovering new drug entities.

d- General and transferable skills The student should be able to:

d 1. Work effectively in team. d 2. Demonstrate written and oral communication skills. d 3. Performing online computer search to develop information technology skills and knowing how to retrieve information from a variety of sources. d 4. Keeping up with the pharmaceutical literature and with new developments of the pharmacy profession and pharmaceutical industry and appreciating the need for independent life-long continuing education, starting the day after the student graduates.

3- Contents Topic No. of hours Lecture Tutorial/Practical

-Introduction to seeds.

-Strophanthus seed.

-Nux vomica seed.

10 4 6

-Stramonium seed.

-Colchicum seed.

-Cardamom seed.

-Nutmeg seed.

-Black mustard seed.

-White mustard seed.

-Almond seed.

-Linseed.

-Fenugreek.

-Plantago seed.

-Castor seed.

10

4

6

-Introduction to fruits -Umbelliferous fruits -Fennel. -Anise -Coriander -Ammi visnaga. -Ammi majus -Caraway. -Dill. -Cumin. -Celery. -Hemlock.

11 5 6

Black pepper. -Colocynth. -Senna pod. -Juniper. -Star anise. Lemon peel. -Bitter orange peel.

11 5 6


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-Hops. -Vanilla. -Ccapsicum. -Poppy Introduction tosubterranean organs(roots & rhizomes)

7 4 3

Rhizomes: -Filix mass. -Veratrum. -Valerian. -Rhubarb. -Podophyllum. -Hydrastis. -Ginger. -Galengal. -Turmeric. -Orris. -Calmus -Colchicum.

6 3 3

Root: -Liquorice. -Ipecacuanha -Dandelion. -Krameria. -Derris. -Rauwolfia. -Alkanna. -Senega. -Calumba. -Althea. -Marshmallow. -Gentian. -Belladonna. -Jalap. -Scammony. -Aconite. -Sasaparilla.

9 3 6

4– Teaching and learning methods

4.1- Lectures (Tools: board, overhead projector, data show). The lectures were added on the internet site of the faculty to be available to the students all the time as an e-learning. 4.2- Practical Session (Tools: labs.,boards, instruments, chemicals, glasswares, equipments). 4.3- Assignments, seminars, researches and posters.

5- Student assessment methods 5.1- Written exam(s) to assess knowledge and understanding and intellectual skills. 5.2- Practical exam(s) to assess practical skills. 5.3- Periodic exam(s) to assess understanding and intellectual skills. 5.4- Oral exam to assess knowledge and understanding and intellectual skills.

Assessment schedule Assessment 1 Periodic exam (Surprise Quizzes) Week -- Assessment 2 Practical exam Week 13 Assessment 3 Written exam Week 15 Assessment 4 Oral exam Week 15

Weighting of assessments Periodic Examination 10%


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Final-Term Written Examination 50% Practical Examination 20 % Oral Examination. 20% Total 100%

6- List of references 6.1- Course notes Lecture and practical notes prepared by instructors 6.2- Essential & Recommended books Trease, G.E.& Evans, W.C.; “Pharmacognosy”, W.B. Saunders Publishers, Ltd, 15th ed., 2002. 6.4- Periodicals, Web sites, … etc http://www.pubmed.com http://www.botanical .com http://www.herbmed.com

7- Facilities required for teaching and learning Study halls, Laboratories, equipment, chemicals, glasswares, books, audiovisual tools.

Course coordinator: Nahla Ayoub, Ph.D., Associate Professor of Pharmacognosy

Head of Department: Nahla Ayoub, Ph.D., Associate Professor of Pharmcognosy

Date: 9/2010


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BOTANY 141

University: Ain Shams University Faculty: Faculty of Pharmacy Course specifications Programme(s) on which the course is given: Bachelor Degree in Pharmaceutical Sciences

Major or minor element of programmes: Single Major Department offering the programme: Interdisciplinary Department offering the course: Pharmacognosy Academic year / Level: Pre-pharmacy year -1st term / 100 Date of specification approval: 11/2005 Date of specification revision: 9/ 2010

A- Basic Information Title: Botany Code: 141/M Credit Hours: 3hr/week Lecture: 2hr/week Tutorial: --------- Practical: 3hr/week Total: 5hr/week B- Professional Information 1 – Overall aims of course

• Upon successful completion of this course, the students will be able to demonstrate knowledge of basic concept in the principle of pharmacognosy

• and to apply this knowledge efficiently in macro- and microscopical examinations of different plants organs.

• Students should also be able to correctly compile the course specification (Plant Taxonomy) through engagement in cooperative self-directed exercise.

• Students should be able to illustrate the proper collection, storage methods of medicinal plants and apply this knowledge in marketing of medicinal plants.

