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1 Osaka University Global Collaboration Technology Transfer and Incubation 2 Contents Osaka University Policy for Global Collaboration Structure for Technology Transfer and Incubation Achievements Joint Research Program Bio Research Biotech Companies Biotech Cluster 3 Policy for Global Collaboration Principles of activities for Global Industry-Academia-Government Collaboration In ever growing globalization of research and development conducted by industries, academia, and governments, the global industry- academia-government collaboration shall be operated in response to the needs of the society, and the fruits thereof shall be returned to University for the activation of its education and research. In order to promote activities related to the global industry-academia- government collaboration, information about research activities of University shall be streamlined and sent out, so as to lead the international liaison activities. 4 Pharmaceutical Pharmaceutical Chemical Chemical Steel Steel Mechanical Mechanical Electronics Electronics Automobile Automobile IT IT other other Industries Industries Center for Advanced Center for Advanced Science and Innovation Science and Innovation Joint Research Program Research Departments Research Departments Osaka Univ. Venture Business Support Office Industry Intellectual Property Office Intellectual Property Office Structure for Technology Transfer Joint Research Division Joint Research Chair Osaka TLO Kansai TLO Hyogo TLO Research Coordination Office 5 Structure for Technology Incubation Center for Advanced Science Center for Advanced Science and Innovation and Innovation Biotech Network Research Departments Research Departments Osaka Univ. 40 Bio Ventures Venture Capitals TLO & Incubators Research Coordination Office Venture Business Support Office IPO M&A Laboratory Fundamental Research Venture Capital:$30M~ Employee:50~ Laboratory Industrial Research Venture Capital:$30M Employee:50 Venture Capital:$10M Employee:20 Seeds Finding Seeds Incubation Venture IncubationIndependent 2~3years 1~2years 2~3years Venture IncubationIPO:2 Bio Ventures Anges MG Soiken Intellectual Property Office Intellectual Property Office 6 Achievements Grant-in-Aid for Scientific Research 0 100 200 300 400 500 600 0.0 2.0 4.0 6.0 8.0 10.0 billion yen case billion yen 4.3 3.6 3.8 5.5 7.8 9.0 9.9 case 397 367 388 401 438 562 565 H.12 (2000) H.13 (2001) H.14 (2002) H.15 (2003) H.16 (2004) H.17 (2005) H.18 (2006) cases B yen

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Page 1: Osaka University Global Collaboration · Industry-Academia-Government Collaboration In ever growing globalization of research and development conducted by industries, academia, and

1

Osaka University

Global Collaboration

Technology Transfer and Incubation

2

Contents

Osaka University

◇ Policy for Global Collaboration

◇ Structure for Technology Transfer and Incubation

◇ Achievements

◇ Joint Research Program

◇ Bio Research

◇ Biotech Companies

◇ Biotech Cluster

3

Policy for Global Collaboration

Principles of activities for Global

Industry-Academia-Government Collaboration

In ever growing globalization of research and development conducted

by industries, academia, and governments, the global industry-

academia-government collaboration shall be operated in response to

the needs of the society, and the fruits thereof shall be returned to

University for the activation of its education and research.

In order to promote activities related to the global industry-academia-government collaboration, information about research activities of University shall be streamlined and sent out, so as to lead the international liaison activities.

4

PharmaceuticalPharmaceutical

ChemicalChemical

SteelSteel

MechanicalMechanical

ElectronicsElectronics

Automobile Automobile

ITIT

other other

IndustriesIndustries

Center for Advanced Center for Advanced

Science and InnovationScience and Innovation

Joint ResearchProgram

ResearchDepartments

ResearchDepartmentsOsaka Univ.

Venture Business SupportOffice

Industry

Intellectual Property OfficeIntellectual Property Office

Structure for Technology Transfer

Joint Research

Division

Joint Research

Chair

Osaka TLOKansai TLOHyogo TLO

Research CoordinationOffice

5

Structure for Technology Incubation

Center for Advanced Science Center for Advanced Science

and Innovationand InnovationBiotech Network

ResearchDepartments

ResearchDepartments

Osaka Univ.

