OMEGA 3’SOMEGA 3’S

TREATMENT FOR

NUTRITION DEFICIT DISORDER

SEARS FAMILY PEDIATRICSSEARS FAMILY PEDIATRICS

FOR PARENTS FOR PARENTS

OF OF

YOUNG YOUNG CHILDRENCHILDREN

SHOCK STATEMENTSSHOCK STATEMENTS“Unless drastic changes are

made in the way American families eat and live one in three children born in year 2000 will later become diabetic.”

- CDC

THE D-EPIDEMICTHE D-EPIDEMIC

ADD SPD

OCD LD

ASD D-IABETES

BPD CVD

““YOUR CHILD HAS NDD!”YOUR CHILD HAS NDD!”

ALZHEIMERS ALZHEIMERS BEGINS IN CHILDHOODBEGINS IN CHILDHOOD

FEEDING THE BRAINFEEDING THE BRAIN

Brain cell mitochondria Brain cell membrane Neuronal mylin formation Neurotransmitter function

FEEDING THE BRAINFEEDING THE BRAIN

Brain utilizes 25% food energy Utilizes 25% of 02 Brain: 1-2% of body weight 60% fat: “fat head” Does not store glucose Brain most affected by nutrition

BEST BRAIN FOODSBEST BRAIN FOODS

Salmon Blueberries Greens: spinach Nuts: walnuts

CHANGE YOUR OILSCHANGE YOUR OILS

Brain health = control inflammation O3’s anti-inflammatory: teflon endothelium O6’s pro-inflammatory: velcro endothelium Omega 6 / Omega 3; AA/EPA 2:1 SAD 20:1 Smart oils: fish, flax, nut, olive Dumb oils: hydrogenated, excess vegetable oil

MY FAVORITE FISH STORYMY FAVORITE FISH STORY

Fat Eskimos Danes

Saturated 22 % 52%

Omega-3’s 13% 2.8%

Omega-6’s 5.4% 10%

O-3 / O-6 ratio 2.5% .3%

Cholesterolmg / 1,000 cal

245 mg 139 mg

WHAT ARE OMEGA 3’S?WHAT ARE OMEGA 3’S?

– Omega-3s are essential fatty acids found in fish & certain plant oils

– Your body cannot produce Omega-3 fatty acids on its own

– At all stages of life, Omega-3 fatty acids are required to ensure overall health and well-being

EPA

DHA

OMEGA-3 INCLUDES:OMEGA-3 INCLUDES:

ALA Alpha-linolenic Acid

Primarily from flax (18 carbons)

EPA Eicosapentaenoic Acid

Primarily from fish (20 carbons)

DHA Docosahexaenoic Acid

Primarily from fish (22 carbons)

EPA and DHA are the key Omega-3 for good heart health & normal growth and development}

These are the vital forms of Omega-3 that support overall good health.

Omega-3 EPA and DHA are readily found in oily fish such as sardines and anchovies.

Plant sources of Omega-3, such as flax and canola oil, contain ALA but your body needs to convert ALA to EPA and DHA to derive the maximum health benefits. This conversion is extremely inefficient.

Only fish oil contains both EPA and DHA.

FISH OIL: FISH OIL: THE BEST SOURCE OF THE BEST SOURCE OF

OMEGA-3OMEGA-3

WHY EPA/DHA WHY EPA/DHA IS THE BEST SOURCE OF IS THE BEST SOURCE OF

OMEGA-3OMEGA-3– EPA/DHA may reduce the risk of cardiovascular disease and

have an FDA qualified heart health claim.

– EPA/DHA have scientifically proven health benefits that are supported by over 14,000 scientific papers, 8000 of which are human clinical studies.

– EPA/DHA are backed by established and emerging evidence suggesting improvements in inflammatory conditions including arthritis, irritable bowel syndrome, etc.

– EPA/DHA play a role in brain development and function as well as visual acuity.

SUPPORT OF THE HEALTH SUPPORT OF THE HEALTH BENEFITS OF OMEGA-3BENEFITS OF OMEGA-3

– American Heart Association (AHA)– British Nutrition Foundation (BNF)– Food and Drug Administration (FDA)– Health Canada– Institute of Medicine (IOM)– International Society for the Study of Fatty

Acids & Lipids (ISSFAL)– National Heart Foundation of Australia

(NHFA)– World Health Organization (WHO)

Health professionals and major health organizations around the world endorse Omega-3 as being essential for overall good health.