• They should be also able to demonstrate knowledge of the active constituents of the lower and higher medicinal plants (secondary metabolites) as well as their medicinal uses

• They should know the methods of propagation of medicinal plants via seeds, factors affecting plant growth, selection and breeding of medicinal plants and preparation of drugs from plants to pharmaceutical products.


a 1. List and differentiate between plant parts; roots, stems, leaves,…etc as well as Algae and Fungi a 2. Name the main elements of the studied organs (macroscopically) a 3. Describe the plant taxonomy a 4. List methods of collection, storage and marketing of medicinal plants


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a 5. Enumerate the factors affecting plant growth, selection and breeding of medicinal plants and preparation of drugs from plants to pharmaceutical products

b- Intellectual skills The student should be able to

b 1. Evaluate the histological character of each organ (microscopically). b 2. Criticize different methods for the detection of adulteration of medicinal plants. b 3. Evaluate the purity of medicinal drug and detection of adulteration

c- Professional and practical skills The student should be able to

c 1. Handle of the microscope. c 2. Manipulate the microscopical specimens. c 3. Classify any plant taxonomically. c 4. Distinguish the different method for detection of adulteration. c 5. Use appropriate lab equipment and tools to evaluate the different Pharmacopoeial constants. c 6. Analyze herbal drugs for the purpose of using such skill in determining adulteration of herbal dugs, controlling the quality of produced medicinal agents, and discovering new drug entities.


d 1. Work effectively in team. d 2. Demonstrate written communication skills. d 3.Performing online computer search to develop information technology skills and knowing how to retrieve information from a variety of sources. d 4. Keeping up with the pharmaceutical literature and with new developments of the pharmacy profession and pharmaceutical industry and appreciating the need for independent life-long continuing education, starting the day after the student graduates.

3- Contents Topic No. of hours Lecture Tutorial/Practical

-General Pharmacognosy -Cultivation of medicinal plants.

13

4

9

-Selection & breeding of medicinal plants. -Factors affecting plant growth

13

4

9

-Preparation of drugs from plants to pharmaceuticals. - Adulteration. - Secondary plant metabolites. -Dusting powder. -Hairs & Fabrics.

17

8

9

-Plant physiology -Plant taxonomy

21

12

9


4.1- Lectures (Tools: board, overhead projector, data show). The lectures were added on the internet site of the faculty to be available to the students all the time as an e-learning. 4.2- Practical Session (Tools: labs., boards, instruments, chemicals, glassware, equipments).


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4.3- Research paper. 5- Student assessment methods

5.1- Written exam(s) to assess knowledge and understanding and intellectual skills. 5.2- Practical exam(s) to assess practical skills. 5.3- Periodic exam(s) to assess understanding and intellectual skills.

Assessment schedule Assessment 1 Periodic exam (Surprise Quizzes) Week -- Assessment 2 Practical exam Week 13 Assessment 3 Written exam Week 15

Weighting of assessments Periodic Examination 10% Final-Term Written Examination 70% Practical Examination 20 % Oral Examination. ----- Total 100%

6- List of references 6.1- Course notes Lecture and practical notes prepared by instructors. 6.2- Essential & Recommended books Trease, G.E.& Evans, W.C.; “Pharmacognosy”, W.B. Saunders Publishers, Ltd, 15th

ed., 2002. 20 6.4- Periodicals, Web sites, … etc http://www.botanical.com http://www.herbmed.com

7- Facilities required for teaching and learning Study halls, laboratories, equipment, chemicals, glassware, books and audiovisual tools.

Course coordinator: Mohammed El-Azizy, Ph.D.; Professor of Pharmacognosy

Head of Department: Nahla Ayoub, Ph.D.; Associate Professor of Pharmacognosy

Date: 9/2010


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CHEMISTRY OF NATURAL PRODUCTS II 441

University: Ain Shams University Faculty: Faculty of Pharmacy Course specifications

Programme(s) on which the course is given: Bachelor Degree in Pharmaceutical Sciences Major or minor element of programmes: Single Major Department offering the programme: Interdisciplinary Department offering the course: Pharmacognosy Academic year / Level: 3rd professional year-1st term / 400 Date of specification approval: 11/2005 Date of specification revision : 9/ 2010

A- Basic Information Title: Chemistry of Natural Products II Code: 441/8 Credit Hours: 4hr/week Lecture: 3hr/week Tutorial: --------- Practical: 3hr/week Total: 6hr/week B- Professional Information 1 – Overall aim of course

• Upon successful completion of this course, the students should illustrate the 2ry

plant metabolites (viz, alkaloids & volatile oil) • Students should be able to apply this knowledge correctly in phytomedicine.


a1. Give an account on the chemistry, biological activity of alkaloids and volatile oils. a2. Describe the mechanism of action of these biologically active components and their structure activity relationship. a3. Recognize or draw the chemical structure of such biologically active compounds. a4. Enumerate the physical and chemical properties of active and inactive chemicals (synthetic, biotech or natural) and the effect that these properties on the design and formulation of medicines. Pharmacists are expected to have a basic understanding of pharmaceutical calculations and biostatistics as well as the history of the profession and professional practice of the pharmacist. a5. Define the concepts of medicinal drugs from plant kingdom; their identification as well as, their proper collection, storage and marketing according to compendial books. a6. Define the role of these medicinal plants in the treatment of different diseased conditions a7. Illustrate the concepts of chemistry of biologically active natural products viz, alkaloids and volatile oil and theories and applications in natural product analysis.

b- Intellectual skills The student should be able to:


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b1. Analyze plant extract and identify their biologically active constituents by different chemical and physical methods, especially for alkaloids and volatile oils. b2. Design and perform chromatographic technique for isolation of alkaloids from their natural sources. b3. Select the appropriate methods of isolation, synthesis, purification, identification, and standardization of active substances from different origins.


c1. Use and design methods to separate biologically active secondary metabolites from plant extracts. c2. Perform experiments for the detection of the biologically active secondary metabolites c3. Analyze herbal drugs for the purpose of using such skill in determining adulteration of herbal dugs, controlling the quality of produced medicinal agents, and discovering new drug entities.


d1. Work effectively in team. d2. Demonstrate written and oral communication skills. d3. Performing online computer search to develop information technology skills and knowing how to retrieve information from a variety of sources. d4. Keeping up with the pharmaceutical literature and with new developments of the pharmacy profession and pharmaceutical industry and appreciating the need for independent life-long continuing education, starting the day after the student graduates.

