Textbook readingOSTEOARTHRITIS

Siti Nur AmiraNursyimaaNor Ezyan SyaminSarinah ArsyadVista Ririn SitoAstrid MariaKintan Ramadhani

PEMBIMBING:dr. Proridr.Wiradr.Edwin

Supervisor : dr. Henry Yurianto, M.Phil, Ph.D, SpOT

DIBAWAKAN DALAM RANGKA TUGAS KEPANITERAAN KLINIKBAGIAN ORTOPEDI DAN TRAUMATOLOGIFAKULTAS KEDOKTERAN UNIVERSITAS HASANUDDINMAKASSAR 2015

Articular cartilagetransmit load and movementfrictional resistance to movement and surface glidinggel-like matrix consisting of a proteoglycan, chondrocytes, type II collagen absorb changes in load and mitigate deformationcollagen network copes with tensile forces

CapsuleThe soft tissues enclosing the joint surfaceLigamentProvide stability

SynoviumProvides a nonadherent covering for the articular surfaces and it produces synovial fluidSynovial fluidReducing friction during movement and has slight adhesive properties which assist in maintaining joint stability

Release of proteolytic enzymesCartilage deformationProteoglycan matrix depletionChondrocyte damageCollagen failure

Cardinal features

More joints are affected in women than in men.

Kellgren JH, Lawrence JS. Radiological assessment of osteoarthritis.Annals of the Rheumatic Diseases 1957;16:494-501

Grade ONo radiological changeGrade 1Doubtful: Minute osteophyte, doubtful significanceGrade 2Minimal: Definite osteophyte, unimpaired joint spaceGrade 3Moderate: Moderate diminution of joint spaceGrade 4Severe: Joint space greatly impaired, with sclerosis of subchondral bone

*******************The pathologic features readily correlate with the radiographic features of knee OA, i.e. loss of joint space, subchondral cysts, and attempts at repair or regeneration such as sclerosis and osteophytes.