TOXOPLASMOSIS PATHWAY
Aviva Product
Not a Aviva Product
Indirect effect
Another molecule, mostly chemical compound
InhibitionDissociationPhosphorylation+pDephosphorylation-p
Nucleus
Pathway diagram below is compiled from data from the Kyote Encylopedia of Genes and GenomesKanehisa, M., Goto, S., Furumichi, M., Tanabe, M., and Hirakawa, M.; KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res. 38, D355-D360 (2010). Kanehisa, M., Goto, S., Hattori, M., Aoki-Kinoshita, K.F., Itoh, M., Kawashima, S., Katayama, T., Araki, M., and Hirakawa, M.; From genomics to chemical genomics: new developments in KEGG. Nucleic Acids Res. 34, D354-357 (2006). Kanehisa, M. and Goto, S.; KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res. 28, 27-30 (2000). 2012 Aviva Systems Biology
Outside
GPI
Glyoo-protein
LPS
Ca2+
LDLMoving junction
www.avivasysbio.com
Decreased antigenpresentation Suppressed
NO production
Apoptosis
Bcl2/XL
IAP
IL12
TNFa
LRG47
IGTP
iNOS
MHCII
MA
PK sig
naling
pa
thwa
y
Jak-STA
T signa
ling p
athw
ay
PI3K
CASP3
p38 ERK
Parasite growth
DNA
DNA
Pro-survival effect
Delayed IL12 production
DNA DNA
LDL
Dendritic cellparalysis
STAg
+p
+p+p+p
+p
+p
+p+p
+p
+p
+p+p
TNFa
Parasitophorus vacuole
Toxoplasma gondiitachyzoite
GRA3/5
ROP2
GRA7
a61
AMA1
RON
Toxoplasma gondii tachyzoite
Parasitophorusvacuole
formation
IL12
Anti-inflammatory effect
Immunosuppression
Apoptosis ofbystander cells
Toll-like receptorsignaling pathway
DNA
Ara
chid
onic
ac
id m
eta
bo
lism
Jak-STA
T signa
ling p
athw
ay
5LO
Gi
ROP16
Jak
STAT3
CytC
CASP9CASP8
CD154C18IL10
CCR5IL10R
TgCDPK1
PLA2SAG
Laminim
MIIC3
Release of parasite factorsHost cell penetration
IKK
IkBNFkB
TgIKK
TAK
TAB1/2
MKK3/6
STAT1
CIITA
JNK
Jak
SOCS1
MID2PFTG
IFNy
IFNGR
TLR11
TLR4
MyD88
IRAK
TRAF6
TLR2
TgHSP70
Gi
LDLRTNFR
PDK1
Endocytosis
PKB
IAP
Mito
cho
ndrio
n
PPC2-hm IL10TGF
CD40
Bcl2/XL
Bad
