Pai JK et al. N Engl J Med 2004; 351:2599-2610.

Relative CHD risk by increasing baseline CRP plasma levels,* relative to CRP<1.0 mg/L (RR=1.0)Population CRP 1.0-2.9

mg/L, RR (95% CI)

CRP >3.0 mg/L, RR (95% CI)

p for trend

Women (patients, n=239; controls, n=469)

1.17(0.69-2.00)

1.53(0.89-2.62)

0.09

Men (patients, n=265; controls, n=529)

1.60(1.09-2.34)

1.79(1.14-2.83)

0.03

Men and women 1.44(1.05-1.96)

1.68(1.18-2.38)

0.008

*Adjusted for age, smoking status, month of blood sampling, parental CHD history, alcohol intake, exercise activity level, total cholesterol/HDL cholesterol ratio, body mass index, diabetes, and hypertension; and in women only, also adjusted for fasting status at time of blood sampling and postmenopausal hormone therapy status.

Relative CHD risk by baseline CRP plasma levels, by quintiles relative to lowest quintile (RR=1.0)

Pai JK et al. N Engl J Med 2004; 351:2599-2610.

Quintiles by sex

Adjusted for case-matching criteria,* RR(95% CI)

Further adjusted for TC:HDL-C, BMI, other risk factors,** RR (95% CI)

Further adjusted for diabetes and hypertension, RR (95% CI)

Women      

•Quintile 2 •1.28•(0.74-2.23)

•1.17•(0.64-2.14)

•1.23•(0.66-2.32)

•Quintile 3 •1.03•(0.59-1.81)

•0.81•(0.43-1.52)

•0.89•(0.46-1.72)

•Quintile 4 •1.54•(0.91-2.63)

•1.17•(0.64-2.14)

•1.22•(0.65-2.30)

•Quintile 5 •2.18•(1.30-3.64)

•1.86•(1.00-3.46)

•1.61•(0.84-3.07)

—p for trend <0.001 0.008 0.08*Age, smoking status, month of blood sampling; in women only, also adjusted for fasting status at time of blood sampling.**Parental CHD history, alcohol intake, exercise activity level, total cholesterol/HDL cholesterol ratio, body mass index (BMI); in women only, also adjusted for postmenopausal hormone therapy status.

Relative CHD risk by baseline CRP plasma levels, by quintiles relative to lowest quintile (RR=1.0)

Pai JK et al. N Engl J Med 2004; 351:2599-2610.

Quintiles by sex

Adjusted for case-matching criteria,* RR(95% CI)

Further adjusted for TC:HDL-C, BMI, other risk factors,** RR (95% CI)

Further adjusted for diabetes and hypertension, RR (95% CI)

Men      

•Quintile 2 •1.81•(1.04-3.17)

•1.75•(0.97-3.14)

•1.75•(0.97-3.16)

•Quintile 3 •2.00•(1.15-3.50)

•1.83•(1.02-3.30)

•1.74•(0.96-3.15)

•Quintile 4 •2.74•(1.59-4.71)

•2.27•(1.26-4.09)

•2.14•(1.18-3.88)

•Quintile 5 •3.29•(1.91-5.65)

•2.73•(1.51-4.96)

•2.55•(1.40-4.65)

—p for trend <0.001 0.007 0.02

*Age, smoking status, month of blood sampling; in women only, also adjusted for fasting status at time of blood sampling.**Parental CHD history, alcohol intake, exercise activity level, total cholesterol/HDL cholesterol ratio, body mass index (BMI); in women only, also adjusted for postmenopausal hormone therapy status.