PersonnelPlacement

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POSITIONS WANTED

Clinical Biochemist-Toxicologist, Ph.D., Biochemis-try, 1974. Wants position as laboratory director orequivalent. Qualified by CAP, CLIA, Medicare, NIDAas director. Will act as consultant to companies needingdrug testing. Please send inquiries to Box 9, SCIENCE.

Ph.D. Experience in phospholipid and arachidonic acidmetabolism. Lipid metabolite analysis by radiometricand immunochromatographic methods, RIA, ELISA,TLC, GC, HPLC. Blood cell separation, organelle isola-tion, PLA2, PLC enzyme assays. Organic synthesis.Experience in immunoassay development, chemical mod-ification and purification of proteins. Seeks academic,industrial, or clinical research position. Box 15,SCIENCE.

Plant Physiologist. Looking for postdoctoral positionfor 1 year (starting from April 1989). Interested in stressphysiology, cellular growth and metabolism, plant struc-ture and related fields. Box 16, SCIENCE.

POSITIONS OPEN

ACADEMIC HEMATOLOGIST/ONCOLOGIST-Board-certified/Board-eihible individual with primary ba-sic research interest to jom the expanding combined hema-tology/oncology program at the Medical College ofVirgin-ia and McGuire Veterans Administration Hospital. Theselected individual will have adequate protected time todevelop his/her research program. Although we welcomeall applications, we are particularly interested in individualswith research programs involving molecular and/or growthfactor biology. Send letter of interest and resume to: BurtAdelhan, M.D., Division of Hematology/Oncology,Veterans Administtion Medical Center, 1201 BroadRock Boulevard, Richmond, VA 23249. An AffirmativeAction/Equal Opportunity Employer.

ACADEMIC INFECTIOUS DISEASESIMMUNOLOGY RESEARCH

GUTHRIE CLINICGUTHRIE RESEARCH INSTITUTE

Applications are invited for a joint staffappointment atthe Guthrie Clinic and the Guthrie Research Institute,the basic research component of the Guthrie ClinicdMedical Center complex located in Sayre, Pennsylvania.The position would involve 25% time doing clinicalinfectious diseases at the Guthrie Medical Center and75% time doing basic immunology research at theASSISTANT OR ASSOCIATE SCIENTIST level.The Institute is directed towards the study of basicimmunology. Existing research programs involve cellularand biochemical aspects of cell-mediated cytotoxic re-sponses; macrophage immunobiology and the produc-non ofcytokines; and the molecular biology oflymphoidsurface antigens and cytokines. Sufficient start-up fundsare available for a developing scientist, and abundantopportunities exist within the Medical Center for clinicalresearch and basic-clinical collaborations. The MedicalCenter and Research Institute are attractively located inscenic northeastern Pennsylvania, and affordable housingis complemented by abundant nearby recreational andcultural facilities. Interested candidates should submittheir curriculum vitae with three references and state-ment of interests to: Frederick B. Rose, M.D., Chief,Infectious Diseases, Guthrie Clinic, Sayre, PA 18840.

ALFRED FITLER MOORE PROFESSORSHIPIN OPTRONICS-A chaired professorship has beenestablished in the Department ofElectrical Engineering.The person appointed to this chair will be a distinguishedscholar who has performed outstanding theoretical andpractical research in optronics as related to communca-tions, sensing, signal processing or device physics forsystem applications. The incumbent should be able toexercise scholarly leadership in the field. It is hoped thatthe appointee wlll be able to assume tenure by September1989. Applications/nominations should be directed by28 February 1989 to: Professor Nabil H. Farhat,Chair, Alfied Fitler Moore Professorship in OptronicsSearch Committee, University ofPc syvania, Electri-cal Eg e Dcpartmennt, Philadelphia, PA 19104-6390. Equal Opportunity/Afirmative Action Employer.

ANATOMY/CELL BIOLOGYTenure-track position as ASSISTANT PROFESSOR

in Human Biology beginning 28 August 1989. Ph.D.required. Primary teaching responsibilities will be introduc-tory anatomy and physiology, cell biology and comparativeanatomy, with contributions to biology and graduateprograms as needed. Opportunities are available for inter-disciplinary teaching and research is expected. Send curricu-lum vitae, transcripts (undergraduate/graduate) and threeletters of reference by 10 March 1989 to: Dr. T. Sager,Human Biology, ES 301, University of WVisonsi-Green Bay, Green Bay, WI 54311-7001. Equal Oppor-tunity/Affirmative Action Employer.

ASSISTANT OR ASSOCIATE PROFESSOR,BIOLOGY: Tenure-track position available August1989 primarily teaching general biology for non-majors.Doctorate preferred, ABD considered; specialty in devel-opmental or population biology or plant ecology desir-able. Send letter of application, curriculum vitae, allundergraduate/graduate transcripts, and three letters ofrecommendation by 14 March 1989 to: WilLiamBrunckhorst, Biology Department, University ofWisconsin-VWhitewater, Whitewater, WI 53190.Women, members of minority groups, persons with disabilitiesand Vietnam-Era veterans are encouraged to apply.

POSITIONS OPEN

ASSISTANT PROFESSORDEPARTMENT OF PATHOLOGY

The Department of Pathology, Medical College ofOhio, seeks an innovative molecular biologist to: (i)Implement a diagnostic molecular biology laboratorv aspart of the clinical pathology laboratorv service and, (ii)Initiate a strong research program in molecular carcino-penesis. Other responsibi ities would include the teach-mg of molecular biology to residents, fellows and gradu-ate students. Applicant should have an M.D. and/orPh.D. with postdoctoral experience. Salary and fringebenefits are competitive. Expected appointment date isJuly 1989. A lication, including curriculum vitae andthe names of three references should be sent to: Jona-than Myles, M.D., Department ofPathology, MedicalCollege of Ohio, P.O. Box 10008, Toledo, OH43699.

ASSISTANT PROFESSOR positions, one tenure-track position and two, 1-year term appointments, sub-ject to renewal, are available. Ph.D. is required. Appli-cants must teach introductory biology and work inpedagogical as well as content biology. The tenure-trackposition is for a Vertebrate Zoologist/Vertebrate Ecolo-gist, #20752. Interest and expertise in animal behavior,aquatic biology, poikilotherm biology, are particularlydesirable. One term position is for a Non-vascular Bota-nist, #21335, to teach introductory botany, and special-ty area. The second term position is for a Microbiologist/Cell Biologist, #20828, to teach microbiology and/orcell biology. Submit by 1 March 1989 a letter ofapplication, resume, three references, transcripts, evi-cence of U.S. citizenship, statement of teaching philoso-phy to: Dr. Ronald Pfae, Coordinator Search andScreen Committee, Department of Biological Sci-ences, University ofNorthern Colorado, Greeley, CO80639. Minorities and women encouraged to apply. TheUniversity is an Equal Employment Opportunity/AfirmativeAction Employer.

ASSISTANT/ASSOCIATE PROFESSOR, TEN-URE-TRACK. Department of Environmental Health,College of Public Health, University of Oklahoma atOklahoma City, Health Sciences Center. Position availableuntil filled. Minimum qualifications indude an earneddoctorate in environmental health or a dosely relateddiscipline, pnrmary expertise in environmental planning/policy-making and/or nsk analysis, demonstrated compe-tence or evidence of outstanding promise in research, androficienc m computer applications to environmental

l Aditional consideration will be given to candidateshaving postdoctoral training, teaching and/or field experi-ence. Applicants should submit a resume and the namesof four references to: Ronald L. Coleman, Ph.D., Chair,Environmental Health Search Committee, College ofPublic Health, Department of Environmental Health,Post Office 26901, Oklahoma City, OK 73190. TheUniversity of Oklahoma is an Equal Opportunity/AfirmativeAction Employer.

ATMOSPHERIC MODELER/Universitv of SouthCarolina. The University of South Carolina invites appli-cations for a tenure-track position in the Marine ScienceProgram and Department of Geological Sciences. Theposition, which is partially funded by the United StatesGeological Survey, will involve climate modeling on theregional scale, coupled atmosphere/ocean modelng, andcoupled atmosphere/hydrologic modeling. Preferencewill be given to applicants with a strong background inmodeling fluid mechanics and thermal processes. Experi-ence with climate models such as the NCAR CommunityClimate Model and the GFDL ocean model and withparallel processing computers will be useful. A Ph.D. isrequired at the time ofemployment. Rank and salary willbe commensurate with experience. The applicant shouldsend a resume, a cover letter stating research and teachinginterests, reprints of representative papers, and threeletters of recommendation to: Dr. James C. Evans,Department of Geological Sciences, the University ofSouth Carolina, Columbia, SC 29208. Foreign nationalsshould indicate current U.S. immigration status. The deadlinefor receipt of application materials is 15 March 1989.The University ofSouth Carolina is an Equal Opportunity/Affirmative Action Employer.

PERSONNEL PLACEMENT 55727 JANUARY I989

POSITIONS OPEN

ASSISTANT/ASSOCIATE PROFESSOR OFMEDICAL ONCOLOGY

The University of Colorado Health Sciences Center,Denver, Colorado, is seeking an M.D. or Ph.D. fortenure-track position (specialty-track may be selectedafter 4 years), who is interested in starting an indepen-dent laboratory-based research program. The posinonwill involve no clinical responsibilities, with 100% pro-tected time for laboratory research. Minor teaching orpatient care roles may be undertaken at individual'sdiscretion, and joint appointments can be arranged withother medical school departments. Laboratory space isavailable with appropriate funds for equipment andtechnical support during the transition to mcdependence.Starting salary will be competitive, commensurate withexperience. Applicants should submit curriculum vitaeto: Dr. L. Michael Glode, Division ofMedical Oncol-0ey,University of Colorado Health Sciences Center,

4200 East 9th Avenue, Denver, CO 80262. An EqualOpportunity/Affirmative Action Employer.

ASSISTANT/ASSOCIATE PROFESSOR-MICROBIOLOGY

The St. Louis College of Pharmacy invites applicationsfor a full-time (9-month) tenure-track position in micro-biology starting fall 1989. Applicants should possess aPh.D. in microbiology with special interest in medicalmicrobiology. Responsibilities include teaching a surveycourse for nursing students and a two-semester sequencefor pharmacy students. Send curriculum vitae, graduatetranscripts, and names, addresses, and telephone num-bers of three references by 1 March 1989 to: Dr. R. J.Cooper, Director, Division of Biological Sciences, St.Louis College of Pharmacy, 4588 Parkview Place, St.Louis, MO 63110. An Equal Opportunity Employer.

BIOCHEMIST, ASSISTANT RESEARCH level,available immediately to study the structure, mechanismof action and regulation of expression of lipogenicenzymes. Candidate must have experience in techniquesof enzymology (enzyme purification and charactenza-tion, kinetic studies, protein chemistry and amino acidsequencing) and molecular biology (DNA library con-struction and screening, DNA cloning, isolation andsequencing). Send resume and names of at least tworeferees to: Children's Hospital Oakland, HumanResources, 747 52nd Street, Oakland, CA 94609.Equal Opportunity Employer.

UNIVERSITY OF ALBERTAFACULTY OF REHABILITATION MEDICINE

CARDIOVASCULAR ORCARDIOPULMONARY POSITION

Applications are invited for a tenure-track position inthe Department of Physical Therapy at the University ofAlberta. Applicants must possess a doctorate and have anactive research program. A physical therapy backgroundand postdoctoral experience would be an asset.The University of Alberta offers Bachelor of Science

and Master of Science degrees in physical therapy. APh.D. in rehabilitation is proposed.

Applicants should have research and teaching capabili-ty in cardiac and/or pulmonary rehabilitation and exer-cise. Other areas such as health education, occupationalphysiology and conditioning would be an asset.

Responsibilities include undergraduate and graduateteaching, graduate supervision, research and scholarlywork and some administrative duties. A strong commit-ment to obtaining external research funding is expected.This appointrnent may be a joint appointment with theDepartment of Physical Education and Sports Studiesand in this case, teaching and graduate supervision inboth departments will be exiected.

Salary commensurate wi qualifications and experi-ence. Range for assistant professor is from $33,144 to$47,280 (per annum); or associate professor, from$41,390 to $59,534 (per annum).

Qualified applicants should send curriculum vitae,stating teaching and research interests, and provide threereferences to: Dr. Martha C. Piper, Dean, Faculty ofRehabilitation Medicine, 316 Corbett Hall, Universi-ty ofAlberta, Edmonton, Alberta, Canada T6G 2G4.

Deadline for receipt of applications is 1 March 1989.The University of Alberta is committed to the principle of

equity in employment.

TRUDEAU INSTITUTE, INC.BASIC RESEARCH SCIENTISTS

The Trudeau Institute is always interested in receivingapplications for tenure-track, full-time research staff posi-tion, from appropriately trained individuals. Appoint-ments may be made at the assistant, associate, or fullmember (professor) levels, depending on scientific abilityand past performance. Successful applications will beexpected to develop independent research programs inimmunology, immunopathology, molecular immu-nology or related fields.The Trudeau Institute is a free-standing, not-for-

profit, basic research Institute with modem facilities, up-to-date equipment, in-house animal production, efficientmanagement and an international reputation for excel-lence. Current staff interests include: Cancer immunolo-gy, transplantation immunology, immnunity to infectiousand parasitic diseases, regulanon of immune responses,and the production and function of cytokines. Adequatestart-up funding for new projects is available from Insti-tute resources. Salaries and benefits are competitive, andworking conditions are conducive to a productive careerin research.

Applications consisting of curriculum vitae, the namesand addresses of three references, and a brief descriptionof research interests should be addressed to:

Dr. Robert J. North, DirectorTrudeau Institute, Inc.

P.O. Box 59Saranac Lake, NY 12983

BIOLOGISTS-The Claremont Colleges: Two full-and one half-time sabbatical replacement positions for1989-90 to teach genetics or physiology plus introduc-tory courses to major or non-major students. Salarynegotiable. Have resume, statement of goals and threereference letters sent by 15 March 1989 to: Daniel A.Guthrie, Joint Science Department, The ClaremontColleges, 150 East 10th Street, Claremont, CA91711. An Affirmative Action/Equal Opportunity Employer.

CHAIR, DEPARTMENT OPPHARMACOLO-GY, Stanford University. Stanford University School ofMedicine is conducting a search for a chair for theDepartment of Pharmacology. Applications are soughtfrom individuals who have both a demonstrated scholarlyproductivity in an active research program and an ac-knowledged history of providing quaity education tomedical and graduate students. Stanford University iscommitted to increasing representation ofwomen and members ofminority groups on its faculty and particularly encouragesapplications from such candidates. Interested persons shouldsubmit their curriculum vitae to: Dr. Byron W. Brown,Jr., Chairman, Pharmacology Search Committee, De-partment of Health Research and Policy, StanfordUJniversity School of Medicine, Stanford, CA 94305.

CHAIR-MICROBIOLOGY AND IMMUNOLOGY

The Oregon Health Sciences University School ofMedicine is seeking applicants for the position of Chairof the Department of Microbiology and Immunology.The faculty of this university-based department are en-gaged in research and in the instruction of medicalstudents, graduate students and fellows. The positionrequires strong scientific, organizational and administra-tive skills. Submit curriculum vitae and references to:Bruce Magun, Ph.D., Chairman, MicrobiologySearch Committee, L 215, Oregon Health SciencesUniversity, Portland, OR 97201. An Afirmative Action!Equal Opportunity Employer.

