PATHOPHYSIOLOGYRV.docx

7/25/2019 PATHOPHYSIOLOGYRV.docx

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Formation of Antibodies against platelets

Platelets recognized as foreign bodies

PATHOPHYSIOLOGY

Idiopathic Thrombocytopenic Purpura branching out to Tonic-Clonic Seizure

P!"ISPOSI#G $ACTOS

Spontaneous development of the disease, Age of 13 years old with the incidence rate increased at the ages of

10-19 years old, Sex Gender of emale as females are !"#1! percent more li$ely to %e diagnosed#

P!CIPITATI#G $ACTOS

&ecent 'iral (nfection )*iarrhea, +ough, +olds, *epleted levels of latelets in the %ody, oor eating ha%its,

lashing lights, .oud noises

Unknown Etiology

Immune system malfunction

Antibodies bind with Antigen of

Platelet Membranes


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Due to the presence of foreign bodies thespleen will increase the destruction by the

macrophages

Pt e%perienced the Sign& and

Symptom& o'(

1. Purpura

. Petechiae!. "ematomas

#. Epista$is

%. &leeding 'ums

Decrease in number of Platelets

Platelets are destroyed by

Macrophages

&one marrow produces the Macrophages


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)edication and Treatment&(

1. (mepra)ole *mg 1tab (D

P( +am

Pt e$perienced abdominal


1. Prednisone *mg 1 tab (D P( ,am for -ong term Maintenance

2. Monthly & testing for Platelet -e/el ount

Pt i& diagno&ed *ith Idiopathic Thrombocytopenic Purpura On +une ,./


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Laboratory and "iagno&tic

e&ult&( Platelet& Count 0C1C2

#ormal ange01%*!2*$1*23-

+an ,34 .54%5 6 1*23-

7-ow8

Most recent monthly & testing


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Imbalanced release of e$citatory and

Partial stimulation of neurotransmitter

"igh 9oltage electrical discharge

"ypere$citability state of neurons in the

Altered Integrity of neuron on the

,6.6.5

Pt e%perienced ,

epi&ode& o' &eizure&

I;P branches out to ;oniclonic


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Lowered seizure threshold

essation of cardio/ascular and

respiratory acti/ity causing apnea and

c anosis

Disruption in the medullary acti/ity

thus alteration in function of

respiratory and cardio/ascular

systems-oss of swallowing refle$Musculature stiffening

Alteration of the acti/ity

in the pons

Alteration of the acti/ity

in the midbrain

TO#IC PHAS!


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Due to physical and ner/ous e$haustion=

the pt may e$perience some post sei)ure

POST-ICTAL PHAS!

Pt e%perienced the Sign& and

Symptom& o'(

1. 9iolent= >erking mo/ements

. Upward rolling of eyeballs

Muscles will contract and rela$

CLO#IC PHAS!

Inhibitory impulse starts from the thalamus

and interrupts the tonic phase into

discontinuous bursts of electrical acti/ity


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e&ult&(

Platelet& Count 0C1C2#ormal ange01%*!2*$1*23-

$eb .4 .57% 6 1*23- 7?ormal8

$eb ,4 .54++ 6 1*23- 7-ow8

Pt *a& re'erred to "r8 P9


e&ult&(

!!G Te&ting ,6:6.5

7@8 (ccasional Epileptiform

discharge= at both frontal 7fp= fp8


1. Dia)epam .! + PB? I9;; for


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L!G!#"

#O $I#AL "IAG#OSIS $O TH! S!I;

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PATHOPHYSIOLOGYRV.docx