Patch test allergens - Dermat Medical Supplies · Bakery Allergens BA 19 Cosmetics COS 20 Cutting Oils I ... TROLAB patch test allergens can be used with ... the numbers will later

June 2009

TROLAB®

Patch test allergens

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TROLAB�

Patch test allergens

AII TROLAB Patch Test Allergens areregistered as MEDICINES in Germany withthe Paul Ehrlich Institute, Langen.

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IndexPage

Patch testing with TROLAB® allergens 5/6

Application of test substances 6-11

Interpretation of test results 12

Information on the irritancy control patch test with Sodiumlaurylsulfate (SLS) 0.25 % in water 13-16

Storage and shelf life 16

Screening series: 17-38

Baseline Series (European) BS 17/18

Control irritant IR 19

Antioxidants AO 19

Bakery Allergens BA 19

Cosmetics COS 20

Cutting Oils I (current) CO I 21/22

Cutting Oils II (historical) CO II 22

Dental Materials DM 23

Disinfectants DIS 24

Epoxy Resin Systems ERS 24

Hairdressing HD 25

Industrial Biocides IB 25/26

Medicaments I - Antibiotics ME I 26

Medicaments II - Antiseptics, Antimycotics ME II 26

Medicaments III - Miscellaneous ME III 27

Medicaments IV - Local Anaesthetics ME IV 27

Medicaments V - Corticosteroids ME V 27

Medicaments VI - Ophthalmics ME VI 28

Metal Compounds MC 28

Methacrylates MA 28/29

Perfumes, Flavours PF 29-31

Photoallergens PA 31/32

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Photographic Chemicals PC 32

Plants PL 33

Plastic Materials PM 33

Preservatives PR 34

Rubber Chemicals RC 35

Shoe Allergens SH 36

Sunscreen Agents SA 36

Textile and Leather Dyes TD 37

Vehicles, Emulsifiers VE 37/38

Miscellaneous MIC 38

Service Items 38

International Standard Series of Patch Testing 39/40

List of test substances 41-49

List of INCI names for TROLAB®

substances 50-53

Ordering procedure 54

List of TROLAB® distributors 54-57

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Patch testing with TROLAB allergens

Patch testing is the most important diagnosticand investigative method currently available forstudying allergic contact dermatitis in clinicalpractice. The method includes the epicutaneousapplication of a specific allergen at a definedconcentration and in a defined vehicle which willinduce a cutaneous inflammatory reaction in asensitised person, but will cause no reaction in anon-sensitised person.

TROLAB patch test allergens have alwaysbeen developed, revised and produced followingthe recommendations of the International ContactDermatitis Research Group (ICDRG) and theEuropean Environmental and Contact DermatitisResearch Group (EECDRG). Their many yearsexperience helped us to select the test sub-stances and determine test concentrations andtest vehicles, so that generally the test allergensdo not trigger toxic reactions whilst allergic onescan be induced. Today we add new test allergensto the TROLAB programme only, if test concentra-tions and vehicles have been proven andconfirmed in clinical trials.

TROLAB patch test allergens are dispersed inpetrolatum (if no other vehicle is indicated) andfilled in 5 ml syringes. Some test allergens containadditives like e.g. sorbitan sesquioleate or solidparaffin. These additives are indicated on thesyringe lable.

Almirall’s experience as a pharmaceuticalcompany specialising in the production of topicaldermatological products also guarantees that thepatch test allergens are produced in a high gale-nic quality.

TROLAB patch test allergens are produced inaccordance with the WHO guidelines of GoodManufacturing Practice. Raw materials are selec-ted carefully. The allergens are homogenouslyincorporated into the ointment in the form of extre-mely small particles. The stability of the final pro-duct is checked by chemical analysis.

AII TROLAB Patch Test Allergens are registe-red as MEDICINES in Germany with the PaulEhrlich Institute, Langen.

Our overall objective is to offer our customershigh quality standardised patch test allergens.However, it should be noted that the interpretationof the test results requires much experience onthe part of the testing physician, i.e. careful anam-nesis and examination of the clinical findings forthe final assessment of the relevance of the testresults.

Application of test substances

TROLAB patch test allergens can be used withall types of patch test plaster. Very well acceptedare Finn Chambers on Scanpor�*. It is important toconsider that all test concentrations were definedby using this test plaster.The following descriptionis for using Finn Chambers on Scanpor� (for othertest plasters please follow instructions of manufac-turers).

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*Product/Trademark of Epitest Ltd. Oy, Finland

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Fig. 1: Marking of the test tape

When using Finn Chambers on Scanpor�, theserial numbers of the substances to be tested mustbe clearly marked on the upper side of the adhesi-ve tape (Fig. 1), for example: S1 - S10 (Standard,substances 1-10). The small tape sections carryingthe numbers will later remain on the skin and allowto perform the reading with the practical ReadingPlate*.

Fig. 2: Removal of the protective foil

Remove the protective foil.

*Product/Trademark of Epitest Ltd. Oy, Finland

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Fig. 3: Application of test ointments

Place the test tape in front of you, as shown inFig. 3. Now you can fill the chambers downwardstarting on the top right row. The test ointments areapplied directly into the aluminium chambers (Fig.3). The chambers must never be filled completelybut only slightly more than half-full (5 mm length).No substance should be brought on the rim of thechamber!

Fig. 4 a + 4 b : Application of test solutions

When using test solutions, a filter paper dischas to be placed into the chamber first (Fig. 4 a).The filter paper has to be saturated with one drop

of the test solution (Fig. 4 b). Please avoid excess.On the other hand, the filter paper disc must notdry up, as in that case false-negative test resultswould have to be expected. We recommend to pre-pare the plaster just before applying it to the pati-ent’s skin in order to achieve relevant test results.

The test tapes that have been prepared asdescribed are applied to the back in normal uprightposition, with the lower margin being fastened first.Thereafter they are pressed against the skin with

the palm, gradually from bottom to top, and thencarefully stroked down. The air can thereby escapefrom the chambers and a good fixation is achieved.Subsequently, the test chambers are again pressedagainst the skin two to three times, exerting slightpressure with the fingers in order to spread the testsubstances evenly on the skin (Fig. 5 a + 5 b). Theadhesive tapes should be applied only to the cleanand dry skin (non-greasy, no ointment residuesetc.). You might use diluted alcohol to clean theskin.

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Fig. 5 a + 5 b: Application of the test tape

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The Reading Plate is a simple aid to recognizethe test reactions without having to mark the skin ofthe patient with ink. As a preparation for the rea-ding, before the test chambers are filled, the num-bers of the substances to be applied have alreadybeen noted on the upper ends of the adhesivetapes (see Fig. 1). Fig. 6 demonstrates how to usethe Reading Plate when the adhesive tape is remo-ved (usually after 48 hours). The cutting edge of theplate is slightly pressed against the test tape at anangle of about 45 degrees. The broader side of theplate should thereby be held on the left. Now,grasp the test tape and tear it off in a brisk upwardmovement, thereby leaving the strip (about 1 cmwide) where the numbers are marked (Fig. 7). Afterthe removal of the Finn Chambers on Scanpor�, cir-cular imprints on the skin reveal whether the testprovided adequate occlusion. If these imprints arenot visible, the test has to be repeated (it is knownfrom experience that this rarely happens if theadhesive test tapes were properly applied).

Fig. 6: Preparations for the readingby means of the Reading Plate

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Fig. 7 demonstrates how the Reading Plate isused during the first as well as during the subse-quent readings when the circular imprints of thetest chambers on the skin have already disappea-red. Place the left corner of the Reading Plate onthe left corner of the remaining strip of the adhesi-ve tape. The holes in the plate now indicate thelocations of the test sites.

Please note:

The first reading should be performed about20 to 30 minutes after the removal of the tape, assome skin sensitive persons will react with rednessafter tape removal. Excessive test ointments haveto be carefully removed with an individual swab forevery substance prior to the first reading. Makesure not to wipe the excessive ointments into theadjacent test areas.

If no Reading Plate is available, the locations ofthe individual test chambers have to be marked onthe skin with a suitable marking pen before remov-ing the test tape, so that positive test results can beclearly identified during further readings after 72and 96 hours.

Fig. 7: Reading by means of the Reading Plate

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Interpretation of test results

When recording the results in the patient’s testsheet, it is important to score according to the reac-tion actually seen and not according to the subjec-tive interpretation placed on the reaction by the read-er. Irritant reactions should be recorded as positiveirritant (IR) and not as negative.

To recognize irritant reactions it may be helpfulto know of the irritability of the skin at the test sideand the time of testing. Almirall is offering Sodium-laurylsulfate (SLS) 0.25 % in water as a control irri-tant for patch testing. Information on the irritancycontrol patch test with SLS 0.25 % in water can befound on the following pages.

Recording of patch test reactions

Score Morphology Interpretation- no reaction negative

?+ faint erythema only doubtful reaction+ erythema, infiltration, possibly papules weak positive reaction++ erythema, infiltration, papules, vesicles strong positive reaktion+++ intense erythema and infiltration and extreme positive reaction

coalescing vesiclesIR irritant reactions of different types irritant reactionNT not tested

Whether or not the positive test reaction demon-strated by the patch testing is relevant to the patient’sdermatitis, either as the primary cause or as anaggravating factor, must be determined by the criti-cal judgement of the physician. If the clinical and his-torical facts are consistent with the patch test result,one can be reasonably certain of its significance.

In doubtful cases, a repeated open applicationtest (ROAT) in the antecubital space or on the outeraspect of the upper arm may be helpful.

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Information on the irritancy control patchtest with Sodiumlaurylsulfate (SLS) 0.25% inwater

Why to do an irritancy control when patchtesting with contact allergens.

