Oxygen Transport Systems Integration of Ventilation, Cardiac,
and Circulatory Functions
Slide 2
Cardiovascular Function transportation of O 2 and CO 2
transportation of nutrients/waste products distribution of hormones
thermoregulation maintenance of blood pressure
Slide 3
Slide 4
Slide 5
Slide 6
Slide 7
Long Refractory Period in Cardiac Muscle Prevents Tetany
Slide 8
Cardiac Fibers Develop Graded Tension Frank-Starling Law of the
Heart graded Ca 2+ release from SR dependent on Ca 2+ influx
through DHP channels
Slide 9
Autorhythmic cells depolarize spontaneously leaky membrane SA
and AV node
Slide 10
Central command input and output Group III
Slide 11
Slide 12
Cardiac output affected by: 1.preload end diastolic pressure
(amount of myocardial stretch) affected by venous return
2.afterload resistance blood encounters as it leaves ventricles
affected by arterial BP 3.contractility strength of cardiac
contraction 4.heart rate
Slide 13
Mechanisms affecting HR VO 2 = HR SV (a-v O 2 ) Sinoatrial node
is pacemaker for heart spontaneously depolarizes leakiness to Na +
influenced by autonomic NS training down-regulates -adrenergic
system causing bradycardia
Slide 14
Cardiac Output Regulation Extrinsic control autonomic nervous
system sympathetic NS (1 control at HR >100 bpm) parasympathetic
NS (1 control at HR
