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Non-fluorescent labels

Grade up your Oligo!

NON-FLUORESCENT LABELS FOR OLIGONUCLEOTIDESModifications for DNA and RNA

Product information

“We were always fully satisfied with the exceptional quality, purity and reliability of the amount of unlabeled and labeled oligonucleotides as well as with the customer support provided by IBA.” Prof. Dr. Markus Sauer, Biotechnology & Biophysics, University Würzburg, Germany

Product information

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Overview of non-fluorescent labels

5’-Non-nucleosidic modifications 5’ 3’ Internal Cat. no. Comments

5'-C9-Alkyne (NEW!) • 5-0209-01X For alkyne modification of oligos

5'-C15-Alkyne (NEW!) • 5-0209-02X For alkyne modification of oligos

5'-Alkyne-PEG3 (NEW!) • 5-0209-00X For alkyne modification of oligos

5’-DBCO-PEG4 (NEW!) • 5-0209-10X For copper-free Click reactions

5'-Amino-C3 • 5-0210-10X For attachment of dyes and modifications

5'-Amino-C6 • 5-0210-11X For attachment of dyes and modifications

5'-Amino-C12 • 5-0210-21X For attachment of dyes and modifications

5'-Branching (5’-Branch) • 5-0210-22X Multiplies attachment sites

5'-Carboxyl • 5-0210-23X For immobilization and coupling

5'-Cholesteryl (5’-Chol) • 5-0210-31X For antisense technology

5'-Hexaethylenglycol (5'-HeGl) • 5-0210-41X 18-Atom spacer

5'-Phosphate (5'-Phos) • 5-0210-51X For ligation

5'-Psoralen-C2 (5'-PsorC2) • 5-0210-61X For nucleic acid cross-linking

5'-Psoralen-C6 (5'-PsorC6) • 5-0210-71X For cross-linking of triple helices

5'-Thiol-C6 (5'-SH) • 5-0210-81X For attachment of dyes and immobilisation

5'-Triethylenglycol (5'-TriGl) • 5-0210-91X 9-Atom spacer

3’-Non-nucleosidic modifications 5’ 3’ Internal Cat. no. Comments

3'-Alkyne-Modifier (NEW!) • 5-0220-50X For alkyne modification of oligos

3’-DBCO-PEG4 (NEW!) • 5-0220-53X For copper-free Click reactions

3'-Amino • 5-0220-01X For attachment of dyes and modifications

3'-Chol • 5-0220-11X For antisense technology

3'-Hex • 5-0220-23X For blocking

3'-Phos • 5-0220-21X For ligation

3'-Puromycin • 5-0220-41X For inhibition of protein synthesis

3'-Thiol • 5-0220-31X For attachment of dyes and immobilisation

Internal/nucleosidic modifications Internal Cat. no. Comments

Adenosines

2-Amino-2'-dA • 5-0230-01X For increase of melting temperature

3'-dA(Cordycepin) • 5-0230-21X For blocking 3'-end

7-Deaza-2'-dA • 5-0230-31X For blocking 3'-end

8-Bromo-2'-dA • 5-0230-41X For crystallographic studies

N6-Methyl-2'-dA • 5-0230-51X To study/use methylation effects

Cytidines

2', 3'-ddC • 5-0231-01X For blocking extension of oligonucleotides

5-Me-2'-dC • 5-0231-11X For increase of melting temperature

5-Bromo-2'-dC • 5-0231-21X For crystallographic studies

5-C6-Amino-2’-dC • 5-0231-32X For internal amino group incorporation

5-Carboxy-dC (NEW!) • 5-0233-12X For DNA damage and repair research

5-Formyl-dC (NEW!) • 5-0233-60X For probing process of DNA demethylation

5-Hydroxymethyl-dC-CEP (NEW!) • 5-0517-11X For DNA methylation

5-Hydroxymethyl-dC II-CEP (NEW!) • 5-0517-12X For DNA methylation

N-4-TriGl-Amino-2’dC • 5-0231-33X For internal amino group incorporation

5-Iodo-2'-dC • 5-0231-31X For crystallographic studies

C8-Alkyne-dC (NEW!) • 5-0233-24X For alkyne modification of oligos

C8-TIPS-dC (NEW!) • 5-0233-25X For conjugation using click chemistry

C8-TMS-dC (NEW!) • 5-0233-26X For coupling

N4-Methyl dC • 5-0231-41X To study/use methylation effects

3'-dC • 5-0231-51X For blocking 3’-end

5-OH-dC (NEW!) • 5-0233-70X For DNA damage and repair research

Guanosines

7-Deaza-2'-dG • 5-0232-01X For reducing secondary structure formation

8-Bromo-2'-dG • 5-0232-11X For crystallographic studies

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Internal/nucleosidic modifications 5’ 3’ Internal Cat. no. Comments