Every contact allergen produces an irritancyeffect on the skin to some degree. It is thought thatthis irritancy is important for a substance to be ableto act as a contact allergen. Due to this particularproperty, irritant or false positive test reactions mayoccur in diagnostic patch testing with contact aller-gens. The frequency and extent of such unwantedreactions differ not only between allergens but alsobetween individuals, depending on their particularsensitivity to irritants. This irritability may vary bet-ween different skin regions and over the course oftime. Therefore, the German Contact DermatitisResearch Group (Deutsche Kontaktallergie-Grup-pe ; DKG) recommends to perform an irritancy con-trol patch test when patch testing with contact all-ergens, in order to assess the individual sensitivityto irritants at the time of patch testing in the testarea.

Which irritant is suitable?

There are different kinds of irritants, e.g. weakbases or acids, or detergents, which disturb theepidermal barrier. For the purpose of an irritancycontrol patch test, Sodiumlaurylsulfate (SLS) hasproved useful. SLS is not an allergen and, tested ata low concentration it causes visible reactions onlyin very sensitive individuals. DKG studies haveshown that patients, in whom SLS 0.25 % in waterelicited an irritant reaction, had questionable andweak positive patch test reactions to contact aller-gens more frequently than others. In most cases,these patch test reactions, too, are irritant, and notallergic, reactions. Thus, patch testing with the irri-tant SLS 0.25 % in water as a marker for sensitive

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skin facilitates the assessment of erythematous andweak positive patch test reactions to contact aller-gens.

How to perform and read the SLS patch testand how to interpret the results.

The irritancy control patch test with SLS 0.25 %in water is performed in exactly the same manneras the classical contact allergen patch test. Forreading and assessment of the test reactions, theDKG recommends the following categories (modi-fied from Tupker et al. 1997):

Score Morphology Interpretationsls0 no reaction negativesls1 very weak/slight erythema or scaling (spotty or diffuse) doubtfulsls2 weak/slight erythema, scaling oedema or roughness weaksls3 moderate erythema, scaling, oedema or roughness, moderate

or weak/slight erosions, vesicles or fissuressls4 strong erythema, scaling, oedema or roughness, strong

or clear erosions, vesicles or fissures

When patch testing with SLS 0.25 % in water,only very rarely reactions of grade sls3 or sls4occur. In the DKG studies, less than 30 % of thepatients tested had a reaction; most of the reac-tions were classified as sls1 or sls2. In patientshaving a visible reaction of this kind, an increasedirritability of the skin is probable.

sls1 - Reaction

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Significance and limitations of the irritancy con-trol patch test.

An irritant reaction (sls1 or stronger) to SLS0.25% in water does not automatically mean thatevery weak patch test reaction to an allergen isalso an irritant; however, the probability that an irri-tant erythema or a weak false positive reactionoccurs in this patient is markedly higher. This isparticularly true for test allergens known to have anincreased irritant potential. The irritancy controlpatch test facilitates the assessment of this kind oftest reactions; however, it does not replace theneed for a thorough interpretation of the test reac-tions (allergic versus irritant) by the physician andfor the assessment of clinical relevance.

sls2 - Reaction (focus on scaling)

sls2 - Reaction (focus on oedema)

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As mentioned above, the irritability of the skinmay vary between body regions and over the cour-se of time. Thus, the irritancy control patch test withSLS only gives information about the irritability ofthe test region (upper back) at the time of patchtesting. It can be considered a regionally limitedsnapshot, which does not allow any generalisationconcerning the patients’ skin irritability.

References:Brasch J, Becker D, Effendy I:

Reproducibility of irritant patch test reactions to sodiumlauryl sulfate in a double-blind placebo-controlled ran-domized study using clinical scoring. Results from astudy group of the German Contact Dermatitis ResearchGroup (Deutsche Kontaktallergie-Gruppe, DKG).Contact Dermatitis 41, 150-155 (1999)

Geier J, Uter W, Pirker C, Frosch PJ:Patch testing with the irritant sodium lauryl sulfate (SLS)is useful in interpreting weak reactions to contact aller-gens as allergic or irritant.Contact Dermatitis 48, 99-107(2003)

Löffler H, Becker D, Brasch J, Geier J for the German ContactDermatitis Research Group (DKG):Simultaneous sodium lauryl sulfate testing improves thediagnostic validity of allergic patch tests. Results from aprospective multicentre study of the German ContactDermatitis Research Group (Deutsche Kontaktallergie-Gruppe, DKG)British Journal of Dermatology 152, 709-719 (2005)

McFadden JP, Basketter DA:Contact allergy, irritancy and ‚danger‘.Contact Dermati-tis 42, 123-127 (2000)

Tupker RA, Willis C, Berardesca E et al.:Guidelines on sodium lauryl sulfate (SLS) exposuretesting. Contact Dermatitis 37, 53-69 (1997)

Storage and shelf life

For each individual TROLAB allergen storage condi-tions are mentioned on the label.

TROLAB allergens should not be used after theexpiry date!

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BS

SerialSubstance

Concen- Art.No. tration No.

1 Potassium Dichromate 0.5 % E0001

2 Neomycin Sulphate 20 % E0010

3 Thiuram Mix 1 % E0023(Tetramethylthiuram Disulphide,Tetraethylthiuram Disulphide, Tetramethylthiuram Monosulphide,Dipentamethylenethiuram Disulphide; 0.25 % each)

4 Fragrance Mix II 14 % E2860(alpha-Hexyl cinnamaldehyde 5 %, Citral 1 %, Citronellol 0.5 %, Farnesol 2.5 %, Coumarin 2.5 %,Hydroxymethylpentylcyclohexenecarboxaldehyde 2.5 %)

5 Cobalt Chloride, 6H2O 1 % E0002

6 4-Phenylenediamine free base 1 % E0034

7 Benzocaine 5 % E0011

8 Formaldehyde (in water) 1 % E0004

9 Colophony 20 % E0017

9 Clioquinol 5 % E0015

11 Balsam of Peru 25 % E0008

12 N-Isopropyl-N’-phenylParaphenylenediamine 0.1 % E1004

13 Wool Alcohols 30 % E0020

14 Epoxy Resin 1 % E0021

15 Mercapto Mix 1 % E0025(N-Cyclohexylbenzothiazyl Sulphenamide, Dibenzothiazyl Disulphide,Morpholinylmercaptobenzothiazole; 0.33 % each)

16 Budesonide 0.1 % E2504

TROLAB® Baseline Series (European)

The Baseline series consists of the minimum recommended test set to be used during routinediagnostic patch test investigations and which will be ordinarily supplemented by additional seriesand other allergens as appropriate to adequately investigate the clinical problem.Assuming that this recommandation is followed we have not placed any substance from theBaseline series in one of the other series to avoid double patch testing.The only exception is the Fragrance Mix (E0029) which is also included in the series Photoallegens.

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Baseline series continued BS

SerialSubstance


17 Paraben Mix 16 % E2469(Methyl Parahydroxybenzoate, Ethyl Parahydroxy-benzoate, Propyl Parahydroxybenzoate, ButylParahydroxybenzoate; 4 % each)

18 Paratertiarybutyl Phenol Formaldehyde Resin 1 % E0030

19 Fragrance Mix 8 % E0029(Cinnamyl Alcohol, Cinnamaldehyde, Eugenol, alpha-Amyl-Cinnamaldehyde, Hydroxycitronellal,Geraniol, Isoeugenol, Oak Moss Absolute; 1 % each; Sorbitan Sesquioleate 5 %)

20 Quaternium-15 1 % E0031

21 Nickel Sulphate, 6H2O 5 % E0003

22 5-Chloro-2-methyl-4-isothiazolin-3-one +2-Methyl-4-isothiazolin-3-one(3:1 in water) 0.01 % E0115

23 Mercaptobenzothiazole 2 % E1010

24 Sesquiterpene Lactone Mix 0.1 % E2459(Alantolactone, Dehydrocostunolide, Costunolide; 0.033 % each)

25 Tixocortol pivalate 1 % E2940

26 Dibromodicyanobutane 0. 3 % E2516

27 Hydroxymethylpentylcyclohexene-carboxaldehyde 5 % E2824

28 Primin (important only in some countries) 0.01 % E0032

RemarksThe single ingredients of the Thiuram Mix and the Mercapto Mix are listedunder Rubber Chemicals, page 35, the Paraben Mix ingredients are listed underPreservatives, page 34, and the constituents of the Fragrance Mix / FragranceMix II are listed under Perfumes, Flavours, pages 29-31.Serial No. 1 Potassium Dichromate: slightly irritant; when relevance is indoubt, retest at 0.25 % (E2506 p. 38).Serial No. 19 Fragrance Mix: contains the emulsifier Sorbitan Sesquioleate (E1703).Serial No. 20 Quaternium-15: formaldehyde releaser.

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Antioxidants AO

SerialSubstance


1 Butyl Hydroxytoluene 2 % E0110

2 Butyl Hydroxyanisole 2 % E0111

3 Dodecyl Gallate (Lauryl Gallate) 0.3 % E2496

4 tert.-Butylhydroquinone 1 % E2434

5 Propyl Gallate 0.5 % E2497

6 Octyl Gallate 0.3 % E2495

Control irritant IR

Sodiumlaurylsulfate (SLS) (in water) 0.25 % E2893

Bakery Allergens BA

1 Vanillin 10 % E1310

2 Eugenol * 1 % E1302

3 Isoeugenol * 1 % E1306

4 Sodium Benzoate 5 % E2385


6 Menthol 1 % E2304

7 Cinnamyl Alcohol * 1 % E1300

8 Cinnamaldehyde * 1 % E1301

9 Butyl Hydroxyanisole 2 % E0111

10 Sorbic Acid 2 % E0113

11 Octyl Gallate 0.3 % E2495

12 Dipentene (dl-Limonene) 2 % E2000

13 Propyl Gallate 0.5 % E2497

14 Dodecyl Gallate (Lauryl Gallate) 0.3 % E2496

* Ingredients of the Fragrance Mix (E0029)

RemarksThe following series should be tested in addition:Baseline Series • Antioxidants • Preservatives • Disinfectants • SunscreenAgents • Vehicles, Emulsifiers • Hairdressing series (in case of head andneck eczema).

