PLM in Digital Transformation

May 2017

Peter Wyser, Head of Digital Transformation

The value of in vitro diagnostics

Transforming data into actionable information

Condition Action Data Information

Sample Test Result

Evaluation

Decision

Support

Product cobas® 6800

A first Insight – Molecular Diagnotics Analyzer

Input/Output of Patient

Samples/Racks

Scanning of each Rack and single sample

barcode, adding of positiv and negativ controlls

DNA Extraction and Test Preparation

Polimerase Chain Reachtion (PCR) and Detection of Viral

Load by multiplying DNA/RNA and Calculation

384 Samples in 8 hours

Roche Diagnostics: Value to patients worldwide

17 billion Roche Diagnostics tests p.a.

150 countries

Inflammation / Autoimmune

Cardiology

Virology / Microbiology

Oncology Women’s Health

Metabolic Diseases Hematology

Hospital /

Commercial Lab ER / ICU Physician’s

office

Pathology Lab Research Lab Patient RNA/DNA-based Protein-based Cell-based

Unparalleled technology breadth Diagnostics wherever needed

Extensive disease area coverage Global presence and expertise

Roche Diagnostics

Global footprint and network

Main Roche Diagnostics sites:

Dia Headquarter

Regional hub

R&D / Manufacturing

Mito

Singapore

St. Cugat

Basel

Mannheim

Penzberg Indianapolis

Branchburg Tucson SF Bay Area

Pleasanton Boston Area

Rotkreuz Shanghai & Suzhou

Digital Transformation for Roche Diagnostics

Customer Lab Engineering

System Engineer

Manufacturing / QC / Logistics Instrument Manager / Quality Engineer

Product Structure Management Lead System Engineer / Configuration Manager

Product Quality Management CIR Quality Manager

Remote Support Call Agent / System Expert

Sales & Marketing IBL / Lab Consultant / Sales Force

On Site Service Field Service Engineer

Business Analytics Business Analyst / Sales Force

3D assembly

guidelines

Visualized Quality

Monitoring 3D Inspection Plan

Mobile Maintenance

3D animated

Service Instructions

Predictive

Maintenance

Digital Supported

Service

3D Spare Parts

Catalogue

Digital Mockup based

Marketing

3D Visual Analytics

3D Visual Engineering

Functional Baselining

3D Printing (AM)

Object Based Requ.

Management

Asset Efficiency

PLC (Product Lifecycle Costing)

Digital Learning

Workflow Simulation

Instrument & LAB

Configuration 360

Value Creation

Configuration

Management 3D

DTP Scope

Quality Doc.

Generation

Global Quality

Dashboard 360

Digital

Academy

Digital Twin Digital Lab

Experience

Customer Feedback

Loop

Condition Monitoring Maximize

Uptime

Customer Centered

Design

CAD 3D Construction, Simulation &

Photorealistic Visualization

Digital Twin Services

Digital Twins to provide Digital Twin Services

Physical Product

Digital Twin

Physical Product

Is represented by different Configurations and Specific Condition:

• As-Built Configuration (m-BoM)

• As-Maintained Configurations (s-BoM)

Digital Twin

Is represented by different information:

• CAD Model

• Electrical, electronical and software information

Represents the product in the appropriate Configuration and is enriched with

other information (e.g. sensor readings) to show specific Condition

Digital Twin Solution

Are performed based on the appropriate Digital Twin and used to:

• Provide the Digital Twin in the appropriate Configuration

• Used to monitor condition for predictive maintenance

• Show Business- and Product Information

• Administer and drive Business Process Objects

Digital Transformation for Roche Diagnostics

Customer Lab Engineering

System Engineer

Manufacturing / QC / Logistics Instrument Manager / Quality Engineer

Product Structure Management Lead System Engineer / Configuration Manager

Product Quality Management CIR Quality Manager

Remote Support Call Agent / System Expert

Sales & Marketing IBL / Lab Consultant / Sales Force

On Site Service Field Service Engineer

Business Analytics Business Analyst / Sales Force

3D assembly

guidelines

Visualized Quality

Monitoring 3D Inspection Plan

Mobile Maintenance

3D animated

Service Instructions

Predictive

Maintenance

Digital Supported

Service

3D Spare Parts

Catalogue

Digital Mockup based

Marketing

3D Visual Analytics

3D Visual Engineering

Functional Baselining

3D Printing (AM)

Object Based Requ.

Management

Asset Efficiency

PLC (Product Lifecycle Costing)

Digital Learning

Workflow Simulation

Instrument & LAB

Configuration 360

Value Creation

Configuration

Management 3D

DTP Scope

Quality Doc.

Generation

Global Quality

Dashboard 360

Digital

Academy

Digital Twin Digital Lab

Experience

Customer Feedback

Loop

Condition Monitoring

Maximize

Uptime

Customer Centered

Design Predictive

Maintenance Condition

Monitoring

Machine

Data

Machine

Learning

100%

Config

Mgmt

3D CAD

Data Model

Config-

uration as

Maintained

Digital Twin

Digital Twin Services

Digital Product, Digital Twin Services

conversion

• different Structure (e.g. MBOM)

• different Assemblies-Setup

(plant, process specific)

• add Animation

• add special Toolings

• add symbols and other Information

• Used for Digital Twin Services

Other CAD/PDM

Software (Label)

Other Information

Digital Twin Service

CAD/PDM CAD/PDM

Product Lifecycle Process and its Configurations

The Digital Twin Services As-Is Configuration

As-Buit

Structure

As-Maintained

Structure

Logical/Node Structure

Sys

tem

Bre

akdow

n

Str

uctu

re

EBOM MBOM SBOM Configured

BOM

As-Configured

Configuration

To-Be Configuration

Technical

To-Be Config.

Supply Chain

To-Be Config.

As-Built

Configuration

As-Maintained

Configuration

Customer Service

To-Be Config.

Development Configuration

R

R R

Requirements

Structure

F

F F

Functions

Structure

A

A

T

Analysis & Test

Structure

Derived Digital Products

original Digital Product,

technical To-Be

Digital Twin

Service Digital Twin

Service

AS-Is

Digital Product

Information enriched Digital Products used for Digital Twin Services

12

As-Specified

As-Designed

As-Planned As-Built

As-Required As-Installed

As-Maintained

(As-Refurbished)

As-Retired

Development &

Assembly

Issues

CAPAs

Customer/

Field Requests

As-Delivered

As-Tested

Field &

Maintenance

Project

Start

LD

DI

pr DO

«Installation» for

each serial number

«Manufacturing

BOM»

«Engineering

BOM»

Changes:

Design Changes

Design Changes

Design and

manufacturing

Changes

Design Changes

Field service and

modifications

Field service and

modifications

Field service

and

modifications

Design and

manufacturing

Changes

Design and

manufacturing

Changes

VALIDATE

PRODUCE

OPERATE

SERVICE

PLAN

DESIGN

Sof tware E lec t ron ic

Mechanica l Manufac tur ing

Serv ice

Connected

Operation

system of system

system of system

system of system

system of system

system of system

system of system

CLOSED LOOP LIFECYCLE

MANAGEMENT

Configuration Management E2E process & PLM

Why CONFIGURATION MANAGEMENT? Effects due to insufficient product data integrity

Example

Integrity level

of 92% means

50%

employee

effectiveness*

Product Lifecycle Process and its Configurations

Animated Maintenance Instruction

Now

Future

Transforming Digital Product Creation & Service

Doing now what patients need next