3- Contents

Topic No. of hours

Lecture Tutorial/Practical

Alkaloids General reactions Phenylalkyl amine alkaloids Pyridine alkaloids Pyrrolizidine alkaloids Pipperine alkaloids Quinoline alkaloids Isoquinoline alkaloids Quinolizidine alkaloids Tropolone alkaloids Purine alkaloids Tropane alkaloids

58 28 30

Volatile oils Terpenes Oxygenated terpenes Lipids & Fixed oil Fats & Waxes Vitamins & minerals

20

14

6


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4– Teaching and learning methods 4.1- Lectures (Tools: board, overhead projector, data show). The lectures were added on the internet site of the faculty to be available to the students all the time as an e-learning. 4.2- Practical Session (Tools: labs., boards, instruments, chemicals, glasswares, equipments). The students were allowed to prepare a volatile oil sample by using a distillation unit. Also, the practical labs were demonstrated as powerpoint and were added on the internet site of the faculty. 4.3- Assignments, seminars, researches and posters.



Weighting of assessments

Periodic Examination 10% Final-Term Written Examination 50% Practical Examination 20 % Oral Examination. 20% Total 100%

6- List of references

6.1- Course notes Lecture and practical notes prepared by instructors 6.2- Essential & Recommended books Trease, G.E. and Evans, W.C.; “Pharmacognosy”, W.B. Saunders Publishers, Ltd, 15th

ed., 2002. 6.4- Periodicals, Web sites, … etc http://www.pubmed.com

7- Facilities required for teaching and learning

Study halls, Laboratories, equipment, chemicals, glassware, books, audiovisual tools.

Course coordinator: Abdel Nasser Singab, Ph.D, Professor of Pharmacognosy

Head of Department: Nahla Ayoub, Ph.D, Associate Professor of Pharmacognosy

Date: 9/2010


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QUALITY CONTROL OF HERBAL PRODUCTS 541

University: Ain Shams University Faculty: Faculty of Pharmacy Course specifications Programme(s) on which the course is given: Bachelor Degree in Pharmaceutical Sciences Major or minor element of programmes: Single Major Department offering the programme: Interdisciplinary Department offering the course: Pharmacognosy Academic year / Level: 4th professional year-1st term / 500 Date of specification approval: 11/2005 Date of specification revision: 9/ 2010 A- Basic Information Title: Quality control of herbal products Code: 541/8 Credit Hours: 3hr/week Lecture: 2hr/week Tutorial: --------- Practical: 3hr/week Total: 5hr/week B- Professional Information 1 – Overall aim of course

• After attending this course the students would be expected to deal with the general principles of quality control: definitions, documentation, environmental monitoring, packaging systems, the finished product, the quarantine, and

• Students should be able to deal with quality control laboratory scheme including quantitative chromatographic analysis of herbal products, storage, preservation, marker determination, validation and applications of the proposed schemes.

• In addition students will be capable of independently using the different spectroscopic methods to elucidate the structures of pure natural products applying different methods of spectral analysis viz, UV, IR, Ms and NMR, also the application of GC and HPLC in the analysis of herbal constituents.

2 – Intended learning outcomes of course (ILOs) a- Knowledge and understanding: The student should be able to:

a1. Give an account on the general principles of quality control, chromatographic analysis of herbal products, storage and preservation of herbal drugs, marker determination, validation and applications of analysis of herbal tea bags. a2. Describe the application of GC and HPLC in the analysis of herbal constituents. a3. Recognize the structure of pure active natural products applying different methods of spectral analysis viz, UV., IR, Ms and NMR. a4. Illustrate the Analytical methods embracing principles, design, development, validation, application, good laboratory practice (GLP) and good storage practice (GSP). a5. Define Complementary therapies, including herbal therapies. a6. Enumerate the concepts of chemistry of biologically active natural products viz, carbohydrates, glycosides, tannins, bitter principles, alkaloids, volatile oil and


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unorganized drugs in addition to principle of chromatography that covers theories and applications in natural product analysis. a7. Explain the principles of quality control of herbal products achieved by focusing on the major steps in quality control scheme including quantitative chromatographic analysis of herbal products, storage, preservation, marker determination, validation and applications of the proposed schemes. Advanced quality control applying GC and HPLC.

b- Intellectual skills The student should be able to: b1. Solve spectroscopic problems of pure natural products. b2. Design and perform chromatographic technique for isolation of secondary metabolites from their natural sources. b3. Apply qualitative and quantitative analytical and biological methods for QC and assay of raw materials as well as pharmaceutical preparations. b4. Select the appropriate methods of isolation, synthesis, purification, identification, and standardization of active substances from different origins.