Thymidines

4-Thio-dT • 5-0233-01X For cross-linking

5-C3-Carboxy-dT • 5-0233-11X For coupling

5-C6-Amino-dT • 5-0233-21X For internal amino-group incorporation

5-C2-Amino-dT • 5-0233-22X For internal amino-group incorporation

Inverse-dT • 5-0233-31X For blocking oligos against extension and ligation

N3-Cyanoethyl-dT (NEW!) • 5-0233-50X For synthesis of oligodeoxynucleotides (ODNs)

Special RNA modifications

2'-NH2-RNA • 5-0511-01X For stabilization against nucleases

2'-F-RNA • 5-0512-01X For stabilization against nucleases; increase of

melting temperature

2'-O-Methyl-RNA • 5-0513-01X For stabilization against nucleases; increase of

melting temperature

In-RNA • 5-0514-01X For ribozyme technology

Other modifications

2-Aminopurin • 5-0230-60X For structural analysis

Abasic-Alkyne (NEW!) • 5-0230-63X For alkyne modification of oligos

Spacer 3 • • • 5-0210-92X For introducing a linker arm

Spacer 6 • • • 5-0210-95X For introducing a linker arm

Spacer 9 (NEW!) • • • 5-0210-96X For introducing a linker arm

Spacer 12 (NEW!) • • • 5-0210-97X For introducing a linker arm

Spacer 18 (NEW!) • • • 5-0210-98X For introducing a linker arm

Stable abasic site • 5-0230-61X One base spacer

Stable abasic ribo site • 5-0230-62X One base spacer

Deoxypurine • 5-0230-70X For DNA stability experiments

2'-dI • 5-0234-01X For increasing base pairing

2'-dU • 5-0235-01X For PCR-product cloning

5-Fluoro-2'-dU • 5-0235-11X For crystallographic studies

5-Bromo-dU coupling • 5-0235-13X For crystallographic studies

5-Iodo-2-dU-modification • 5-0235-21X For crystallographic studies

5-OH-dU (NEW!) • 5-0233-80X For DNA damage and repair research

5-hm-dU (NEW!) • 5-0517-13X For DNA base excision repair research

C8-Alkyne-dU (NEW!) • 5-0233-23X For alkyne modification of oligos

DBCO-PEG4-dT (NEW!) • 5-0233-27X For copper-free Click reactions

Non-nucleosidic modifications 5’ 3’ Internal Cat. no. Comments

Biotin/Digoxigenin and more

Biotin • • • 5-0320-0XX Hapten marker

Iminobiotin • • 5-0322-0XX Analogue of biotin

Desthiobiotin • • • 5-0322-0XX Derivative of biotin that lacks a sulfur atom

Digoxigenin • • • 5-0321-0XX Hapten with low endogenous background

Different synthesis scales are available (e.g. 0.05, 0.2 and 1.0 µmol). For more details see www.oligo-specialist.com.

Any questions? Do you require advice?Contact us at oligoexpert@iba-lifesciences.com. We will be glad to assist you.

www.oligo-specialist.com

Request a quote via our Oligo Shop at www.oligo-specialist.comIBA GmbH Rudolf-Wissell-Str. 28 · 37079 Goettingen · Germany · Phone +49 551 50672-0 · Fax +49 551 50672-181 · info@iba-lifesciences.com IBA US Distribution Center 1328 Ashby Road · Olivette · MO 63132 · USA · Phone 1-877-IBA-GmbH (1-877-422-4624) · Fax 1-888-531-6813 · info@iba-lifesciences.com

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Product information

TAKE ADVANTAGE OF 20 YEARS EXPERIENCE IN OLIGONUCLEOTIDE PRODUCTION AND LABELING!

High quality custom-made modified DNA and RNA products for high-end research

More than 80 internal, 5’- and 3’- DNA and RNA modifications to choose from

Modified DNA oligos for DNA microarrays Non-fluorescent labeled DNA and modified RNA for surface

binding and hybridization experiments DNA labeled for PNA and protein binding

Modified oligonucleotides for cross-linking and crystallography studies Oligos labeled with Biotin, Iminobiotin, Desthiobiotin and

Digoxigenin

Highest QC standards

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