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MOLUSCUM CONTAGIOSUM

Histopathology:At low magnification the "domedpapule" is divided into pearshaped nodules of proliferating

epidermis which on the surfaceappear as volcanic micro craters(arrow 2) separated by theepidermal lips of the crater (arrow1).The characteristic and keyfeature is the presence ofmolluscum bodies also known asHenderson-Patterson bodiesinthe depths of the "volcanos".These bodies appear about 1-2layers above the basal cell layer

(arrow 5) of the epidermis as pinkto red inclusions (arrow 3) andprogress to become large brightred inclusions in the upper layersof the epidermis.Finally, they may exceed the sizeof the original cell (arrows 3 inhigh mag images). The inclusionsdisplace the nucleus and leaveonly a thin crescent of basophilicmaterial. In the granular layer theinclusions at first are surrounded

by blue granules (arrow 4) andeventually may even appearslightly basophilic in the upperlayers.

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The stratum corneum or cornifiedlayer is oftendisintegrated as theinclusions enlarge (arrow 2). Atthe peak the molluscum bodiesmay reach a diameter of 35microns. Ultrastructure shows

each inclusion is composed ofbrick shaped viruses withdumbbell shaped nucleoidssurrounded by the amorphouslayer of capsids

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CARCINOMA PLANOCELLULARE

Keratinized squamous stratified epithelium Basement membrane of the stratified squamousepthelium is penetrated by atypical cells with

invasion to the underlying connective tissue

1. Islands of neoplastic squamous cells2. Keratinous pearls

3. Stroma with immune cells

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CARCINOMA BASOCELLULARE

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NEVUS PIGMENTOSUS

Micro Findings

1. Small nests or bundles of nevuscells in dermis with thinned

overlying epidermis.

2. Nevus cells: (no necessarity to

differentiate these cells described

below).

3. Cuboidal cells with regular,

spheroid, moderately

hyperchromatic nuclei.

Upper: larger cells (type A)

with some multinucleated

giant melanocytes.

Middle: smaller cells (type

B) like lymphocytes.

Lower: spindle shaped

(type C) in neuroid bundles

(presumed schwannian

derivation)

4. No cellular atypia nor junctional

activity.

Junctional activity:

melanocytes proliferation

or dropping off restricted

to basal portion.

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MELANOMA MALIGNA

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