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ORGANIC AND PHARMACEUTICAL LAB
Pharmacy faculty
2013 – 2014
Chapter 4
Classification of organic
chemistry research studies
Course of study
Synthesis studies
Work-up(purification) studies
Yield calculation
Literature search
Sources to obtain chemicals
Qualitative and quantitative analysis
Instrumental analysis (introductory level)
IntroductionOrganic Chemistry research involves the synthesis of organic molecules and the study of their reaction paths, interactions, and applications. Advanced interests include diverse topics such as the development of new synthetic methods for the assembly of complex organic molecules and polymeric materials, organometallic catalysis, organocatalysis, the synthesis of natural and non-natural products with unique biological and physical properties, structure and mechanistic analysis, natural product biosynthesis, theoretical chemistry and molecular modeling, diversity-oriented synthesis, and carbohydrate synthesis.
Synthesis studies
Organic compounds that has been never synthesis before
Strategy:
Pharmaceutical chemistry research studies
on the design and synthesis of novel drug candidate molecules is a good representative example to this category
Organic compounds that has been synthesis previously
:Strategy
In these synthesis types is the discover of a novel synthetic approach that supplies high yields and the lowers the synthesis cost
Work-up and purification studies
Work-up
Purification
Which factors are important in work-up
Reaction condition
Reaction yield
Chemical and physical properties(reactants, regents, products)
Number of products and reactants
Yield calculation
Mechanism of acetophenone
Literature search
Why literature is very important?
Notice:An effective literature search must be performed before making a practice in laboratory
Sources to obtain chemicals
Qualitative and quantitative analysis
Instrumental analysis-structure identification (Brief introduction)
High performance liquid chromatography (HPLC)
Ultra performance liquid chromatography(UPLC)
Mass spectroscopy (MS)
Infrared spectroscopy (IR)
Ultraviolet spectroscopy (UV)
High performance liquid chromatography (HPLC)
Ultra performance liquid chromatography
(UPLC)Qualitative and quantitative measurement
Gas chromatography-Mass spectroscopy (GC-MS)
Infrared spectroscopy (IR)
Ultraviolet spectroscopy (UV)