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25 O PTIMIZING COMMUNICATION IN THE EVOLVING MULTIPLE SCLEROSIS BENEFIT : RISK LANDSCAPE A position statement from the Navigating MS Steering Committee O PTIMIZING COMMUNICATION IN THE EVOLVING MULTIPLE SCLEROSIS BENEFIT : RISK LANDSCAPE

OPTIMIZING COMMUNICATION IN THE EVOLVING MULTIPLE … · 2017-10-20 · 25 OPTIMIZING COMMUNICATION IN THE EVOLVING MULTIPLE SCLEROSIS BENEFIT:RISK LANDSCAPE A position statement

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Page 1: OPTIMIZING COMMUNICATION IN THE EVOLVING MULTIPLE … · 2017-10-20 · 25 OPTIMIZING COMMUNICATION IN THE EVOLVING MULTIPLE SCLEROSIS BENEFIT:RISK LANDSCAPE A position statement

25

OPTIMIZING COMMUNICATION IN

THE EVOLVING MULTIPLE SCLEROSIS

BENEFIT:RISK LANDSCAPE

A position statement from the Navigating MS Steering Committee

OPTIMIZING COMMUNICATION IN

THE EVOLVING MULTIPLE SCLEROSIS

BENEFIT:RISK LANDSCAPE

Page 2: OPTIMIZING COMMUNICATION IN THE EVOLVING MULTIPLE … · 2017-10-20 · 25 OPTIMIZING COMMUNICATION IN THE EVOLVING MULTIPLE SCLEROSIS BENEFIT:RISK LANDSCAPE A position statement

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1. James Q. Miller Multiple Sclerosis Clinic, Department of Neurology, University of Virginia,

Charlottesville, VA, USA; 2. Division of Clinical Neuroscience, University of Nottingham,

Nottingham, UK; 3. Multiple Sclerosis Association of America, Seattle, WA, USA; 4. Gold Coast

University Hospital, Southport, QLD, Australia; 5. Horizon Rehabilitation Centers, Omaha, NE,

USA; 6. Neuroimmunology Unit, European Centre for Brain Research, Fondazione Santa Lucia,

Rome, Italy; 7. Keck School of Medicine of USC, Los Angeles, CA, USA; 8. European Multiple

Sclerosis Platform, Brussels, Belgium; 9. Tulane MS Center, Tulane University School of Medicine,

New Orleans, LA, USA; 10. Clinic and Centre of the B’ Department of Neurology, AHEPA

University Hospital, Thessaloniki, Greece; 11. University of Arizona College of Medicine,

Phoenix, AZ, USA; 12. Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA;

13. University of Utah, Department of Neurology, MS Clinic Salt Lake City, UT, USA; 14. Stanford

Multiple Sclerosis and Neuroimmunology Program, Stanford, CA, USA; 15. MS Australia, Sydney,

NSW, Australia; 16. Mellen Center, Cleveland Clinic, Cleveland, OH, USA; 17. Tarrant County

College, Fort Worth, TX, USA; 18. The MS Center for Innovations in Care, St. Louis, MO, USA;

19. Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK;

20. Santa Monica Neurological Consultants, Santa Monica, CA, USA. !

!

Optimizing communication in the evolving multiple sclerosisbenefit:risk landscape

A position statement from the Navigating MS Steering Committee

Page 3: OPTIMIZING COMMUNICATION IN THE EVOLVING MULTIPLE … · 2017-10-20 · 25 OPTIMIZING COMMUNICATION IN THE EVOLVING MULTIPLE SCLEROSIS BENEFIT:RISK LANDSCAPE A position statement

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&1(19&!*(.!(<1'3!(!4'3&+/d&!13'(1*'/1!0+(<&!(/,!3%&E!1+<'3(/>'B!(/,!=%<<!<%E'<.!=(33(/1!>2(/0'&!%/!12'!

