Performance Evaluation of an MRI-CompatiblePre-Clinical PET System Using Long Optical Fibers

Chairman: Hung-Chi Yang Presenter: Ming-Lin Wang Adviser: Jenq-Ruey Hrong Date:2012/12/19

Jane E. Mackewn, Philip Halsted, Geoffrey Charles-Edwards, Richard Page, John J. Totman, Kavitha Sunassee,Daniel Strul, William A. Hallett, Maite Jauregui-Osoro, Peter Liepins, Steven C. R. Williams, Tobias Schaeffter,Stephen F. Keevil, and Paul K. Marsden

Materials and Methods

(a) Complete PET scanner. (b) Crystal ring of the scanner including diagram of crystal configuration. (c) Single crystal attached to an optical fiber.

System Description

ResultsInteraction Between the PET and the MRI System

(a) PET acquired in MR, (b) PET acquired outside MR, and (c) (a)–(b), scaled to noise.

(a) (b) (c)

ResultsSimultaneous PET and MR Imaging

Simultaneously acquired (a) static PET and (b) MR images of the mouse neck. (c) PET image superimposed on the MR image.

References [1] Y. P. Shao, S. R. Cherry, K. Farahani, K. Meadors, S. Siegel, R. W.

Silverman, and P. K. Marsden, “Simultaneous PET and MR imaging,”

Phys. Med. Biol., vol. 42, pp. 1965–1970, Oct. 1997.

[2] C. Catana, D. Procissi, Y. B. Wu, M. S. Judenhofer, J. Y. Qi, B. J. Pichler, R. E. Jacobs, and S. R. Cherry, “Simultaneous in

vivo positron emission tomography and magnetic resonance imaging,” in Proc. Natl. Acad. Sci. USA, Mar. 2008, vol. 105,

pp. 3705–3710.

[3] A. J. Lucas, R. C. Hawkes, R. E. Ansorge, G. B. Williams, R. E. Nutt, J. C. Clark, T. A. Fryer, and T. A. Carpenter,

“Development of a combined microPET(R)-MR system,” Technol. Cancer Res. Treat., vol. 5, pp. 337–341, Aug. 2006.

[4] D. Schlyer, P. Vaska, D. Tomasi, C. Woody, S. Maramraju, S. Southekal, J. Pratte, S. Junnarkar, S. Solis-Najera, S.

Krishnamoorthy, A. Kriplani, and S. Stoll, “A simultaneous PET/MRI scanner based on RatCAP in small animals,” in

IEEENuclear Science Symp. Conf. Rec., 2007, pp. 3256–3259.

[5] A. J. Lucas, R. C. Hawkes, R. E. Ansorge, G. B. Williams, R. E. Nutt, J. C. Clark, T. A. Fryer, and T. A. Carpenter, “Development

of a combined microPET(R)-MR system,” Technol. Cancer Res. Treat., vol. 5, pp. 337–341, Aug. 2006.

[6] R. R. Raylman, S. Majewski, S. S. Velan, S. Lemieux, B. Kross, V. Popov, M. F. Smith, and A. G. Weisenberger, “Simultaneous

acquisition of magnetic resonance spectroscopy (MRS) data and positron emission tomography (PET) images with a

prototype MR-compatible, small animal PET imager,” J. Magn. Reson., vol. 186, pp. 305–310, Jun. 2007.

[7] S. Yamamoto, H. Mashino, S. Takamatsu, K. Matsumoto, and M. Senda, “A multi-slice dual layer MR-compatible animal PET

system: K-PET I,” in World Congr. Med. Phys. Biomed. Eng. 2006, vol. 14, pp. 1708–1711.

[8] J. E. Mackewn, D. Strul, W. A. Hallett, P. Halsted, R. A. Page, S. F. Keevil, S. C. R. Williams, S. R. Cherry, and P. K. Marsden,

“Design and development of an MR-compatible PET scanner for imaging small animals,” IEEE Trans. Nucl. Sci., vol. 52, pp.

1376–1380, Oct. 2005.