40 Bio Ventures

Venture Capitals

TLO & Incubators

Research CoordinationOffice

Venture Business SupportOffice

IPO

M&A

Laboratory

FundamentalResearch

Venture

Capital:$30M~Employee:50~

Laboratory

IndustrialResearch

Venture

Capital:$30MEmployee:50

Venture

Capital:$10MEmployee:20

SeedsFinding

SeedsIncubation

VentureIncubation①①①①

Independent

2~3years 1~2years 2~3years

VentureIncubation②②②②

IPO:2 Bio Ventures

Anges MG

SoikenIntellectual Property OfficeIntellectual Property Office

6

Achievements

Grant-in-Aid for Scientific Research

0

100

200

300

400

500

600

0.0

2.0

4.0

6.0

8.0

10.0

billion yen

case

billion yen 4.3 3.6 3.8 5.5 7.8 9.0 9.9

case 397 367 388 401 438 562 565

H.12

(2000)

H.13

(2001)

H.14

(2002)

H.15

(2003)

H.16

(2004)

H.17

(2005)

H.18

(2006)

casesB yen

Page 2: Osaka University Global Collaboration · Industry-Academia-Government Collaboration In ever growing globalization of research and development conducted by industries, academia, and

7

Achievements

Joint Research

0

100

200

300

400

500

600

700

0

500

1000

1500

2000

2500

million yen

case

million yen 733 892 1212 1250 1810 2163 2352

case 165 204 265 306 457 586 643

H.12

(2000)

H.13

(2001)

H.14

(2002)

H.15

(2003)

H.16

(2004)

H.17

(2005)

H.18

(2006)

casesM yen

8

Joint Research Program

Joint Research Chair

Duration of 2 to 10 years

Fully devoted to joint research

Arrangement with emphasis on use of

intellectual properties

Jointly operated by sponsoring

corporations and Osaka University

Joint Research Chair /Joint Research Division

researchers, premises,

facilities etc.

funds, researchers,

research materials etc.

Osaka University Industry etc.

Through this system, Osaka University aims to enhance its researches and

provide answers to the diverse needs of society by working together with the

industrial world in creating within the university platforms for long-term

research for fields that contribute to social development.

9

List of Current Joint Research Chair

January, 2008Fundamental Research for Electron Optics Joint Research Division

July, 2007Kringle Pharma Joint Research Division for Drug Discovery

April, 2007Electronic Device Production Technology Joint Reaserch Chair

June, 2006Joint Research Chair of Fluorine Chemistry

July, 2006Joint Research Chair of Microwave Chemistry

October, 2007Joint Research Chair of Iron Making Process, Nippon Steel Co., Ltd

June, 2007Joint Research Chair of Iron & Steel Surface Frontier, Nisshin Steel Co., Ltd.

May, 2007Joint Research Chair of Elemental Resource Circulation Engineering for Iron & Steel, Sumitomo Metals Co., Ltd

April, 2007Joint Research Chair of Pipeline Engineering, Japan Petroleum Exploration Co., Ltd.

July, 2007Mitsui Engineering & Shipbuilding Joint Research Chair

July, 2006Komatsu Joint Research Laboratory

established inName of Chair / Division

Joint Research Program

10

Bio Research

9 Main Research Departments

School of Medicine (slide:6)

School of Frontier Bio Science

School of Pharmaceutical Science

School of Dentistry

Institute for Protein Research

Institute of Scientific and Industrial Research

Research Institute for Microbial Diseases (slide:7)

University Hospital

Medical Center for Translational Research (slide:8,9)

1,200 Researchers

7,000 Graduate students

$650Million Research Budgets

Dynamic Bio Research Activity

11

Nature

Vol. 450, pp475-477, 2007

Reprinted by permission from Nature

Copyright: Nature Publishing Group

Nature

Vol. 450, pp475-477, 2007

Reprinted by permission from Nature

Copyright: Nature Publishing Group

News Feature “ INNATE ABILITY”

With keen immunological insight and a knockout mouse `factory`,

Shizuo Akira leads by quiet

example.