c- Professional and practical skills The student should be able to: c1. Analyze herbal mixtures in the lab. c2. Use the microscope to decide the components of a given unknown herbal mixture is pure or adulterated. c3. Determine the pharmacopoeial constants of the herbal mixture. c4. Identify different classes of natural compounds using spectroscopic methods. c5. apply samples to be analyzed using certain chromatographic techniques GC and HPLC. c6. structural elucidation of samples by measuring UV absorbance of natural products using the UV spectrophotometer and they analyze it by themselves c7. Implement/Perform standard industrial and/or pharmaceutical instrumentation and laboratory procedures and applying such skill in quality control of pharmaceuticals. Apply validation aspect effectively. c8. Analyze herbal drugs for the purpose of using such skill in determining adulteration of herbal dugs, controlling the quality of produced medicinal agents, and discovering new drug entities.

d- General and transferable skills The student should be able to: d1. Work effectively in team. d2. Demonstrate written and oral communication skills. d3. Performing online computer search to develop information technology skills and knowing how to retrieve information from a variety of sources. d4. Keeping up with the pharmaceutical literature and with new developments of the pharmacy profession and pharmaceutical industry and appreciating the need for independent life-long continuing education, starting the day after the student graduates.

3- Contents Topic No. of

hours Lecture Tutorial/

PracticalQuality control of herbal products Validation of methods

4

Tissue culture

13 4

9

Gas chromatography (basis, instrumental, applications, 15 6 9


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Q.C. by finger print by GLC analysis of natural products) HPLC (basis, , instrumental, applications, Q.C. by finger print by HPLC analysis of natural products)

15 6 9

Structural elucidation of natural products (UV, IR, 1D &2D NMR and Mass spectrometry)

17 8 9


4.1- Lectures (Tools: board, overhead projector, data show). The lectures were added on the internet site of the faculty to be available to the students all the time as an e-learning. 4.2- Practical Session (Tools: labs., boards, instruments, chemicals, glassware, equipments). They were allowed to apply samples to the equipments available as the GLC, HPLC and UV spectrophotometers. Examine the runs and analyze the data obtained. 4.3- Assignments, seminars, researches and posters.



Weighting of assessments Periodic Examination 10% Final-Term Written Examination 50% Practical Examination 20 % Oral Examination. 20% Total 100%

6- List of references 6.1- Course notes Lecture and practical notes prepared by instructors 6.2- Essential & Recommended books Trease, G.E.and Evans, W.C.; “Pharmacognosy”, W.B. Saunders Publishers, Ltd, 15th ed., 2002. 2D NMR spectroscopy, Silverstein. 6.4- Periodicals, Web sites, … etc http://www.pubmed.com

7- Facilities required for teaching and learning Study halls, Laboratories, equipment, chemicals, glasswares, books, audiovisual tools.

Course coordinator: Nahla Ayoub, Ph.D., Associate Professor of Pharmacognosy

Head of Department: Nahla Ayoub, Ph.D, Associate Professor of Pharmacognosy Date: 9/2010


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Psychology and Sociology

261

University: Ain Shams University

Faculty: Faculty of Pharmacy

Course specifications

Programme(s) on which the course is given: Bachelor Degree in Pharmaceutical Sciences Major or minor element of programmes: Single Major Department offering the programme: Interdisciplinary Department offering the course: Psychology, Faculty of Arts, Ain Shams University Academic year / Level: First year -1st term / 2009 Date of specification approval: 11/2005

Date of specification revision : 9/2010

A- Basic Information

Title: Psychology Code: 261/M Credit Hours: 2hr/week Lecture: 2hr/week Tutorial: --------- Practical: --------- Total: 2hr/week

B- Professional Information

1 – Overall aims of course • Upon successful completion of this course, the students will be able to

demonstrate and apply knowledge of basic concept in the principle of Psychology

• They should also be able to correctly compile the course specification through engagement in cooperative self-directed exercise.

2 – Intended learning outcomes of course (ILOs)

a- Knowledge and understanding:

The student should be able to a 1- List and differentiate between branches of Psychology. a 2- Name the Psychological diseases. a 3- numerate types of addiction. a 4-Give an account of the physiological and psychological disorders resulted from addiction. a 5.Understand ways of protection against addiction.


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a 6.Define pain. a 7.Name different types of pain. a 8.Describe the psychological effect of pain. a 9.Determine the psychological crises and its ways of adjustment.

b- Intellectual skills The student should be able to

b 1.Diagnose the case study. b 2.Identify the psychological disorders. b 3.Evaluate the cases based upon psychological point of view. b 4.Analyze the cases, diadnosis and treatment.

d-General and transferable skills

The student should be able to: d 1. Work effectively in team. d 2.Demonstrate written communication skills. d 3. Open discussion to criticize the case study.

3- Contents

Topic No. of hours Lecture Basics of psychology 2 2 Types of psychological diseases 2 2 Analysis of Psychological disorders

2 2

Addiction 2 2 Physiological & psychological effects of addiction

2 2

Pain , types, effects 2 2 Memory , causes, types, hypothesis 1 1 Psychological crises and its way of adjustment

1 1

4– Teaching and learning methods 4.1- Lectures (Tools: board).

5- Student assessment methods

5.1- Written exam(s) to assess knowledge and understanding and intellectual skills.

Assessment schedule Assessment 1 Written exam Week 15


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Weighting of assessments Final-Term Written Examination 100%

6- List of references 6.1- Course notes Lecture and notes prepared by instructors

6.2- Essential books (text books)

-------------------------------------------------------------

6.3- Recommended books

---------------------------------------------------------------

6.4- Periodicals, Web sites, … etc

--------------------------------------------------------------

7- Facilities required for teaching and learning Study halls, books, audiovisual tools.

