Organs affected with AIDS-lymphoid tissue

HIV in the nervous system AIDS dementia

• First reported by Hungarian physician: Moritz Karposi in 1872

• Multifocal cancer: dominant type is called spindle cells: endothelial origin

• Typically in older man in Mediterranian rim• In HIV-1: very aggressive: occurs in 20% of

infected homosexual man, only 2% in others• Evidence that Herpes virus (HHV8) is necessary

is strong

Karposi Sarkoma

Karposi Sarkoma

Karposi Sarkoma

• HAART: highly efficient triple combination therapy: (2x anti-reverse transcriptase, 1xprotease inhib.)

Treatment of AIDS

Viral decay on drug treatment

Resistance of HIV to protease inhibitors

HIV Infection is spreading over all continents

Difficulties:• Rapid mutations in virus• Danger to cause an inappropriate immune

response• Necessity to target privileged sites

(mucosa, brain)• Small animal models not available• Ethical issues of vaccination: people

should adjust behaviour

Immune Therapies/Prophylactic vaccine development

• Prevention!!!!!• Multiple steps in viral replication offer new

targets

Perspectives

“Innate Immunity”Adelheid Cerwenka, PhD, D080

Theodor Boveri-Group since April 2003

PhD studentsNorman NauschKai Zanzinger

Anja Schmidtke

TechnicianSandra Kosten