CHAIRMAN OF PATHOLOGYNEW YORK MEDICAL COLLEGE

A MEDICAL UNIVERSITYVALHALLA, NEW YORK

Nominations and applications are invited for the posi-tion of Chairman and Professor of Pathology. Candi-dates must have an M.D. degree, a distinguished researchrecord in pathology, experience in teaching students ofmedicine, an interest in graduate education, and havedemonstrated leadership and administrative abilities. Ap-plications with curriculum vitae and bibliography andnames of three references should be sent to: Joh C.McGiff, M.D., Chairman of the Search Committee,Department of Pharmacology, New York MedicalCollege, Valhalla, NY 10595. New York Medical Collegeis an Afirmnative Action/Equal Opportunity Employer.

BIOTECHNOLOGY PROGRAM DIRECTORCOLORADO ADVANCED

TECHNOLOGY INSTITUTE (CATI)A new position reporting to the Executive Director.

Responsible for:* Directing a bioprocessing center* Establishing an incubator* Directing a university/industry consortiumThe position requires an advanced degree in science or

engineering; 10 or more years of P&L and/or academicexperience; management of a product from concept tomarket release; and interface with academic/governmentorganizations.To submit curriculum vitae/resume, salauy requirements,

and three references or to request a written positiondescription contact: Mary Jackson, CATI, 555 17thStreet, Denver, CO 80202. Equal Opportunity Employer.

CELL AND MOLECULAR BIOLOGYSUNY Plattsburgh seeks applicants for a SABBATI-

CAL REPLACEMENT position for the 1989-90 aca-demic year in the Department of Biological Sciences.

Duties: Requires teaching in a unique biotechnologyprogram and other courses. A background in animal cellculture and/or immunology is desirable.

Qualifications: Ph.D. in biology required. Teachingexperience necessary.We encourage applications from candidates who can serve as

role modelsfor women and minority students.Plattsburgh is located on the shore of Lake Champlain,

an hour from Montreal, Lake Placid and Burlington,Vermont.

Closing date is 1 March 1989 or until position is filled.Send letter of application, current resume, and three

current letters of reference to:Chair, Search Committee

c/o Office of Personnel/Affirmative ActionSUNY PlattsburghBox 1581-246

Plattsburgh, NY 12901SUNY is an Equal Opportunity/Affirmative

Action Employer.

CRYSTALLOGRAPHY-A FACULTY POSI-TION (tenure-track or tenured) is available in theProgram in Molecular Medicine at the University ofMassachusetts Medical School. Applicants should have aPh.D. and extensive postdoctoral experience, with arecord of productivity in protein or nucleic acid structuredetermination by x-ray diffraction analysis. The success-ful applicant will be provided with funds to set up acrystallographic laboratory and research program, andwil pursue extramural funds for the vigorous growth ofthat program. Extensive opportunities for collaborationexist in the Departments ofBiochemistry, Cell Biology,Pharmacology, Physiology, and Molecular Genetics andMicrobiology. Please forward curriculum vitae, a sum-mary (one to two pages) of future research plans, andnames of three references to: Crystallographic SearchCommittee, Department of Pharmacology Universi-ty of Massachusetts Medical School, 55 Lake AvenueNorth, Worcester, MA 01655. Applications will bereviewed beginning in January 1989, but will be accept-ed until the position is filled. The University ofMassachu-setts is an Equal Opportunity/Affirmative Action Employer.

DIRECTOR, GENETIC DIAGNOSTIC LABO-RATORY: A position available immediately for a Ph.D.with experience in molecular biology/biochemical genet-icsto ect a genetic diagnostic laboratory. There isample opportunity for independent research and facultyappointment at Duke University Medical Center (rankdependent on experience). The candidate will join anestablished and growing, comprehensive academic genet-ic and metabolic program with expertise in clinicalgenetics, molecular and biochemical genetics associatedwith a major mass spectrometry facility. Duke University isan Equal Opportunity/Affirmative Action Employer. Sendcurriculum vitae and three references to:

Y. T. Chen, M.D., Ph.D.Associate Professor of Pediatrics

Division of Genetics and MetabolismDepartment of Pediatrics

P.O. Box 3028Duke University Medical Center

Durham, NC 27710

SCIENCE, VOL. 243

POSITIONS OPEN POSITIONS OPEN

BS/MS DEVELOPMENTAL TOXICOLOGIST

Toxicology Division

Equal OppowunityEnvloyer

For more than a century, scientists at ELI LILLYAND COMPANY havedeveloped innovative, high quality pharmaceutical products. In 1988, Lillyinvested over $500 million in research-and-development programs. More than3,000 scientists at the company's Lilly Research Laboratories are pursuingcreative research programs that involve many important health care needs.

To further build its research capabilities, Lilly is seeking self-motivated,innovative scientists for the Toxicology Division.* To design and supervise reproduction/teratology studies on potentialpharmaceutical and agricultural products.

. To analyze data and write reports for studies performed in DevelopmentalToxicology area.

* Bachelor's or Master's degree in Biology, Anatomy, Toxicology,Pharmacology, Physiology, or a related discipline is required.

* Expertise in conducting and reporting Reproduction and Teratology studiesis preferred.

* Excellent oral and written communication skills are necessary.Eli Lilly and Company is committed to scientific excellence. Lilly

provides a stimulating professional atmosphere with many opportunities forcollaborative, multidisciplinary research. The company offers an attractivetotal compensation program. Entry level and salary will be based upon eachcandidate's experience.

For prompt consideration, please forward your resume to:Maria L. PoorScience Recruitnent (AT4)Eli Lilly and CompanyLilly Cororate CenterIndianapolis, Indiana 46285

The Projed Management Division of Smith Kline & FrenchLaboratories is seeking individuals for multiple level positions withthe appropriate knowledge and experience to assist in the designof new drug development strategies and identification of projectmilestones and objectives. Working with a Project Director andProject Team, the Project Manager will identify problems anddetermine solutions, coordinate and manage the submission ofplans, monitor and document project-related activities.The successful candidates will have:* B.S./M.S. in a biomedical field.* MBA, M.D., Ph.D. & Pharm. D. strongly encouraged -to apply.* Some experience in a biomedical field highly desirable.* Proven analytical and organizational skills as well as

outstanding interpersonal skills.* Experience managing multidisciplinary teams in a leadership

role is a definite plus.Smith Kline & French Laboratories is located in a new, state-of-the-art research and development complex near Valley Forge, PA.We offer an excellent compensation, benefits and relocationpackage, as well as opportunities for significant career growth.Qualified candidates should send resume to Barbara J. Schwartz,Employment Administrator, S0071, SK&F Laboratories, P.O. Box1539, King of Prussia, PA 19406-0939. We are an equalopportunity employer, M/F/H/V.

DIRECTOREPPLEY INSTITUTE FOR RESEARCH IN

CANCER AND ALLIED DISEASESUNIVERSITY OF NEBRASKA MEDICAL CENTER

The University of Nebraska Medical Center invites nominations/applications for the position of Director of the Eppley Institute. TheEppley Institute currently has a multidisciplinary faculty of approxi-mately 20 members holding joint appointments in various academicdepartments, and a total staff of approximately 120. It has beendesignated as one of 15 NCI Laboratory Cancer Research Centersand has received a Special Institutional Grant from the AmericanCancer Society. Graduate students and postdoctoral fellows aresupported partially by an NIH Training Grant. The Director isresponsible for all the activities of the Institute and reports directly tothe Chancellor of the Medical Center.The successful applicant should have an outstanding record ofscientific accomplishment that would qualify him/her for the rank ofProfessor in a basic science department. The individual must befamiliar with the activities of a modern health science center, cancerresearch funding programs and/or agencies, and have significantadministrative experience. Evidence of an ongoing program in basiccancer research also is essential. Applicants should submit a currentcurriculum vitae and the names of three individuals who will serve asreferences. Closing date for receipt of applications/nominations is 15February 1989. Applications/nominations should be sent to:

William 0. Berndt, Ph.D.Vice Chancellor for Academic AffairsRoom 5009 Conkling HallUniversity of Nebraska Medical Center42nd and Dewey AvenueOmaha, Nebraska 68105

The University of Nebraska Medical Center is an Affirmative Action!Equal Employment Opportunity Employer.

POSITIONS OPEN

DIRECTOR OF BIOSAFETYThe Collegc ofVeterinary Medicine at Cornell Univer-

sity seeks a Director of Biosafety. The successful candi-date will have College-wide responsibility for institution-al compliance with University, Local, State, and Federalregulations regarding the acquisition, use, and disposalofhazardous substances. The Biosafety Director will alsohave faculty responsibilities in the Toxicology Section ofthe New York State Diagnostic Laboratory which is anoperating unit of the College.

Qualified candidates should possess a D.V.M./V.M.D.degree and have advanced training in clinical toxicology,toxicology or environmental health. Preference will begiven to individuals who have board certification oreligibility in toxicology. Candidates should have exhibit-edorganizational ability, initiative, and skill in correctingbiohaxard problems.

Candidates should submit a resume and at least tworeferences by 15 April 1989 to:

Dr. Douglas D. McGregorAs8Ociatel)can for Research

College of Veterinary MedicineCornell UniversityIthaca, NY 14853

Comell University is an Equal Opportunity/AfirmativeAction Employer.

ECOLOGIST-Tenure-track position, ecosystemsfocus, available fall 1989. The successf alicant willdevelop a quality, externally-funded program,

and teach undergraduate, M.S., and Ph.D. students.Appointrnent expected at assistant professor lcvel, butexceptional candates may bc considered at advancedlevels. Lehigh University has both marine and freshwaterresearch stations and is actively developing interdisciplin-ary programs. SEND CURRICULUM VITAE, RE-PRINTS, STATEMENT OF RESEARCH INTER-ESTS, AND NAMES, ADDRESSES AND TELE-PHONE NUMBERS OF THREE REFERENCESby 10 February 1989 to: Dr. Craig Williamson, SearchCommittoe Chair, Depar t of Biology # 31,Lehigh University, E em, PA 18015. Lehigh Uni-versity is an Equal Opportunity/Affirnative Action Employer.

EXPERT WITNESS NEEDED: I seek an expertqualified to analyze the quality of research project andpapers in the area of Nudear Physics. Topics of paperswere 1. "Diffraction Intensity from Vibrating Crystals."2. Dccay Scheme of 188Hg." 3. Study of Alpha Decay ofNeutron Deficient Isotopes in the Lead Region Indud-ing The New Isotopes Pb (A'-188) and Ti (A=182)."Must be willing to testifyr in court case against VirginiaTech, will pay fees and expenses, contact: Gerald T.Zerkin, Esq., 2nd and Franklin Streets, Linden Tow-er Professional Centre, Suite 108, Richmond, VA23219; Tclephonc: 804-788-4412.

FACULTY POSMONCELL BIOLOGY

The Department of Biology of the University ofWisconsin-River Falls (UW-RF) invites applications fora tenure-track facult position at the assistant professorlevel, effective 1 September 1989. Teaching responsibil-ities will include cell biology and bacteriology, alternateyear offerings in virology and animal cell culture, andparticipation in introductory biology. Research involv-mng students is encouraged and supported. Applicantsmust have a Ph.D., experience in cell or tissue cuiture anddemonstrated potential for excellence in teaching. A well-equipped cell culture facility is available in the depart-ment and the successful applicant will have the opportu-nity to participate in implementing a n-ew interdisciplin-ary major in biotechnology. Applications from qualifiedwomen and members ofminority groups are particularly encour-aged. Please send a letter of application, curriculum vitae,transcripts and three letters ol reference by 6 March 1989to: Dr. Clarke E. Garry, Biology Search Committee,Department of Biology, University of Wisconsin-River Falls, River Falls, WI 54022. UW-RF, a com-prehensive university with over 5000 students, offersbachelors and masteres degrees and is ideally located inthe scenic Kinnickinnic River Valley just 30 miles fromMinneapolis/St. Paul, Minnesota. The University of Wis-consin-River Falls is an Equal Opportunity/Afirmative ActionEmployer.

560

The Sterling Research Group, the worldwide pharmaceuticalresearch and development organization of Sterling Drug, Inc.,announces two openings in the expanding antiviral researchprogram in the Microbiology Department at Sterling'sRensselaer, New York facility.

OPPORTNITIES GROUP LEADEROPPOnRTU NITIE The successful candidate will possess a Ph.D. degree in virologyor molecular biology with relevant postdoctoral training and a

FOr minimum of 3-5 years industrial experience. The scientist willF^OR ^ ^be expected to supervise and participate in a group applyingMOLECULAR current moleculartechniques to the analysis ot the replicationand pathogenesis of several viruses of biomedical importance.VIaROIOGISTS Supervision of senior scientific staff is expected and strong in-____-____________________ terpersonal and communication skills are required.

Committed ToScientificExcellence

SENIOR RESEARCH BIOLOGISTThe successful candidate will possess a Ph.D. in virology ormolecular virology with relevant postdoctoral experience. Thescientist will be expected to participate in the identification ofnew molecular targets for chemotherapeutic intervention.Located nearAlbany, New York, we offer an attractive salary andbenefits package as well as opportunities for professionaldevelopment in a dynamic environment utilizing a multidiscip-linary approach to research. Interested scientists should sendcurriculum vitae in confidence to:

Mr. John P. HarvyEmployment Manager

STERLING RESEARCH GROUPA Division of Sterling Drug Inc.Columbia TurnpikeRensselaer, New York 12144A Subsidiary ofEastman Kodak CompanyEqual Opportunit Empksyr M/F/HV

Career Opportunities in

Plant Biology

The Plant Genetics Department at Pfizer Central Research, in conjunction withnumerous plant breeding stations worldwide, conducts research and develop-ment for DeKalb-Pfizer Genetics, a leading agricultural seed company. We in-vite applications from scientists eager to join our multidisciplinary team focusedon the genetic manipulation of maize. Depending on your experience and in-terests, you will participate in innovative research focused towards understand-ing the biochemical and molecular basis of important agronomic traits of maize,and the development of technology to permit the in vitro manipulation of themaize genome. You should have an MS or BS degree with postgraduateresearch experience in one or more of the following areas of plant biology:

* Tissue Culture* Cell Biology* Molecular Biology* Biochemistry

In addition to a stimulating scientific environment, we offer a competitive com-pensation/benefit package and relocation assistance to an attractivesoutheastern Connecticut shore community. Qualified applicants should submittheir resume and the names, addresses and phone numbers of three profes-sional references to: Mrs. Lorraine C. Corr, Personnel Associate, Pfizer Cen-tral Research, Eastern Point Road, Groton, CT 06340. An equal opportunityemployer.

I

KUWAIT INSTITUTE FORSCIENTIFIC RESEARCH

Kuwait Institute for Scientific Research (KISR) is anonprofit organization with a staff of more than onethousand employees engaged in applied research inthe fields of environmental and earth sciences; foodresources; engineering; petroleum, petrochemicalsand materials and techno-economics.KISR has the following vacancies:

ORNAMENTAL HORTICULTURIST* Major Duties:- Studying performance of ornamental trees,

shrubs and ground covers under arid environ-ment.

- Investigating and introducing new ornamentalplants suitable for hot and arid environmentand under saline water conditions.

- Assessing various cultural practices for estab-lishment of landscaping and ornamentalplants.

- Recommending necessary landscaping prac-tices, greenery activities and turf manage-ment.

* Qualifications:Applicants should have a Ph.D. in Horticulturewith 4 to 6 years experience in ornamental plants,afforestation and landscaping in addition toknowledge of plantation in arid regions and phys-iological stresses of plants.