Course coordinator: Dalia Ezzat Moemen, Ph.D Aly Hasan Aly Farghaly, Ph.D

Head of Department:

Nahla Ayoub, Ph.D

Date: 9/2010.

Pharmacognosy department 2010/2011 course specifications

MEDICAL BOTANY

142




Programme(s) on which the course is given: Bachelor Degree in Pharmaceutical Sciences Major or minor element of programmes: Single Major Department offering the programme: Interdisciplinary Department offering the course: Pharmacognosy Academic year / Level: Pre-pharmacy year-2nd term / 100 Date of specification approval: 11/2005

Date of specification revision : 9/2010

A-Basic Information

Title: Medical Botany Code: 142/M Credit Hours: 3/week Lecture: 2/week Tutorial: --------- Practical: 3/week Total: 5/week


1 – Overall aim of course • Upon successful completion of this course, the students should be able to

illustrate the morphological and histological structures of different organs of medicinal plants such as leaves, barks, woods, flowers.

• The students should be also able to discuss role of these medicinal plants in the treatment of different disease conditions.




The student should be able to a 1.Describe the histological structure of the different medicinal plant parts, leaves, barks, woods, flowers. a 2.Give an account on the biologically active principles in each plant part (leaves, barks, woods, flowers) as well as their biological activity. a 3.Define Complementary therapies, including herbal therapies.


2

a 4.Explain the concepts of medicinal drugs from plant kingdom; their identification as well as, their proper collection, storage and marketing according to compendial books.

b- Intellectual skills

The student should be capable of: b 1.Determine unknown drugs, leaves, barks, barks, flowers. (morphologically and microscopically) b 2.Judge whatever the powdered drug is related to leaves, barks, woods, flowers.


c 1.Use the microscope to decide a given unknown plant powder is related to leaves, barks, woods, flowers. c 2.Design and perform experiments for detection of adulteration c 3.Analyze herbal drugs for the purpose of using such skill in determining adulteration of herbal dugs, controlling the quality of produced medicinal agents, and discovering new drug entities.

d- General and transferable skills

The student should be able to: d 1.Work effectively in team. Demonstrate written communication skills. d 2.Performing online computer search to develop information technology skills and knowing how to retrieve information from a variety of sources. d 3.Keeping up with the pharmaceutical literature and with new developments of the pharmacy profession and pharmaceutical industry and appreciating the need for independent life-long continuing education, starting the day after the student graduates.

3- Contents

Topic No. of hours Lecture Tutorial/Practical -Introduction to Leaves. -Senna leaf. -Digitalis leaf. -Squill leaf. -Buchu leaf. -Uva ursi leaf.

10

4

6

-Belladonna leaf. -Stramonium leaf. -Egyptian henbane. -European henbane.

7

4

3

-Coca leaf. -Boldo leaf. -Jaborandi leaf. -Eucalyptus leaf. -Cherry laurel leaf. -Hamammelis leaf. -Henna leaf. -Tea leaf.

10

4

6

-Introduction to barks -Cascara bark. -Frangula bark.

6

3

3

-Cinchona bark. -Cinnamon bark. -Cassia bark. -Canella bark.

10

4

6


3

-Quillaia bark. -Galls. -Introduction to wood. -Quassia wood. -Guaiacum wood. -Introduction to flower. -Roman chamomile. -German chamomile.

9

3

6

-Pyrethrum

-Santonica.

-Saffron.

-Safflower.

-Calendula.

-Clove.

-Lavander.

12

6

6

4– Teaching and learning methods 4.1- Lectures (Tools: board, overhead projector, data show). The lectures were added on the internet site of the faculty to be available to the students all the time as an e-learning. 4.2- Practical Session (Tools: labs.,boards, instruments, chemicals, glasswares, equipments). 4.3-Research paper.


5.1- Written exam(s) to assess knowledge and understanding and intellectual skills. 5.2- Practical exam(s) to assess practical skills. 5.3- Periodic exam(s) to assess understanding and intellectual skills.

Assessment schedule Assessment 1 Periodic exam (Surprise Quizzes) Week -- Assessment 2 Practical exam Week 13 Assessment 3 Written exam Week 15

Weighting of assessments Periodic Examination 10% Final-Term Written Examination 70% Practical Examination 20 % Oral Examination. ----- Total 100%

6- List of references 6.1- Course notes Lecture and practical notes prepared by instructors

6.2- Essential & Recommended books


4

Trease, G.E.& Evans, W.C.; “Pharmacognosy”, W.B. Saunders Publishers, Ltd, 15th ed., 2002

6.3 - Periodicals, Web sites, … etc http://www.botanical .com http://www.herbmed.com

7- Facilities required for teaching and learning Study halls, Laboratories, equipment, chemicals, glasswares, books, audio-visual tools.

Course coordinator: Nahla Ayoub, Ph.D ., Professor of Pharmacognosy

Head of Department: Nahla Ayoub, Ph.D ., Professor of Pharmacognosy

Date: 9/2010

University: Ain shams University Faculty: Faculty of pharmacy Department: Pharmacognosy Department

Course matrix

Course ILOs covered Course content Week

Knowledge and understanding

Intellectual skills

Practical and professional skills

General and transferable skills

-Introduction to Leaves. -Senna leaf. -Digitalis leaf. -Squill leaf. -Buchu leaf. -Uva ursi leaf.