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SerialSubstance


Cosmetics COS

1 Hydroquinone 1 % E0800

2 Toluenesulphonamide FormaldehydeResin 10 % E0908

3 Abitol� 10 % E0915

4 Benzyl Salicylate 1 % E1102


6 Lemon Grass Oil 2 % E1355

7 Balsam of Tolu 20 % E1652

8 Cocamidopropylbetaine (in water) 1 % E2303

9 Abietic Acid 10 % E2382

10 Sodium Benzoate 5 % E2385

11 Benzyl Alcohol 1 % E2388

12 Dexpanthenol 5 % E2387

13 Sodium Metabisulfite 1 % E2412

14 Benzophenone 4 10 % E2500

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SerialSubstance


Cutting oils I (current) CO I

1 7-Ethylbicyclooxazolidine * 1 % E2422

2 1,3,5-Tris(2-hydroxyethyl)-hexahydrotriazine 1 % E0119

3 Triclosan 2 % E0158

4 Benzotriazole 1 % E0159

5 Benzylhemiformal * 1 % E2450

6 Trolamine (Triethanolamine) 2.5 % E1701

7 Monoethanolamine 2 % E2445


9 Diethanolamine 2 % E2401

10 Octylisothiazolinone 0.025 % E2427

11 Methylene-bis(methyloxazolidine) * 1 % E2452

12 Paratertiary Butylphenol 1 % E0920

13 Di-n-Butylphthalate 5 % E0903

14 Di-2-Ethylhexyl-Phthalate 5 % E0960

15 Tricresyl Phosphate (isomere blend) 5 % E2511

16 Polyethylene Glycol Ointment 100 % E2337

17 Isopropyl Myristate 10 % E2336

18 Adeps lanae 30 % E2335

19 Propyleneglycol 5 % E2323


21 Phenoxyethanol 1 % E2392

22 tert.-Butylhydroquinone 1 % E2434

23 Cetyl/Stearyl Alcohol 20 % E1704

24 Bis(diethyldithiocarbamato) Zinc 1 % E1009

25 1,2-Benzisothiazolin-3-one, Na-Salt 0.1 % E2471

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SerialSubstance


Cutting oils II (historical) CO II

1 Chloroxylenol 1 % E0106

2 Chloracetamide 0.2 % E0117


4 Coconut Diethanolamide 0.5 % E2424

5 Nitrobutylmorpholine /Ethylnitrotrimethylenedimorpholine * 1 % E2426

6 Dibromodicyanobutane 0.2 % E2939

7 Hexamethylenetetramine 1 % E2318

8 Chlorocresol 1 % E0105

9 Morpholinylmercaptobenzothiazole 0.5 % E1015

10 Ethylenediamine Dihydrochloride 1 % E0027

11 Bronopol * 0.5 % E0107

RemarksFurther substances used in the past in cutting oils are included in the BaselineSeries: E0008, E2469, E0029.Serial No. 6 Dibromodicyanobutane: content of Dibromodicyanobutane/Phenoxyethanol (1:4) (E2515)* formaldehyde releaser.

Cutting oils I (current) continued CO I

26 Diglycolamine 1 % E2884

27 Iodopropynyl Butylcarbamate 0. 2 % E2883

Remarks to Cutting oils I (current)Further substances currently used in cutting oils are included in the BaselineSeries: E0020, E0017, E1010, E0004, E0115.Serial No. 19 Propyleneglycol: retesting at 20 % in water (E2472) can benecessary.Serial No. 21 Phenoxyethanol: content of Dibromodicyanobutane/Phenoxyethanol (1:4) (E2515)* formaldehyde releaser.

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SerialSubstance


Dental Materials DM

1 Menthol 1 % E2304

2 Peppermint Oil 2 % E1358

3 Benzoyl Peroxide 1 % E0201


5 Bisphenol A 1 % E0965

6 Methyl Methacrylate 2 % E1800

7 N,N-Dimethyl-p-Toluidine 2 % E0963

8 Ethyleneglycol Dimethacrylate 2 % E1850

9 Triethyleneglycol Dimethacrylate 2 % E1851

10 BIS-GMA 2 % E1852

11 Diurethane Dimethacrylate 2 % E2475

12 (2-Hydroxyethyl) Methacrylate (2-HEMA) 1 % E2477

13 Eugenol 1 % E1302

14 Ammoniated Mercury 1 % E0602

15 Potassium Dicyanoaurate (in water) 0.002 % E0605

16 Sodium Thiosulfatoaurate 0.25 % E2507

17 Palladium Chloride 1 % E0651

18 Ammonium Tetrachloroplatinate 0.25 % E0650

19 Amalgam 5 % E2509

20 Amalgam Alloying Metals 20 % E2508

RemarksSerial No. 3 Benzoyl Peroxide: slightly irritant; when relevance is in doubt,retest at 0.5 % or open testing.Serial No. 13 Eugenol: ingredient of the Fragrance Mix.

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SerialSubstance


Disinfectants DIS

1 Chlorhexidine Digluconate (in water) 0.5 % E0114

2 Glutar(di)aldehyde 0.3 % E2498

3 Benzalkonium Chloride 0.1 % E2339

4 Cetylpyridinium Chloride 0.1 % E2315

5 Glyoxal Trimer (Dihydrate) 1 % E2517

6 Cetalkonium Chloride 0.1 % E2433

Epoxy Resin Systems ERS

Reactive diluents

1 Cresylglycidylether 0.25 % E0917

2 Phenylglycidlyether 0.25 % E2807

3 Butylglycidylether 0.25 % E2808

4 1,6-Hexanedioldiglycidylether (techn. grade) 0.25 % E2876

5 1,4-Butanedioldiglycidylether 0.25 % E2875

6 p-tert-Butylphenylglycidylether 0.25 % E2880

Hardeners


8 Triethylenetetramine 0.5 % E0905

9 4,4’-Diaminodiphenyl Methane 0.5 % E0906

10 Isophoronediamine 0.5 % E0914


12 Trimethylhexane-1,6-diamine(isomere blend) 0. 5 % E2946

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SerialSubstance


Industrial Biocides IB

1 7-Ethylbicyclooxazolidine * 1 % E2422



4 1,3,5-Tris(2-hydroxyethyl)-hexahydrotriazine * 1 % E0119


6 Benzylhemiformal * 1 % E2450

7 Nitrobutylmorpholine /Ethylnitrotrimethylenedimorpholine * 1 % E2426


9 Methylene-bis(methyloxazolidine) * 1 % E2452

10 Dibromodicyanobutane 0.2 % E2939

11 1,2-Benzisothiazolin-3-one, Na-Salt 0.1 % E2471

RemarkSerial No. 4 Ammonium Persulphate: Caution: This allergen might elicit a Type I reaction.

Hairdressing HD

1 4-Toluenediamine (dye complex) 1 % E0308

2 Glyceryl Monothioglycolate 1 % E0311

3 Monoethanolamine 2 % E2445

4 Ammonium Persulphate 2.5 % E0306

5 4-Aminophenol 1 % E2302


7 Cocamidopropylbetaine (in water) 1 % E2303


9 Resorcinol 1 % E2865

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SerialSubstance


ME II

1 Nystatin 2 % E2491

2 Chlorquinaldol 5 % E0104

3 Fusidic Acid Sodium Salt 2 % E2454

4 Clotrimazole 5 % E2389

5 Dichlorophene 0.5 % E2316

Medicaments II -Antiseptics, Antimycotics

RemarksSerial No. 10 Dibromodicyanobutane: content of Dibromodicyanobutane/Phenoxyethanol (1:4) (E2515).* formaldehyde releaser.

Medicaments I - Antibiotics ME I

1 Bacitracin 20 % E2151

2 Chloramphenicol 5 % E2152

3 Gentamycin Sulphate 20 % E2154

4 Kanamycin Sulphate 10 % E2313

5 Tetracycline Hydrochloride 2 % E2306

6 Sulfanilamide 5 % E2160

7 Erythromycin 1 % E2499

8 Oxytetracycline 3 % E2416

9 Framycetin Sulphate 10 % E2311

Industrial Biocides continued IB


13 Benzotriazole 1 % E0159

14 Iodopropynyl Butylcarbamate 0.2 % E2883

15 Methylisothiazolinone (in water) 0.05 % E2950

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SerialSubstance


Medicaments III - Miscellaneous ME III

1 Benzoyl Peroxide 1 % E0201


3 Bufexamac 5 % E2395

4 Propolis 10 % E1207

5 Resorcinol 1 % E2865

ME IV

1 Cinchocaine Hydrochloride 5 % E0401

2 Tetracaine (Amethocaine) Hydrochloride 1 % E0402

3 Lidocaine Hydrochloride 15 % E0403

4 Polidocanol 3 % E2501

5 Procaine Hydrochloride 2 % E2308

Medicaments IV -Local Anaesthetics

Medicaments V - Corticosteroids ME V

1 Amcinonide 0.1 % E2481

2 Betamethasone-17-valerate 0.12 % E2482

3 Clobetasol-17-propionate 0.25 % E2483

4 Hydrocortisone 1 % E2484

5 Hydrocortisone-17-butyrate 0.1 % E2485

6 Triamcinolone Acetonide 0.1 % E2486

7 Prednisolone 1 % E2505RemarkCorticosteroids: Rebound effect; late readings at 72 h or later for clinicalrelevance.

RemarkSerial No. 1 Benzoyl Peroxide: slightly irritant; when relevance is in doubt,retest at 0.5 % or open testing.

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SerialSubstance


Metal Compounds MC

1 Ammoniated Mercury 1 % E0602

2 Potassium Dicyanoaurate (in water) 0.002 % E0605

3 Sodium Thiosulfatoaurate 0.25 % E2507

4 Ammonium Tetrachloroplatinate 0.25 % E0650

5 Palladium Chloride 1 % E0651

6 Copper Sulphate, 5H2O (in water) 1 % E0604

7 Tin (II)-chloride 0.5 % E2419

RemarkSerial No. 5 Palladium Chloride: cross-reacting especially with Nickel.