DATE PALM TISSUE CULTURIST* Major Duties:- Developing plant tissue culture methodology

for micropropagation research on date palms,with eventual inclusion of other plant species.

- Supervising and coordinating plant tissue cul-ture laboratory activities and providing train-ing in plant tissue culture methodology.

- Optimizing micropropagation systems for ulti-mate commercial application.

- Conducting intensive plant research includingnutrition, metabolism, and environmental tol-erance.

- Overseeing and guiding greenhouse acclima-tion and establishment of micropropagatedplants.

* Oualifications:Applicants should have a Ph.D. in one of thebasic plant sciences (Botany, Breeding, Physiolo-gy) with emphasis on tissue culture and/or ad-vanced molecular genetics and its application indeveloping new cultivars. Strong background inplant physiology is an advantage. Five or moreyears of research experience in tissue culture withdocumented expertise in date palm tissue culture(somatic embryogenesis and/or organogenesis)as well as use of somaclonal variation in develop-ing stress tolerant crop plants. Working experi-ence overseas is an advantage.

KISR offers attractive tax free salaries commensu-rate with qualifications and experience and generousbenefits that include gratuity, free furnished air-conditioned accommodation, school tuition fees forchildren, contribution to a savings plan, six weeksannual paid vacation, air tickets, free medical careand life insurance.

Interested applicants are requested to send theirCurriculum Vitae with supporting information notlater than one month from the date of this publica-tion, to:

Director GeneralKuwait Institute for Scientific Research

P.O. Box 24885 Safat13109 Safat-KUWAIT

Wyeth-Ayerst Research is a leading developer and producer ofprescription drugs, biologicals and infant nutritionals. We're firmlycommitted to advancing the art and science of medicine, havingresearched and developed hundreds of valuable drug products for thehealth and well-being of people throughout the world. We have an im-mediate opportunity in our Clinical R&D department in Radnor fora Manager of Clinical Writers.As Manager, you will direct and coordinate the daily activities ofwriters who are preparing new drug applications, manuscripts andabstracts for a wide variety of clinical products. As liaison betweenwriters and other departments, you will provide technical guidance,schedule and review, as well as provide quality control for all writingprojects.The candidate we seek will have a minimum of a BA/BS degree(preferably in biological or chemical sciences) - Ph.D degree prefer-red - and a minimum of 2 years experience supervising technicalwriters. A pharmaceutical background and clinical research ex-perience would be significant assets. Proven writing skills as well asexcellent organizational and leadership qualities are also required.We offer a competitive salary and extensive company benefits. For im-mediate consideration, please send resume and salary history to:

Recruitment Manager, Position #316,A \ \IEflYTH Wyeth-Ayerst Laboratories, Clinical

t5ULYAYERST R&D, PaBox8299, Philadelphia, PATM

ERSTAIIV19101. An equal opportunity employer,M/F/H/V/ responses encouraged.

POSITIONS OPEN

THE UNIVERSITY OF CALIFORNIA,LOS ANGELES

UCLA School of Medicine and the Molecular BiologyInstitute are expanding programs in Molecular Immu-nology and Molecular Genetics. Several tenure-trackpositions are available at a level commensurate withexperience for faculty with outstanding research pro-grams. UCLA is an Affirmative Action/Equal OpportunityEmployer. For those interested in molecular immunolo-gy, write to: Professor Owen N. Witte, MolecularBiology Institute, Room 364, 10833 Le Conte Ave-nue, Los Angeles, CA 90024-1570. For those interest-ed in molecular genetics, write to: Professor Larry J.Shapiro, Harbor/UCLA Medical Center, Division ofMedical Genetics, Building E4, Room 28, 1000 WestCarson Street, Torrance, CA 90509-1768.

FACULTY POSITION. The Department of Phar-macology, Creighton University School of Medicine,invites applications for a tenure-track position at the levelof assistant or associate professor. Applicants should havea Ph.D. in pharmacology and 2 vears of postdoctoralexperience, as well as a commitment to research and aninterest in teaching professional students, and graduatestudents. Current research interests in the Departmentinclude pharmacology of: secretion, the centra nervoussystem, smooth muscle, adrenergic receptors and pep-tides, as well as renal pharmacology and mediators ofinflammation. Individuals interested in receptor mecha-nisms, membrane transport, intracellular mediators orcytopharmacology in these areas are encouraged to ap-

Ilv. Interested individuals should send an outline offture research plans, curriculum vitae, and the names ofthree references to: Dr. Frank Dowd, Chairman, De-partment of Pharmacology, Creighton University,Omaha, NE 68178. Creighton Uniiversity is atn EquialOpportunity/Afirmnative Actiot Emnployer.

FLORICULTURE FACULTY POSITION. Nine-month tenure-track in horticulture, interior plantscapingemphasis av,ailable 16 September 1989. Instructor orassistant professor dependent on qualifications. Mini-mum: Master's or all but dissertation, at least one degreein horticulture, plant science, or closely related field;successful teaching experience. To apphl send applicationletter; resume including cducation, dates and tpes ofwork experience, honors, professional organizations,publications; official transcripts; three current referenceletters; names, addresses and phone numbers of twoadditional references by 10 Februarv 1989; or for adetailed job description or for further information, con-tact: Robert Krumwiede, University of MinnesotaTechnical College, Waseca, Waseca,MN 56093. Tele-phone: 507-835-1000. The Utniversity of Mitnnesota is antEqUal Opportun1ity Educator atnd Employer atnd specificallyinvites and encourages applications from womeni anid mninorities.

GENETICS APPLICATIONS COMPUTERPROGRAMMER. Position Responsibilities: Opportu-nitv to become involved in Human Genome Initiative(genetic mapping, physical mapping, and sequencing)and help develop systems for data analvsis and integra-tion of data sets at the Center for Genetics in Medicine atWashington University Medical School. Major responsi-bilitv will be construction of genetic linkage maps ofhuman chromosomes. Established program packages willbe implemented and new analvsis methods and programswill be developed. Will work directly with laboratonrhead and other laboratorv members and interact on acollaborative basis with members of Genetics Depart-ment, Biomedical Computer Laboratorv and ComputerScience Department.

Qualifications: Masters or equivalent experience ineither computer science/mathematics with some geneticsbackground or major strength in biology/genetics withexceptional skills in mathematics and programming.Experience in developing programs in C language re-quired; familiaritv with APL language would be useful.Familiaritv with VAX or MICROVAX desirable. Coursework in sratistics and basic probability theorv as well asintermediate calculus and biology required. Start datc:February/March 1989. Salarv: Commensurate with expe-rience. Send curriculum v*itae to: Dr. Helen Donis-Keller, Professor of Genetics, Genetics Department,Washinpton University Medical School, Box 8031,St. Louis, MO 63110.

POSITIONS OPEN

FACULTY POSITIONCELL BIOLOGIST

PRINCETON UNIVERSITYWe are soliciting applications for an assistant profes-

sorship as part of our program to strengthen molecularand biochemical cell biology at Princeton. The positionwill be in the Department of Biologv which resultedfrom the recent fusion of the preexisting Departments ofBiology and Molecular Biology.Submit a brief description of proposed research pro-

gram, curriculum vitae, and a list of references to: Dr. J.E. Rothman, c/o L. Abele, Department of Biology,Lewis Thomas Laboratory, Princeton University,Princeton, NJ 08544-1014.

Princeton Utniversity is atn Equal Opportunity/AffirmativeAction Employer.

FACULTY POSITION IN EUKARYOTICAND/OR DEVELOPMENTAL GENETICSThe newly designated Department of Molecular and

Cell Biologv seeks to fill a position in its Division ofGenetics at either a junior (tenure-track) or senior leveleffective 1 Jully 1989 (pending budgetary approval).The successful applicant will be expected to develop a

vigorous research program that utilizes molecular and/orclassical genetics to approach problems of eukarvotic cellor developmental biology. Responsibilities will includeundergraduate and graduate teaching in genetics.

Applicants should submit curriculum vitae including astatement of research and teaching interests, reprints, andnames and address of at least three references bv 1 March1989 to:

Dr. Corey GoodmanDepartment of Biochemistry

University of California at BerkeleyBerkeley, CA 94720

The Utniveristy of California is atn Equal Opportunity/Affinnative Actiotn Employer.

GRAPHICS CONSULTANT/COMPUTATIONAL CHEMIST

The Life Sciences Division of SRI International has anopening for a computational chemist who will wvork inclose collaboration with experimentalists in the applica-tion of quantum chemical and empirical energy methodsand molecular graphics to specific interdisciplinarv pro-jects. Such collaborative projects will include drug designand structural studies of bioactive peptides, proteins, andnucleic acids. Additional responsibilities will includetraining and consulting with users of molecular graphicsworkstations. The successfil candidate should have theabilit to develop their own research programs in themolecular modeling field.The position requires a Ph.D. in computational chem-

istry with some knowledge of ab initio and semi-empiri-cal quantum mechanics, as well as application of t esemethods to problems in drug development. Some knowl-edge of statistical mechanics, including molecular dv-namic simulations and scientific progranuming is desir-able.Send resume to: R. A. Solomon, AA-211, SRI

International, 333 Ravenswood Avenue, Menlo Park,CA 94025. An Equal Opportunity Etnployer.

LECTURER IN BIOLOGYCARLETON COLLEGE

The Department of Biology invites applications for afull-time, -vear, nontenure-track appointment with thepossibilit of renewal. The position begins September1989. Teaching duties include full responsibilitv for anintermediate-level course in vertebrate biology, participa-tion in several team-taught introductory biology coursesand, where appropriate, a seminar in the field of interest.Minimum requirements: A Ph.D. is preferred, and the

degree may be in biology, ecology and zoology.Please send resumr, undergraduate and graduate tran-

scripts and three letters of reference to:

Dr. John L. Tymoczko, ChairmanDepartment of Biology

Carleton CollegeNorthfield, MN 55057

Closing date for applications is 1 March 1989. CarletonCollege is ant Affirnative Actioni/Equial Opportunrlity Enployer.

POSITIONS OPEN

FUNGAL GENE EXPRESSIONTWO POSTDOCTORAL POSITIONS to join a

project studying proteins and DNA sequences involvedin co-regulating N. crassa ribosomal RNA and proteingenes. Approaches will include in vitro mutagenesis, invitro transcription, fungal transformation, transcriptionfactor isolation. Experience required in protein chemistryor molecular biology. One position available immediate-lv, the second from April 1989. Salaries $20,000 to$27,000, depending on experience. Send cuirriculumvitae plus names of three referees to: Brett Tyler,Department of Plant Pathology, University of Cali-fornia-Davis, Davis CA 95616.

FUNGAL MOLECULAR BIOLOGISTThe Department of Botany invites applications for a

tenure-track position in fungal molecular biology at theassistant professor level starting 15 August 1989. Re-search experience in fungal molecular biology or geneticsis required and postdoctoral experience preferred. Thesuccessful applicant will be expected to develop anextramurallv funded research program emploving molec-ular techniques to investigate fungal pathogenicitv inhigher plants and to contribute to the curriculum in his/her area of specialty. Send curriculum vitae, summary ofplanned research, reprints of published work, and ar-range that three letters of recommendation be sent bv 15March 1989 to: Dr. Steven W. Hutcheson, Chair,Fungal Molecular Biology Search, Department ofBotany, University of Maryland, College Park, MD20742-5815.

The University of Maryland is at Equal Opportnity/Afirmative Actioni Etnployer.

KARISOKE RESEARCH DIRECTOR. Positionopen 1 December 1989 for director of Karisoke Re-search Center, Rwanda, Africa. Director supervises per-sonnel in studies and observation of mountain gorilas.Carries out independent research and also sees that long-term data files are analvzed and updated. Responsible forefficient camp operations (including trackers, guards,anti-poaching patrols), maintenance of accurate financialrecords, and submission of required reports. Must beable to communicate in French and English (Swahilihelpful) with governmental, park, camp and other per-sonnel. Requires a knowledge of observational methodsand protocols. Center personnel includes 25 Rwandannationals and three to six graduate researchers. Contractfor 1 vear, renewable for a second year. Send letter ofapplication, curriculum vitae (or resume), and names ofthree references to: The Digit Fund, 45 InvernessDrive East, Englewood, CO 80112.

LANDSCAPE FACULTY POSMON. Nine-monthtenure-track in horticulture, landscape emphasis available16 September 1989. Instructor or assistant professordependent on qualifications. Minimum: Master's or allbut dissertation, at least one degree in horticulture, plantscience, or closelv related field; successful teaching expe-rience. To apply, send application letter; resume includ-ing education, dates and tpes of work experience,honors, professional organizations, publications; officialtranscripts; three current reference letters; names, ad-dresses and phone numbers of two additional referencesbv 10 Februarv 1989; or for a detailed job description orfurther information, contact: Robert Krumwiede, Uni-versity of Minnesota Technical College, Waseca, Wa-seca, MN 56093. Telephone: 507-835-1000. TheUniversity ofMinnesota is ani Equial Opporttnity Educator andEmnployer and specifcally invites atid encourages applicationsfrom womeni atid mninorities.

MAYTAG FELLOW IN ZOOLOGYARIZONA STATE UNIVERSITY

Intended for recent Ph.D.'s showing exceptional abili-tv in research, this 1-vear postdoctoral research fellow-ship emphasizes collaborative research with a facultymember in the Department. Applications must includecurriculum vitae, three letters of recommendation, astatement of research plans, and a letter from the intend-ed faculty collaborator at ASU. Review of applicationswill end 1 March 1989. Starting date 16 August 1989.Applications from two individuals wishing to share theposition will be considered. ASU is ani Affirmative Actioni/Equial Opportutnity Emnployer. For more information con-tact: Dr. Steven W. Rissing, Department of Zoology,Arizona State University, Tempe, AZ 85287-1501.Telephone: 602-965-3847.

SCIENCE, VOL. 243562

| ~~~M.C. ChangPostdoctoral Fellowships

inI

Male Fertility Researchsupported by the AndrewW Mellon Foundation at

The Worcester Foundation for Experimental BiologyThe Worcester Foundation's Male Fertility Program emphasizes multidisciplinary approaches to the study of male reproductive biology utilizing state-of-the-art techniques in biophysics, biochemistry, and cell and molecular biology. The faculty and their research interests are:

LawrenceJ. Dangott: Receptors and mechanisms of chemical signal- George B. Witman: Control of sperm motility during maturation anding in spermatozoa capacitation; phosphorylation of sperm flagellar proteins

Grant Fairbanks: Mechanism of sperm plasma membrane modifica- David E. Wolf: Diffusion and control of membrane regionalization,tion during epididymal maturation sperm maturation, capacitation, and fertilization

Daniel L. Kilpatrick: Gene transcription during spermatogenesis using Carol A. Ziomek: Membrane structure and cell polarity in early mousetransgenic mice; paracrine function of testicular peptides development

John A. McCracken: Studies on sperm maturation, motility, and The Worcester Foundation is a private, nonprofit biomedical researchcapacitation using surgical diversion of the male and female ducts institute offering excellent facilities and a stimulating research environ-

ment. Please send curriculum vitae and names of three referencesClaraM.O'Connor:Regulationofproteinmodificationandturnover to the faculty member of interest, c/o Male Fertility Program,during gametogenesis Personnel Office, Worcester Foundation for Experimental

Biology, Shrewsbury, MA 01545.

