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• Peripheral neuropathy is the term for damage to nerves of the peripheral nervous system.
classification
• Anatomical
• Etiological :causes
• Pathological
• symptomology
Anatomical
• Mononeuropathy
• mononeuropathy multiplex
• Generalized: polyneuropathy
etiological
• acquired • VITAMIN D• V:vascuilities, SLE,PAN,..• I:infection,HIV,CMV,EBV,leprosy• T: truma • A:autimmune• M:Metabolic:DM,vit B12 defciency,hypothyrodism,renal hepatic ,porphyria• I:Infiltrative:sarcidosis, amylodosis • N:Neoplasm: paraneoplastic• D:Demyelinating ,GBS(Guillian barre syndrome or Drugs
• Hereditary
,
pathological
•
• Axonal
• demyelinating
• onset
• Acute chronic
Signs and symptoms
• Motor :weakness+ lower motor neuron signs
• Sensory: +ve or –ve symptoms, gloves and stalk distribution
• Autonomic:incotenance, postural hypotention,
Work UP
• EMG and nerve coduction study
• Look for the causes
• LP: protien, glu,WBC (cytoalbumin dissociation)..GBS
• ANA,RF,vit B12,TFT,Glu leve,renal,…
• Nerve biopsy
GBS
• Acute inflamatory demyelinating poly radiculopathy
• Preceded by URTI, diarrhea
• Asending weaknesss
• It is emergency
• Diagnosed by EMG ,NCS and LP(cyto albumin dissociation)