Medicaments VI - Ophthalmics ME VI

1 Atropine Sulfate (in water) 1 % E2415

2 Edetic Acid Disodium Salt 1 % E2384

3 Phenylephrine Hydrochloride (in water) 10 % E2414

4 Pilocarpine Hydrochloride (in water) 1 % E2407

5 Polymyxin B Sulfate 3 % E2437

Methacrylates MA

1 (2-Hydroxyethyl) Methacrylate (2-HEMA) 1 % E2477

2 Methyl Methacrylate 2 % E1800

3 Ethyleneglycol Dimethacrylate 2 % E1850

4 Triethyleneglycol Dimethacrylate 2 % E1851

5 BIS-GMA 2 % E1852

6 Diurethane Dimethacrylate 2 % E2475


29

SerialSubstance


Methacrylates continued MA

8 N,N-Dimethyl-p-Toluidine 2 % E0963

9 Benzoyl Peroxide 1 % E0201RemarkSerial No. 9 Benzoyl Peroxide: slightly irritant; when relevance is in doubt,retest at 0.5 % or open testing.

Perfumes, Flavours PF

1 Benzyl Salicylate 1 % E1102

2 Benzylcinnamate 5 % E1351

3 Salicylaldehyde 2 % E1359


5 Benzyl Alcohol 1 % E2388

6 Benzaldehyde 5 % E1350

7 Menthol 1 % E2304


9 Gamma Methyl Ionone 1 % E2886

10 Anisyl Alcohol 1 % E2887

11 alpha-Amylcinnamyl Alcohol 1 % E2888

12 Benzyl Benzoate 1 % E2889

13 Lilial 10 % E2892

14 Linalool (stabilized) 10 % E2930

15 Methyl Heptine Carbonate 1 % E2933

16 Majantol 5 % E2885

Essential Oils / Extracts

17 Tree Moss 1 % E2947

18 Clove Oil 2 % E1308

19 Orange Oil 2 % E1309

30

SerialSubstance


Perfumes, Flavours continued PF

20 Cedarwood Oil 10 % E1352

21 Eucalyptus Oil 2 % E1353

22 Laurel Leaf Oil 2 % E1354

23 Lemon Grass Oil 2 % E1355

24 Lemon Oil 2 % E1356

25 Neroli Oil 2 % E1357

26 Peppermint Oil 2 % E1358

27 Ylang-ylang (I+II)-Oil 10 % E2891

28 Narcissus absolute 2 % E2934

29 Jasmin absolute 5 % E2935

30 Sandalwood oil 10 % E2936

31 Patchouli oil 10 % E2937

Constituents of the Fragrance Mix 8% in pet (E0029)

32 Cinnamyl Alcohol 1 % E1300

33 Cinnamaldehyde 1 % E1301

34 Eugenol 1 % E1302

35 alpha-Amyl-Cinnmaldehyde 1 % E1303

36 Hydroxycitronellal 1 % E1304

37 Geraniol 1 % E1305

38 Isoeugenol 1 % E1306

39 Oak Moss Absolute 1 % E1307

40 Sorbitan Sesquioleate 20 % E1703

Constituents of the Fragrance Mix II 14% in pet (E2860)

41 Citral 2 % E2839

42 Citronellol 1 % E2842

43 Farnesol 5 % E2848

31

SerialSubstance


Photoallergens PA

1 5-Bromo-4’-chlorosalicylanilide 1 % E2354

2 Hexachlorophene 1 % E0101

3 Bithionol 1 % E0100

4 Sulfanilamide 5 % E2160

5 Promethazine Hydrochloride 0.1 % E2356

6 Quinidine Sulphate 1 % E2358

7 Fragrance Mix 8 % E0029

8 4-Aminobenzoic Acid (PABA)* 10 % E2359

9 2-Ethylhexyl-4-Dimethylaminobenzoate* 10 % E2365

10 Benzophenone 4 * 10 % E2500

11 4-tert-Butyl-4’-Methoxy-Dibenzoylmethane * 10 % E2364

12 Isoamyl-4-methoxycinnamate * 10 % E2368

13 2-Ethylhexyl-4-Methoxycinnamate * 10 % E2366

14 3-(4-Methylbenzylidene)-Camphor * 10 % E2362

15 2-Phenyl-5-benzimidazole-Sulphonic Acid* 10 % E2367

16 Oxybenzone * 10 % E2361

Perfumes, Flavours continued PF

RemarkSerial Nos. 32-39 contain the emulsifier Sorbitan Sesquioleate (E1703).

44 Coumarin 5 % E2845

45 alpha-Hexyl cinnamaldehyde 10 % E2836

Hydroxymethylpentylcyclohexene-carboxaldehyde (Lyral®) is part of the Fragrance Mix II. Lyral® is not included in this test series as Lyral® is alreadytested in the Baseline Series 5 % E2824

32

SerialSubstance


Photographic Chemicals PC

1 Ammonium Persulphate 2.5 % E0306

2 4-Methylaminophenol Sulphate (Metol) 1 % E0801

3 Color Developer CD 2 1 % E0803



6 Pyrogallol 1 % E0350



9 Triphenyl Phosphate 5 % E0959


11 Edetic Acid Disodium Salt 1 % E2384

12 Diethanolamine 2 % E2401



RemarksPhotoallergens have to be patch tested in duplicate; one series is irradiatedwith 5 to 10 J UV-A. * Sunscreen Agents.Serial No. 7 Fragrance Mix: the single constituants are listed under Perfumes,Flavours, pages 29-31.

33

SerialSubstance


Plastic Materials PM

1 Phenol Formaldehyde Resin, Novolac * 5 % E0901

2 Abitol® 10 % E0915

3 Turpentine Oil 10 % E2322

4 Parateriary Butylphenol 1 % E0920

5 Di-n-Butylphthalate 5 % E0903

6 Tricresyl Phosphate 5 % E2511

7 Triphenyl Phosphate 5 % E0959

8 Dimethylphthalate 5 % E0954

9 Di-2-Ethylhexyl-Phthalate 5 % E0960

10 Bisphenol A 1 % E0965


12 4-tert.-Butylcatechol 0.25 % E2810

Plants PL


2 Usnic Acid 0.1 % E2052

Remark* Patch testing of the patient’s own resin is recommended.

34

SerialSubstance


Remarks* content of Dibromodicyanobutane/Phenoxyethanol (1:4) (E2515).** formaldehyde releaser.

Preservatives PR



3 Bronopol ** 0.5 % E0107

4 Imidazolidinyl Urea ** 2 % E0109

5 Phenylmercuric Acetate 0.01 % E2863

6 Sorbic Acid 2 % E0113


8 Thiomersal 0.1 % E0600

9 Chlorquinaldol 5 % E0104


11 Diazolidinyl Urea ** 2 % E2386

12 Dibromodicyanobutane/Phenoxyethanol (1:4) 1 % E2515

13 DMDM Hydantoin (in water) ** 2 % E2476

14 Phenoxyethanol * 1 % E2392


16 Dibromodicyanobutane * 0.2 % E2939

17 Iodopropynyl Butylcarbamate 0.2 % E2883

18 Methylisothiazolinone (in water) 0.05 % E2950

Constituents of the Paraben Mix

19 Methyl Parahydroxybenzoate 3 % E0151

20 Ethyl Parahydroxybenzoate 3 % E0152

21 Propyl Parahydroxybenzoate 3 % E0153

22 Butyl Parahydroxybenzoate 3 % E0154

35


2 Diphenylthiourea 1 % E1021

3 Dibutylthiourea 1 % E1025

4 1,3-Diphenylguanidine 1 % E1002

5 Bis(diethyldithiocarbamato) Zinc 1 % E1009

6 N,N’-Diphenyl Paraphenylenediamine 0.25 % E1013

7 Bis(dibutyldithiocarbamato) Zinc 1 % E1019

8 Cyclohexyl Thiophthalimide 0.5 % E2805

9 4,4’-Dihydroxybiphenyl 0.1 % E1005

10 Zinc dibenzyldithiocarbamate 1 % E2864

11 4-tert.-Butylcatechol 0.25 % E2810

Constituents of the Thiuram Mix

12 Tetramethylthiuram Disulphide 0.25 % E1011

13 Tetraethylthiuram Disulphide 0.25 % E1016

14 Tetramethylthiuram Monosulphide 0.25 % E1008

15 Dipentamethylenethiuram Disulphide 0.25 % E1017

Constituents of the Mercapto Mix

16 Dibenzothiazyl Disulphide 1 % E1014

17 N-Cyclohexylbenzothiazyl Sulphenamide 1 % E1000

18 Morpholinylmercaptobenzothiazole 0.5 % E1015

Rubber Chemical RC

SerialSubstance


36

Sunscreen Agents SA

1 2-Phenyl-5-benzimidazole-Sulphonic 10 % E2367Acid

2 4-tert-Butyl-4’- 10 % E2364Methoxy-Dibenzoylmethane

3 4-Aminobenzoic Acid (PABA) 10 % E2359

4 2-Ethylhexyl- 10 % E23654-Dimethylaminobenzoate

5 2-Ethylhexyl-4-Methoxycinnamate 10 % E2366

6 3-(4-Methylbenzylidene)-Camphor 10 % E2362

7 Oxybenzone 10 % E2361

8 Isoamyl-4-methoxycinnamate 10 % E2368

9 Benzophenone 4 10 % E2500

SerialSubstance


RemarkSunscreen Agents might also elicit photoallergic reactions.

Shoe Allergens SH


2 Disperse Orange 3 1 % E0502

3 Acid Yellow 36 1 % E2403

4 Monobenzone 1 % E1001

5 Diphenylthiourea 1 % E1021

6 1,3-Diphenylguanidine 1 % E1002

7 Dibutylthiourea 1 % E1025


1 Disperse Orange 3 1 % E0502

2 Disperse Yellow 3 1 % E0503

3 Disperse Red 1 1 % E0504


5 Disperse Blue 3 1 % E0506


7 Disperse Yellow 9 1 % E2479

8 Naphthol AS 1 % E2474


10 Acid Yellow 36 1 % E2403

11 Bismarck Brown R 0.5 % E2428

12 Disperse blue 106 0.3 % E2948

13 Disperse blue 124 0.3 % E2949

37

Textile and Leather Dyes TD

SerialSubstance


RemarkSerial No. 8 Naphthol AS: dye coupler.