13'(1*'/1!4<(/@!G9&1!(&!6?!>2(/0'&!+;'3!1%*'B!(!4'3&+/d&!13'(1*'/1!4<(/!*(.!>2(/0'!+;'3!1%*'N!2+=';'3B!

12'!1'/'1&!+-!'--'>1%;'!>+**9/%>(1%+/B!&2(3',!,'>%&%+/)*(E%/0B!(/,!(/!'*42(&%&!+/!12'!'/1%3'!%/,%;%,9(<!

<%E'<.!3'*(%/!43%+3%1%'&@!

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5

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72'!-%3&1!F(;%0(1%/0!6?!>+/-'3'/>'!=(&!2'<,!%/!G9/'!#H"I!1+!,';'<+4!(!0<+C(<!'J4'31!4+&%1%+/!&1(1'*'/1!+/!

'--'>1%;'!>+**9/%>(1%+/!(/,!&2(3',!,'>%&%+/)*(E%/0!C'1=''/!4'+4<'!=%12!6?B!12'%3!>(3'!4(31/'3&B!(/,!

AKL&@!72'!*''1%/0!=(&!(11'/,',!C.!+;'3!TZ!AKL&!5%/><9,%/0!6?!/'93+<+0%&1&B!6?!PKL&B!6?!/93&'&B!42.&%>(<!

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12'!W?B!UW!(/,!P9&13(<%(@!b2%<'!12'3'!='3'!=%,'!,%--'3'/>'&!%/!>9<193'!(/,!2'(<12>(3'!&.&1'*&!C'1=''/!

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,%&>9&&!,%&'(&'!*(/(0'*'/1!=%12!%/,%;%,9(<&!=%12!6?!(/,!12'%3!>(3'!4(31/'3&@!?4'>%-%>(<<.B!12'!/'',!1+!

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>+**9/%>(1%+/!(/,!&2(3',!,'>%&%+/)*(E%/0!1+!09%,'!-9<<.!%/-+3*',!13'(1*'/1!,'>%&%+/&!%/!6?@!

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6

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2(;'!C''/!%,'/1%-%',B!(&!2(;'!+;'3!#HH!,%--'3'/1!0'/'1%>!<+>%!12(1!%/>3'(&'!12'!3%&E!+-!12%&!,%&'(&'@!e%;'/!12%&!

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';%,'/>')C(&',!*',%>%/'!,%,!/+1!&900'&1!12(1!(!<(>E!+-!';%,'/>'!=(&!(/!'J>9&'!-+3!12'3(4'91%>!%/'31%(!+3!

/%2%<%&*@##!A%&1+3%>(<<.B!*(/.!+-!12'!><%/%>(<!13%(<&!&944+31%/0!12'!9&'!+-!$67&!%/!6?!2(;'!C''/!>+*4(3%&+/&!

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+91>+*'&B!12'!'(3<.!9&'!+-!(!2%02<.!'--%>(>%+9&!5C91!=%12!4+1'/1%(<<.!*+3'!&'3%+9&!(,;'3&'!';'/1&8!$67!>(/!

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5(/,!(309(C<.!&2+9<,8!C'!<'(3/',!C.!C+12!AKL&!(/,!4(1%'/1&@!?2(3',!,'>%&%+/)*(E%/0!%&!(!>+<<(C+3(1%;'!

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Page 8: OPTIMIZING COMMUNICATION IN THE EVOLVING MULTIPLE … · 2017-10-20 · 25 OPTIMIZING COMMUNICATION IN THE EVOLVING MULTIPLE SCLEROSIS BENEFIT:RISK LANDSCAPE A position statement

7

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Page 9: OPTIMIZING COMMUNICATION IN THE EVOLVING MULTIPLE … · 2017-10-20 · 25 OPTIMIZING COMMUNICATION IN THE EVOLVING MULTIPLE SCLEROSIS BENEFIT:RISK LANDSCAPE A position statement

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Page 10: OPTIMIZING COMMUNICATION IN THE EVOLVING MULTIPLE … · 2017-10-20 · 25 OPTIMIZING COMMUNICATION IN THE EVOLVING MULTIPLE SCLEROSIS BENEFIT:RISK LANDSCAPE A position statement

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Page 11: OPTIMIZING COMMUNICATION IN THE EVOLVING MULTIPLE … · 2017-10-20 · 25 OPTIMIZING COMMUNICATION IN THE EVOLVING MULTIPLE SCLEROSIS BENEFIT:RISK LANDSCAPE A position statement

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14

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F/5/3/(*/2!