VWORCESTER FOUNDATIONFOR EXPERIMENTAL BIOLOGYAN EQUAL OPPORTUNITY/AFFIRMATIVE ACTION EMPLOYER M/F/H

~~~~~~Formore than a century, scientists at ELI LILLY AND COMPANY have

developed innovative, high quality pharmaceutical products. In 1988, Lillyc ~~~~invested over $500 million in research-and-development programs. More than

3,000 scientists at the company's Lilly Research Laboratories are pursuingcreative research programs that involve many important health care needs.

To further build its research capabilities, Lilly Is seeking a self-motivated,innovative scientist to join the Molecular Biology department and work in a

laboratory dedicat'ed to analytical biochemistry. The scientist will work with a

state-of-the-art two-dimensional gel electrophoresis image analysis systeinand a gas phase sequencer.

Bachelor's degree with experience or Master's degree in protein chemistryor biochemistry is required.

Knowledg'e of protein/enzyme purification methodology is essential,

including HPLC, column chromatography, and electrophoresis.

. Experience in protein sequencing and characterization are desirable.

Eli Lilly and Company is committed to scientific excellence. Lillyprovides a stimulating professional atmosphere with many opportunities for

collaborative, multidisciplinary research. The company offers an attractive

total compensation program. Entry level and salary will be based upon each

candidate's experience.

For prompt consideration, please forward your resumed to:

Maria L Poor

Science Recruitment (AMBi1)Eli Lily and CompanyLilly Corporate Center

Indianapolis, Indiana 46285

Applications are invited for theI 0

POSITIONS OPEN

MOLECULAR NEUROTOXICOLOGYOne-vear renewable appointment at the RESEARCH

ASSOCIATE III level (state-funded, nontenure-track)available on or after 1 Januarv 1989 to join a multidis-ciplinarv research team investigating molecular mecha-nisms of insecticide neurotoxicitv and the role of alteredtarget sites in insecticide resistance. This person willassume responsibility for ongoing studies of messengerRNA-directed expression and pharmacological charac-terization of mammalian and insect neuroreceptors andion channels in Xenopus oocytes. In addition, he/she willhave opportunities to interact with and participate inparallel studies of the isolation of receptor and ionchannel genes and the biochemical characterization ofinsecticide interactions with target macromolecules. APh.D. in phvsiologv, pharmacology, toxicology, or otherrelevant discipline is required; applicants with priorexperience in intracellular microelectrode recording andvoltage clamp techniques will be given preference. Toapply, send curriculum vitae, publication list, and namesof three references to: Dr. David M. Soderlund, Insec-ticide Toxicology Laboratory, Department of Ento-mology, NYSAES, Cornell University, Geneva, NY14456. Telephone: 315-787-2364. Cornell University isan Equal Opportunity/Afirmative Action Employer.

MOLECULAR VIROLOGISTA staff position is available for a person with experi-

ence in the molecular biology of primate viruses. Thesuccessful candidate would be expected to become in-volved with research programs involving simian immu-nodeficiency disease as well as to establsh his/her ownarea of research. Ongoing research includes studies inves-tigating the interrelationships of opportunistic viruseswith Simian Immunodeficiency Virus. The applicantwould be expected to obtain research support as well asto work collaboratively with other investigators. Pleasesend resume, a summarv of research interests, and thenames of three references bv 15 February 1989 to: Dr.Michael Murphey-Corb, Delta Regional Primate Re-search Center, Three Rivers Road, Covington, LA70433.

NEUROBIOLOGIST POSITION available. TheDepartments of Anatomy and Physiologv invite applica-tions for faculty positions at the rank of assistant orassociate professor. Candidates should have a Ph.D. orM.D. degree with sound training and research experi-ence. The successful candidate will be expected to devel-op and maintain a strong independent research program,and to participate in teaching medical and graduatestudents. Some emphasis will be placed on research at thecellular, metabolic or molecular level, but other areas willbe considered as well. Start-up funds are available. Salarvwill be commensurate with qualifications. The startingdate is negotiable. Recruitment will continue until suit-able candidates are identified. Please send a description ofresearch interests, curriculum vitae, and the names ofthree references to: Dr. Timothy Hansen, Neurobiolo-gy Program Coordinator, University of Health Sci-ence- ihe Chicago Medical School, 3333 Green BayRoad, North Chicago, IL 60064.

NEUROCHEMISTThe Institute for Sensory Research at Syracuse Univer-

sitv seeks applications from individuals working in thearea of neurochemistry for a tenure-track position at thelevel of assistant or associate professor. The successfulcandidate is expected to develop a strong independentresearch program and to teach in the graduate neurosci-ence program. The appointment will begin 1 September1989. The position is supported by substantial start-upfunds and newly constructed laboratorv space. Applica-tions should include curriculum vitae, representativereprints, and a statement of aims for future research.Applicants should have three individuals send letters ofrecommendation. Send all material to: Dr. Gustav A.Engbretson, Neurochemistry Search Committee, In-stitute for Sensory Research, Syracuse University,Syracuse, NY 13244-5290. Deadline for applications is28 February 1989. Syracuse University is an Equal Opportu-nity Employer.

564

Berlex Laboratories, Inc. is a leader in basic research of endothelial cellfunction. We currently seek an internationally recognized scientist inendothelial cell biology to join our highly visible team to ensure progress ofon-going programs, to initiate new research directions and to be part of futurebreakthroughs which can be applied to better understanding and noveltreatment of atherosclerosis. The successful candidate will have the title ofInvestigator, the second highest rank in our scientific ladder.To qualify, your background should include a Ph.D. in cell biology,biochemistry, physiology or molecular biology, at least five (5) years of post-doctoral training and an excellent publication record. Experience withendothelial cell biology is highly desirable.Berlex Laboratories is part of a global family of companies engaged in theresearch, development, manufacturing and marketing of chemical-pharmaceutical products in 120 plants and subsidiaries in 140 countries,employing over 25,000 people. Combined sales are in excess of $2.7 billion.At Berlex Laboratories, you will be supported, recognized and encouraged topursue your scientific career and ideas. In addition to the excellent resourcesand stimulating research environment, the position offers an attractive salaryand benefit package. For immediate, confidential consideration, send your CVand salary history to: Lila Bernstein, Manager, Human Resources, BERLEXLABORATORIES, INC., 110 East Hanover Avenue, Cedar Knolls, NJ 07927.Equal opportunity employer M /W/H /V.

SCIENCE, VOL. 243

ENSYS INC.

EnSys Inc. is applying biotechnology princi-ples to the development of proprietary test kitsfor the environmental industry. Situated in Re-search Triangle Park, North Carolina, we areseeking to fill senior technical positions. EnSysoffers competitive salaries, benefits, and equityparticipation.

FABRICATION ENGINEER. Responsibilitiesinclude the design and fabrication of an immu-noassay test device. Technical degree and expe-rience with small fluid handling/delivery devicesare required.

SENIOR SCIENTIST-IMMUNOLOGY. Re-sponsibilities include the organization and su-pervision of an immunoserology departmentthat will produce and characterize anti-haptenpolyclonal/monoclonal antibody. A Ph.D. andtwo years supervisory experience in Hybridomatechnology are required.

SENIOR SCIENTIST-BIOORGANIC CHEM-IST. Responsibilities include the organizationand supervision of a BioOrganic Chemistry de-partment that will produce and synthesize hap-ten conjugates and develop sample processingprotocols. A Ph.D. and two years supervisoryexperience are required.

Forward resumes to: Dr. Stephen B. Fried-man, EnSys Inc., P.O. Box 14063, ResearchTriangle Park, NC 27709.

FACULTY POSITIONPRINCETON UNIVERSITY

The Program in Atmospheric and OceanicSciences and the Department of Geological andGeophysical Sciences at Princeton Universityinvite applications for a faculty position withinthe Program. The position can be filled at eithera junior or senior level. Applicants with expertisein any of the scientific fields covered by theProgram (geophysical fluid dynamics, meteorol-ogy, physical oceanography, climate dynamics,atmospheric and oceanic chemistry) will be con-sidered. We encourage applicants whose re-search would have strong links with the ongoingactivities at the Geophysical Fluid DynamicsLaboratory of the National Oceanic and Atmo-spheric Administration, many of whose scien-tists hold faculty positions within the Program.We also seek to build stronger ties between theProgram and the Department of Geological andGeophysical Sciences, particularly in the area ofpaleoclimatology. Those with expertise in theinteraction between land surface processes andclimate or in other interdisciplinary areas closelyrelated to the research interests of the Programfaculty are also encouraged to apply. Pleasesend curriculum vita, statement of researchinterests, and the names, addresses, and phonenumers of three references to:

Prof. Jorge Sarmiento, DirectorProgram in Atmospheric and Oceanic

SciencesPrinceton UniversityP.O. Box 308Princeton, NJ 08542

Princeton University is an equal opportunity!affirmative action employer.

Glaxo Inc. is not only one of the Top 5 ethical pharmaceuticalfirms in America, we're also tbefastestgrowing researcb-oriented company in the country. As such, we can offer exceptional careeropportunities, state-of- the-art facilities, and afirm commitment to producing the most effectivepbarmaceuticals that experience, imagination, and advanced tecbnology can create. Join Glaxo, andapply your knowledge and career ambitions where they'll do you the most good.

We currently bave tbefollowing positions available at our Corporate Headquarters located inResearch Triangle Park, N. C

RESEARCH GROUP LEADERAnalytical DevelopmentClinical Pharmacokinetics DepartmentThis person uill be responsiblefor analytical method development to support clinical studiesforinvestigational drugs. Tbejob responsibility includes development of quantitative drug lmetaboliteassays employing HPLC, GLC, GC or LC/MS; transferring assaysfrom otber Glaxo research laboratoriesand improving existing assays. This person uwill uwork in collaboration with cbemists responsibleforautomated assays, pbarmacokineticists uho uwill design and assist in the data analysis of clinicalstudies, and chemistsfrom a preclinical drug metabolism department who perform drug/metaboliteisolation and identification. This person u'ill hire and supervise two M.S. or Ph.D. level people.Background must include a Ph.D. in Analytical Chemistry or a related area with 3-5 years' experiencein the pbarmaceutical industry or academia. A strong chromatography background witb excellentproblem solving skills are required, as well as experience u'ith a variety ofchromatographic tecbniques(e.g. EC/LC, HPTLC, GC, LC, GC/MS). RIA experience u'ill be useful, but is not required. Computerliteracy will be helpful using micro and mainframes and experience using data acquisition systems(e.g. LAS, MAXIMA, NELSON).Candidates responding to this position should refer to Job#8620X830 on all resumes.

RESEARCH ASSISTANTWorking witb ourgrouing researchlteain u'ithin the Chemotberapy Department, this key individual willperform basic research studying the biologic, biochemicaland molecularbasis oftumorprogression andmetastasis. The individual 'ill be r-esponsibleforthe isolation, selection and characterization ofmetastatictumor cell variants both in ritvo and in lissue culture. Other responsibilities will include: isoloation,purification andcloning o.fgenestcoding for ipol.rtant prosteins/glycoproteins wbich regulate tbe metastaticprocess; and assiting in the operation of screetning operations withinthe laboratory.Background must incuItIde an MS with 2 - 5 years of experienice or BS/BA uith 5-10 years experience. Theideal candidate must hare experience in tissuie culture, electrophoresis (ID/2D) andprotein Purificationtecbniques. Experientce in antibod3' prodtuction, animal handling, DNA/mRNA isolation, preparation ofDNA libraries anda dlesire to work indepidlentI)i are higbly desirable.Candidate responding to this position shotild refer to Job #9120X942 on all resumes

At Glaxo Inc., growth opp,lortunities ta,dl up1-tlo-date facilities are complemented by a location (nearRaleigb/Durbam) tlJat has excellentt resources int close proximity. Presitigious universities, scenic vistas,lively recreational areas, anid exciting cultur-al opportunities are all a part of the daily life ofthe Glaxo professionial. Fitrthe: ine r-ewiard11talent anid creativity uith an excellent salary and benefitspackage (including a comnpXltel' eqjuippeld on -site athletic facility). Candidates interested in thesepositions, please sentit ouwr resume. iiit indinig salarb history and CORRESPONDINGJOB ASMENTIONED ABOVE. 1X:

Humani Resources I)paertnment

Glaxo IncM IPO Box 13398

Research Triangle Park, N.C. 27709(No Phone Calls, Please)

No Private Agency Referrals, PleaseAn Equal Opportunity Employer M/F/H/IV

Paving the way to a healthier world.

-

Wal 0

M-- I

POSITIONS OPEN

OCCUPATIONAL MEDICINE/ENVIRON-MENTAL HEALTH (OM/EH). Tenure-track facultvposition for senior scientist to direct a newlv establishedSoutheastern Clinical OM/EH Evaluation Center atEmory University and an OM/EH educational track inEmory's MPH Program. Nominations and applicationsare invited from established clinicians Board-certified inOM and eligible for licensure in Georgia. responsibilitiesinclude the direction, management, planning and devel-opment of an OM/EH Center and educational trackcommitted to excellence in patient care, teaching andresearch. Also required are demonstrated leadership ca-pabilities, previous academic, teaching, and administra-tive responsibilities, and a strong record in research.Salarv is negotiable. Applications should include currentcuriculum vitae, the names of three references, and besubmitted by 1 February 1989 to Chair, Search Com-mittee, Emory Department of Community Health,69 Butler Street, SE, Atlanta, GA 30303-3219. AnAffirmative Action/Equal Opportunity Employer.

PHARMACOLOGISTNortheastern University College of Pharmacv and

Allied Health Professions is seeking applicants for a full-time tenure-track position at the level of assistant/asso-ciate professor of pharmacology. Candidates will beexpected to bring or establish an independent extramu-raly funded research program in their area of interest aswell as teach pharmacology to graduate and undergradu-ate pharmacy students. Teaching experience is preferred.Minimum qualifications required are Ph.D. in pharma-cology with 2 vears of postdoctoral experience. A phar-macy background is desirable. Applicants should sendcurriculum vitae, including relevant reprints and namesof three references, to the following address by 15 March1989: Dr. Norman R. Boisse, Search CommitteeChairman, Section of Pharmacology, Mugar Hall,Northeastern University, 360 Huntington Avenue,Boston, MA 02115. Northeastem is an Equal OpportunitylAfirmative Action Educational Institution and Employer.

TWO Ph.D. STAFF POSITIONS available for ahuman geneticist, any discipline, and a molecular cvtoge-neticist. Appointee will develop independent researchprograms and provide technical and amnistrative sup-port for the Human Genetic Mutant Cell Repository.Development funds and joint medical school appoint-ments are available. Newlv constructed laboratorv spaceand technical assistance will be provided. Salarv com-mensurate with qualifications. Please send curriculumvitae and names of three references to: Dr. Gerard J.McGarrity, President, Coriell Institute for MedicalResearch, Copewood Street, Camden, NJ 08103.Affirmative Action/Equal Opportunity Employer.