Vehicles, Emulsifiers VE


2 Propyleneglycol 5 % E2323

3 Sorbitan Sesquioleate 20 % E1703

4 Cetyl/Stearyl Alcohol 20 % E1704

5 Amerchol� L 101 50 % E1750

6 Polyethylene Glycol Ointment 100 % E2337

7 Isopropyl Myristate 10 % E2336

8 Adeps lanae 30 % E2335

9 Coconut Diethanolamide 0.5 % E2424

38

SerialSubstance


Service Items

1 Empty service and storage box for 12 substanceswith 1 blank drawer insert D9100

2 Empty service and storage box for 24 substanceswith 2 blank drawer inserts E9101

3 Empty service and storage box for 36 substanceswith 3 blank drawer inserts D9229

4 Empty service and storage box for 60 substanceswith 5 blank drawer inserts D9102

5 Blank drawer inserts for service and storage box D9112

6 Patient's test sheet E9104

7 TROLAB® Brochure E9105

Miscellaneous MIC

1 Hexylresorcinol 0.25 % E0312

2 Potassium Dichromate 0.25 % E2506

3 Propyleneglycol (in water) 20 % E2472

4 White Petrolatum 100 % E8999

5 4-Aminoazobenzene 1 % E2435

RemarksSerial No. 2 Propyleneglycol: retesting at 20 % in water (E2472) can be necessary.Serial No. 3 Sorbitan Sesquioleate: as emulsifier used in Fragrance Mix and in thesingle ingredients of the Fragrance Mix.Serial No. 6 Polyethylene Glycol Ointment: 1:1 mixture of Polyethylene Glycol300 & 1500.

39

International Standard Series of Patch TestingProposed allergens for a modified international standard series by the InternationalContact Dermatitis Research Group - ICDRG. Contact Dermatitis 1997, 36, 121-123

1) Potassium Dichromate 0.5 %2) Neomycine Sulfate 20 %3) Thiuram Mix 1 % a

4) Parapheneylendiamine (PPD) base 1 % b

5) Formaldehyde 1 % aq.

6) Colophony 20 %7) Balsam of Peru 25 %8) Wool (lanolin) Alcohols 30 %9) Mercapto Mix 1 % c

10) Epoxy Resin 1 %11) Paratertiarybutyl Phenol Formaldehyde (BPF) Resin 1 %12) Fragrance Mix 8 % d

13) Nickel Sulfate (NiSO4 · 6H2O) 2.5 % 1

14) Mercaptobenzothiazole (MBT) 1 % e

15) Budesonide 0.1 % f

16) Quaternium 15 2 % g

17) Cl + Me-isothiazolinone 0.01 % aq.h

18) Imidazolidinyl Urea 2 % aq.19) Tixocortol Pivalate 1 % 20) Dibromodicyanobutane 0.1 % i

Statements given by the ICDRG:a) Thiuram Mix lacks high specificity and sensitivity

b) Some cases of hair dye dermatitis could be missed with the use of PPD alone.

c) Mercapto Mix lacks high specificity and sensitivity. The 1% mix, used in the NorthAmerican standard series, is chosen since its stability has been proven by Hermal andapproved by the FDA.

d) If positive, breakdown is needed.

e) MBT can identify cases of allergic contact dermatitis negative to Mercapto Mix, andvice versa.

f) Despite its absence in 3 standard series, Budesonide is highly recommended in aninternational standard series, since it is considered an important marker forcorticosteroid allergy.

g) It is an important allergen in the United Kingdom, while it is not used in Japan.

h) Mainly used in Japan.

i) Syn: 1,2-dibromo-2,4-dicyanobutane; methyldibromoglutaronile. Present inEuxyl ® K 400 (dibromodicyanobutane + phenoxyethanol 1:4)

40

Comments by Almirall to this proposal:

1. Nickel Sulphate is in the North American Standard Series 2,5 % as the waterfree salt;in Europe the NiS04 · 6H2O salt 5 % is approved by the authorities. The molecularcontent of nickel ions of both test allergens is almost equal.

Testing NiS04 · 6H2O at 2,5 % as proposed by the ICDRG means testing only 50 % ofthe Nickel content that is being tested in Europe and North America.

41

A Abietic Acid 10 % E2382 COS, CO I, PMAbitol® 10 % E0915 COS, PMAcid Yellow 36 1 % E2403 SH, TDAdeps lanae 30 % E2335 CO I, VEalpha-Amyl-Cinnamaldehyde 1 % E1303 PFalpha-Amylcinnamyl Alcohol 1 % E2888 PFAmalgam 5 % E2509 DMAmalgam Alloying Metals 20 % E2508 DMAmcinonide 0.1 % E2481 ME VAmethocaine see Tetracaine Hydrochloride 1 % E0402 ME IVAmerchol® L 101 50 % E1750 VE4-Aminoazobenzene 1 % E2435 MIC4-Aminobenzoic Acid (PABA) 10 % E2359 PA, SA3-Aminophenol 1 % E2301 HD4-Aminophenol 1 % E2302 HD, PC, TDm-Aminophenol see 3-Aminophenol 1 % E2301 HDp-Aminophenol see 4-Aminophenol 1 % E2302 HD, PC, TDAmmoniated Mercury 1 % E0602 DM, MCAmmonium Persulphate 2.5 % E0306 HD, PCAmmonium Tetrachloroplatinate 0.25 % E0650 DM, MCAnisyl Alcohol 1 % E2887 PFAtropine Sulfate (in water) 1 % E2415 ME VI

B Bacitracin 20 % E2151 ME IBalsam of Peru 25 % E0008 BSBalsam of Tolu 20 % E1652 COSBenzaldehyde 5 % E1350 PFBenzalkonium Chloride 0.1 % E2339 DIS1,2-Benzisothiazolin-3-one, Na-Salt 0.1 % E2471 CO I, IBBenzocaine 5 % E0011 BSBenzophenone 3 see Oxybenzone 10 % E2361 PA, SABenzophenone 4 10 % E2500 PA, SA, COSBenzotriazole 1 % E0159 CO I, IBBenzoyl Peroxide 1 % E0201 DM, ME III, MABenzyl Alcohol 1 % E2388 COS, PFBenzyl Benzoate 1 % E2889 PFBenzylcinnamate 5 % E1351 PFBenzylhemiformal 1 % E2450 CO I, IBBenzyl Salicylate 1 % E1102 COS, PFBetamethasone-17-valerate 0.12 % E2482 ME VBHA see Butyl Hydroxyanisole 2 % E0111 AO, BABHT see Butyl Hydroxytoluene 2 % E0110 AO, BA, CO IBioban® CS-1246 see 7-Ethylbicyclooxazolidine 1 % E2422 CO I, IB

List of test substances

Substance / Synonyms Concentration Art. No. Series

42

Bioban® P 1487 see Nitrobutylmorpholine/Ethylnitrotrimethylenedimorpholine 1 % E2426 CO II, IBBis(dibutyldithiocarbamato) Zinc 1 % E1019 RCBis(diethyldithiocarbamato) Zinc 1 % E1009 CO I, RCBIS-GMA 2 % E1852 DM, MABismarck Brown R 0.5 % E2428 TDBisphenol A 1 % E0965 DM, PMBithionol 1 % E0100 PABPF-Resin see Paratertiarybutyl PhenolFormaldehyde Resin 1 % E0030 BS5-Bromo-4’-chlorosalicylanilide 1 % E2354 PA2-Bromo-2-nitropropane-1,3-diol see Bronopol 0.5 % E0107 CO II, PRBronopol 0.5 % E0107 CO II, PRBudesonide 0.1 % E2504 BSBufexamac 5 % E2395 ME III1,4-Butanedioldiglycidylether 0.25 % E2875 ERS4-tert.-Butylcatechol 0.25 % E2810 PM, RCButylglycidylether 0.25 % E2808 ERStert.-Butylhydroquinone 1 % E2434 AO, CO IButyl Hydroxyanisole 2 % E0111 AO, BAButyl Hydroxytoluene 2 % E0110 AO, BA, CO I4-tert-Butyl-4’-Methoxy-Dibenzoylmethane 10 % E2364 PA, SAButyl Paraben see Butyl Parahydroxybenzoate 3 % E0154 PRButyl Parahydroxybenzoate 3 % E0154 PRp-tert Butylphenylglycidylether 0.25 % E2880 ERSDi-n-Butylphthalate 5 % E0903 CO I, PM

C CBS see N-Cyclohexylbenzothiazyl Sulphenamide 1 % E1000 RCCedarwood Oil 10 % E1352 PFCetalkonium Chloride 0.1 % E2433 DISCetearylalcohol see Cetyl/Stearyl Alcohol 20 % E1704 CO I, VECetylpyridinium Chloride 0.1 % E2315 DISCetyl/Stearyl Alcohol 20 % E1704 CO I, VEChinoform see Clioquinol 5 % E0015 BSChloracetamide 0.2 % E0117 CO II, IB, PRChloramphenicol 5 % E2152 ME IChlorhexidine Digluconate (in water) 0.5 % E0114 DIS1-(3-Chloroallyl)-3,5,7-triaza-1-azonia-adamantane Chloride see Quaternium-15 1 % E0031 BSChlorocresol 1 % E0105 CO II, IB, PR5-Chloro-2-methyl-4-isothiazolin-3-one +2-Methyl-4-isothiazolin-3-one (3:1 in water) 0.01 % E0115 BSChloroxylenol 1 % E0106 CO II, IB, PRChlorquinaldol 5 % E0104 ME II, PRCinchocaine Hydrochloride 5 % E0401 ME IV


