Parkinson's Disease Ver 10

8/20/2019 Parkinson's Disease Ver 10

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American Parkinson Disease Association Inc.

Parkinson’s Disease

HANDBOOK

A Guide for Patients and Their Families


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ELIZABETH BRAUN, RN

ROBERT BROWNE, DC

GARY CHU

JOSEPH CONTE

+ NICHOLAS CORRADO

GEORGE A. ESPOSITO, JR., ESQ.LISA ESPOSITO, DVM

MARIO ESPOSITO, JR

MICHAEL ESPOSITO

+ SALLY ANN ESPOSITO-BROWNE

DONNA FANELLI

ANDREW J. FINN, ESQ.

DONNA MARIE FOTI

+ VINCENT N. GATTULLO

+ FRED GREENE

ADAM B. HAHN. ESQ.

MARVIN HENICK

ELENA IMPERATO

JOHN LAGANA, JR

+ ROBERT LEVINE

SOPHIA MAESTRONE

+ JOHN Z. MARANGOS, ESQ

+ PATRICK McDERMOTT

MICHAEL MELNICKE

JOEL A. MIELE, JR.

+ JOEL A. MIELE, SR, P.E.

DONALD MULLIGAN

THOMAS K. PENETT, ESQ

MICHAEL A. PIETRANGELO, ESQ.

ROBERT PIRRELLOWILLIAM POWERS

CYNTHIA REIMER

+ RICHARD A. RUSSO

JOHN P. SCHWINNING, MD, FACS, PC

+ ELLIOT SHAPIRO, P.E.

+ J. PATRICK WAGNER

+ JERRY WELLS, ESQ

DANIEL WHEELER

Regional Representatives_______________________

BARBARA BERGER

MAXINE DUST

JOAN DUVAL

DAVID RICHTER

GLADYS TIEDEMANN

+ Executive Committee

SCIenTIfIC advISory Board

G. FREDERICK WOOTEN, MD, CHAIRMAN

JAMES BENNETT, JR., MD, PhD

MARIE-FRANCOISE CHESSELET, MD,PhD

MAHLON R. DELONG, MD

DENNIS DICKSON, MD

UN JUNG KANG, MD

LAURA MARSH, MD

ERWIN MONTGOMERY, JR., MD

MARY MARAL MOURADIAN, MD

RICHARD MYERS, PhD.JOEL S. PERLMUTTER, M.D.JACOB I. SAGE, MDMARIE SAINT-HILAIRE, MDEVAN YALE SNYDER, MD, PhDDAVID G. STANDAERT, MD. PhDRAY L. WATTS. MD

April 2010

aMerICan parKInSon dISeaSe aSSoCIaTIon, InC.

offICerS

JOEL A. MIELE, SR., P.E., President

FRED GREENE, 1st Vice President

PATRICK McDERMOTT, 2nd Vice President

JOHN Z. MARANGOS, ESQ., 3rd Vice President

ELLIOT J. SHAPIRO, P.E., 4th Vice President JERRY WELLS, ESQ., Secretary

SALLY ANN ESPOSITO- BROWNE, Treasurer

Board of dIreCTorS

Honorary CHaIrMan of reSearCH developMenT

MUHAMMAD ALI

eMerITUS Board MeMBerSHON. JOHN FUSCO

PAUL G. GAZZARA, MD

MICHAEL HALKIAS

FRANK PETRUZZI

DOROTHY REIMERS

SCOTT SCHEFRIN

JAY SPRINGER, ESQ.

MARTIN TUCHMAN

Honorary Board MeMBerS

MATILDA CUOMO

ISTAVAN F. ELEK

RICHARD GRASSO

MS. MICHAEL LEARNED

CLIFF ROBERTSON

BROOKE SHIELDS


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PARKINSON’S

DISEASE

HANDBOOK

BY

Lawrence I. Golbe, MD GG

Margery H. Mark, MD AGG=H GG

Jacob I. Sage, MD GG D=H, D=J=G= JH

D=GG


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A Message From The APDA’s President