RECOMMENDED DAILY INTAKE RECOMMENDED DAILY INTAKE OF OMEGA-3 EPA/DHAOF OMEGA-3 EPA/DHA

– On average, North Americans consumeonly 150mg/day of Omega-3 EPA/DHA.2

– Europeans consume 300mg/day.3

– Meanwhile, Japanese who have the lowest rate of cardiovascular disease deaths, consume over 700mg/day. 3

1. AHA and ISSFAL

2. Kris-Etherton, et al. Am J Clin Nutr 2000;71(suppl):179s-88s.

3. Hibbeln. J Affect Disorders 2002;69(1-3):15-29.

1

ISSFAL and AHA

DIETARY DEFICIENCY IN DIETARY DEFICIENCY IN EPA/DHAEPA/DHA

OMEGA-3: OMEGA-3: HOW MUCH IS ENOUGH?HOW MUCH IS ENOUGH?

“Do you eat at least two 4oz. servings of oily fish per week?

If your answer is no, you are not getting your recommended daily intake of Omega-3… according to the US Department of Health and Human Services.”

OMEGA-3 EPA/DHA BENEFITSOMEGA-3 EPA/DHA BENEFITS

OMEGA-3’s: OMEGA-3’s: THE NUTRIENT FOR ALL AGESTHE NUTRIENT FOR ALL AGES Prenatal:

Increased brain functionIncreased visual activity

Lactation and Formula:Increased cognitive functionIncreased visual activity

Childhood:Decreased learning, behavior and mood disorder

Adulthood:Decreased cognitive declineDecreased CVCDecreased “it is” illnesses

FEEDING BABY BRAINSFEEDING BABY BRAINS

Breastfeeding: intellectual advantage Dose-related effect DHA – enriched infant formulas

Increased cognitive performances Increased visual acuity

Brain Development: Brain Development: Helland IQ StudyHelland IQ Study

Helland, Helland, et al.,et al., Pediatrics 2003;111;39-44. Pediatrics 2003;111;39-44.

Supplementation:Cod liver oil Group: 1183mg/10mL DHA; 803mg/10mL EPACorn oil Group: 4747mg/10mL Linoleic Acid; 92mg/10mL ALA– Amounts of fat soluble vitamins were identicalDuration:– Pregnant women were supplemented from week 18 of their pregnancies to

3 months post-deliveryResults:– Children whose mothers received EPA and DHA supplementation scored

significantly higher on the Mental Processing Composite of the K-ABC at 4 years of age than those whose mothers received corn oil.

Conclusion:“This study indicates that maternal supplementation with very-long-chain n-3 PUFAs during pregnancy and lactation improves the intelligence of children at 4 years of age.”

The Oxford-Durham Study:The Oxford-Durham Study:Dietary Supplementation with Fatty Acids in Children

with Developmental Coordination Disorder (DCD)Richardson, AP and P. Montgomery Pediatrics, 2005. 115(5): p. 1360-6.

Daily Dosage vs. Placebo:– 558mg of EPA, 174mg of DHA, 60mg of -linoleic acid, 9.6mg of

vitamin E (natural form, -tocopherol) Duration: 3 months Sample Size: 117 children with DCDResults:– Reading: +9.5 Months (vs. 3.3 for placebo)– Spelling: +6.5 Months (vs. 1.2 for placebo)

Note: After 3 month study, children on placebo were given supplement and gained 13.5 months reading & 6 months spelling within 3 months

OXFORD DURHAM STUDY:OXFORD DURHAM STUDY:WRITING SAMPLEWRITING SAMPLE

Before After

Richardson, AP and P. Montgomery Pediatrics, 2005. 115(5): p. 1360-6.

BIG IMPROVEMENT IN ADHDBIG IMPROVEMENT IN ADHD

“Food affects behavior …” -Dr. A. Richardson

Richardson, AP and P. Montgomery Pediatrics, 2005. 115(5): p. 1360-6.

GO FISH, BEHAVE BETTERGO FISH, BEHAVE BETTER Boys with most severe ADHD lowest O-3’s 96 boys with ADHD greatest impulsivity

lowest O-3’s Children with highest O-3, fewest learning

problems Japanese students less hostility and stress

during exams Increase dopamine and receptors

GO FISH, BE SMARTERGO FISH, BE SMARTER Medicine meal Help cells maintain their fluidity Form the structural component of membranes Enable optimal function of neurotransmitters Diets high in Omega-3’s: less CNS

degeneration Seniors who eat the most fish, least mental

decline

GO FISH, BE HAPPIERGO FISH, BE HAPPIER

Omega 3’s as mood stabilizer Diets low in Omega 3, higher depression Salmon study Animal studies Omega 3’s increased

dopamine receptors

Seafood for a “Happy Meal”

EAT FISH STAY YOUNGEAT FISH STAY YOUNG

A salmon a day can keep;the brain doctor away….the eye doctor away…

the heart doctor away…the bone doctor away.