43

Cinnamal see Cinnamaldehyde 1 % E1301 BA, PFCinnamaldehyde 1 % E1301 BA, PFCinnamyl Alcohol 1 % E1300 BA, PFCitral 2 % E2839 PFCitronellol 1 % E2842 PFClioquinol 5 % E0015 BSClobetasol-17-propionate 0.25 % E2483 ME VClotrimazole 5 % E2389 ME IIClove Oil 2 % E1308 PFCobalt Chloride, 6H2O 1 % E0002 BSCocamide DEA see Coconut Diethanolamide 0.5 % E2424 CO IICocamidopropylbetaine (in water) 1 % E2303 COS, HDCoconut Diethanolamide 0.5 % E2424 CO II, VEColophony 20 % E0017 BSColor Developer CD 2 1 % E0803 PCColor Developer CD 3 1 % E0804 PCColor Developer CD 4 1 % E0806 PCCopper Sulphate, 5H2O (in water) 1 % E0604 MCCoumarin 5 % E2845 PFCresylglycidylether 0.25 % E0917 ERSN-Cyclohexylbenzothiazyl Sulphenamide 1 % E1000 RCCyclohexyl Thiophthalimide 0.5 % E2805 RC

D Dexpanthenol 5 % E2387 COS4,4’-Diaminodiphenyl Methane 0.5 % E0906 ERSDiazolidinyl Urea 2 % E2386 PRDibenzothiazyl Disulphide 1 % E1014 RCDibromodicyanobutane 0.2 % E2939 CO II, IB, PRDibromodicyanobutane 0.3 % E2516 BSDibromodicyanobutane/Phenoxyethanol (1:4) 1 % E2515 PRDi-n-Butylphthalate 5 % E0903 CO I, PMDibutylthiourea 1 % E1025 RC, SHDichlorophene 0.5 % E2316 ME IIDiethanolamine 2 % E2401 CO I, PCDi-2-Ethylhexyl-Phthalate 5 % E0960 CO I, PMDiglycolamine 1 % E2884 CO I4,4’-Dihydroxybiphenyl 0.1 % E1005 RCDimethylphthalate 5 % E0954 PMN,N-Dimethyl-p-Toluidine 2 % E0963 DM, MADipentamethylenethiuram Disulphide 0.25 % E1017 RCDipentene (dl-Limonene) 2 % E2000 BA, CO II, PF, PL1,3-Diphenylguanidine 1 % E1002 RC, SHN,N’-Diphenyl Paraphenylenediamine 0.25 % E1013 RCDiphenylthiourea 1 % E1021 RC, SHDisodium EDTA seeEdetic Acid Disodium Salt 1 % E2384 ME VI, PCDisperse Blue 3 1 % E0506 TD


44

Disperse blue 106 0.3 % E2948 TDDisperse blue 124 0.3 % E2949 TDDisperse Orange 3 1 % E0502 SH, TDDisperse Red 1 1 % E0504 TDDisperse Red 11 1 % E2478 TDDisperse Red 17 1 % E0505 TDDisperse Yellow 3 1 % E0503 TDDisperse Yellow 9 1 % E2479 TDDiurethane Dimethacrylate 2 % E2475 DM, MADMDM Hydantoin (in water) 2 % E2476 PRDodecyl Gallate (Lauryl Gallate) 0.3 % E2496 AO, BADPG see 1,3-Diphenylguanidine 1 % E1002 RC, SH

E Edetic Acid Disodium Salt 1 % E2384 ME VI, PCEGDMA see Ethyleneglycol Dimethacrylate 2 % E1850 DM, MAEpoxy Resin 1 % E0021 BSErythromycin 1 % E2499 ME IEscalol® 507 see 2-Ethylhexyl-4-Dimethylaminobenzoate 10 % E2365 PA, SAEthanolamine see Monoethanolamine 2 % E2445 CO I, HD7-Ethylbicyclooxazolidine 1 % E2422 CO I, IBEthylenediamine Dihydrochloride 1 % E0027 CO II, ERS, ME IIIEthyleneglycol Dimethacrylate 2 % E1850 DM, MA2-Ethylhexyl-4-Dimethylaminobenzoate 10 % E2365 PA, SA2-Ethylhexyl-4-Methoxycinnamate 10 % E2366 PA, SAEthyl Paraben see Ethyl Parahydroxybenzoate 3 % E0152 PREthyl Parahydroxybenzoate 3 % E0152 PREucalyptus Oil 2 % E1353 PFEugenol 1 % E1302 BA, DM, PFEusolex® 232 see 2-Phenyl-5-benzimidazol-sulphonic Acid 10 % E2367 PA, SAEusolex® 4360 see Oxybenzone 10 % E2361 PA, SAEusolex® 6300 see 3-(4-Methylbenzylidene)-Camphor 10 % E2362 PA, SAEuxyl® K400 see Dibromodicyanobutane/Phenoxyethanol (1:4) 1 % E2515 PR

F Farnesol 5 % E2848 PFFormaldehyde (in water) 1 % E0004 BSFragrance Mix 8 % E0029 BS, PAFragrance Mix II 14 % E2860 BSFramycetin Sulphate 10 % E2311 ME IFusidic Acid Sodium Salt 2 % E2454 ME II

G Gamma Methyl Ionone 1 % E2886 PFGentamycin Sulphate 20 % E2154 ME IGeraniol 1 % E1305 PFGermall II see Diazolidinyl Urea 2 % E2386 PRGermall 115 see Imidazolidinyl Urea 2 % E0109 PR


45

Glutar(di)aldehyde 0.3 % E2498 DIS, PC, SHGlyceryl Monothioglycolate 1 % E0311 HDGlyceryl Thioglycolate see Glyceryl Monothioglycolate 1 % E0311 HDGlyoxal Trimer (Dihydrate) 1 % E2517 DISGTG see Glyceryl Monothioglycolate 1 % E0311 HD

H 2-HEMA see (2-Hydroxyethyl) Methacrylate 1 % E2477 DM, MAHexachlorophene 1 % E0101 PAHexamethylenetetramine 1 % E2318 CO II, ERS, RC1,6-Hexanedioldiglycidylether(techn. grade) 0.25 % E2876 ERSalpha-Hexyl cinnamaldehyde 10 % E2836 PFHexylresorcinol 0.25 % E0312 MICHydroabietyl Alcohol see Abitol® 10 % E0915 COS, PMHydrocortisone 1 % E2484 ME VHydrocortisone-17-butyrate 0.1 % E2485 ME VHydroquinone 1 % E0800 COS, DM, HD,

PC, MAHydroxycitronellal 1 % E1304 PF(2-Hydroxyethyl) Methacrylate (2-HEMA) 1 % E2477 DM, MAHydroxymethylpentylcyclohexene-carboxaldehyde 5 % E2824 BS

I Imidazolidinyl Urea 2 % E0109 PRIodopropynyl Butylcarbamate 0.2 % E2883 CO I, IB, PRIPCB see Iodopropynyl butylcarbamate 0.2 % E2883 CO I, IB, PRIPPD see N-Isopropyl-N’-phenyl Paraphenylenediamine 0.1 % E1004 BSIsoamyl-4-methoxycinnamate 10 % E2368 PA, SAIsoeugenol 1 % E1306 BA, PFIsophoronediamine 0.5 % E0914 ERS4,4’-Isopropylidenediphenol see Bisphenol A 1 % E0965 DM, PMIsopropyl Myristate 10 % E2336 CO I, VEN-Isopropyl-N’-phenyl Paraphenylenediamine 0.1 % E1004 BS

J Jasmine absolute 5 % E2935 PFK Kanamycin Sulphate 10 % E2313 ME I

Kathon® CG see 5-Chloro-2-methyl-4-isothiazolin-3-one +2-Methyl-4-isothiazolin-3-one (3:1 in water) 0.01 % E0115 BSKovanol® seeHydroxymethylpentylcyclohexene-carboxaldehyde 5 % E2824 BS

L Laurel Leaf Oil 2 % E1354 PFLauryl Gallate see Dodecyl Gallate 0.3 % E2496 AO, BALemon Grass Oil 2 % E1355 COS, PF


46

Lemon Oil 2 % E1356 PFLidocaine Hydrochloride 15 % E0403 ME IVLilial 10 % E2892 PFdl-Limonene see Dipentene 2 % E2000 BA, CO II, PF, PLLinalool (stabilized) 10 % E2930 PFLyral® see Hydroxymethylpentylcyclohexene-carboxaldehyde 5 % E2824 BS

M Majantol 5 % E2885 PFm-Aminophenol see 3-Aminophenol 1 % E2301 HDMBT see Mercaptobenzothiazole 2 % E1010 BSMDBGN see Dibromodicyanobutane 0.3 % E2516 CO II, IB, PRMenthol 1 % E2304 BA, DMMercaptobenzothiazole 2 % E1010 BSMercapto Mix 1 % E0025 BSMethenamine see Hexamethylenetetramine 1 % E2318 CO II, ERS, RC4-Methylaminophenol Sulphate 1 % E0801 PC3-(4-Methylbenzylidene)-Camphor 10 % E2362 PA, SAMethylchloroisothiazolinone see 5-Chloro-2-methyl-4-isothiazolin-3-one +2-Methyl-4-isothiazolin-3-one (3:1 in water) 0.01 % E0115 BSMethyldibromo glutaronitrile seeDibromodicyanobutane 0.3 % E2516 CO II, IB, PRMethylene-bis(methyloxazolidine) 1 % E2452 CO I, IBMethyl Heptine Carbonate 1 % E2933 PFMethylisothiazolinone (in water) 0.05 % E2950 PR, IBMethyl Methacrylate 2 % E1800 DM, MAMethyl Paraben see Methyl Parahydroxybenzoate 3 % E0151 PRMethyl Parahydroxybenzoate 3 % E0151 PRMetol see p-Methylaminophenol Sulphate (Metol) 1 % E0801 PCMonobenzone 1 % E1001 SHMonoethanolamine 2 % E2445 CO I, HDMorpholinylmercaptobenzothiazole 0.5 % E1015 CO II, RC

