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Building Blocks and BeyondBuilding Blocks and Beyond
U.S. Based Manufacturing U.S. Based Manufacturing Since 1928Since 1928
GFS ChemicalsGFS Chemicals
• Specialty chemical Specialty chemical manufacturingmanufacturing
• Volumes from Volumes from research toresearch to bulk bulk
• Focused on Core Focused on Core CompetenciesCompetencies
Core CompetenciesCore Competencies
• Acetylene Acetylene chemistrychemistry
• Propargylic aminesPropargylic amines
• Grignard chemistryGrignard chemistry
• Specialty halidesSpecialty halides
• Si blocked Si blocked compoundscompounds
• Birch reductionsBirch reductions
• Alpha/omega Alpha/omega functionalizationfunctionalization
Acetylene ChemistryAcetylene Chemistry
HC CH R1C CR2
O
O
(CH2)9CH3
Propargylic AminesPropargylic Amines
H2N
NH
N
NH
NH
Recently Manufactured Recently Manufactured GrignardsGrignards
O
MgBr
CH3(CH2)nMgX
n = 0 - 7; X = Cl, BrMgBr
MgBr
RC CMgX
R = H
Scale: 10's - 1000's LT
10's of LT
1000's of LT
10's - 1000's of LT
100's of LT
Specialty HalidesSpecialty Halides
I
Br
Si(CH3)3
X
X = Cl, Br, I
Br
Br
X
ClX = F, Cl
Si Blocked CompoundsSi Blocked Compounds
Br
Si(CH3)3X
Si(CH3)3
X = OH, Br
Si CH2MgCl (H3C)3Si Si(CH3)3
Si
(H3C)3Si Si(CH3)3
Birch ReductionsBirch Reductions
Y
Z H3COOH
O
H3CO CH3
Y,Z = H, R, OR, COOH
αα,,ωω Functionalized Functionalized MoleculesMolecules
Br
Cl NH2
OH
ICl
BrBr
New TechnologiesNew Technologies
• ThiophenesThiophenes
• Bridged orthoestersBridged orthoesters
Specialty ThiophenesSpecialty Thiophenes
• OLED/Conductive Polymer ApplicationsOLED/Conductive Polymer Applications
• Pharmaceutical and Biotechnology ApplicationsPharmaceutical and Biotechnology Applications
SS
S
Br
R
S
O
H
O
H
S
O O
Bridged OrthoestersBridged Orthoesters• Protected Carboxylic acidsProtected Carboxylic acids
OCH2OH
CH3
O
O
O
Br
O
O
O
R
R OR'
O
R = alkyl, aryl, vinyl, alkynyl
Protecting Group Reagent:
Contact GFS ChemicalsContact GFS ChemicalsDavid K. Baust – General Manager –Specialty Organic ManufacturingDavid K. Baust – General Manager –Specialty Organic Manufacturing
[email protected]@gfschemicals.com
Office: 614-224-5013 extension 103Office: 614-224-5013 extension 103
Cell: 614-975-6304Cell: 614-975-6304 visit us at www.gfschemicals.com
Coming in June www.gfsorganics.comComing in June www.gfsorganics.com