I


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TABLE OF CONTENTS

. *DC .................................................................................1

. +g+ AD ++ ..................................................................3

A. =H=@ +MHG

B. =M +MHG

C. +MHG *@H H HH

D. +M +MHG

E. +MHG *@H H HH=, B


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1

Parkinson’s disease (PD) KG =GH G= M D. G =G =

@=HH@ H=H@ A% E**a0 &% +e Sa"!%g Pa#*0 , I@=G


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=@@GG M H GG=@M @@K GI=H = H


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3

A @ I G=G (K


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5

H H H=J H= H JH @@ H GI@HG = >IGH H


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Swallowing: @G K=H< GK@@K= ( d0*ag!a ), K


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7

A=@ =GHH= @H= M @G I = D, G=@@M

M IG G===H =GH. IG J=H= M I = IHHD, IH G JG H =H=G IG H HH D,G=@@M = H


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AM IG@ M H M MGH= MGH= =, =@I= HK, G, @G H.B@


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9

=


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III. OTHER PARKINSONISMS

D =G not @H H H


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11

(+D+), *+!a+&%!ga# dege%ea+!&% (+D). A@@ H


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HM @G, IH +&/!%


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13

=J M J= H


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IV. THE CAUSE OF

PARKINSON’S DISEASE


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15

G


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H=H'G H


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17

Loss of Dopamine-Producing Brain Cells: H MH K K


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ga%g#!a =H G H H = D. ("g@=" @ @IGHG = @@G.)


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19

Are the Mitochondria Involved?: B= @@G =< = =H


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I M @G


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21


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23

G=@= G


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Amantadine ( Symmetrel ® ): A$a%+ad!%e M


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25

GH=I@H= H


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!%!b!+& , MAO-B !%!b!+& H @J. H=HG K


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27

Seborrheic dermatitis: AH==G =H=G, G= @H=G

I G


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29

*e&+&%!% e+a"e !%!b!+&* , @= G=H@ ($LP), GH@= (@HP),

LH= (L=@P), M H=J GG=. + K IG


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GM


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J. Exercise

A I GHI=G


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32


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VII. GLOSSARY

I+a#!c!1ed KG GG- = H


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34

deep brain stimulation - @H=@ GH=I@H= H= HG H


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hallucinations - @G H= GH


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36

pallalia - GHIHH= GH= G< = D.

pallidal stimulation - @H=@ GH=I@H= H


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serotonin - %e&+a%*$!++e .

sialorrhea - @=.

striatum - H H


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w

Alabama, BirminghamUniversity of Alabama atBirmingham205-934-9100

Arizona, Phoenix

Banner Good SamaritanMedical Center602-839-3542

Arizona, TucsonUniversity of Arizona520-626-5055866-897-1261

Arkansas, Hot SpringsSt. Joseph’s RegionalHealth Center800-345-6621501-622-3990

California, Fountain ValleyOrange Coast MemorialMedical Center714-378-5022877-610-2732

California, Laguna HillsSaddleback MemorialMedical Center877-610-2732714-378-5022

California, Long BeachLong Beach MemorialMedical Center

877-610-2732714-378-5022

California, Los AngelesCedars-Sinai Health System310-423-7933877-223-3277

California, Los Angeles (UCLA)Reed NeurologicalResearch Center310-206-9799

California, NorthridgeCenter for Aging Research

818-885-8623866-499-2732

California, PasadenaHuntington Hospital626-397-2684

California, San DiegoInformation & Referral Center858-273-6763

California, StanfordStanford UniversityMedical Center650-724-6090

866-250-2414

Connecticut, New HavenHospital of Saint Raphael203-789-3936

Florida, JacksonvilleMayo Clinic, Jacksonville904-953-7030

Florida, Deerfield BeachNorth Broward Medical Center800-825-2732954-786-2305

Florida, St. Petersburg

Edward White Hospital727-328-6246

Georgia, AtlantaEmory University Schoolof Medicine404-728-6552

Illinois, Chicago

800-223-9776 (out of IL.)630-933-4383

Iowa, DesMoinesIowa Health - DesMoines

515-241-6379877-872-6386

Kentucky, LexingtonUniversity of Kentucky859-257-2732866-554-2732

Louisiana, New OrleansOchsner Clinic Foundation

Louisiana, ShreveportLouisiana State University318-675-6142

Maine, FalmouthMaine Medical Center207-781-1735800-832-4116

Maryland, BaltimoreUniversity of Maryland800-862-5457

Massachusetts, BostonBoston University Schoolof Medicine

617-638-7737800-651-8466

Minnesota, Minneapolis Abbott Northwestern HospitalMinneapolis Neuroscience Inst.612-863-5850888-302-7762