N Naphthol AS 1 % E2474 TDNarcissus absolute 2 % E2934 PFN-Cyclohexylbenzothiazyl Sulphenamide 1 % E1000 RCN,N-Dimethyl-p-Toluidine 2 % E0963 DM, MAN,N’-Diphenyl Paraphenylenediamine 0.25 % E1013 RCNeomycin Sulphate 20 % E0010 BSNeroli Oil 2 % E1357 PFNickel Sulphate, 6H2O 5 % E0003 BSN-Isopropyl-N’-phenyl Paraphenylenediamine 0.1 % E1004 BSNitrobutylmorpholine/Ethylnitrotrimethylenedimorpholine 1 % E2426 CO II, IB


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Nystatin 2 % E2491 ME IIO Oak Moss Absolute 1 % E1307 PF

Octyl Dimethyl PABA see 2-Ethylhexyl-p-Dimethylaminobenzoate 10 % E2365 PA, SAOctyl Gallate 0.3 % E2495 AO, BAOctylisothiazolinone 0.025 % E2427 CO I, IB, SHOctyl Methoxycinnamate see 2-Ethylhexyl-p-Methoxycinnamate 10 % E2366 PA, SAOrange Oil 2 % E1309 PFOxybenzone 10 % E2361 PA, SAOxytetracycline 3 % E2416 ME I

P p-Methylaminophenol Sulphate (Metol) 1 % E0801 PCp-Toluenediamine 1 % E0308 HDPABA see p-Aminobenzoic Acid 10 % E2359 PA, SAPalladium Chloride 1 % E0651 DM, MCp-Aminophenol see 4-Aminophenol 1 % E2302 HD, PC, TDPanthenol see Dexpanthenol 5 % E2387 COSParaben Mix 16 % E2469 BSParaphenylenediamine free base 1 % E0034 BSParatertiary Butylphenol 1 % E0920 CO I, PMParatertiarybutyl Phenol Formaldehyde Resin 1 % E0030 BSParsol® 1789 see 4-tert-Butyl-4’-Methoxy-Dibenzoylmethane 10 % E2364 PA, SAPatchouli oil 10 % E2937 PFParsol® MCX see 2-Ethylhexyl-p-Methoxycinnamate 10 % E2366 PA, SAPatchouli oil 10 % E2937 PFPCMC see Chlorocresol 1 % E0105 CO II, IB, PRPCMX see Chloroxylenol 1 % E0106 CO II, IB, PRPeppermint Oil 2 % E1358 DM, PFPhenol Formaldehyde Resin, Novolac 5 % E0901 PMPhenoxyethanol 1 % E2392 CO I, PR2-Phenyl-5-benzimidazole-Sulphonic Acid 10 % E2367 PA, SAPhenylephrine Hydrochloride (in water) 10 % E2414 ME VIPhenylglycidylether 0.25 % E2807 ERSPhenylmercuric Acetate 0.01 % E2863 PRPilocarpine Hydrochloride (in water) 1 % E2407 ME VIPolidocanol 3 % E2501 ME IVPolyethylene Glycol Ointment 100 % E2337 CO I, VEPolymyxin B Sulfate 3 % E2437 ME VIPotassium Dichromate 0.5 % E0001 BSPotassium Dichromate 0.25 % E2506 MICPotassium Dicyanoaurate (in water) 0.002 % E0605 DM, MCPrednisolone 1 % E2505 ME VPrimin 0.01 % E0032 BSProcaine Hydrochloride 2 % E2308 ME IV


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Promethazine Hydrochloride 0.1 % E2356 PAPropolis 10 % E1207 ME IIIPropyl Gallate 0.5 % E2497 AO, BAPropyleneglycol 5 % E2323 CO I, VEPropyleneglycol (in water) 20 % E2472 MICPropyl Paraben see Propyl Parahydroxybenzoate 3 % E0153 PRPropyl Parahydroxybenzoate 3 % E0153 PRp-Toluenediamine 1 % E0308 HDPyrogallol 1 % E0350 PC

Q Quaternium-15 1 % E0031 BSQuinidine Sulphate 1 % E2358 PA

R Resorcinol 1 % E2865 HD, ME IIIRosin see Colophony 20 % E0017 BS

S Salicylaldehyde 2 % E1359 PFSandalwood oil 10 % E2936 PFSesquiterpene Lactone Mix 0.1 % E2459 BSSodiumlaurylsulfate (SLS) (in water)(Control irritant) 0.25 % E2893 IRSodium Benzoate 5 % E2385 BA, COSSodium Metabisulfite 1 % E2412 PC, PRSodium Thiosulfatoaurate 0.25 % E2507 DM, MCSorbic Acid 2 % E0113 BA, PRSorbitan Sesquioleate 20 % E1703 PF, PL, VESulfanilamide 5 % E2160 ME I, PA

T TEGDMA see Triethyleneglycol Dimethacrylate 2 % E1851 DM, MAtert.-Butylhydroquinone 1 % E2434 AO, CO ITetracaine Hydrochloride 1 % E0402 ME IVTetracycline Hydrochloride 2 % E2306 ME ITetraethylthiuram Disulphide 0.25 % E1016 RCTetramethylthiuram Disulphide 0.25 % E1011 RCTetramethylthiuram Monosulphide 0.25 % E1008 RCThimerosal see Thiomersal 0.1 % E0600 PRThiomersal 0.1 % E0600 PRThiram see Tetramethylthiuram Disulphide 0.25 % E1011 RCThiuram Mix 1 % E0023 BSTin(II)-chloride 0.5 % E2419 MCTixocortol pivalate 1 % E2940 BSTMTD see Tetramethylthiuram Disulphide 0.25 % E1011 RCTMTM see Tetramethylthiuram Monosulphide 0.25 % E1008 RC4-Toluenediamine (dye complex) 1 % E0308 HDToluenesulphonamide Formaldehyde Resin 10 % E0908 COSTree Moss 1 % E2947 PFTriamcinolone Acetonide 0.1 % E2486 ME VTriclosan 2 % E0158 CO I, IB, PR



49

Tricresyl Phosphate (isomer blend) 5 % E2511 CO I, PMTriethanolamine see Trolamine 2.5 % E1701 CO I, PC, VETriethyleneglycol Dimethacrylate 2 % E1851 DM, MATriethylenetetramine 0.5 % E0905 ERSTrimethylhexane-1,6-diamine (isomere blend) 0.5 % E2946 ERSTriphenyl Phosphate 5 % E0959 PC, PM1,3,5-Tris(2-hydroxyethyl)-hexahydrotriazine 1 % E0119 CO I, IBTrolamine 2.5 % E1701 CO I, PC, VETurpentine Oil 10 % E2322 PM

U Usnic Acid 0.1 % E2052 PLV Vanillin 10 % E1310 BA, COS, PFW White Petrolatum 100 % E8999 MIC

Wool Alcohols 30 % E0020 BSY Ylang-ylang (I+II)-Oil 10 % E2891 PFZ ZDC see Bis(diethyldithiocarbamate)Zinc 1 % E1009 CO I, RC

Zinc dibenzyldithiocarbamate 1 % E2864 RC

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A Abietic Acid Abietic Acid E2382Abitol® Hydroabietyl Alcohol E0915Adeps lanae Lanolin E2335alpha-Amyl-Cinnamaldehyde Amyl Cinnamal E1303alpha-Amylcinnamyl Alcohol Amylcinnamyl alcohol E2888Amerchol® L 101 Lanolin Alcohol (and) Paraffinum Liquidum E17504-Aminobenzoic Acid PABA E23593-Aminophenol m-Aminophenol E23014-Aminophenol p-Aminophenol E2302Ammonium Persulphate Ammonium Persulfate E0306Anisyl Alcohol Anise alcohol E2887

B Balsam of Peru Myroxylon Pereirae E0008Balsam of Tolu Myroxylon Toluiferum E1652Benzaldehyde Benzaldehyde E1350Benzalkonium Chloride Benzalkonium Chloride E23391,2-Benzisothiazolin-3-one, Na-Salt Benzisothiazolinone E2471Benzophenone 4 Benzophenone-4 E2500Benzotriazole Benzotriazole E0159Benzyl Alcohol Benzyl Alcohol E2388Benzyl Benzoate Benzyl benzoate E2889Benzylcinnamate Benzyl Cinnamate E1351Benzylhemiformal Benzylhemiformal E2450Benzyl Salicylate Benzyl Salicylate E1102Bisphenol A 4,4’-Isopropylidenediphenol E0965Bronopol 2-Bromo-2-nitropropane-1,3-diol E0107tert.-Butylhydroquinone t-Butyl Hydroquinone E2434Butyl Hydroxyanisole BHA E0111Butyl Hydroxytoluene BHT E01104-tert-Butyl-4’-Methoxy-Dibenzoylmethane Butyl Methoxydibenzoylmethane E2364Butyl Parahydroxybenzoate Butylparaben E0154Di-n-Butylphthalate Dibutyl Phthalate E0903

C Cedarwood Oil Juniperus Virginiana Oil E1352Cetalkonium Chloride Cetalkonium Chloride E2433Cetylpyridinium Chloride Cetylpyridinium Chloride E2315Cetyl/Stearyl Alcohol Cetearyl Alcohol E1704Chloracetamide Chloroacetamide E0117Chlorhexidine Digluconate Chlorhexidine Digluconate E0114Chlorocresol p-Chloro-m-Cresol E01055-Chloro-2-methyl-4-isothia- Methylchloroisothiazolinone (and) zolin-3-one + 2-Methyl-4-iso- Methylisothiazolinonethiazolin-3-one (3:1 in water) E0115Chloroxylenol Chloroxylenol E0106Cinnamaldehyde Cinnamal E1301

TROLAB INCI name Article-No. substance / synonym

TROLAB® substances versus INCI* names(*International Nomenclature of Cosmetic Ingredients)

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Cinnamyl Alcohol Cinnamyl Alcohol E1300Citral Citral E2839Citronellol Citronellol E2842Clove Oil Eugenia Caryophyllus E1308Cobalt Chloride, 6H2O Cobalt Chloride E0002Cocamidopropylbetaine Cocamidopropyl Betaine E2303Coconut Diethanolamide Cocamide DEA E2424Colophony Colophonium E0017Copper Sulphate, 5H2O Copper Sulfate E0604Coumarin Coumarin E2845

