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Patologia Pneumococcica dell’adulto : nuovi vaccini e nuovi modelli di vaccinazione Un saluto. Da Antonio Pesenti Scuola di Medicina Università degli Studi Milano Bicocca. - PowerPoint PPT Presentation
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Patologia Pneumococcica dell’adulto: nuovi vaccini e nuovi modelli di
vaccinazione
Un saluto
Da Antonio Pesenti
Scuola di MedicinaUniversità degli Studi Milano Bicocca
The global mortality rate from the 1918/1919 pandemic is not known, but an estimated 10% to 20% of those who were infected died. With about a third of the world population infected, this case-fatality ratio means 3% to 6% of the entire global population died.[Influenza may have killed as many as 25 million people in its first 25 weeks. estimates say it killed 50–100 million people worldwide were killed. A common deadly complication was bacterial pneumonia
Angus, DC, et al: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29(7):1303-1310.
SEPSIS
In the United States, approximately 750,000 cases of severe sepsis occur each year
29% mortality rate with 215,000 deaths annually 10th leading cause of death in United States in
2000 Estimated $16.7 billion national health care
costs each year
Ranieri VM NEJM 2012
Ranieri VM NEJM 2012
Ranieri VM NEJM 2012
Angus DC Crit Care Med 2004; 32:2199
SEPSI Uno sguardo al passato
• HMS Victory , Capitan Uncino e la battaglia di Trafalgar
• Il 13° reggimento di cavalleria leggera e la battaglia di Waterloo
• HMS Victory, flagship Royal navy
William Beatty, the surgeon of HMS Victory, listed the 102 on board who
were wounded at the Battle of Trafalgar, six of whom subsequently died.
Injuries suffered were mainly fractures or splinter wounds.
There were 10 amputations, the majority involving the leg, as well as instances of death through gangrene and tetanus.
Alex[ander] PalmerMidnShot through the thigh by a Musket Ball, Bone and large Vessels untouched 28 October Died of Tetanus, Cold affusion and [?] digitalis[?] with large doses of Opium, were tried in this case
13th Light Dragoons at Waterloo
Three of those reported wounded subsequently died of their wounds.
Offrs Sergeant-Majors
Sergnts Corporals Trumpters Priv
KIA 3 -- -- -- -- 12Wound 8 3 6 2 2 52Miss -- -- -- -- -- 8 ___ ___ ___ ___ ___ ___Total 11 3 6 2 2 75
13th Light Dragoons Casualties report Battle of WaterlooSurgeon Logan, Veterinary-Surgeon Constant
Horses killed, 15; wounded, 46; missing, 52; total, 113.Grand Total: 96 men and 113. horses.
Ignaz Semmelweiss 1818- 1865
Martin e Al. NEJM 2003; 348; 16:1546