Organophosphate poisoning

1030717

Pralidoxime• I.V.: • Loading dose: 1000-2000 mg; Maintenance: Repeat bolus of 1000-

2000 mg after 1 hour and repeated every 10-12 hours thereafter, as needed. Alternatively, administer a loading dose of 30 mg/kg followed by a maintenance infusion of 8 mg/kg/hour (unlabeled dose; Roberts, 2007).

• I.M.:• Mild symptoms: 600 mg; repeat as needed for persistent mild

symptoms every 15 minutes to a maximum total dose of 1800 mg; may administer doses in rapid succession if severe symptoms develop

• Severe symptoms: 600 mg; repeat twice in rapid succession to deliver a total dose of 1800 mg

• Pralidoxime chloride inj. 500mg