D Dexpanthenol Panthenol E2387Diazolidinyl Urea Diazolidinyl Urea E2386Dibromodicyanobutane 0.2 % Methyldibromo Glutaronitrile E2939Dibromodicyanobutane 0.3 % Methyldibromo Glutaronitrile E2516Dibromodicyanobutane/ Methyldibromo Glutaronitrile (and) Phenoxyethanol (1:4) Phenoxyethanol E2515Diethanolamine Diethanolamine E2401Di-n-Butylphthalate Dibutyl Phthalate E0903Dichlorophene Dichlorophene E2316Di-2-Ethylhexyl-Phthalate Diethylhexyl Phthalate E0960Dimethylphthalate Dimethyl Phthalate E0954Dipentene (dl-Limonene) Limonene E2000Disperse Blue 3 Disperse Blue 3 E0506Disperse Orange 3 Disperse Orange 3 E0502Disperse Red 11 Disperse Red 11 E2478Disperse Red 17 Disperse Red 17 E0505DMDM Hydantoin DMDM Hydantoin E2476Dodecyl Gallate Dodecyl Gallate E2496

E Edetic Acid Disodium Salt Disodium EDTA E23842-Ethylhexyl-4-Dimethyl-aminobenzoate Ethylhexyl Dimethyl PABA E23652-Ethylhexyl-4-Methoxy-cinnamate Ethylhexyl Methoxycinnamate E2366Ethyl Parahydroxybenzoate Ethylparaben E0152Eucalyptus Oil Eucalyptus Globulus E1353Eugenol Eugenol E1302

F Farnesol Farnesol E2848Formaldehyde Formaldehyde E0004

G Gamma Methyl Ionone Alpha-isomethyl ionone E2886Geraniol Geraniol E1305Glutar(di)aldehyde Glutaral E2498Glyceryl Monothioglycolate Glyceryl Thioglycolate E0311Glyoxal Trimer (Dihydrate) Glyoxal E2517

H Hexamethylenetetramine Methenamine E2318alpha-Hexyl cinnamaldehyde Hexyl cinnamal E2836Hydroquinone Hydroquinone E0800


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Hydroxycitronellal Hydroxycitronellal E1304Hydroxymethylpentyl- Hydroxyisohexyl cyclohexenecarboxaldehyde 3-cyclohexene carboxaldehyde E2824

I Imidazolidinyl Urea Imidazolidinyl Urea E0109Iodopropynyl IodopropynylButylcarbamate Butylcarbamate E2883Isoamyl-4-methoxycinnamate Isoamyl-p-Methoxycinnamate E2368Isoeugenol Isoeugenol E1306Isopropyl Myristate Isopropyl Myristate E2336

J Jasmine absolute Jasminum Officinala E2935L Laurel Leaf Oil Laurus Nobilis E1354

Lemon Grass Oil Cymbopogon Schoenanthus E1355Lemon Oil Citrus Limonum E1356Lilial Butylphenyl Methylpropional E2892Linalool (stabilized) Linalool E2930

M Menthol Menthol E23044-MethylaminophenolSulphate (Metol) p-Methylaminophenol Sulfate E08013-(4-Methylbenzylidene)-Camphor 4-Methylbenzylidene Camphor E2362Methylisothiazolinone Methylisothiazolinone E2950Methyl Heptine Carbonate Methyl 2-octynoate E2933Methyl Parahydroxybenzoate Methylparaben E0151Monoethanolamine Ethanolamine E2445

N Neroli Oil Citrus Amara E1357O Oak Moss Absolute Evernia Prunastri Extract E1307

Octyl Gallate Octyl Gallate E2495Orange Oil Citrus Dulcis E1309Oxybenzone Benzophenone-3 E2361

P p-Methylaminophenol Sulphate (Metol) p-Methylaminophenol Sulfate E0801p-Toluenediamine Toluene-2,5-Diamine E0308Paraben Mix please see single ingredients of the mix E2469Paraphenylenediamine free base p-Phenylenediamine E0034Patchouli oil Pogestemon Cablin E2937Peppermint Oil Mentha Piperita E1358Phenoxyethanol Phenoxyethanol E23922-Phenyl-5-benzimidazole-Sulphonic Acid Phenylbenzimidazole Sulfonic Acid E2367Phenylmercuric Acetate Phenyl Mercuric Acetate E2863Polyethylene Glycol Ointment PEG 6 (and) PEG 32 E2337Propolis Propolis Cera E1207Propyl Gallate Propyl Gallate E2497Propyleneglycol Propylene Glycol E2323Propyleneglycol Propylene Glycol E2472Propyl Parahydroxybenzoate Propylparaben E0153

Q Quaternium-15 Quaternium-15 E0031


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R Resorcinol Resorcinol E2865S Sandalwood oil Santalum Album E2936

Sodium Benzoate Sodium Benzoate E2385Sodium Metabisulfite Sodium Metabisulfite E2412Sorbic Acid Sorbic Acid E0113Sorbitan Sesquioleate Sorbitan Sesquioleate E1703

T tert.-Butylhydroquinone t-Butyl Hydroquinone E2434Thiomersal Thimerosal E0600Tin (II)-chloride Stannous Chloride E24194-Toluenediamine (dye complex) Toluene-2,5-Diamine E0308ToluenesulphonamideFormaldehyde Resin Tosylamide/Formaldehyde Resin E0908Tree Moss Evernia Furfuracea Extract E2947Triclosan Triclosan E0158Tricresyl Phosphate (isomer blend) Tricresyl Phosphate E2511Trolamine Triethanolamine E1701Turpentine Oil Turpentine E2322

U Usnic Acid Usnic Acid E2052V Vanillin Vanillin E1310Y Ylang-ylang (I+II)-oil Cananga Odorata E2891W White Petrolatum Petrolatum E8999

Wool Alcohols Lanolin Alcohol E0020


Ordering procedure

For all questions concerning ordering, conditions ofsale, prices, delivery, terms of payment, etc. pleasecontact your local distributor or otherwise

Almirall Hermal GmbHD-21462 Reinbek · GermanyPhone: + 49-40-727 04-0Telefax: + 49-40-722 92 96e-mail: [email protected]

List of TROLAB distributors

Australia and New ZealandW.E. & M. SchroederP. O. Box 11AUS-Thornleigh, 2120 N. S. W.

Appartment 1104/185 Macquarie StreetAUS-Sydney, 2000 N. S. W.Tel.: 02-9233-3348Telefax: 02-9233-3368Mobile: 0418 976 359e-mail: [email protected]

CanadaOmniderm Pharma Canada Inc.997 SeguinVaudreuil-Dorion, Quebec J7V OK2Tel.: 450-458-0158Telefax: 450-458-7499e-mail: [email protected]

ChilePromedar Ltda.Antonio Bellet 310ProvidenciaRCH-SantiagoTel.: 02-23 56 851 Telefax: 02-23 51 032e-mail: [email protected] site: www.promedar.com

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Czech RepublicCorrespondence address:PHARMIX s.r.o.MUDr. Tomás̆ MiksaLevského 3188/4143 00 Praha 4Tel.: 0241 404 302Telefax: 0241 404 301e-mail: [email protected]

FinlandTamro Oyj / PharmakonRajatorpantie 41BFIN-01640 VantaaTel.: 020 445 11 Telefax: 020 445 4665

FranceSTALLERGENES6 rue Alexis de Tocqueville92160 Antony - FranceLigne Information Médecins: 01 55 59 20 15Fax: 01 55 59 20 01www.stallergenes.fr

Great Britain and the Republic of IrelandBio-Diagnostics Ltd.Upton Industrial EstateRectory RoadUpton upon SevernGB-Worcestershire WR8 OLXTel.: 01684-59 22 62Telefax: 01684-59 25 01e-mail: [email protected] site: www.bio-diagnostics.co.uk

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HongkongHua Tai Pharmaceuticals Co., Ltd.Unit 301DD, Block B, 3rd Floor,Sea View Estate, 2-8 Watson Road,Causeway Bay, Hong KongTel.: 24 73 33 67

25 70 18 99 Telefax: 24 71 88 45e-mail: [email protected]

ItalyAllergopharma S.p.a.Via Stephenson 94I-20157 MilanoTel.: 02-33 20 35-1Telefax: 02-33 20 35-524e-mail: [email protected]

The Netherlands, Belgium, Luxembourgvan der Bend B. V.P. O. Box 73NL-3230 AB BrielleTel.: 0181 - 41 - 80 55Telefax: 0181 - 41 - 74 50e-mail: [email protected]

PortugalDERMIS Produtos de Saúde S.A.Rua José Estêvão, nr° 171169-300 LisboaTel.: 021 3144 402Telefax: 021 3144 404e-mail: [email protected]

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Slovak RepublicOrders:PHARMIX s.r.o.Druz̆stevná 1834 01 BratislavaTel.: 0241 404 302Telefax: 0241 404 301e-mail: [email protected]:PHOENIXZdravotnicke zásobovanie a.s.Vlárska 48831 01 BratislavaTel.: 02 49999245Telefax: 02 49999268

South AfricaMednomP.O.Box 485Bergvliet 7864Cape TownTel.: 021 - 671 - 19 96Telefax: 021 - 671 - 19 96e-mail: [email protected]

SpainFarmacia Diaz Morenoc/. Serafin Olave, 15Pamplona31008 NavarraTel.: 0948 257 942Fax: 0948 174 411

Notes:

Notes:

Notes:

06/0

9 –

E 9

105

Almirall Hermal GmbH

D-21462 Reinbek

Internet service

Under www.hermal.com you will findinformation on each TROLAB@ allergen.

The data are taken from literature.

Any comments and additional informationfrom you are welcome.

Documents

Patch test allergens - Dermat Medical Supplies · Bakery Allergens BA 19 Cosmetics COS 20 Cutting Oils I ... TROLAB patch test allergens can be used with ... the numbers will later