PLANT PATHOLOGIST OR ASSOCIATEPLANT PATHOLOGIST

Position available immediately at the InternationalRice Research Institute (IRRI), Philippines, for a virolo-gist to become part of an interdisciplinarv team focusingon rice varietal improvement and integrated pest man-agement. The person selected will conduct basic andapplied research on rice viruses, virus-vector relation-ships, and virus disease management, and develop aninnovative disease control program. Background in mo-lecular biology preferred. Qualifications include a Ph.D.degree with specialization in plant viruses and virusdiseases. Experience in serology and electron microscopvessential. Salary and benefits will be commensurate withthose of similar international agricultural research institu-tions. Applications will be accepted until 1 March 1989or until position is filled. Applicants should send curricu-lum vitae and names of three or more references to: Dr.Klaus Lampe, Director General, IRRI P.O. Box 933,1099 Manila, Philippines.

POSTDOCTORAL FELLOW: HHMI-SANFRANCISCO-UCSF Immunologv-Molecular Neurobi-ology. A position is available beginning summer 1989 ina laboratory studving neuropeptide receptor function,gene structure and regulation. Applicants should have anM.D./Ph.D. or Ph.D. Experience with recombinantDNA techniques is essential. Send curriculum vitaestatement of interests and three letters of reference to:Dr. Donald G. Payan, U-426, University of Califor-nia San Francisco, 3rd and Parnassus, San Francisco,CA 94143.

POSITIONS OPEN

TRUDEAU INSTITUTE, INC.POSTDOCTORAL ASSOCIATE TO

STUDY T CELL-MEDIATED IMMUNITYA vacancy exists for a postdoctoral fellow interested in

studying immunitv to tumor and histocompatibility anti-gens. Current studies deal with various aspects ofT cell-mediated rejection of tumors and allografts. The oppor-tunity to study T cell-mediated immunity to bacterialinfection also exists. Applicants should have basic train-ing in immunobiology. Starting salarv will be commen-surate with experience and includes liberal fringe bene-fits. Subsidized institute housing is available.The Trudeau Institute is a private, not-for-profit, basic

medical research institution located on the shore ofSaranac Lake and near Lake Placid, New York.Send curriculum vitae and names of three references

to:Dr. Robert J. North, Director

Trudeau Institute, Inc.P.O. Box 59

Saranac Lake, NY 12983

POSTDOCTORAL ASSOCIATE to perform openchest surgical procedures on anesthetized pigs, isolatedperfusion techniques, and microdissection and cannula-tion of small coronarv arterioles. Conduct in vitro experi-ments on cannulated arterioles using videomicroscopicequipment including micrometer, timer, monitor, pres-sure transducers, temperature and chart recorders, perfu-sion systems and computer. Calibrate equipment. Con-struct micropipettes using micropipette Puller and micro-forge. Collect and analyze experimental data using vari-ous computer programs; present results at scientificmeetings. Design new experimental protocols and stud-ies and author scientific manuscripts. Requires Ph.D. inmicrocirculatory physiology. $19,440 annually. Applyat: The Texas Employment Commission, Bryan, Tex-as, or send resume to: The Texas Employment Com-mission, TEC Building, Austin, TX 78778, J.O. #5424112. Ad paid by an Equal Employment OpportunityEmployer.

POSTDOCTORAL FELLOW POSITIONS BIO-CHEMISTRY AND GENETICS OF PROTEINTRANSPORT. Positions are available to examine themolecular genetics of protein and ribonuclear proteintransport across organelle membranes in yeast. Studieswill focuS on in vitro transport methods in conjunctionwith available genetic an immunological probes todefine structure function relationships of the transportapparatus within the nuclear envelope and mitochondrialmembranes. Send curriculum vitae or call: 214-688-2120, Dr. Michael G. Douglas, Department of Bio-chemistry, UT Southwestern Medical Center, 5323Harry Hines Boulevard, Dallas, TX 75235-9038. AnEqual Opportunity Employer.

POSTDOCTORAL FELLOWSHIP-NIH/NRSAposition available for recent Ph.D. with background inorganic, organometallic or medicinal chemistry withinterest in the preparation of structurally diverse pharma-ceuticals and receptor ligands for positron emissiontomography (PET) imaging studies; the development ofnovel chemical reaction methodology for incorporationof halogens into pharmaceutical substrates. Expertise intotal synthesis and analytical instrumentation an asset.U.S. citizenship or permanent resident status required. Sendresurne and names of three references to: Dr. John M.Gerdes, Research Medicine/Radiation Biophysics Di-vision, Lawrence Berkeley Laboratory, M.S. 55-121,1 Cyclotron Road, Berkeley, CA 94720. An AffirmativeAction/Equal Opportunity Employer, M/F/H.

POSTDOCTORAL FELLOWSHIP. Postdoctoralfellowship available immediately for an individual toundertake research with a project investigating the struc-ture and regulation of human glutamate dehydrogenaseand its involvement in neurodegenerative disorders. Po-tential candidates requlre a strong background in thefield of protein purification and biochemistry and/orgene cloning. Salary on the scale of $18,000 to $24,000per annum plus benefits commensurate with qualifica-tions. Location: New York City. Applications, includingcurriculum vitae, should be sent to: Dr. Andrew Plaita-kis, Neurology Department, Box 1137, Mount SinaiSchool ofMedicine, One Gustave L. Levy Place, NewYork, NY 10029-6574. Telephone: 212-241-7310.An Equal Opportunity Emnployer.

POSITIONS OPEN

POSTDOCTORAL FELLOW. Research positionavailable for M.D. or Ph.D. to study respiratory diseasesin one of two areas: control of breathing or connectivetissue ofthe lung and pulmonary circulation. Respiratorycontrol studies involve interaction of control of breath-ing with the cerebral circulation, brain tissue hypoxia,neurotransmitters, and sleep. Connective tissue studiesinvolve biochemical and molecular biology studies of theregulation of connective tissue metabolism in hvperten-sive pulmonary arteries and vascular cells. Send curricu-lum vitae, statement of research interests and career goalsto: David J. Riley, M.D., or Norman H. Edelman,M.D., Pulmonary and Critical Care Division, Depart-ment of Medicine, University of Medicine and Den-tistry ofNew Jersey-Robert Wood Johnson MedicalSchool, CN 19, New Branswick, NJ 08903-0019.The UMDNJ is an Affinnative Action/Equal EmploymentOpportunity Employer M/F/H/V.

POSTDOCTORAL NEUROBIOLOGIST to joinNIH-funded investigation into the function, distributionand regulation of ion channels in vertebrate neuronal andcardiac cells using patch clamp techniques. The labora-tory is located in Newport, on the central Oregon coast.Send curriculum vitae, names of three references and adescription ofexperience and career goals by 28 February1989 to: Dr. Donald T. Campbell, Hatfield MarineScience Center, Oregon State University, Newport,OR 97365. Telephone: 503-867-3011. Affirmative Ac-tion/Equal Opportunity Employer.

POSTDOCTORAL POSITION available for multi-disciplinary studies concerning (i) structure, function,and regulation ofexpression of neuronal nicotinic acetyl-choline receptors, or (ii) second messenger signaling,protein phosphorylation, and gene expression in neuro-nal differentiation. Investigations are to encompass bio-chemical, immunological, pharmacologic an molecu-lar genetic approaches with model cell culture systems ina unique and dynamic institution. Send curriculum vitae,names and addresses of three references and a briefstatement of research experience and objectives to: R. J.Lukas, Divison of Neurobiology, Barrow Neurologi-cal Institute, 350 West Thomas Road, Phoenix, AZ85013. Equal Opportunity Employer.

POSTDOCTORAL POSITION to investigate thebiochemistry and genetics of antibiotic production byStreptomyces and related bacteria with the aim of unravel-ing novel enzymology and producing new drugs. Experi-ence with enzyme purification and protein biochemistryrequired, and recombinant DNA methods desirable.Available after 1 March 1989 for a period of 2 years.Salary: $20,000 to $22,000 per year depending onqualifications. Apply to: Professor C. R. Hutchinson,University of Wisconsin, 425 North Charter Street,Madison, WI 53706. Telephone: 608-262-7582 withresume and two references.

POSTDOCTORAL POSITION available immedi-ately to study the regulation of heat shock proteins inmanmalian postimplantation embryogenesis. Applicantshould have a Ph.D. with a strong background inmolecular biology. Send curriculum vitae, description ofcurrent and past research and names of at least tworeferences to: Dr. Phillip E. Mirkes, Department ofPediatrics, RD-20, University of Washington, Seat-tle, WA 98195.

POSTDOCTORAL POSITION available 1 July1989 to join group using molecular and immunochemi-cal approaches to study synapse formation in vivo and invitro [see Soc. Neurosci. Abstracts, 254-13/254-14(1988)]. Experience in tissue culture and/or immunologydesirable. Send curriculum vitae and three letters ofreference to: Dr. James W. Gurd, Scarborough Cam-pus, University ofToronto, West Hill, Ontario MlCMA4, Canada.

POSTDOCTORAL POSITION and technical posi-tion available for 2 years to studv population genetics ofspiny lobster and finfish. Molecular biology training andexperience with mtDNA methods are assets. Send curric-ulurn vitae and names of references to: Dr. Patrick J.Walsh, Division of Biology and Living Resources,Rosenstiel School of Marine and Atmospheric Sci-ence, University of Mianii 4600 RickenbackerCauseway, Miami, FL 33149.

SCIENCE, VOL. 243566

POSITIONS OPEN

POSTDOCTORAL POSITION available to studvsite-specific delivery ofpolvmer bound drugs. Experiencein synthethic polymer chemistry and/or biochemistry isdesirable. Funding ($18,000 to $20,000 per vear) isavailable immediately. Send application letter with expe-rience and research interests, curriculum vitae and threeletters of recommendation to: Dr. Jindrich Kopecek,Center for Controlled Chemical Delivery, Depart-ment of Pharmaceutics, University of Utah, 421Wakara Way, Suite 318, Salt Lake City, UT 84108.

POSTDOCTORAL POSITIONUNIVERSITY OF COLORADO, BOULDERPosition available immediately for a recent Ph.D. to

join an ongoing diversified program investigating theregulation of lung function. Research will emphasizebiochemical aspects of lung biology. Applicants shouldhave a strong background in biochemistrv or a relateddiscipline. Send curriculum vitae and names of threereferences to: Ralph J. Altiere, Ph.D., University ofColorado, School of Pharmacy, Campus Box 297,Boulder, CO 80309-0297. The University ofColorado isan Equal Opportunity/Afirmative Action Employer.

POSTDOCTORAL POSITIONPostdoctoral fellows/research associates: Positions

available now through fall 1989 to studv insulin/growthfactor-regulated (SeriThr) protein kinases and tyrosinekinase substrates. Multidisciplinary program ongoing inwell-equipped, newly renovated laboratories. Experiencerequired in protein purification or monoclonal antibodytechnology. Send curriculum vitae with names of threereferences, brief description of background and intereststo: J. Avruch, Diabetes Unit, MGH East, Building149, 13th Street, Charlestown, MA 02129.

POSTDOCTORAL POSITION available immedi-ately to studv EMC virus-induced diabetes. Projectsinclude site directed mutagenesis and construction ofrecombinant DNA molecules. Preference to recent Ph.D.experienced in cloning. Starting salary: $24,000. Sendcurriculum vitae and names of three references to:George W. Jordan, M.D., Division of Infectious Dis-eases, University of California, Davis, School ofMedicine, 4301 "X" Street, Sacramento, CA 95817.Equal Opportunity/Affirmative Action Employer.

POSTDOCTORAL POSITION IN MOLECU-LAR VIROLOGY. We are seeking a recent Ph.D. withstrong background in molecular biology to join sixinvestigators studying the molecular basis of herpessimplex and varicella zoster virus pathogenesis. Priorexperience in virology is not required. Salary range:$21,000 to $25,000. Submit curriculum vitae and briefdescription of prior research to: Lawrence StanberryM.D., Ph.D., Infectious Diseases, Children's HospitalResearch Foundation (CHRF), University of Cincin-nati, Elland and Bethesda Avenues, Cincinnati, OH45229. CHRF is an Equal Opportunity/Afinnative ActionEmployer.

POSTDOCTORAL POSITIONS available to studvDNA transformation in the nematode C. elegans, toinvestigate RNA processing especially focusing on mech-anisms ofboth cis- and trans-splicing, or to study the roleof cellular growth factors in development. The work issupported by NIH funding and will be carried out in theDevelopment Biology Laboratorv at Svnergen, Inc.Background in molecular biology, genetics, or biochem-istry required. Please send curriculum vitae, bibliographyand names of references to: Dr. David Hirsh, Synergen,Inc., 1885 33rd Street, Boulder, CO 80301.

POSTDOCTORAL POSITIONSare available to work on the molecular biology of adren-ergic receptors: Cloning, expression, gene structure, site-directed mutagenesis. Applicants should have a strongbackground in recombinant DNA technology. Sendcurriculum vitae and two to three letters of reference to:Dr. Robert J. Lefkowitz and Dr. Marc G. Caron

Howard Hughes Medical InstituteBox 3821

Department of MedicineDuke University Medical Center

Durham, NC 27710

27 JANUARY I989

MONOCLONAL ANTIBODY DEVELOPMENTResearch Scientist

to establish new laboratoryAffymax Research Institute is a new venture in therapeutic drugdiscovery based on organic chemistry and advanced immunologicalscience with participation of leading academic and industrial scientists.Affymax seeks a person with extensive knowledge and experience inmonoclonal antibody production with the ability to establish a laboratoryand produce, independently, purdied MAbs to a wide range of haptenatedimmunogens and to develop related new methodologies including anti-idiotypes.Skill requirements include Immunization techniques, cell cufture, fusion,hybridoma screening, antibody purification and characterization.Experience with In-vitro techniques Is desirable.A graduate degree In Immunology, cell biology or biochemistry is desired.A bachelor's degree with extensive experience will be considered.Attractive employment conditions In a new, first class facility make thisan outstanding opportunity.

Send Resume To:

Chief ScientistAffymax Research Institute

3180 Porter DrivePalo Alto, California 94304

HIGH TECHNOLOGY WITH AN6NTERNATIOINALLLAIR

As one of the largest oil-producing companies in the free-world,Aramco can provide you with state-of-the-art equipment in an in-novative technological environment, and also with an exciting lifestylein Saudi Arabia.

SENIOR SCIENTISTRequires a BS or advanced degree in Chemistry and 9 years expe-rience in oilfield related geochemistry problem solving. Will beresponsible for analytical methods development, testing/evaluationand training. Hands-on experience in mineralogical work by X-ray dif-fraction/X-ray fluorescence spectrometry and a working knowledgeof Scanning Electron Microscopy required.

RESEARCH SCIENTISTRequires a BS or advanced degree in Chemistry or CorrosionEngineenng with 9 years experience utilizing high pressure autoclavesystems in the area of corrosion testing. Responsibilities will includeroutine high pressure testing of treatment and oilfield chemicals (cor-rosion inhibitors and demulsifiers, coating and associated materials)and preparation of materials including pre and post evaluation of testresults.

For confidential consideration, please send your resume to: ASC,Employment Dept. 06E-010-9, P.O. Box 4530, Houston,Texas 77210-4530.

ARAMCO

POSITIONS OPEN

POSTDOCTORAL POSITIONSMOLECULAR BIOLOGY,

VIROLOGY, IMMUNOLOGYPostdoctoral positions (three) are available for persons