Top Immunologist

• A pioneer in innate immunity

• THOMSON SCIENTIFIC

HOTTEST RESEARCHERS2006,2007

•Robert Koch Prize (2005))))

•William B Coley Award ((((2006))))

• Imperial Prizes and Japan Academy Prizes

Professor

Shizuo AKIRA

Professor

Shizuo AKIRA

Top Immunologist

Bio Research

His group is

investigating host

defense mechanisms,

particularly the in vivo

signaling pathways

that participate in

innate immunity.12

‣ Professor AKIRA was awarded the World Premier International Research

Center grant from Japan’s Science ministry. The grant will provide billions

of yen to set up new institutions, Starting with 700million yen for to build

the Immunology Frontier Research Center at Osaka University.

‣ To develop new strategies for diagnosis and treatment

of infectious diseases, autoimmune diseases, allergy

and cancer through immuno-imaging.

‣ Center consists of 10-20 world-class immunologists

and imaging scientists as principal investigators.

30% of researchers are from abroad.

Immunology Frontier Research Center (IFReC) of Osaka University

World Premier Initiative (WPI) Program

Center of Immunology

Bio Research

Page 3: Osaka University Global Collaboration · Industry-Academia-Government Collaboration In ever growing globalization of research and development conducted by industries, academia, and

13

In 2003, MTR was established in Osaka In 2003, MTR was established in Osaka

University Hospital as a translational research University Hospital as a translational research

center for future medical technology.center for future medical technology.

�Translational Research

Regenerative Medicine, Cell therapy, Robotics Surgery,

Surgical Assistance System, Surgery Training System,

New Diagnostic Imaging

�CPC Operation

�Future Medical Technology

Basic Research on stem cells and biomaterials

Introduction of IT to Surgical Suites

�Physician-oriented Clinical Trial

�Education / Human Resource Development

Medical Center for Translational Research

Bio Research

14

�Myocardial regeneration therapy by autologous stem cell transplantation

�Bone tissue engineering

– Integrating novel ceramic scaffold and mesenchymal stem cells

� Transplantation of cultured epithelial sheet to intractable corneal and

conjunctival diseases

�Immunotherapy against gastrointestinal cancers using newly developed

dendritic cell vaccine

� Therapy for intractable differentation pain with navigation-guided repetitive

transcranial magnetic stimulation

� Neuroprotective therapy for ischemic optic neuropathy using trans-corneal

electrical stimulation

� Regeneration therapy using myoblast sheet against dilated type

cardiomyopathy

Ongoing TR projects

Bio Research

15

• Discovery of IL-6 and its multi functions

• Development of anti-IL-6 receptor antibody

and its application

Avail treatment of Rheumatoid Arthritis and

Castleman’s Disease et.

• Joint Research with Roche

Market prospect $10 Billion worldwide

Joint Research for Drug Discovery

Roche

by Dr. T. Kishimoto, Emeritus Professor

Bio Research

16

1. To make a contribution to global healthcare by joint research for drug discovery aiming at treatment of cancer and incurable diseases

2. To make contribution to society through education of medical andpharmaceutical researchers

Mission of the Joint Research Division

Research projects・ Studies on therapeutic effects of HGF on

incurable diseases and its mechanisms

・ Researches to create novel drugs superiorto HGF based on structural based drug design

・ Researches on HGF inducer and its application

・ Researches to discover novel functions of HGF and its intramolecular fragments

HGF

Joint Research for Drug Discovery

Kringle Pharma, Inc.

Bio Research

17

The Research Foundation for Microbial Diseases of Osaka University was founded on June 6, 1934 as an applied research-oriented counterpart of the Research Institute for Microbial Diseases, Osaka University.

