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Adverse Childhood Experiences and their Relationship to
Adult Well-being and Disease : Turning gold into lead
A collaborative effort between
Kaiser Permanente and the Centers for Disease Control
Robert F. Anda, M.D. Vincent J. Felitti, M.D.
Office on Women’s Health, US Dept. of HHSChicago, IL July 20, 2011
Origins of the ACE Study
51 weeks later
What is the core problem here?
408 132 lbs
>400 lbs. in a shorter period of time than the weight was lost.
Why?
Weeks
ACE Study Design
Survey Wave 171% response (9,508/13,454)
n=13,000
Survey Wave IIn=13,000
All medical evaluationsabstracted
PresentHealth Status
MortalityNational Death Index
MorbidityHospitalizationDoctor Office VisitsEmergency Room VisitsPharmacy Utilization
All medical evaluationsabstracted
vs.
N = 17, 337
Prevalence of Adverse Childhood Experiences
Abuse, by CategoryPsychological (by parents) 11%Physical (by parents) 28%Sexual (anyone) 22%
Neglect, by CategoryEmotional 15%Physical 10%
Household Dysfunction, by CategoryAlcoholism or drug use in home 27%Loss of biological parent < age 18 23%Depression or mental illness in home 17%Mother treated violently 13%Imprisoned household member 5%
Prevalence (%)
Adverse Childhood Experiences ScoreNumber of categories (not events) is summed…
ACE Score Prevalence0 33%1 25%2 15%3 10%4 6%5 or more 11%*
• Two out of three experienced at least one category of ACE.• If any one ACE is present, there is an 87% chance at least one
other category of ACE is present.* Women are 50% more likely than men to have a Score >5.
ÒIn my beginning is my end. Ó
T.S.Eliot, Quartets
Depression:
Most say depression is a disease.Many say depression is genetic.Some say it is due to a chemical imbalance.
Childhood Experiences Underlie Chronic Depression
01020304050607080
% W
ith a
Life
time
His
tory
of
Dep
ress
ion
0 1 2 3 >=4ACE Score
WomenMen
Mental Health
Childhood Experiences Underlie Suicide Attempts
0
5
10
15
20
25
% A
ttem
ptin
g Su
icid
e
ACE Score
12
0
3
4+
Mental Health
ACE Score and Rates of Antidepressant Prescriptions
0102030405060708090
100
Pres
crip
tion
rate
pe
r 100
per
son-
year
s)
01
23
45 ormore
Mental Health; Costs
approximately 50 years later
ACE Score
0
2
4
6
8
10
12
0 1 2 3 4 5 6 >=7
NoYes
ACE Score
Ever
Hal
luci
nate
d* (%
)
AbusedAlcoholor Drugs
*Adjusted for age, sex, race, and education.
ACE Score and HallucinationsMental Health
“Addiction is due to the characteristics intrinsic
in the molecular structure of some substance.”
The traditional concept:
Addiction highly correlates with characteristics intrinsic to that
individual’s childhood experiences.
The ACE Study shows that:
Adverse Childhood Experiences vs. Smoking as an Adult
02468
101214161820
0 1 2 3 4-5 6 or moreACE Score
%
p< .001
Health Risks
Childhood Experiences vs. Adult Alcoholism
0
2
4
6
8
10
12
14
16
18
% A
lcoh
olic
ACE Score
0
1
23
4+
Health Risks
ACE Score vs Injection Drug Use
00.5
11.5
22.5
33.5
% H
ave
Inje
cted
Dru
gs
0 1 2 3 4 or more
ACE Score
p<0.001
Health Risks
ACE Scoreand Teen Sexual Behaviors
0
5
10
15
20
25
30
35
40
45
Perc
ent W
ith H
ealth
Pro
blem
(%
) 0 1 2 3 4 or moreACE Score
Intercourse by Age 15
Teen Pregnancy Teen Paternity
Social function
Intercourse by 15
Teen Pregnancy
TeenPaternity
Childhood Experiences Underlie Later Being Raped
0
5
10
15
20
25
30
35
% R
epor
ting
Rap
e
ACE Score
0
1
23
4+
Well-being
ACE Score and theRisk of Perpetrating Domestic Violence
__________________________________
0
5
10
15Women Men
0 1 2 3 4 >5 0 1 2 3 4 >5
ACE Score
Social function
Social function
ACE Score and Indicators ofImpaired Worker Performance
0
5
10
15
20
25
0 1 2 3 4 or moreACE Score
Absenteeism(>2 days/month)
SeriousFinancialProblems
SeriousProblems
Performing job
The ACE Score and the Prevalence of Liver Disease (Hepatitis/Jaundice)
0
2
4
6
8
10
12
0 1 2 3 >=4
AACE CE Score
Perc
ent
(%)
ACE Score
Biomedical Disease
ACE Score vs. COPD
Biomedical Disease
0 1 2 3 4
02468
1012141618
ACE Score
ACEs Increase Likelihood of Heart Disease*
• Emotional abuse 1.7x• Physical abuse 1.5x• Sexual abuse 1.4x• Domestic violence 1.4x• Mental illness 1.4x• Substance abuse 1.3x• Household criminal 1.7x• Emotional neglect 1.3x• Physical neglect 1.4x
*After correction for age, race, education, and conventional risk factors like smoking and diabetes. Circulation, Sept 2004.
omedical disease
How and why doAdverse Childhood Experiences
exert their influence throughout life?
Why is treatment so difficult?
In Summary, the ACE Study indicates:
Adverse childhood experiences are the most basic and long-lastingdeterminants of health risk behaviors, mental illness, social malfunction, disease, disability, death, and healthcare costs.
What are conventionally viewed as Public Health problems are oftenpersonal solutions to long-concealed
adverse childhood experiences.
“It’s hard to give up something that almost works.”
A Public Health Paradox
Translating Research into Practicea beginning
1.3 million comprehensive patient evaluations since 1975
6th Floor
Interventions
An Individual, Population-based Health Appraisal System:
A Biopsychosocial Concept
• Comprehensive history(not symptom-initiated)obtained at home bydetailed questionnaire,better by Internet.
Includes ACE Questions
Unconventional R.O.S. Questions of Demonstrated Value
• Have you ever lived in a war zone?• Have you been a combat soldier?• Who in your family has committed suicide?• Who in your family has been murdered?• Who in your family has had a nervous breakdown?• Were you molested as a child?• Have you ever been held prisoner?• Have you been tortured?• Have you been raped?
Interventions
Benefits of a Biopsychosocial Preventive Approach
Biopsychosocial evaluation: 35% reduction in DOVsin subsequent year.(120,000 patient sample)
Biomedical evaluation: 11% reduction in DOVs(Control group) in subsequent year.
(700 patient sample)
Effect of Interventions
Final Insights from the ACE Study• Adverse childhood experiences are common but typically unrecognized.
• Their link to major problems later in life is strong, proportionate, and logical.
• They are the nation’s most basic public health problem.
• It is comforting to mistake intermediary mechanism for basic cause.
• What presents as the ‘Problem’ may in fact be an attempted solution.
• Treating the solution may be threatening and cause flight from treatment.
• Primary prevention is presently the only feasible population approach.
• Using this information clinically will be resisted, by us.
Further Informationwww.acestudy.org
Google or Medline (Anda or Felitti as author name)
[email protected] (Documentary DVDs)
www.HumaneExposures.com (3 books)