Upload
ruzzlle-delos-santos
View
153
Download
0
Tags:
Embed Size (px)
DESCRIPTION
FInals PPT from Arianne\'s USB
Citation preview
Final Examination Review Slides
liezl_emdi
Pathology 2B
Diseases of the Endocrine Glands
Acute Pancreatitis, Pancreas
Enzymatic Fat Necrosis Gland can return to
Normal if the cause is remove
Sequelae: sterile pancreatic abscess, pseudocyst
Causes: Alcoholism- Male Biliary Tract Disease-
Female
Hemorrhage
Acini
Necr
oti
c A
cini
Hemorrhage
Saponified fat cells
Necrotic Acini with Neutrophilic Infiltrates
Kimmelstiel-Wilson nodule
Afferent arteriole
Kimmelstiel-Wilson nodule/ nodular diabetic glomerulosclerosis
Diffuse mesangial sclerosis
Diffuse mesangial sclerosis
Capillary Basement Membrane (thickened)
Capillary Basement Membrane (thickened)
Acute Pyelonephritis, Kidney
One of the forms of Renal Lesions secondary to DM
Begins in the interstitium tubules
Formation of cystic cavity containing purulent fluid
Neutrophils
Abscess formation
Neutrophils
Irregular shapes and sizes of follicles
Colloid/ Non-Toxic (Simple) Goiter, Thyroid Gland
Diffuse involvement without nodularity
Not associated with hypo/hyperfunctioning
Can be Endemic or Sporadic Endemic- low level of
Iodine in soil, water and food supply
Sporadic- ingestion of substance that interferes with thyroid hormone synthesis or enzymatic defects
Thyroid follicles are lined by flattened epithelium
Flattening of
epitheliu
m
colloid
colloid
Colloid/ Non-Toxic (Simple) Goiter, Thyroid Gland
Grave’s Disease (Thyrotoxicosis), Thyroid Gland
Most common cause of endogenous hyperthyroidism
Hypertrophy of the Thyroid Follicles + Epithelium
Antibodies to TSH Receptor, TSI, TGI, TSH-BII
Triad Hyperthyroidism Exopthalmos Pretibial Myxedema
Scallop appearance of Thyroid follicles
papilla
Tall epithelial cells
Hashimoto’s Thyroiditis, Thyroid Gland
Chronic Lymphocytic Thyroiditis
Struma lymphomatosa Lymphadenoid Goiter Most common cause
of Goitrous Hypothroidism in areas that have sufficient Iodine
Major cause of Non-Endemic Goiter in Children
Long Term Complication- NHL
GC
GC
GC
GC
Lymphoid follicles
GC
GCA
A
A
GC
A- Acini GC- Germinal Center L- Lymphocytic infiltration
LL
GC
Atrophic thyroid Follicles/ Acini
fibrosis
GC
Hurthle cells- lines residual thyroid follicles
**Eosinopilic in Staining, granular cytoplasm, enlarged nuclei, squamous epithelial cells
Papillary CA, Thyroid Gland
papilla
Most common morphologic form of Thyroid CA (75-85%)
Risk Factor: Irradiation of the head and neck area during the first two decades
Most significant diagnostic basis is the presence of nuclear grooving
Pattern of Spread: Lymphatics
s
s
s
s
papilla
Thyroid follicles
s- stroma Orphan Annie Eye- nuclei of cells (clear)
Parathyroid Adenoma
Cause of 75-80% of Hyperparathyroidism Hypercalcemia
Solitary Capsulated
Proliferating chief cells
Hemorrhage, Adrenal Gland
Blood vessel
Area of hemorrhage
Area of hemorrhage