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David A. Steenblock, D.O. Inc

Personalized Regenerative Medicine

Parkinson's Disease

Parkinson's disease (PD) refers to a group of conditions called motor system disorders,

which are the end result of the die-off of dopamine-producing cells in an area of the brain

that includes the substantia nigra. It is a variably progressive disease that is typicallycharacterized by tremor or trembling in hands, arms, legs, jaw, and face; stiffness or

rigidity of the limbs and trunk; slowness when it comes to getting around or moving

about; and impaired balance and coordination. As the disease progresses sufferers may

experience difficulty walking, talking, or completing other simple routine tasks. Inaddition, some sufferers experience depression and other emotional changes; difficulty

swallowing, chewing, and speaking; incontinence or conversely, constipation; variouskinds of skin issues; and sleep disruptions or disturbances.

Parkinson's disease usually affects people over the age of fifty (50) with the earlysymptoms being typically subtle and gradual in nature. In some folks it progresses more

quickly than in others. The suspected triggers of this insidious disease are many and

varied and include genetic factors and exposure to specific pesticides. One medical

innovator, Dr. David Steenblock, has fingered a number of hitherto overlooked or under-

examined players in PD which he discusses in this thought provoking article.

Currently, there is no cure for PD, though a variety of drugs exist that confer sometimes

dramatic relief from the disconcerting symptoms. Most patients are placed on (levodopahttp://en.wikipedia.org/wiki/Levodopa) which the brain uses to make the neurotransmitter

dopamine, and carbidopa which slows the conversion of levodopa into dopamine untilit reaches the brain. Although levodopa is beneficial in about 75% of PD patients, not allsymptoms respond equally to the drug. Slowness of movement (Bradykinesia) and

rigidity respond best, while tremor may only be nominally impacted. Balance issues and

other symptoms may not be helped at all. A class of drugs called anticholinergics helps

some PD patients manage tremor and rigidity. Drugs such as bromocriptine,

pramipexole, and ropinirole can help too, owed to the fact they all mimic the role ofdopamine in the brain and by so doing cause neurons to react as they would to the actual

neurotransmitter itself. During May 2006, the FDA approved rasagiline for use withlevodopa for patients with advanced PD or as a single-drug treatment measure for early

PD.

Some PD sufferers who do not respond adequately to pharmaceutical or other treatments

benefit from deep brain stimulation (DBS), which enjoys FDA approval. In DBS,

electrodes are implanted into the brain and hooked up to a small electrical device called a

http://en.wikipedia.org/wiki/Substantia_nigrahttp://www.strokedoctor.com/component/content/article/248http://en.wikipedia.org/wiki/Dopaminehttp://en.wikipedia.org/wiki/Carbidopahttp://en.wikipedia.org/wiki/Anticholinergichttp://en.wikipedia.org/wiki/Bromocriptinehttp://en.wikipedia.org/wiki/Pramipexolehttp://en.wikipedia.org/wiki/Ropinirolehttp://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000344http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000344http://en.wikipedia.org/wiki/Ropinirolehttp://en.wikipedia.org/wiki/Pramipexolehttp://en.wikipedia.org/wiki/Bromocriptinehttp://en.wikipedia.org/wiki/Anticholinergichttp://en.wikipedia.org/wiki/Carbidopahttp://en.wikipedia.org/wiki/Dopaminehttp://www.strokedoctor.com/component/content/article/248http://en.wikipedia.org/wiki/Substantia_nigra

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pulse generator that is externally programmable. DBS can reduce reliance on levodopaand related drugs, which in turn decreases involuntary movements called dyskinesias that

are a common side effect of this drug. It also reduces tremors, slowness of movements,

and gait issues.

PD is both chronic and progressive in nature, meaning its symptoms tend to grow worsewith the passage of time. Although some sufferers become severely disabled, otherswrestle with only minor motor disruptions. Tremor is the principle symptom for some

patients, while others experience little of this but may experience other symptoms that are

more troublesome. No one can yet precisely predict which symptoms will affect

individual patients and to what degree over time.

The question arises: What, if anything, can extant forms of stem therapies afford PD

sufferers? On the one hand, published research points to lots of promise, yes but little interms of definitive studies or such. On the other, powerful anecdotal evidence has

emerged that suggests that specific adult stem cell treatment approaches can confer

tremendous benefits to PD sufferers. Dr. David Steenblock (mentioned previously) has,in fact, come up with a treatment protocol including legal use of a PD patient's own bone

marrow that is fast racking up clinical successes. The highpoints of this novel clinical

approach are as follows:

- Following a comprehensive physical from their personal physician, patients inject an

FDA approved stem cell mobilizing drug over a specific period of time prior to getting abone marrow transplant.