4 weeks a1,a2,a3,a4 b1,b2



-Coca leaf. -Boldo leaf. -Jaborandi leaf. -Eucalyptus leaf. -Cherry laurel leaf. -Hamammelis leaf. -Henna leaf. -Tea leaf.


Course name Medical Botany

code 142/M

-Introduction to barks -Cascara bark. -Frangula bark.

3 weeks a1,a2,a3a4 b1,b2

-Cinchona bark. -Cinnamon bark. -Cassia bark. -Canella bark. -Quillaia bark. -Galls. -Introduction to wood. -Quassia wood. -Guaiacum wood.


-Introduction to flower. -Roman chamomile. -German chamomile.


-Pyrethrum

-Santonica.

-Saffron.

-Safflower.

-Calendula.

-Clove.

-Lavander.

6 weeks

a1,a2,a3,a4 b1,b2

Practical -Introduction to Leaves. -Senna leaf. -Digitalis leaf. -Squill leaf. -Buchu leaf. -Uva ursi leaf.

1 weeks c1,c2,c3 d1,d2,d3,d4



-Coca leaf. -Boldo leaf. 2 weeks c1,c2,c3 d1,d2,d3,d4

-Jaborandi leaf. -Eucalyptus leaf. -Cherry laurel leaf. -Hamammelis leaf. -Henna leaf. -Tea leaf. -Introduction to barks -Cascara bark. -Frangula bark.


-Cinchona bark. -Cinnamon bark. -Cassia bark. -Canella bark. -Quillaia bark. -Galls. -Introduction to wood. -Quassia wood. -Guaiacum wood.

1 week c1,c2,c3 d1,d2,d3,d4

-Introduction to flower. -Roman chamomile. -German chamomile.


-Pyrethrum

-Santonica.

-Saffron.

-Safflower.

-Calendula.

-Clove.

-Lavander.


Course members: Nahla Ayoub, Ph.D., Professor of Pharmacognosy Sherweit ElAhmady, Ph.D, Lecturer of Pharmacognosy Rola Milad Labib, Ph.D, Lecturer of Pharmacognosy Head of the department: Prof. Nahla Ayoub


PHARMACOGNOSY II

232




Programme(s) on which the course is given: Bachelor Degree in Pharmaceutical Sciences Major or minor element of programmes: Single Major Department offering the programme: Interdisciplinary Department offering the course: Pharmacognosy Academic year / Level: 1st professional year-2nd term / 200 Date of specification approval: 11/2005

Date of specification revision: 9/2010


Title: Pharmacognosy Code: 232/8 Credit Hours: 3hr/week Lecture: 2hr/week Tutorial: --------- Practical: 3hr/week Total: 5hr/week


1 – Overall aim of course

• Upon successful completion of this course, the students should be able to illustrate the morphological and histological structures of different organs of medicinal plants such as herbs and unorganized drugs.

• The students should be also able to discuss role of these medicinal plants in the treatment of different disease conditions is also studied.


• They should be able to demonstrate knowledge of basic concepts of optimum nutrition.

2 – Intended learning outcomes of course (ILOs) a- Knowledge and understanding:

The student should be able to a 1.Describe the histological structure of the different medicinal plant parts viz. herbs and unorganized drugs.


2

a 2.Give an account on the biologically active principles in each plant part viz. (herbs and unorganized drugs) as well as their biological activity. a 3.Design a regime for optimum nutrition (minerals and vitamins). a 4.Define Complementary therapies, including herbal therapies. a 5.Explain the concepts of medicinal drugs from plant kingdom; their identification as well as, their proper collection, storage and marketing according to compendial books.


b1.Determine unknown drugs viz. herbs and unorganized drugs. (morphologically, microscopically and chemically) b2.Judge whatever the powdered drug is related to herbs and identify unorganized drugs through chemical tests.


c1.Use the microscope to decide a given unknown plant powder is related to herbs and unorganized drugs. c2.Design and perform experiments for detection of adulteration.

c3.Perform some experiments to know the nature of unorganized. c4.Analyze herbal drugs for the purpose of using such skill in determining adulteration of herbal dugs, controlling the quality of produced medicinal agents, and discovering new drug entities.


The student should be able to: d1.Work effectively in team. d2.Demonstrate written and oral communication skills. d3.Performing online computer search to develop information technology skills and knowing how to retrieve information from a variety of sources. d4.Keeping up with the pharmaceutical literature and with new developments of the pharmacy profession and pharmaceutical industry and appreciating the need for independent life-long continuing education, starting the day after the student graduates.

3- Contents

Topic No. of hours Lecture Tutorial/Practical Introduction to herbs Hyoscyamus Lobelia Vinca Mentha Thyme Ergot

9 3 6

Cannabis Diatoms Focus &laminaria Carrageen Saccharomyces. Penicillium Mushroom. Cetraria Ephedra Sabina Broom tops

15 6 9


3

Introduction to unorganized drugs Opium Agar Gelatin

10 4 6

Gambier Cutch Aloes Ehinacea Kinos Colophony Rectified oil of turpentine. Guaiacum resin Jhan resin

12 6 6

Cannabis resin

Mastic

Copaiba

Canada turpentine

Myrrh

Asafetida

Galbanum

Ammoniacum

Olibanum

Benzoin

Balsam Peru

Balsam Tolu

Storax

Gum acacia

Gum tragacanth

Karaya gum

Manna

Guar gum

Simbhal

Tamal

Evening primrose

Theobroma oil

Castor oil

Linseed oil

Olive oil

Almond oil

Bees wax

Carnuba wax

Purified honey

Royal jelly

15 6 9


4

Bee propolis

Bee pollen

Bee venom

Unorganized drugs in the Egyptian market.

