Per ordine alfabetico

•Consumer Health Databases ClinicalTrials.gov , MEDLINEplus

•Databases about AIDS AIDS Information Resources , AIDSLINE , AIDSTRIALS and AIDSDRUGS

•Databases about Chemicals and Toxicology Chemical Carcinogenesis Research Information System , ChemID , ChemIDplus , Developmental and Reproductive Toxicology Database , EMIC , Gene-Tox Program of the U.S. Environmental Protection Agency , Integrated Risk Information System , Toxic Chemical Release Inventory , Toxicology Data Network , TEHIP , TOXLINE

•Databases about Genetics Human Genome Resources , Entrez Molecular Sequence Database System , GenBank Retrieval and Sequence Similarity Searching by Internet Electronic Mail, Nat'l Center for Biotechnology Information , Submitting Data to GenBank

•Databases about Health Services Research , HealthSTAR (incorporates Health Planning & Administration and HSTAR Databases), Health Services Research Projects in Progress , Health Services/Technology Assessment Texts (HSTAT)

•NLM Image Databases , Images from the History of Medicine on Internet , Visible Human Project

•Other Specific NLM Databases DIRLINE , DOCLINE , HISTLINE , SERHOLD

NLM DATABASES

Fetal growth

Clinicaltrials.gov• Per chi: pazienti e familiari, media ma anche medici

• Quali informazioni: abstract dei protocolli (obiettivi, stato di reclutamento, criteri per reclutamento e partecipazione, contact info), informazioni aggiuntive (study design, fase del trial, malattia in studio)

• Quando è stato fatto: in seguito a atto dell’FDA del 1997 registro degli studi finanziati da NIH e enti privati su “trattamento sperimentale della malattie gravi e/o con rischio di vita”

• Status: non richiede registrazione. Recensisce oltre 5200 studi sponsorizzati da NIH. Studi sponsorizzati da industria privata saranno aggiunti nel 2000-2001.

Descrive in maniera schematica i dettagli dello studio

Criteri di inclusione ed

esclusione

Premesse e

razionale

Clinical trials: Resource information

• Understanding clinical trials• Informations about specific types of clinical trials

(cancer trials, vision research..)

• NIH Clinical Alerts• Information about drugs (recently approved, electronic

orange book)

• General health information (Medline plus, FDA consumer magazine, NIH health info)

• Related information

Trial interrotto per chiara

dimostrazione di inefficacia

Suggerimento clinico

Farmaci di recente

approvazione

Farmaci di recente

approvazione

Farmaci di recente

approvazione: scheda tecnica

About HSDB

HSDB contains over 4500 chemical records, each of which can have as many as 150 or so fields of data.

HSDB's road scope covers human and animal toxicity, safety and handling, environmental fate, and more.

HSDB data undergoes a high level of peer review by the HSDB Scientific Review Panel.

HSDB contains one record per chemical.

Dati dell’EPA su human risk assessment, focus su dose response

CCRIS: dati di carcinogenesi, mutagenesi, e inibizione della crescita tumorale dal NCI

Chemical Carcinogenesis Research Information

About GENE-TOX

GENE-TOX is created by the U.S. Environmental Protection Agency (EPA) and contains genetic toxicology (mutagenicity) test data, resulting from expert peer review of the open scientific literature, on some 3000 chemicals.

The GENE-TOX program was established to select assay systems for evaluation, review data in the scientific literature, and recommend proper testing protocols and evaluation procedures for these systems.

Each of TOXNET's toxicology data files (HSDB, IRIS, CCRIS, and GENE-TOX) contains one record per chemical.

GENE-TOX: dati di genotossicità sottoposti a peer review dall’EPA

Database di letteratura tossicologica

TOXLINE: database mirato su efetti biochimici, farmacologici, fisiologici e tossicologici di farmaci e composti chimici

EMIC: Environmental Mutagen Information Center: letteratura corrente su agenti testati per attività genotossica

DART/ETIC: Developmental and Reproductive Toxicology and Environmental Teratology Information Center: dati di tossicologia della riproduzione e dello sviluppo

About DART

The Developmental and Reproductive Toxicology (DART) database consists of citations to literature on chemical, physical, and biological agents that may cause birth defects.

It contains citations to literature published since 1989.

Approximately 60 percent of DART is derived from MEDLINE.

Database di interesse ambientale

TRI: Toxic Release Information: report dall’anno 1995 dall’EPA sul rilascio ambientale di sostanze tossiche

Database di Informazione Chimica e Biochimica

ChemIDplus: informazioni su sinonimi, struttura e link ad altri database contenenti informazioni su sostanze chimiche e farmaci

HSDB Structures: informazioni sulla struttura bidimensionale dei composti presenti nel data base HSDB (hazardous Substances DB)

NCI-3D: informazioni sulla struttura 2D e 3D a cura del National Cancer Institute