to participate in multidisciplinary experimental studies ofSimian Immunodeficiency Virus expression relative to:(i) mechanisms of pathogenesis and development ofeffective immunoprophlaxis, (ii) evaluation of antiviraldrugs in vitro and m vivo, and (iii) identification ofhumoral and cell-mediated immune responses to SIVinfection. Please send curriculum vitae, a summary ofresearch interests, and the names of three references to:Drs. Michael Murphey-Corb, Kenneth Soike, or Lou-is Martin, respectively, Delta Regional Primate Re-search Center, Three Rivers Road, Covington, LA70433.

TWO POSTDOCTORAL POSITIONS are avail-able. (i) Protein chemist with experience in immuno-chemistry or protein modification chemistry to investi-gate monoclonal antibody-photosensitizer conjugates aspotential agents of cancer photochemotherapy. Familiar-ity with cel biology and photobiology highly desirable.(ii) Biochemist/ce biologist to investigate the biochemi-cal mechanisms of photosensitized damage to mitochon-dria of carcinoma cells. Experience in mitochondrialfunction studies desirable. Send curriculum vitae to: Dr.T. Hasan, Wellman Laboratories of Photomedicine,Harvard Medical School, Massachusetts GeneralHospital, Boston, MA 02114. Telephone: 617-726-6996.

POSTDOCTORAL/RESEARCH ASSISTANTMOLECULAR VIROLOGY-ST. LOUISUNIVERSITY MEDICAL SCHOOL

Research on functional protein domains of immuno-deficiency virus, adenovirus, and papillomaviruses. Sendcurriculum vitae and names of three references to: Dr.Maurice Green, Chairman, Institute for MolecularVirology, St. Louis University Medical School, 3681Park Avenue, St. Louis, MO 63110. An Equal Opportu-nity Employer/M/F/V/H.

POSTDOCTORAL RESEARCH ASSOCIATEA position is available at the level of postdoctoral

research associate to plan and carry out research to testfor presence of adenosine triphosphate (ATP) and aden-osine (ADO) receptors in skin microcirculation, localizethem and determine their physiologic role; investigateinfluence ofATP and ADO on neurogenic and myogeniccontrol of vascular bed in skin; determine influence ofATP and ADO on angiogenesis. Research tools: micro-surgical techniques for preparation of skin microcircula-tion and development of suitable chambers for "hamsterskin fold window preparation" (model); bioengineeringmethods applicable to studies of microcirculation;knowledge of various microscopic techniques; study ofmodulator-receptor/modulator-neurotransmitter interac-tions. Other duties: participate in teaching program. Theannual salary will be $18,900. Applicants with an M.D.degree with 1 year of experience send curriculum vitaeand the names of three references to: Mr. Jack Hilz-heim, State of Tennessee, Department of Employ-ment Security, 1309 Poplar Avenue, Memphis, TN38104. An Equal Opportunity/Afirmative Action Employer.Minorities and women are encouraged to apply.

POSTDOCTORAL RESEARCH ASSOCIATEposition is available to study the acute and chronicaspects of the negative effect of alcohol on antihyperten-sive therapy. Studies will involve hemodvnamic andelectrophysiologic measurements in chronically instru-mented conscious rats as well as central administration ofdrugs to investigate the role of central sympatheticpathways in the interaction. Candidates must have aPh.D., M.D., D.V.M. or equivalent degree. Familiaritywith hemodynamic measurements is desirable. Send cur-riculum vitae, description of research experience, andnames of three references to: Dr. Abdel A. Abdel-Rahman, Department of Pharmacology, School ofMedicine, East Carolina University, Greenville, NC27858. Federal law requires proper documentation of identityand employability at the time ofemployment. It is requested thatthis documentation be included with your application. AnAfirmative Action/Equal Employment Opportunity Employer.

POSTDOCTORAL RESEARCH ASSOCIATEposition available immediately for up to 5 years to joincollaborative studies of neural mechanisms of motionperception in cats. Techniques include visual psycho-physics, neurotoxic cortical lesions, optic nerve block,histology, single unit recordings and monitoring ofeye position with magnetic search coils. Ph.D. withtraining in visual neurophysiology, anatomy, or relatedareas is required. Annual salary commensurate withexperience. Send curriculum vitae to: Tatiana Paster-nak, Ph.D., Center for Visual Science, University ofRochester, Rochester, NY 14627. An Equal Opportuni-ty Employer M/F.

POSTDOCTORAL RESEARCH ASSOCIATEPosition available immediately at Stanford University

Medical Center to investigate mechanisms of acute lunginjury and strategies for prevention. Laboratory investi-gates lung injury utilizing small animal models, cellculture techniques, neutrophil signal transduction path-way biochemistry, patch-cfamping' and receptor interac-tion studies. This position will have some supervisoryresponsibility. Approximate annual salary is $332,000.Please send curriculum vitae, names of three references,and brief description of interests, experience, and mas-tered investigative techniques to: Thomas A. Raffin,M.D., Acting Chief, Division of Respiratory Medi-cine, Room C-356, Stanford, CA 94305.

POSTDOCTORAL RESEARCHFELLOW/ASSOCIATE

Position is available for research on biochemistrv ofglutathione metabolism and functions involving enzv-mology, molecular biology, structural studies, and chem-ical synthesis. Applicant should have Ph.D. or equivalenttraining. Send curriculum vitae, list of publications, andnames oftwo references to: Dr. Alton Meister, Depart-ment of Biochemistry, Cornell University MedicalCollege, 1300 York Avenue, New York, NY 10021.Affirmative Action/Equal Opportunity Employer.

"Equal Opportunity in Action"An equal opportunity employer M/F/H/V

TECHNICAL STAFF POSITIONSAccelerator Mass Spectrometry FacilitySeveral technical positions available to support new NSF-sponsored National AMS facility for ocean sciences within Geolo-gy and Geophysics Department at the institution.Staff Chemlst PhD in Chenistry; experience in radiocarbonresearch or carbon-based chemical systems to design and operatehigh throughput sample preparation lab for producing miligram-carbon sputter targets. Multiple preparation lines will be developedusing a high degree of automation to ensure high precision; com-parative studies of sample preparation methods are anticipated.Evaluation of AMS precision and accuracy will be carried out withother AMS and radiocarbon labs. Available May 1, 1989.Staff Eagiee/Phydeslc PhD or MS in Physics or Engineer-ing; experience in computer and microprocessor control of acceler-ators, ion sources, test instruments and robotics required to designand manage hardware and software systems for (1) automatedsample preparation lab, and (2) automated control systems for theAMS and its associated data acquisition, analysis and archiving.Available May 1, 1989.Accelrator Engineer: BS or MS in Electrical or MechanicalEngineering or Physics; experience in electronics, vacuum technol-ogy, high voltage equipment required with computer contro/robot-ics experience desirable, to operate and maintain 3 MV tandemaccelerator, 2 automated ion sources and vacuum systems, and su-pervise lab utlties. Will participate in testing and installing of sys-tem and assist AMS staff in design and construction of fullyautomated sample preparation lab. Available July 1, 1989.

All inquiries with resume should be sent to Personnel Maager,Box 54P, Woods Hole.

A°rv*+, WOODS HOLE"Ikv\ OCEANOGRAPHICt ^ > ~INSTITUTION

0 0 ~~~~~Woods Hole, MA 02543

Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, has an immediate opening for anAssistant Scientist in the Arthritis/inflammation Section ofthe Pharmacology Department at their PharmaceuticalResearch Facility in Ann Arbor, Michigan.Responsibilities of the position will be to evaluate com-pounds for effects on human leukocyte functions and applybiochemical techniques to characterize compound mecha-nisms.The successful candidate will have:* BS/MS in biological sciences, with a background in cell

biology and biochemistry* 2-4 years' experience with tissue culture techniques

highly desirable* Excellent written and oral communications skills* Outstanding ability to work as part of a team effortEmployment will be at our modern facilities adjacent to TheUniversity of Michigan campus. We offer excellent benefits.Interested, qualified applicants should send curriculumvitae and salary requirements, in confidence to Ms. S.Huftqulst, Human Resources Representative, Parke-Davis, 2800 Plymouth Road, Ann Arbor, Ml 48105.

PARKE-DAVISDIVISION OF VARNER LAMBERT COMPANY

rov

I i.

I

m

;I

POSITIONS OPEN POSITIONS OPEN

V. I A.. *

: 0 * uThe BOC Group, an innovative world leader In health care products andIndustrial and specialty gases, has two challenging career opportunIies atour state-d-the-art central research laboratories of the BOC Grouplocated a Murray Hill, New Jersey.

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MOLECULARBIOLOGISTThe selected candidate will be research oriented and have a broadknoAwledge of biotechnology in the pharmaceutical Industry. You willparticipate in defining a biotechnology program within Health Care R&D,for acute and crltical care pharmaceutical agents. Additionally, you willserve as the focal point for external contacts with universities andbiotechnology companies. The qualified individual will have a Ph.D. inMolecular Biology with at least three years experience and a knowledge ofcloning methods, preferably in the area of expression cloning, genetransfer mehods, and site directed mutagenesis.

BIOCHEMIST.'The selected candidate will be interested in contrbuting their expertise toa team of computational and medicinal chemists, pharmacologists andmolecular biologists Identilying new approaches to acute and critical carepharmaceutical agents. This position requires a Ph.D. and 0-2 years ofpostdoctoral experience, a knowledge d enzymology and proteincharacterization and ligand interactions. The successful candidate willhave excellent analytical skills and be familiar with radioligand bindingtechniques, methods of enzyme assay, and chromatographic methods.

BOC offers a challenging, and stimulating scientific research careerenvironment, with the opportunity to interact with scientists from manydisciplines. We provide an excellent compensation and benefits package.For prompt, cornfidential consideration, please forward your resume, withsalary history/requirements to Jules DuParc, Employee Relations Mgr:

THE BOC GROUP

Technical CenterBox 101, 100 Mountain Ave, Murray Hill, N.J. 07974

(An Equal Opportuniy Emrployer (M/F NIH).

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BOEHRINGER INGELHEIM PHARMACEUTICALS.INC., a major researcher, developer, manufacturer andmarketer of prescription and over-the-counter drugs, iscurrently seeking a Cytogeneticist for the Department ofToxicology and Safety Assessment. This position is located atour Research and Development facility in Danbury, Connecticut.

This position requires a Ph.D. with a minimum of 5 yearsexperience in Cytogenetics including the following areas:

* Micronucleus test in vivo and in vitro

* Metaphase analysis in vivo and in vitro* Sister-chromatid exchange in vivo and in vitro

* Cell culture techniques* Use of various techniques to investigate mechanisms of action

The successful candidate will test pharmaceutical productsfor their clastogenic potential in vivo and in vitro.

BOEHRINGER INGELHEIM PHARMACEUTICALS,INC.. offers a highly competitive compensation and benefitspackage, relocation assistance, and excellent work environmentand the opportunity to have your contributions recognized.

Please send your resume and salary requirements to: Dept.JC-IS-907, BOEHRINGER INGELHEIM PHARMACEUTICALS,INC.. 90 East Ridge, P.O. Box 368. Ridgefield. Cf 06877. Weare an equal opportunity employer m / f/ h / v.

X1111111 BoehringerBO\HRINGER

REEACH ASsOCIATECARVDIOVASCULARPHARMoACOLOGY.

X.0-

AssistantlAssociateDirector of Clinical Research

Immunex Corporation, a Seattle-based biotechnologycorporationin thefoont ofresearch anddevelopmentinimmune regulation, hematopoiesis and wound heal-ing, currently has an immediate opportunity for anAssistant/Associate Director of Clinical Research.

The primary responsibilities for this position will in-clude managing and interpreting clinical trials forFDAsubmission, overseeing data collection activities;monitoring medical questions; and interaction withresearch and development, manufacturing, regulatoryaffairs, and physician investigators.The qualified applicant will have aPhD orMD and 2-5years of clinical research experience. Experience withbiologics is advantageous.

Immunex offers a challenging and rewarding work en-vironment, as well as an excellent compensation andbenefits package. For consideration, please submitresume together with the names of three references to:Immunex Corporation, Human Resources Director,Dept. NYT, 51 University Street, Seattle, WA 98101.EOE.

The Squibb Institute for Medical Research is recogniz-ed internationally as a leader in the research anddevelopment of novel therapeutic agents for the treat-ment of cardiovascular and infectious diseases. Wecurrently have an exceptional opportunity available forResearch Associates to join our Department ofPharmacology.Qualified candidates will have an MS in Biology orequivalent or a BS with a minimum of 3 years rele-vant laboratory experience.

You will be part of a team conducting research on thecardiovascular, renal and hormonal actions of atrialnatriuretic peptide with a focus on hypertension andcongestive heart failure. This involves setting upmodels in small and large animals, with an emphasison in vivo measurements of cardiac, vascular and renalfunction. Responsibilities also include the acquisitionand analysis of data using online and offline software.For confidential consideration, please submit yourresume to: The Squibb Institute For Medical Research,Human Resource Department 013, P.O. Box 4000,Princeton, NJ 08543. An equal opportunity employer.

SQU1BB

--II

POSITIONS OPEN

POSTDOCTORAL RESEARCH POSITION isavailable to studv the role of the inositol lipid cascade andintracellular pH and Ca2 changes during frog andmouse egg activation and earlv pattern formation. Tech-niques to be applied include Tsien's ratio imaging svstemfor fura-2 and BCECF fluorescence, Ca2 -specific micro-electrodes, vibrating probe, patch clamp, HPLC andNMR. This appointment will be for 2 to 3 vears. Salary:$22,000 per vear. Closing date: 1 March 1989. Pleasesend r6sum6 and names of three references to: Dr.Richard Nuccitelli, Zoology Department, Universityof California, Davis, CA 95616. An Equal Opportunity!Afirmative Action Employer.

PROFESSOR AND CHAIRMANDEPARTMENT OF MEDICINAL CHEMISTRYUNIVERSITY OF TENNESSEE, MEMPHIS

THE HEALTH SCIENCE CENTERCOLLEGE OF PHARMACY

The Universitv of Tennessee College of Pharmacy isseeking outstanding candidates for the position of Pro-fessor and Chair ofthe Department of Medicinal Chem-istrv. Senior and accomplished scientists with extramural-ly funded research programs in the pharmaceutical orbiomedical sciences are invited to register their candida-cv. The Chairperson will be expected to guide the majorexpansion of the research and research training programsof the Department. Minimum qualifications include aneamed doctorate in related discipline, an establishedresearch program in the pharmaceutical or biomedicalsciences, administrative experience in an academic envi-ronment and a demonstrated abilitv to work collaborati-velv in a universitv health science center. Applicantsshould send a letter of interest along with a copy of theircurriculum vitae to: Michael R. Ryan, Dean, Collegeof Pharmacy, University of Tennessee, Memphis, 874Union Avenue, Memphis, TN 38163. The Uniiversity oljTennessee is an Equal Etnploymetnt/Afirinative Action Em-ployer. Minorities anid wometn are encouraged to apply.