"@!$%<+E12+3/&(E9<!LB!l(<9>E!QGB!F(%3!ilB!K+3C+.!GQB!P<<'/!QQB!K(*4C'<<!G$@!69<1%4<'!&><'3+&%&!43';(<'/>'!%/!

12'!W/%1',!?1(1'&!>+**'3>%(<<.!%/&93',!4+49<(1%+/@!F'93+<+0.!#H"IN\IM"H"V)#"@!

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V@!6(!lqB!K2(/!gB!K(33912'3&!iG@!S/>%,'/>'B!43';(<'/>'B!>+&1&B!(/,!%*4(>1!+/!,%&(C%<%1.!+-!>+**+/!

>+/,%1%+/&!3'R9%3%/0!3'2(C%<%1(1%+/!%/!12'!W/%1',!?1(1'&M!&13+E'B!&4%/(<!>+3,!%/f93.B!13(9*(1%>!C3(%/!%/f93.B!

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"H@!i(44+&!gB!U,(/!eB!D3'',*(/!6?B!'1!(<@!72'!"").'(3!<+/0)1'3*!-+<<+=)94!&19,.!-3+*!12'!3(/,+*%:',!

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""@!i%/E'<!QLB!i+<<*(/!KB!cjK+//+3!LB!'1!(<@!S6!%/1'3-'3+/!C'1()"(!,'<(.&!,'-%/%1'!*9<1%4<'!&><'3+&%&!Z!.'(3&!

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"#@!6%<<'3!PUB!b+<%/&E.!G?B!i(44+&!gB!'1!(<@!c3(<!1'3%-<9/+*%,'!-+3!4(1%'/1&!=%12!(!-%3&1!><%/%>(<!'4%&+,'!

&900'&1%;'!+-!*9<1%4<'!&><'3+&%&!57cLSK8M!(!3(/,+*%&',B!,+9C<')C<%/,B!4<(>'C+)>+/13+<<',B!42(&'!T!13%(<@!

g(/>'1!F'93+<!#H"VN"TM^__)\I@!

"T@!cjK+//+3!LB!D%<%44%!6B!P3/(&+/!]B!'1!(<@!#ZH!*%>3+0!+3!ZHH!*%>3+0!%/1'3-'3+/!C'1()"C!;'3&9&!#H!*0!

0<(1%3(*'3!(>'1(1'!%/!3'<(4&%/0)3'*%11%/0!*9<1%4<'!&><'3+&%&M!(!43+&4'>1%;'B!3(/,+*%&',B!*9<1%>'/13'!&19,.@!

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*+,%-.%/0!,390&!%/!69<1%4<'!?><'3+&%&!4(1%'/1&M!P!&.&1'*(1%>!3';%'=@!L(1%'/1!U,9>!K+9/&!#H"_N"HHM"HT")V\@!

Page 23: OPTIMIZING COMMUNICATION IN THE EVOLVING MULTIPLE … · 2017-10-20 · 25 OPTIMIZING COMMUNICATION IN THE EVOLVING MULTIPLE SCLEROSIS BENEFIT:RISK LANDSCAPE A position statement

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"\@!Q''/!eiB!?%<C'3!UB!g(/0,+/!$b@!69<1%4<'!&><'3+&%&!4(1%'/1&j!9/,'3&1(/,%/0!(/,!43'-'3'/>'&!-+3!3%&E&!(/,!

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