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Osteomyelitis
Dr/Wael H. Mansy, M.D.Assistant Professor
King Saud University
Objectives of this session:
Familiarize the audience with major types of Osteomyelitis, relationship to the age of the host, mechanism of infection, bacteriology of the disease.
Clues that help in the diagnosis Overview of the management of
Osteomyelitis.
Osteomyelitis: Definition
Infection of the bone and bone marrow (osteo,
myelitis)
Mostly bacterial, can be fungal
Epidemiology
Pre-antibiotic era had 25% mortality Significant morbidity/disability worldwide due to
lack of access to care Leading cause for amputations in the US Significant cause of pediatric disability
worldwide.
Prevalence:
Children 1: 5000 Sickle cell patients 3.6: 1000 Post puncture wound to foot 16% Neonates 1: 1000 Post puncture wound to foot in
diabetics 30 – 40% Higher in developing countries
Jose R. Jimenez MD, UTHCT 7
Osteomyelitis
Usually subdivided clinically into: Pediatric Adult Hematogenous vs. Direct spread Special cases of Intravenous Drug
Abusers (IVDA) and Sickle cell Anemia.
Pediatric Osteomyelitis
Hematogenous spread affecting the long bones.
Usual sites are the long bones: tibia, humerus, femur.
Some to Spine: direct contact (TB)
Why the long bones?
Non-anastomosing capillary ends of nutrient
arteries form sharp loops under the growth
plates and enter large venous sinusoids
where the blood flow is slow and turbulent,
trapping the organisms.
Usual causative organisms: Pedi. Osteo. Staphylococcal aureus Streptococcus suppurefaticus. Hemophilus. influenza. Sickle cell disease: Long bone
osteomyelitis often due to salmonella.
Adult Osteomyelitis
Most Cases: Direct extension of infection to the bone from a skin ulceration, leading cause of amputations
Direct inoculation to the bone from an open/contaminated fracture.
Hematogenous from IVDA
Adult Osteomyelitis
IVDA: Hematogenous site more likely to be
spine or pelvis only occasionally to the long
bones.
Adult Osteomyelitis
Most common: Foot ulcer extending into the bony structures.
Neuropathic foot ulcer Mixed infection is common with s.aureus, Gram
negatives, some strep. Open fractures Infected prostheses Foot injuries
Jose R. Jimenez MD, UTHCT 17
Management: Admit
OrthoSurg consultation Closed needle biopsy/drainage C/S obtained Started on I.V. vancomycin
empirically Switched to oxacillin after C/S
grew meth. Sensitive staph. A.
Hosp. Course
Over 6 to 8 days on I.V. antibiotic therapy, patient became afebrile, leg tenderness subsided, less pain w/ ambulation.
On 9th day patient switched to oral penicillin, sent home to complete 6 weeks of therapy.
Full recovery when seen for follow up visit in clinic.
Osteomyelitits
Follow up: can consider repeat ESR have it return to normal level.
Follow up films, radiologic recovery slower than clinical recovery