Universitv of North Carolina at Chapel Hill has anopening for a RESEARCH ASSISTANT PROFES-SOR. The appointment will be made based on potentialfor academic excellence and without regard to the disci-plinary specialization of the successful applicant. Re-search interests compatible with one or more of theongoing programs in marine ecologv, geology, chemistrand phvsics wil be sought. The appointment will carry a9-month salarv and utilize office/ aboratory space at theInstitute in Morehead Citv. The appointment wAill be fora 2-year term, renewable once and will be available fall1989. Applications will be reviewed after 1 March 1989and will be acce pted until the position is filled. Sendcurriculum vitae, letter describing interests, and names ofthree references to: Dr. Dirk Frankenberg, Director,Institute of Marine Sciences, 3407 Arendell Street,Morehead City, NC 28557. The Utniversity of NorthCarolina at Chapel Hill is ani Equal Opportunity/AfirmnativeAction Employer.

RESEARCH ASSOCIATE-conduct research onthe mechanism of oncogene regulation during differenti-ation of F9 teratocarcinoma cells using molecular biolog-ical approaches. Requirements include M.D. or Ph.D. inbiochemistrv; strong background in independent experi-mental techniques and methodology including cloning,transfection, Southern and Northern analyses in the areaof teratocarcinoma cell lines; thorough knowledge ofnuclear protooncogene expression and molecular basisfor retinoid action, Salarv $22,000, 40 hours per week.Respond with resume onlv to: Job Order #9307,Division of Employment Security, Government Cen-ter, Boston, MA 02114.

RESEARCH ASSOCIATE IN CELL AND MO-LECULAR BIOLOGY: Position available to studymechanisms of anti-sense RNA inhibition of geneexpression in higher eukarvotes. Retroviral vectors areemploved to deliver anti-sense constructs targeted togenes of clinical and biological interest. The applicantshould have an M.D. or Ph.D. with a background in celland/or molecular biology. Send curriculum vitae andreferences to: Dr. Edward Holmes, Department ofMedicine and Biochemistry, Box 3034, Duke MedicalCenter, Durham, NC 27710.

POSITIONS OPEN

MASSACHUSETTS GENERAL HOSPITALHARVARD MEDICAL SCHOOLPROFESSOR OF GENETICS

Massachusetts General Hospital and Han-ard MedicalSchool are seeking a Professor of Genetics in the Depart-ment of Molecular Biologv at MGH. The successfulcandidate will be expected to develop a major researchand training program in the molecular genetics of devel-opment, and participate in the teaching of medical andgraduate students. Candidates should have demonstratedscholarly achievement and promise of the highest order.Harvard University is committed to increasing representationi ofwomen and minority metmbers amonZg its faculty anid partictularlyencourages applicatiotns from such catndidates. Candidatesshould send curriculum vitae and statement of researchinterests to: Dr. Howard Goodman, Chief, MolecularBiology, Massachusetts General Hospital, FruitStreet, Boston, MA 02114.

Harvard Medical School and Massachusetts Genieral Hospitalare Affirmative Actioni/Equal Opporttutity Employers.

RESEARCH ASSOCIATE position available imme-diately to investigate drug mechanisms influencing thefunctional and structural properties of Ca2+ channel andpump proteins of cardiac and vascular smooth muscle. APh.D. in biochemistry, molecular pharmacology, and/ortoxicologv, or neurobiology essential. Experience in re-ceptor isolation, radioligand binding, ion flux measure-ments, and HPLC preferred. Initial appointment for 2years, extension possible. Send curriculum vitae andnames and addresses of three references to: Dr. Isaac N.Pessah, Department ofVeterinary Pharmacology andToxicology, University of California, Davis, CA95616.

RESEARCH POSTDOCTORAL FELLOWSHIP.Biochemical and molecular mechanisms of hormone(angiotensin) actions in heart. Receptor-G protein inter-actions, second messenger generation (Ca2 and phos-pholipids), protein svnthesis. Available: June 1989. Sala-rv: PGY basis. Contact: Kenneth M. Baker, M.D., WeisC~enter for Research, Geisinger Clinic, North AcademyAvenue, Danville, PA 17822-2611.

RESEARCH PSYCHOLOGIST GS-14$46,679 to $60,683 per annum

The Walter Reed Army Institute of Research is cur-rentlv accepting applications for a research psvchologistto create, design and conduct, within broad guidelines, aresearch program on the effects of radiofrequency radia-tion on the behavior and physiologic function on intact,living experimental animals.

Interested applicants may submit applications (SF-171) to:

Walter Reed Army Medical CenterCivilian Personnel OfficeBuilding 11, Room 2-89

Washington, DC 20307-5001Attention: Ms. Edna GibsonTelephone: 202-576-2725Equal Opportunity Emnployer.

SCIENTIST FORINTERMEDIATE VOLTAGE EM FACILITYThe Lawrence Berkelev Laboratorv, in association

with the University of California, Berkelev, is establish-ing a West Coast Facilitv for Intermediate VoltageElectron Microscopy. Special features of this facility willinclude a 400-kV EM with high resolution, high tilt, andcryo stage capabilities. The facility will serve two coreprojects and collaborative and service projects. To main-tain the day-to-day operation of this facility, we arelooking for an independent, experienced scientist with aPh.D. degree in biologv. The successful candidate wvillhave an understanding of electron optics, substantialpractical experience in TEM, and knowledge of accessorytechniques such as crvo-EM and image analysis. He/shewill advise users on the proper operation of the instru-ment and conduct research on new% applications ofIVEMtechnology. Applicants should send their curriculumvitae, and three letters of reference to: Dr. ManfredSchliwa, c/o Ron Lowder, LBL (Refer to JOB # A/5063) Employment, Building 90-1012, #1 Cyclo-tron Road, Berkeley, CA 94720. Ant Eqtal OpporttuityEmployer, M/F/H.

POSITIONS OPEN

RESEARCH SCIENTIST-The Department ofSurgery at North Shore Universitv Hospital invitesappicatons for an anticipated full-time research positionin the Division of Basic Science Research. Candidatesconducting basic research in Adult Respiratory DistressSyndrome or cardiac calcium metabolism are encouragedto apply, although other fields of interest will be consid-ered. Applicants completing postdoctoral training readyto conduct independent research would be stronglyconsidered. Candidates wvill be expected to develop anactive research program with the potential of attractingextramural funding. Ph.D. and/or M.D. degree with aminimum of 3 to 5 vears of postdoctoral experience arerequired. Please respond by proiding a brief statementof research interests and plans, curriculum vitae andbibliography, and the names of three references to: Dr.Saul R. Powell, North Shore University Hospital,Boas-Marks Biomedical Research Building, 350Community Drive, Manhasset, NY 11030. Equial Op-portunity Emnployer MIF.

SENIOR POSTDOCTORALRESEARCH ASSOCIATE

The responsibility includes operating and maintainingthe Tissue Culture Laboratorv, participating in ongoingresearch projects on arachidonic acid metabolism, andproviding expertise in cell culture techniques to otherinvestigators. Extensive experience in cell culture anddoctoral degree in biological sciences are required. Annu-al salary is $30,000. This position will be in the Penning-ton Biomedical Research Center, a major newr facility inthe Louisiana State Universitv system with the mission ofimproving human health through research in nutritionand preventive medicine. When responding to this ad,please reference #8741201020. Please send curriculumvitae and three letters of reference directly to: Dr.George Bray, Pennington Biomedical Research Cen-ter, 6400 Perkins Road, Baton Rouge, LA 70808-4124. LSU is ani Affirmative Actiont Emnployer.

STATISTICIAN/DATA ANALYSTThe Smithsonian Tropical Research Institute antici-

pates an opening in earlv 1989. M.S. or equivalentexperience. Good working knowledge of repeated mea-sures, multivariate, and time series analvses. Backgroundin ecologv, microcomputers, Dbase, Svstat, BMDP, andgraphics. Contracted appointment without benefits start-ing at $20,000 per annum. Possible continuations until1992. Send application, curriculum vitae, and names ofthree references by 28 Februarv 1989 to: SmithsonianTropical Research Institute, Attention: Dr. B. Keller,APO Miami 34002-0011.

UNIVERSITY OF COLORADOHEALTH SCIENCES CENTERSTRUCTURAL BIOLOGY

The Department of Cellular and Structural Biologyseeks candidates for a tenure-track FACULTY POSI-TION in structural biology and anatomy.The position offers excellent research facilities, espe-

cially state-of-the-art equipment for computed imagingof macroscopic and microscopic structures. These re-sources present unique opportunities for individualsfamiliar with human anatomy and computer approachesto imaging for research and teaching.

Applicants should have an M.D. and/or Ph.D. degreewith a strong academic background including evidenceof research contributions in molecular structure, cellularor developmental biology, or neurobiology. Contribu-tions in biodvnamics, artificial intelligence or other areasof modern research also will be considered. Candidateswho are interested in or have experience in teachinghuman anatomy are particularlv encouraged to apply.Depending on qualifications, ranks and salary are nego-tiable.

Interested individuals should submit a complete cur-riculum vitae including a one-page description of re-search plans and the names of three or more refereesfamiliar with their work. Applications will be revievedcommencing 15 February 1989, and should be sent to:

David G. Whitlock, M.D., Ph.D.Chairman: Search Committee for Structural Biology

Department of Cellular and Structural BiologyUniversity of Colorado School of Medicine

4200 East Ninth Avenue, B-111Denver, CO 80262

The U(niversity of Colorado is ant Equial Opporttiunity/Affirmative Actionl Employer.

SCIENCE, VOL. 243570

RESELARCH SCIENTISTPHARMACOLOGY

Amgen is a dynamic, growing organization producing humantherapeutic products through recombinant DNA technology. Ourleadership in the development of Erythropoietin and Granu-locyte Colony Stimulating Factor has placed us at the leadingedge of the biotechnology industry. Our continued growth hascreated an immediate opportunity for a Research Scientist in ourPharmacology Group.

Applicants must possess a Ph.D. in Pharmacology or a relateddiscipline with a strong background in whole animal researchand experience in one or more of the following areas: inflam-mation, wound repair, immunopharmacology, hematology andoncology. Proficiency in statistical analysis of data is essential,and postdoctoral training is highly desirable.

Amgen offers a competitive compensation and benefitspackage, including equity participation, as well as a challengingand stimulating research environment. Our location one hournorthwest of Los Angeles offers the best in Southern Californialiving. Qualified applicants should direct a resume and a list of 3references, in confidence, to:

Recruitment, Dept. #372AMGEN1900 Oak Terrace LaneThousand OaksCA 91320Equal

Opportunity

Employer

Scientist

Division of Surgical ResearchThe Hospital for Sick ChildrenA Scientist position is currently open in the Division ofSurgical Research in the Research Institute of TheHospital for Sick Children. The research focus in thisDivision is transplantation physiology and immunol-ogy. The Research Institute of The Hospital for SickChildren is the largest paediatric research institute inCanada. The Institute is based on a firm and securedlong-term endowment. Currently, the Institute has 18research divisions with over 150 principal investiga-tors and 200 trainees supported by a full range ofexcellent research services. The existing researchprogrammes are strong, innovative and collaborative.

Applicants should have a Ph.D. or M.D. Degree withpost-doctoral research training in one of the followingareas: transplantation immunology, pharmacologyor biochemistry; tumor immunology. The successful

candidate will be expected to establish a strongindependent programme and will be encouraged tointeract with other basic or clinician scientists in theResearch Institute. Excellent office and laboratoryspace and equipment are available in the Division ofSurgical Research. Salary, rankand start-up funds arenegotiable. The successfulcandidatewillbeappointedto the Department of Surgery of the University ofToronto.

Please send a curriculum vitae and the names ofthreereferences should be submitted, quoting file #C160Aand post-marked no later than March 15, 1989, to:Cho Y. Pang, Ph.D., Chairman of the Search Commit-tee, Division of Surgical Research, The Hospital forSick Children, 555 University Avenue, Toronto,Ontario, Canada M5G 1X8

I-- THE HOSPI1ALFORSICKCHITLREN

I1

Research Scientist!Peptide Chemist

Triton Biosciences Inc., a subsidiary of Shell OilCompany, is a fully integrated pharmaceutical anddiagnostics company focused on product develop-ment opportunities in the area of cancer and otherlife-threatening diseases.The successful candidate will manage a state-of-the-artpeptide chemistry laboratory. Specific responsibilitiesinclude solid phase peptide synthesis using t-bocand f-moc chemistry, rapid synthesis technology,peptide structure-function studies, analog develop-ment, and epitope mapping for several R&D programsin the cytokine and oncogene area. The positioninvolves both active scientific collaboration and aservice component. Candidates should have a PhDin peptide chemistry, 4+ years experience, andgood organizational and communication skills.Triton is located in the San Francisco Bay Area andoffers competitive salaries and benefits, includ-ing relocation assistance. For consideration, sendCV. with salary history and references to: TritonBiosciences Inc., Box PH, 1501 Harbor Bay Parkway,Alameda, CA 94501. An Equal Opportunity Employer.

*Triton Biosciences Inc.

I

i

POSITIONS OPEN

VETERINARY MICROBIOLOGISTDIAGNOSTIC LABORATORY

Assistant director of multi-functional veterinarv bacte-riology and mycolopy laboratory. Share with directortechnical and operational responsibilities; must developstrong individual research program in bacteriology orinfectious diseases of animals commensurate with mis-sion ofthe Diagnostic Laboratory. D.V.M. and/or Ph.D.in microbiology with appropriate experience and knowl-edge in clinical microbiology and infectious diseases.Preference for emphasis, interest in anaerobic and entericbacteriology, mycoplasmology, or clinical mvcology. Ti-tle and salary commensurate with qualifications andexperience. Tenure-track appointment available. Submitcurriculum vitae to: Sang Shin, D.V.M., ChairmanSearch Committee, Diagnostic Laboratory, Collegeof Veterinary Medicine, Cornell University, Ithaca,NY 14853-6401.

Cornell University is an Equal Opportunity/AfirmativeAction Employer/Educator.

VIROLOGISTTechnician performing disinfectant testing and tissue

culture cytotoxicity. Experience with HSV, Polio, Influ-enza, and Rhino viruses helpful. Salary: $18,000 to$24,000 per year. Gibraltar Labs, 122 Fairfield Road,Fairfield, NJ 07006.

ASSISTANTSHIPS

ASSISTANTSHIPSGRADUATE PROGRAM IN NEUROSCIENCEThe Neuroscience Program at University Hospital at

The Milton S. Hershey Medical Center of the Pennsylva-nia State University has assistantships available in August1989. This interdepartmental program is designed toconfer a Ph.D. degree with a major in neuroscience.Participating faculty have established research programsin molecular biology of the nervous system, neurophysi-ology, neuroendocrinology, behavioral science, neuro-pharmacology neurovirology, and cerebral blood flowand metabolism. Interested candidates are invited toapply to: Dr. Robert B. Page, Director, NeuroscienceProgram, P.O. Box 850, Hershey, PA 17033. AnEqual Opportunity/Afirmative Action Employer.

Minimum 4-year GRADUATE RESEARCH AND/OR TEACHING ASSISTANTSHIPS in plant biolo-gy are available for highly qualified students seekingPh.D. degree starting September 1989. Specific programspecializations include, but are not restricted to, photo-synthesis; cell and molecular biology, developmentalanatomy and morphology; physiological, population andcommunity ecology; systematics and evolution; weedscience.For information, contact: Dr. Alan Stemler, Botany

Graduate Group Admissions Chair, Botany Depart-ment, University of California-Davis, Davis, CA95616, or call: 916-752-7094, Graduate Group Admis-sions Office.

The University of California-Davis is an Affirmative Ac-tion/Equal Opportunity Employer.

COURSES