Vitamins and minerals 3 3 -

4– Teaching and learning methods 4.1- Lectures (Tools: board, overhead projector, data show). The lectures were added on the internet site of the faculty to be available to the students all the time as an e-learning. 4.2- Practical Session (Tools: labs., boards, instruments, chemicals, glassware, equipments). 4.3- Assignments, seminars, researches and posters.


5.1- Written exam(s) to assess knowledge and understanding and intellectual skills. 5.2- Practical exam(s) to assess practical skills. 5.3- Periodic exam(s) to assess understanding and intellectual skills. 5.4- Oral exam to assess knowledge and understanding and intellectual skills.


Weighting of assessments Periodic Examination 10% Final-Term Written Examination 50% Practical Examination 20 % Oral Examination. 20% Total 100%

6- List of references 6.1- Course notes Lecture and practical notes prepared by instructors 6.2- Essential & Recommended books Trease, G.E.and Evans, W.C.; “Pharmacognosy”, W.B. Saunders Publishers, Ltd, 15th ed., 2002. 6.3 - Periodicals, Web sites, … etc http://www.pubmed.com http://www.botanical .com http://www.herbmed.com


5

7- Facilities required for teaching and learning Study halls, Laboratories, equipment, chemicals, glassware, books, audio-visual tools.

Course coordinator: Abdel Nasser Singab, Ph.D., Professor of Pharmacognosy Head of Department: Nahla Ayoub, Ph.D., Professor of Pharmacognosy.

Date: 9/2010


Course matrix



Intellectual skills



Introduction to herbs Hyoscyamus Lobelia Vinca Mentha Thyme Ergot


Cannabis Diatoms Focus &laminaria Carrageen Saccharomyces. Penicillium Mushroom. Cetraria Ephedra Sabina


Course name Pharmacognosy II

code 232/8

Broom tops Introduction to unorganized drugs Opium Agar Gelatin


Gambier Cutch Aloes Ehinacea Kinos Colophony Rectified oil of turpentine. Guaiacum resin Jhan resin


Cannabis resin Mastic Copaiba Canada turpentine Myrrh Asafetida Galbanum Ammoniacum Olibanum Benzoin Balsam Peru Balsam Tolu Storax Gum acacia Gum tragacanth Karaya gum Manna Guar gum Simbhal Tamal Evening primrose


Theobroma oil Castor oil Linseed oil Olive oil Almond oil Bees wax Carnuba wax Purified honey Royal jelly Bee propolis Bee pollen Bee venom Unorganized drugs in the Egyptian market. Vitamins and minerals 3 weeks a3,a4,a5 b1,b2 Practical Introduction to herbs Hyoscyamus Lobelia Vinca Mentha Thyme Ergot


Cannabis Diatoms Focus &laminaria Carrageen Saccharomyces. Penicillium Mushroom. Cetraria Ephedra Sabina Broom tops


Introduction to unorganized drugs


Opium Agar Gelatin Gambier Cutch Aloes Ehinacea Kinos Colophony Rectified oil of turpentine. Guaiacum resin Jhan resin


Cannabis resin Mastic Copaiba Canada turpentine Myrrh Asafetida Galbanum Ammoniacum Olibanum Benzoin Balsam Peru Balsam Tolu Storax Gum acacia Gum tragacanth Karaya gum Manna Guar gum Simbhal Tamal Evening primrose Theobroma oil Castor oil Linseed oil


Olive oil Almond oil Bees wax Carnuba wax Purified honey Royal jelly Bee propolis Bee pollen Bee venom Unorganized drugs in the Egyptian market. Vitamins and minerals --- c2,c4 d1,d2,d3,d4 Course members: Abdel Nasser Singab, Ph.D., Professor of Pharmacognosy Sherweit Hamed Elahmady, Ph.D, Lecturer of Pharmacognosy Mohamed Lotfy Ashour, Ph.D, Lecturer of Pharmacognosy Head of the department: Prof. Nahla Ayoub


CHEMISTRY OF NATURAL PRODUCTS I

342/8




Programme(s) on which the course is given: Bachelor Degree in Pharmaceutical Sciences Major or minor element of programmes: Single Major Department offering the programme: Interdisciplinary Department offering the course: Pharmacognosy Academic year / Level: 2nd professional year-2nd term / 300 Date of specification approval: 11/2005

Date of specification revision: 9/2010


Title: Chemistry of Natural Products I Code: 342/8 Credit Hours: 4hr/week Lecture: 3hr/week Tutorial: --------- Practical: 3hr/week Total: 6hr/week


1 – Overall aim of course • Upon successful completion of this course, the students should illustrate the

2ry plant metabolites (viz, carbohydrates, glycosides, tannins, bitter principles) • Students should be able to apply this knowledge correctly in medicine. • They should be also able to demonstrate knowledge of basic concepts of

chromatography and apply the theories of chromatography independently to analyze and separate mixture of biologically active natural products



The student should be able to a 1.Give an account on the chemistry, biological activity of carbohydrates, glycosides, tannins, bitter principles a 2.Describe the mechanism of action of these biologically active components and their structure activity relation ship. a 3.Design a method for separation the biologically active principles from their extract. a 4.Recognize or draw the chemical structure of such biologically active compounds.