GOOD ARTERIESGOOD ARTERIES

BAD ARTERIESBAD ARTERIES

SEAFOOD – SEAFOOD – TOP HEALTH FOODTOP HEALTH FOOD

Brain

Eyes

Heart & blood vessels

Pancreas (diabetes)

GUT (colon)

Joints, knee joint

S-S-SS-S-SNO NO SSHARK OR HARK OR SSWORDFISH WORDFISH

FOR FOR SSENIORSENIORS

FISH OIL vs. FLAX OILFISH OIL vs. FLAX OIL

Flax oil: complicated biochemical conversion Ala conversion to DHA, 4% Fish and flax oil

Current Ratio Desired Ratio

Our current ratio is VERY high!

BALANCED RATIO OF OMEGA-6 BALANCED RATIO OF OMEGA-6 TO OMEGA-3 IS KEYTO OMEGA-3 IS KEY

Simopoulos, AP. Am J Clin Nutr 1999;70(suppl):560S-9S.

Simopoulos, AP. Biomed Pharmacother 2006 Nov;60(9):502-7.

Balancing Pro & Balancing Pro & Anti-inflammatory EicosanoidsAnti-inflammatory Eicosanoids

MINDSET SHIFT:MINDSET SHIFT:CAUSE OF CVDCAUSE OF CVD

OLD“High Cholesterol” = Rx: Statins, Aspirin

NEWHigh O-6 / O-3 = Rx: Oil Change! Go Fish!

New “Inflammation”

SOURCES OF SOURCES OF OMEGA-3 AND OMEGA-6OMEGA-3 AND OMEGA-6

– Oily Fish– Flax– Walnuts– Canola Oil

– Safflower Oil– Sunflower Oil– Corn Oil– Sesame Oil– Soybean Oil

SchemaSchemaMetabolicMetabolicPathwayPathway

GISSI PREVENZIONE STUDYGISSI PREVENZIONE STUDYA 45% reduction in sudden cardiac death mortality when

supplemented with fish oil (EPA/DHA)

Marchioli, et al. Lancet 1999:354;447-455

(Relative risk of sudden death declineswith higher levels of Omega-3 in the blood)

PHYSICIAN’S HEALTH STUDYPHYSICIAN’S HEALTH STUDY

Albert, et al. NEJM 2002:346(15);1113-1118

MINIMUM ADEQUATE MINIMUM ADEQUATE INTAKE OF EPA AND DHAINTAKE OF EPA AND DHA

Source:Workshop on the Essentiality of and Recommended Dietary Intakes for Omega-6 and Omega-3 Fatty Acids, National Institute of Health (NIH), 1999

RIGHTRIGHT CARB DIET CARB DIETNOT LOW CARB DIETNOT LOW CARB DIETIS RIGHT FOR KIDSIS RIGHT FOR KIDS

RIGHTRIGHT FAT DIET FAT DIETNOT NOT LOWLOW FAT DIET FAT DIETIS RIGHT FOR KIDSIS RIGHT FOR KIDS

TEACHING KIDS TEACHING KIDS ABOUT CARBSABOUT CARBS

SALMON vs. SIRLOINSALMON vs. SIRLOIN

DR. BILL’S DR. BILL’S RULE OF TWO’SRULE OF TWO’S

Eat twice as often,

Half as much,

Chew twice as long

GRAZING IS GOOD GRAZING IS GOOD FOR THE BRAINFOR THE BRAIN

Steady glucose supply Neurotransmitter balance Shorten the space between feeding,

and you are less likely to have spacey kids

24 Hours

GorgingGrazing

BLOOD INSULIN LEVELSBLOOD INSULIN LEVELS

TERRIBLE THREE’STERRIBLE THREE’S

Corn Syrup - HFCS Hydrogenated “Numbers” e.g. Red#40

NUTRIGENETICSNUTRIGENETICS

OMEGA 3’S: OMEGA 3’S: HEAD TO TOE NUTRITIONHEAD TO TOE NUTRITION

Smarter Brain Happier Brain Better Vision Healthier Gums Healthier Heart Healthier Guts Healthier Joints Smoother Skin

www.AskDrSears.com/MEGwww.AskDrSears.com/MEG