- After the patient has finished the injections, he or she comes to Dr. Steenblock's

Clinic where they get five (5) daily IV infusions of stem cell activating factors.

- At a specific point-in-time after their last injection of the FDA approved stem cell

mobilizing drug mentioned above, they again use this drug to increase the number of

hematopoietic stem cells in the blood.

- Next, the patient has the bone marrow harvesting followed by its infusion by IV drip,in tandem with injections of a proprietary blend of FDA approved stem cell mobilizing

drugs followed by forty-five (45) minutes ofintermittent hypoxia, Functional

electrical stimulation and Whole Body Periodic Acceleration Therapy.

- The combination ofintermittent hypoxia, Functional electrical stimulation andWhole Body Periodic Acceleration Therapy is done every day while patients are atDr. Steenblock's clinic, always on the heels of daily IV drip infusions of stem cell

activating factors. This regimen is geared to mobilize a patient's own stem cells and to

both increase levels ofVEGF and dilate blood vessels via increased Nitric Oxide

production.

http://www.stemcell.md/contacthttp://www.stemcell.md/contacthttp://en.wikipedia.org/wiki/Intermittent_hypoxic_traininghttp://en.wikipedia.org/wiki/Functional_electrical_stimulationhttp://en.wikipedia.org/wiki/Functional_electrical_stimulationhttp://www.nims-us.com/studysupport.aspxhttp://en.wikipedia.org/wiki/Intermittent_hypoxic_traininghttp://en.wikipedia.org/wiki/Functional_electrical_stimulationhttp://www.nims-us.com/studysupport.aspxhttp://en.wikipedia.org/wiki/Vascular_endothelial_growth_factorhttp://en.wikipedia.org/wiki/Nitric_oxidehttp://en.wikipedia.org/wiki/Nitric_oxidehttp://en.wikipedia.org/wiki/Nitric_oxidehttp://en.wikipedia.org/wiki/Nitric_oxidehttp://en.wikipedia.org/wiki/Vascular_endothelial_growth_factorhttp://www.nims-us.com/studysupport.aspxhttp://en.wikipedia.org/wiki/Functional_electrical_stimulationhttp://en.wikipedia.org/wiki/Intermittent_hypoxic_traininghttp://www.nims-us.com/studysupport.aspxhttp://en.wikipedia.org/wiki/Functional_electrical_stimulationhttp://en.wikipedia.org/wiki/Functional_electrical_stimulationhttp://en.wikipedia.org/wiki/Intermittent_hypoxic_traininghttp://www.stemcell.md/contacthttp://www.stemcell.md/contact

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Readers interested in learning more about Dr. Steenblock and his leading edge treatment

for PD are invited to call his clinic at 1-949-367-8870 or use this on-line contact form

which can be readily accessed by clicking this link.

It should be noted that at least a modicum of research has accrued suggesting thatumbilical cord blood derived stem cells can impact PD. Click this link to access some

of these studies.

StemCell.MD works with clinics in Mexico that have been successfully employing adult

(non-embryonic) stem cell treatments for Parkinson's disease for many years now,primarily human umbilical cord derived cells. Their case history evidence of efficacy

includes many impressive responses and date back many years. You can learn more by

calling 1-800-288-7016 (8 am to 5 pm Pacific Time. If you call before or after businesshours, please leave a message and someone on StemCell.MD's staff will get back to you

as soon as possible) or e-mailing us at info@stemcell.md.

Tel:(949) 367-8870 ~ Fax:(949) 367-9779 ~ Toll Free: 1-800-900-1063

26381 Crown Valley Parkway, Suite 130 ~ Mission Viejo, California 92691 ~ WWW.STEMCELL.MD

http://www.stemcell.md/contacthttp://www.stemcelltherapies.org/umresearch/parkinsons-research.htmlhttp://www.stemcelltherapies.org/umresearch/parkinsons-research.htmlhttp://www.stemcelltherapies.org/umresearch/parkinsons-research.htmlhttp://www.stemcelltherapies.org/umresearch/parkinsons-research.htmlhttp://www.stemcell.md/contact