MARICULTURE: CULTURE OF MARINE IN-VERTEBRATES FOR RESEARCH PURPOSES.Designed to teach the basics of mariculture to advancedstudents, this course is scheduled for 21-27 May 1989.Tuition: $850 (includes room and board). Applicationdeadline is 1 April 1989. For further information, con-tact: Admissions Coordinator, Marine BiologicalLaboratory, Woods Hole, MA 02543. Telephone:508-548-3705, extension 216.

AUTORADIOGRAPHYIN

ELECTRON MICROSCOPYa residential laboratory courseWoods Hole, 21-26 May 1989

Woods Hole Educational AssociatesPO Box EM

Woods Hole, MA 02543Telephone: 508-540-5594

572

Research

Scientists

IMMUNOLOGY AND MOLECULAR BIOLOGYBionetics Research Institute conducts cancer research and product development aspart of the Pharma Division of Akzo, NV, an organization operating in 50 countriesworldwide.

IMMUNOLOGY-We are currentlyseeking an experienced Research Scientisttodevelop and characterize new murine monoclonal antibodies for use in commercialimmuniassay development and supervise the hybridoma laboratory staff of four. Dutieswill be performed in cooperation with the animal resources and product developmentlaboratories. This position will report to the Director, Diagnostic Product ResearchLaboratory. The successful candidate will have a Ph.D. in immunology or related disci-pline and several years' postdoctoral monoclonal antibody research with publications.MOLECULAR BIOLOGY- We are also seeking a Research Scientist to direct asmall technical staff in basic research for diagnostic test development. Antigens to betargeted include human retroviruses. The successful candidate will have a Ph.D.in molecular biology or related discipline and expertise in the generation ofcDNA libraries; manipulation of plasmids and vectors; expression in prokaryoticand eukaryotic cells; assay development; DNA sequencing, as well asproven writing skills through publications.BRI offers excellent benefits including health, life and dentalinsurance and a generous, company-matched savings plan.For consideration, please submit a C.V., including salaryrequirements to:

BIONETICS RESEARCH INSTITUTE1330-A Piccard Drive, Dept. S-127Rockville, MD 20850 _BRI is an equal opportunity employer, M/F/HN. Principals Only.

Monsanto CompanyAnimal Sciences Division -

ResearchSenior Research Biologist/Biochemist

We're Monsanto, a worldwide company that continues to make technologicaladvances in a range of products and industries. We currently have an excitingopportunity available in our Animal Science Division.You will join a dynamic research team organized to identify and developnew products that enhance the quality and efficiency of meat animal growth.You will specifically be responsible for organizing a research effort focusedin the regulation of cellular growth and developmentTo qualify, you must have a Ph.D. in Animal Science, Biology or Biochemistry,with emphasis on cellular growth and development Post-doc experienceis desirable but not essential. Muscle, chandrocyte and/or adipose cell cultureexperience is also required. The incumbent will have a strong in vitro basewith a desire and ability to relate these results to whole animal physiology.We offer a highly competitive salary and benefits package. For consideration,send your resume to: John R. Amato; MONSANTO COMPANY; BB2A,700 Chesterfield VMage Parkway; Chesterfield, MO 63198. An EqualOpportunity Employer M/F/H/V.

Monsanto

BSMS INALATON TOXICOOGISTToxicology Division

Equal Opportunity Employer

For more than a century, scientists at ELI LILLY AND COMPANY havedeveloped innovative, high quality pharmaceutical products. In 1988, Lillyinvested over $500 million in research-and-development programs. Morethan 3,000 scientists at the company's Lilly Research Laboratories arepursuing creative research programs that involve many important healthcare needs.

To further build its research capabilities, Lilly is seeking a self-motivated, innovative scientist for the Toxicology Division. The idealcandidate will have the following qualifications:* Bachelor's or Master's degree in toxicology, pharmacology,bioengineering, or a related discipline.

* Experience in conducting inhalation toxicology studies withanimal models.

* Experience in pulmonary physiology is desirable, but not essential.* Excellent organizational and communication skills.

Eli Lilly and Company is committed to scientific excellence. Lillyprovides a stimulating professional atmosphere with many opportunitiesfor collaborative, multidisciplinary research. The company offers anattractive total compensation program. Entry level and salary will be basedupon each candidate's experience.

For prompt consideration, please forward your resume to:Dr. Ronald K. Wolff (AIT-1)Eli Lily and CompanyP.O. Box 708Greenfield, IN 46140

Carer unityIn Phy al OceanographyBattelle, Pacific Northwest Laboratories has anopening in its Marine Science Laboratory atSequim, Washington, for a Senior ResearchScientist-Physica Oceanographer.

The successful candidate will be the lead scien-tist for physical oceanographic research projectsconducted in the Global Change Program. Thisprogram involves research in the following areas:air-sea interactions; modeling of mixing andradiative transfer in the surface layer; numericalexperiments on convection and thermohaline cir-culation in the ocean; parameterizations ofsubgrid-scale prcesses in 3-dmensional circula-tion models; coupling coastal ocean-estuarineand upland hydrologic models for studies atregional scales.

A doctor's degree is needed, preferably withstrong programming skills, supercomputer ex-perience and program development expertise.For consideration, submit resumes to: AnthonyF. Gasperino, Battelle, Pacific NorthwestLaboatorle, P.O. Box 999, Dept. 079, Rlchland,WA 99352. U.S. Citizenship Required. An EqualOpportunity Employer.

0, BalteIlePafcNrhetLbrtre

CAREER OPPORTUNITIESFOR SENIOR SCIENTISTS

As one of California's most progressive pharmaceutical companies, Vical is focus-ing on new drug designs and more effective drug delivery methodologies. Current-ly, we're developing new therapeutic products in the areas of antiviral agents andtherapeutic protein delivery enhancement, and several other major programs areunderway. This translates into outstanding opportunities for the following expefiencedprofessionals.

DIRECTOR OF BASIC RESEARCHMajor responsibilities entail supervision of research in pharmacology, endocrinology,organic chemistry and virology. The ideal candidate will be a senior scientist with8-12 years' experience in the pharmaceutical industry in the design and manage-ment of pharmacological research programs.

PHARMACOOGY GROUP LEADERLeading our PharmacologylPhysiology Department, major responsibilities entail direc-tion of research in therapeutic protein delivery, pharmacokinetics and toxicology.The ideal candidate will have significant pharmaceutical experience in one or moreof the following areas: animal models of disease, pharmacokinetics, toxicologyand immunoassay.Vical rewards your efforts with excellent benefits. Salary and equity commensuratewith experience. For immediate consideration, please send resume to: HumanResources Dept., Vical Inc., 9373 Towne Centre Dr., Suite 100, San Diego, CA 92121.

EVIEALItENmlI

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COURSES

FLOW CYTOMETRY APPLICATIONSCOURSE will be presented at the Los Alamos NationalLaboratorv, Los Alamos, New Mexico, 21 to 26 May1989. This course will emphasize applications in immu-nologyv and cell biologv. Course tuition: $550 (U.S.).For information contact: Mary Cassidy, NFCR, MSM888, Los Alamos National Laboratory, Los Ala-mos, NM 87545; telephone: 505-667-3914.

SYMPOSIUM

INTERNATIONAL SYMPOSIUMMacroMolecules, Genes and Computers: Chapter

Two is scheduled for 13-18 August 1989 at the WhiteMountain Conference Center, Waterville Valley, NewHarnpshire. This International Symposium has beendesigned to facilitate the exchange of information in theinterdisciplinarv domain overlapping computer science,mathematics, genetics, medicine, and molecular biologv.Session topics will include the fundamental propertiesof biological systems, the enabling technologies re-quired for their understanding, the practical applicationof these technologies and the anticipated future chal-lenges within this interdisciplinarv domain. Also includ-ed will be computer hardware/software workshops andboth electronic and traditional poster sessions. The meet-ing is sponsored bv the National Librarv ofMedicine andorganized by the Molecular Biology Computer ResearchResource of the Dana-Farber Cancer Institute/HarardSchool of Public Health. Those interested in attendingshould contact: Temple Smith, MBCRR-J815,Dana-Farber Cancer Institute, 44 Binney Street, Bos-ton, MA 02115.

WORKSHOP

STRUCTURAL AND CHEMICAL BASIS FORCELL FUNCTION.

Sponsors: Annenberg Center for Health Sciences, TheResearch Institute of Scripps Clinic, 25 to 28 April 1989.A conference designed to create a forum for integrat-

ing chemistry, biophysics and cell biology. Poster sessionavailable to participants.

Topics: Macromolecular Assemblies, Regulation ofGene Expression, Intracellular Transport, Signal Trans-duction, Motilitv, and Cell Surface/Membrane Channels.

Organizing Committee: N. B. Gilula, L. Gerace, J.Hogle, B. Huang, R. Milligan, I. Wilson, N. Unwin.

Invited participants: J. Abelson, Pasadena; D. Agard,San Francisco, C. Alkey, England; H. Betz, FRG; H.Bourne, San Francisco; D. Eisenberg, Los Angeles; S.Fuller, FRG; L. Gerace, La Jolla; S. Harrison, Cam-bridge, MA; T. Hunter, La Jolla; S. H. Kim, Berkeley;M. Kirschner, San Francisco; B. Kretsinger, Char-lottesville, VA; T. D. Pollard, Baltimore; D. Rees, LosAngeles; J. Sedat, San Francisco; K. Simons, FRG; J.Spudich, Palo Alto; R. Vallee, Worcester, MA; P.Walter, San Francisco.

Registration information: Registration fee is $125. Itcovers the conference, coffee breaks, and reception. Forregistration forms, poster session forms and additionalinformation: Annenberg Center, 39000 Bob HopeDrive, Rancho Mirage, CA 92270 or call: 800-321-3690 US, 800-621-7322 CA, FAX: 619-7734513,TELEX: 188979 ANNENBERG CTR.

FELLOWSHIPS

CHARLES A. DANA FOUNDATIONFELLOWSHIPS

are available at theCOLUMBIA-PRESBYTERIAN

MEDICAL CENTERTo prepare clinical investigators by providing training

in basic science. Candidates or neurology awards in Julv1990 should be residents now and should request infor-mation by 1 September 1989 from:

Ronald 0. Rieder, M.D., CoordinatorDana Clinical Neurosciences

Training Program722 West 168th StreetNew York, NY 10032

CPMC is an Equal Employment Opportunity!Affirmative Actioni Emnployer.

GRADUATE TRAINING PROGRAM

GRADUATE ASSISTANTSHIPS IN MOLECU-LAR BIOLOGY AND BIOCHEMISTRY. Severalpositions are available in the Department of MolecularBiologv and Biochemistry, Weslevan University (Mid-dletown, Connecticut). Research interests of the facultyemphasize regulation of gene expression in embrvogene-sis and development; protein structure, function anddesign; DNA replication; yeast genes homologous toprotein kinase oncogenes; structure and function ofchromosomal proteins; protein-nucleic acid interactions;chemistry of reactions at phosphorus; nuclear magneticresonance spectroscopy and computer modeling. Allstudents receive tuition remission, good fringe benefits,and dependencv allowance if applicable. Opportunitiesto teach. Write to: Dr. Norma Allewell, DirectorGraduate Admissions, Department of Molecular Bi-ology and Biochemistry, Wesleyan University, Mid-dletown, CT 06457 or call: 203-347-9411, X2524.

FELLOWSHIPS

GEORGE S. WISEPOSTDOCTORAL FELLOWSHIPS

The George S. Wise Faculty of Life Sciences at Tel AvivUniversity offers each vear postdoctoral fellowships com-mencing on 1 October in basic and applied biology.The facultv is engaged in such research areas as

anatomy, taxonomv and physiology of plants; anatomv,sociobiology and physiologv of animals; marine biology;cellular and molecular biologv and genetics; lipid andprotein research; bioenergetics; neurobiology; immunol-ogy; virology; cancer biology; biotechnology and naturepreserv,ation.

Application forms can be obtained from: The Dean,The George S. Wise Faculty of Life Sciences, Tel AvivUniversity, Tel Aviv 69978, Israel. Deadline for appli-cations is 30 May of each year.

POSTDOCTORAL FELLOWSHIPBIOCHEMISTRY ANDMOLECULAR BIOLOGYOF RECEPTORS FOR

VASOACTIVE HORMONESAvailable immediately for 2 to 3 vears, for a qualified

M.D. or Ph.D. Sponsored bv the Department ofuPathol-ogy and the Division of Cardiology to study receptor(s)for angiotensin II and other vasoactive hormones. Thegroup provides expertise and state of the art technologyin molecular and cell biology. Position could lead tofaculty appointment. Experience in receptor biologv andbiochemistry required. Salarv negotiable. Please sendcurriculum vitae and references to: Ken Bernstein,M.D. or Wayne Alexander, M.D., Room 713 WMB,Emory University, Atlanta, GA 30322. Equal Opportu-nity/Aflirmative Action Employer.

HARVARD SCHOOL OF PUBLIC HEALTHINTERDISCIPLINARY PROGRAMS

IN HEALTHPOSTDOCTORAL FELLOWSHIPS

RWL

The Program in Environmental Health and PublicPolicy invites applications from promising graduates ofadvanced degree programs in the natural or social sci-ences. The program focuses on the scientific and analvti-cal foundations for environmental decisions. In additionto conducting individual research, fellows are encour-aged to collaborate with each other and faculty memberson projects of mutual interest. Recent group projectshave considered approaches for regulation of toxic airpollutants, strategies for environmental monitoring andimplications of distributions of susceptibility.

Fellows will be appointed for a term of 1 'ear startingSeptember 1989. Award mav be renewed. Applicationsdeadline: 10 March 1989. Decisions announced in April.

For information write to:Professor John S. EvansAttention: Fellowships

Harvard School of Public Health665 Huntington Avenue

Boston, MA 02115Telephone: 617-732-1258

FELLOWSHIPS

PREDOCTORAL FELLOWSHIPSIN BIOMEDICAL AND PHYSICAL SCIENCES

Applied Mathematics 0 Biochemistrv * Biology SBiomathematics * Biomedical Engineering * BiophysicalSciences * Biostatistics 0 Chemistrv * Computer Science* Cell Biologv and Anatomv * Environmental Health mEpidemiology * Genetics * Immunology * MaterialsEngineering* Materials Science 0 M.D.-Ph.D. 0 Medi-cal Genetics * Medical Psvchology * Microbiologv 0Molecular Cell Biology 0 Neuroscience 0 NutritionSciences 0 Pathology * Pharmacology * Physics * Phvs-iological Optics * Physiology * Virology

Well-funded facultv with diverse interests. Good post-graduation placement record. Above average stipendsinclude payment of tuition. Ready access to Crav-XMPsupercomputer. Speical fellowship opportunities for mi-nority students. Contact: The Graduate School (A),University of Alabama at Birmingham, Birmingham,AL 35294; telephone: 205-934-8246. Equal Opportu-nity/Afirmative Action Institution.

PRE-AND POSTDOCTORAL FELLOWSHIPS.Opportunities are available through an NIH-sponsoredprogram in the areas of cancer cell/molecular biology,carcinogenesis, biochemistrv, endocrinology, virology,pathophysiologv of cancer, environmental cancer, and nu-trition. Predoctoral students will have the option of enroll-ing in the departments of Biochemistrv, Pathology andMicrobiologv and Pharmaceutical Sciences. Postdoctoralfellows should forward curriculum vitae, three letters ofrecommendation, and an expression of research interest.Funding is restricted to U. S. citizens or permanienit residentts.For complete information write to: Donald Nagel,Ph.D., Eppley Institute for Research in Cancer, Uni-versity of Nebraska Medical Center, Omaha, NE68105. Affinnative Actioni/Equal Opportunity Employer.

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SCIENCE, VOL. 243

1. Gilford M240 Spectrophotometer(under continuous service contract)

2. Beckman DU Monochromator3. Beckman Sequenator A9OC4. Zeiss (Jena) Laboratory Interferometer5. Zeiss Microscope with Nomarski opticsAll in excellent condition. Prices negotiable.Call D.R. Sanadi

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