Mississippi, GulfportGulfport Memorial Hospital228-575-1330601-618-2772

Missouri, St. LouisWashington UniversityMedical Center314-362-3299

Montana, Great FallsBenefis Health Care406-455-2964800-233-9040

Nebraska, OmahaCreighton University402-449-4535866-626-7347

Nevada, Las Vegas

702-464-3132

Nevada, Reno V.A. Medical Center775-328-1715

New Hampshire, LebanonDartmouth-Hitchcock Medical Center603-650-5280

New Jersey, New Brunswick Robert Wood Johnson

University Hospital732-745-7520

New York, AlbanyThe Albany Medical College518-262-6402

New York, Far RockawayPeninsula Hospital

718-734-2876

New York, ManhattanNew York University212-983-1379

New York, Old WestburyNew York College ofOsteopathic Medicine516-626-6114

New York, SmithtownSt. Catherine’s of Siena Hospital631-862-3560

Ne York, Staten IslandStaten Island University Hospital718-226-1856

Ohio, KetteringKettering Medical Center937-903-0699

Oklahoma, TulsaHillcrest Medical Center System918-747-3747

Pennsylvania, ErieHealth South RehabilitationHospital814-456-4210

Pennsylvania, Pittsburgh Allegheny General Hospital412-441-4100

Rhode Island, Warwick Kent Hospital401-736-1046

Tennessee, MemphisMethodist Hospital901-516-0677

Tennessee, NashvilleCentennial Medical Center615-342-4635800-493-2842

Texas, Dallas

Baylor University Medical Center214-820-3800

Texas, Lubbock Convenant Hospital806-785-2732800-687-5498

Texas, San AntonioThe University of Texas HSC210-450-0551

Texas, TylerEast Texas Medical Center903-596-3648866-491-2732

Utah, Salt Lake CityUniversity of Utah801-585-2354

Vermont, BurlingtonUniversity of Vermont802-847-3366888-763-3366

Virginia, CharlottesvilleUniversity of VirginiaMedical Center434-982-4482

Washington, Seattle

University of Washington206-277-5516

Wisconsin, MadisonSt. Mary’s Hospital

608-229-7628

DEDICATED CENTERS

Armed Forces VeteransReno, NV775-328-1715

Please contact the nearest I & R Center for information regarding Support

Groups and Chapters or call the National Office at 1-800-223-2732.

Rev. 3/10

504-842-4272

New Mexico, AlbuquerqueUniversity of New Mexico877-515-4560

Young Onset CenterCentral DuPage Hospital

Winfield, IL

800-329-8387

Central DuPage Hospital

Pennsylvania, PhiladelphiaCrozer-Chester Medical Center610-447-2911

New York, Westfield

Westfield Memorial Hospital

716-793-2112

APDA Information and Referral (I & R) Centers


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American Parkinson Disease Association, Inc.

Parkinson Plaza

135 Parkinson Ave.

Staten Island, NY 10305-19461-800-223-2732

www.apdaparkinson.org

[email protected]

APDA Young Onset Center

Central DuPage Hospital

25 N. Winfield Road

Winfield, IL 601901-877-223-3801

www.youngparkinsons.org

[email protected]

APDA West Coast Office

10850 Wilshire Boulevard, Suite 730

Los Angeles, CA 90024

1-800-908-2732

www.parkinsonsapda.org

[email protected]

APDA National Resource Center for Rehabilitation

Boston University College of Health & Rehabilitation Sciences - Sargent College

635 Commonwealth Avenue

Boston. MA 02215

1-888-606-1688

www.bu.edu/[email protected]

Th i ti f thi h db k d ibl b

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Parkinson's Disease Ver 10