Vaccine for Human UseViral vaccineInactivated VaccinesInfluenza HA Vaccine Japanese Encephalitis VaccineLive VaccineFreeze-dried Live Attenuated Measles VaccineFreeze-dried Live Attenuated Rubella VaccineFreeze-dried Live Attenuated Varicella VaccineFreeze-dried Live Attenuated Measles, Rubella Combined Vaccine Bacterial Vaccine

Adsorbed Diphtheria-purified Pertussis-Tetanus Combined VaccineAdsorbed Diphtheria-Tetanus Combined ToxoidAdsorbed Diphtheria Toxoid for Adult UseAdsorbed Tetanus Toxoid

Vaccines for Veterinary Use

For Fish

Inactivated Iridovirus Vaccine

Inactivated Iridovirus-Streptococcicosis Combined

Products for Laboratory Diagnosis

Varicella Skin Test Antigen

BIKEN’s Main Products

The First Biotech Company

The Research Foundation for Microbial Diseases of Osaka University

Biotech Company

18

Research and development of:

Target diseases: acute and chronic failure

2. NK4 (HGF antagonist/angiogenesis inhibitor)

Target diseases: solid tumors

1. HGF (hepatocyte growth factor)

Main projects

� Established in November 2001� Originating from Osaka University� Capital: 1 billion 3957.8 million yen

(as of November 2007)

� Employee: 17 (as of November 2007)

New Biotech

Kringle Pharma, Inc.

Head office: Osaka

Biotech Company

Page 4: Osaka University Global Collaboration · Industry-Academia-Government Collaboration In ever growing globalization of research and development conducted by industries, academia, and

19

Biotech Company

Kringle Pharma, Inc.

20

Main projects

New Biotech

SOSHO, Inc.

Biotech Company

◇ Established:July 1, 2005

◇ Representative Director:

Hiroaki ADACHI (President), Yusuke MORI

◇ Capital:55 million yen

◇ Employees:8

■■■■Screening for crystallization by laser irradiation

■■■■Optimization of growth condition

Improvement of crystallinity, Large crystal growth

■■■■X-ray diffraction measurement and data collection

■■■■Structural analysis

■■■■Consulting for crystal growth

21

SOSHO, Inc.

Biotech Company

Information of three dimensional structure of protein molecular

Understand function of protein

Structure-based-Drag design

Scheme of structure analysis

Protein DataBank

Conventionalapproach

Ourapproach 1 mm

supersaturatedprotein solution

DiffractQualityCrystal

X-ray diffraction(XRD)

3D structural

analysis

supersaturatedprotein solution

Only waiting

Produce large and high quality crystals

Control of Nucleation, Crystal Growth

Develop new technique for control of nucleation and crystal growth

Bottle neck

22

SOSHO, Inc.

Biotech Company

Two-liquidsystem

Lasernucleation

1mm1mm0.1 mm

Protein floating on the FluorinertProtein floating on the Fluorinert

Crystal samples for XRD measurementCrystal samples for XRD measurementCrystal samples for XRD measurementCrystal samples for XRD measurementCrystal samples for XRD measurementCrystal samples for XRD measurementCrystal samples for XRD measurementCrystal samples for XRD measurement

Femtosecond

laser system

Femtosecond

laser system

Forced NucleationForced Nucleation

Control grow

th process

Control grow

th process

Control grow

th process

Control grow

th process

Control grow

th process

Control grow

th process

Control grow

th process

Control grow

th process

Improve resolution limits

Solutionstirring

Laserprocessing

High quality growthHigh quality growth

Desired trimmingDesired trimmingFew damage and denaturation

23

Biotech Cluster

Kansai (Greater Osaka) Bio Cluster

○Universities: 18 (Kyoto Univ., Kobe Univ., Osaka Pref. Univ., etc)

○Bio-ventures companies successfully launched so far : 100

(Osaka University has launched 40 bio ventures)

○Pharmaceutical Companies: 20 (Takeda,Shionogi,Mitsubishi-Tanabe,etc.)

○Public Sector Sources of support and funding: 5

Osaka Prefecture government

Osaka City government

Kansai Bureau of Economy, Trade

and Industry (METI-Kansai), etc

Biotech Network40 Bio Ventures have been launched

24

Biotech Cluster

Screening/Hit Generation

ClinicalResearch

LeadOptimization

Pre-ClinicalResearch

AnimalTesting

Manufacturing

Dynamic Bio Value Chain

Expanding to Global Network

Venture CapitalsPublic Funds

Kyoto Univ. Kobe Univ. National Hospitals Osaka City Univ.

Osaka Univ. Osaka Pref. Univ. National Institutes Biotech Companies