Short report Low risk for transmission of zoonotic Giardia duodenalis from dogs to humans in rural Cambodia Tawin Inpankaew 1 2 * , Fabian Schär 3 4 , Peter Odermatt 3 4 , Anders Dalsgaard 1 , Wissanuwat Chimnoi 2 , Virak Khieu 3 4 5 , Sinuon Muth 5 and Rebecca J Traub 6 Parasites & Vectors 2014, 7:412 doi:10.1186/175633057412 Published: 29 August 2014 Corresponding author: Tawin Inpankaew Email: Tawin Inpankaew [email protected] Fabian Schär [email protected] Peter Odermatt [email protected] Anders Dalsgaard [email protected] Wissanuwat Chimnoi [email protected] Virak Khieu [email protected] Sinuon Muth [email protected] Rebecca J Traub [email protected] * [email protected]

Parasites & Vectors _ Abstract _ Low Risk for Transmission of Zoonotic Giardia Duodenalis From Dogs to Humans in Rural Cambodia

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6/3/2015 Parasites&Vectors|Abstract|LowriskfortransmissionofzoonoticGiardiaduodenalisfromdogstohumansinruralCambodia

http://www.parasitesandvectors.com/content/7/1/412/abstract 1/2

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Abstract

BackgroundAnumberofepidemiologicalstudieshavedemonstratedGiardiaasprevalentinbothhumansanddogsworldwideandhavepostulatedtheoccurrenceofanthroponotic,zoonoticandanimalspecificcyclesoftransmission,whichmaybegeographicallyandregionallyuniqueinitsepidemiology.Theaimofthisstudywastoutilisemoleculartoolstodeterminetheprevalenceand COMPARE genotypesofGiardiaduodenalisinfectinghumansanddogslivinginapreviouslyidentifiedGiardiaendemicvillageinruralCambodiainordertoascertainzoonotictransmissionrisk.

FindingsTheprevalenceofG.duodenalisinhumansanddogswas18.3%(40/218)and10.6%(10/94)byPCR,respectively.MolecularcharacterisationofthesmallsubunitofribosomalRNA(SSUrRNA)gene,triosephosphateisomerase(TPI)geneandsubassemblagecharacterisationoftheglutamatedehydrogenase(gdh)geneplaced27.5%(11/40)ofGiardiapositivehumansintoassemblageAIIand72.5%(29/40)intoassemblageBIIIofG.duodenalis.Indogs,20.0%(2/10)ofGiardiapositivesampleswerecharacterisedasG.duodenalisassemblageBIII,40.0%(4/10)asassemblageCand40.0%(4/10)asmixinfectionbetweenassemblageCandD.

ConclusionOverall,justover2%ofdogsharbouredpotentiallyzoonoticassemblagesofG.duodenalisinthestudiedcommunitiesandhenceposeaminimalzoonoticriskforthetransmissionofGiardiatohumans.

Keywords:GiardiaduodenalisHumansDogsZoonosisCambodia

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Shortreport

LowriskfortransmissionofzoonoticGiardiaduodenalisfromdogstohumansinruralCambodiaTawinInpankaew12*,FabianSchr34,PeterOdermatt34,AndersDalsgaard1,WissanuwatChimnoi2,VirakKhieu345,SinuonMuth5 andRebeccaJTraub6

Parasites&Vectors2014,7:412 doi:10.1186/175633057412

Published:29August2014

Correspondingauthor:TawinInpankaew

Email:[email protected]@unibas.chPeterOdermattPeter.Odermatt@[email protected]@[email protected]@[email protected]

* [email protected]
6/3/2015 Parasites&Vectors|Abstract|LowriskfortransmissionofzoonoticGiardiaduodenalisfromdogstohumansinruralCambodia

http://www.parasitesandvectors.com/content/7/1/412/abstract 2/2