2

a 5.Enumerate the physical and chemical properties of active and inactive chemicals (synthetic, biotech or natural) and the effect that these properties on the design and formulation of medicines. Pharmacists are expected to have a basic understanding of pharmaceutical calculations and biostatistics as well as the history of the profession and professional practice of the pharmacist. a 6.Define the concepts of medicinal drugs from plant kingdom; their identification as well as, their proper collection, storage and marketing according to compendial books. The role of these medicinal plants in the treatment of different diseased conditions a 7.Define the concepts of chemistry of biologically active natural products viz, carbohydrates, glycosides, tannins, bitter principles, alkaloids, volatile oil and unorganized drugs in addition to principle of chromatography that covers theories and applications in natural product analysis.


b 1.Analyze plant extract. b 2.Identify their biologically active constituents by different chemical and physical methods. b 3.Design and perform chromatographic technique for isolation of biologically active compounds from their natural sources. b 4.Select the appropriate methods of isolation, synthesis, purification, identification, and standardization of active substances from different origins.


c 1.Use and design methods to separate biologically active secondary metabolites from plant extracts. c 2.Perform experiments for the detection of the biologically active secondary metabolites c 3.Analyze herbal drugs for the purpose of using such skill in determining adulteration of herbal dugs, controlling the quality of produced medicinal agents, and discovering new drug entities.


The student should be able to: d 1.Work effectively in team. d 2.Demonstrate written and oral communication skills. d 3.Performing online computer search to develop information technology skills and knowing how to retrieve information from a variety of sources. d 4.Keeping up with the pharmaceutical literature and with new developments of the pharmacy profession and pharmaceutical industry and appreciating the need for independent life-long continuing education, starting the day after the student graduates.

3- Contents

Topic No. of hours

Lecture Tutorial/Practical

Carbohydrates, introduction, classification, biosynthesis, reactions, Application of carbohydrates

29 14 15

Anthracene glycosides , flavonoids Steroidal cardioactive glycosides

29 14 15


3

Terpenoid glycosides Miscellaneous glycosides Bitter principles Tannins Chromatography (CC, TLC, PC) 20 14 6

4– Teaching and learning methods 4.1- Lectures (Tools: board, overhead projector, data show). The lectures were added on the internet site of the faculty to be available to the students all the time as an e-learning. 4.2- Practical Session (Tools: labs.,boards, instruments, chemicals, glasswares, equipments). The students were allowed to prepare the plant extracts and dry them using the rotary vaccum. 4.3- Assignments, seminars, researches and posters.


5.1- Written exam(s) to assess knowledge and understanding and intellectual skills. 5.2- Practical exam(s) to assess practical skills. 5.3- Periodic exam(s) to assess understanding and intellectual skills. 5.4- Oral exam to assess knowledge and understanding and intellectual skills.


Weighting of assessments Periodic Written Examination 50% Practical Examination 20 % Oral Examination. 20% Total 100%

6- List of references 6.1- Course notes Lecture and practical notes prepared by instructors

6.2- Essential & Recommended books

Trease, G.E.and Evans, W.C.; “Pharmacognosy”, W.B. Saunders Publishers, Ltd, 15th ed., 2002.

6.4- Periodicals, Web sites, … etc http://www.pubmed.com


4

7- Facilities required for teaching and learning Study halls, Laboratories, equipment, chemicals, glassware, books, audio-visual tools.

Course coordinator: Nahla Ayoub, Ph.D., Professor of Pharmacognosy

Head of Department:

Nahla Ayoub, Ph.D , Professor of Pharmacognosy

Date: 9/2010


Course matrix



Intellectual skills



Carbohydrates, introduction, classification, biosynthesis, reactions, Application of carbohydrates

14 weeks a1,a2,a3,a4,a6,a7 b1,b2,b3,b4

Anthracene glycosides , flavonoids Steroidal cardioactive glycosides Terpenoid glycosides Miscellaneous glycosides Bitter principles Tannins

14 weeks

a1,a2,a3,a4,a5,a6,a7

b1,b2,b3,b4

Chromatography (CC, 14 weeks a1,a2 b1,b2,b3,b4

Course name Chemistry of Natural

Products I code 342/8

TLC, PC) Practical Carbohydrates, introduction, classification, biosynthesis, reactions, Application of carbohydrates


Anthracene glycosides , flavonoids Steroidal cardioactive glycosides Terpenoid glycosides Miscellaneous glycosides Bitter principles Tannins

4 weeks

c1,c2,c3

d1,d2,d3,d4

Chromatography (CC, TLC, PC)


Course members: Abdel Nasser Singab, Ph.D., Professor of Pharmacognosy Nahla Ayoub, Ph.D., Professor of Pharmacognosy Omayma Eldahshan, Ph.D., Lecturer of Pharmacognosy Head of the department: Prof. Nahla Ayoub

Documents

PHARMACOGNOSY I 241 Ain Shams University Faculty: …s3.amazonaws.com/.../pharm.shams.edu.eg/ContentPages/2464996652… · Pharmacognosy department ... 6.1- Course notes Lecture and