ROUTES OF DRUG ROUTES OF DRUG ADMINISTRATIOADMINISTRATIO
Formal Definition of Formal Definition of DrugDrug
“A drug is a chemical which is used for diagnosis, prevention and cure of a disease”
Routes of Administration of Drugs
Dugs can be given by various routes. The goal is to deliver the drug to target organ or tissue, so that it can exert its maximum effect
ENTERAL ROUTE ENTERAL ROUTE OF OF
ORAL ROUTE OF ORAL ROUTE OF ADMINISTRATIONADMINISTRATION
By Mouth FOR SYSTEMIC EFFECT:Advantage:Convenient MethodDisadvantages: Absorption may be delayed or enhanced
after food intake. Presence of food in stomach delays gastric
emptying. So drugs like penicillin, insulin and oxytocin are destroyed in stomach by acids
FOR EFFECT IN THE GUT:
Advantage:Drug is placed at the site of action and local concentration can be higher than would be safe in blood, e.g., Neomycin, Anthelminthics.
Disadvantages: Drug distribution may be uneven and in
some diseases the whole thickness of gut wall is affected, e.g., in severe bacillary dysentery, typhoid.
Drug passes through stomach, intestinal wall and then through liver before it is transported via blood stream to target organ. The intestinal wall and liver metabolizes drug thus decreasing amount of drug reaching the blood stream.