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CURRICULUM VITAE

OLGA KLEPITSKAYA, M.D.

Academic Address: Clinic Address University of Colorado Denver University of Colorado Hospital Academic Office 1, Mr. 5219 1635 Aurora Ct. 12631 East 17th Avenue, Box B185 4th Floor, Neurology Aurora, CO 80045 Aurora, CO 80045 Phone: (303) 724-2210 Phone: (720) 848-2080 Fax: (303) 724-2212 Fax: (720) 848-2106 Research Affiliation: Veteran Administration Hospital Clinical Translational 1055 Clermont Street Research Center Denver, CO 80220 12401 E 17th Ave, B141, Phone: (303) 393-2874 Aurora, CO 80045 Fax: (303) 393-4648

1. Education:

• 1973-1983 School #5, Khabarovsk, Russia, graduated with Gold Medal, GPA 5.00 of 5.00 • 1983-1989 Far Eastern State Medical University (Khabarovsk State Medical

Institute), Khabarovsk, Russia, GPA 5.00 of 5.00, graduated with Honors, • 1989-1996 Neurology Residency, Far Eastern State Medical University, Khabarovsk, Russia • 1996 Neurophysiology Fellowship, Far Eastern State Medical University, Khabarovsk • 2001-2002 Internal Medicine Internship, Resurrection Medical Center, Westlake Hospital

Melrose Park, Illinois • 2002-2005 Neurology Residency, University of Colorado Denver, Aurora, Colorado • 2005-2006 Movement Disorders Fellowship, Stanford University Medical Center, Stanford,

California 2. Academic Appointments:

• 1990-1992 Instructor in Neurology, Department of Speech Disorders and Therapy, Far Eastern State Pedagogical University, Khabarovsk, Russia

• 1990-1992 Instructor in Neurology, Department of Neurology, Far Eastern State Medical University, Khabarovsk, Russia

• 1994-1998 Instructor in Neurophysiology, Department of Continued Medical Education, Far Eastern State Medical University, Khabarovsk, Russia

• 2006-2008 Clinical Instructor, Department of Neurology, University of Colorado Denver, Aurora, CO

• 2008-2014 Assistant Professor, Department of Neurology, University of Colorado Denver, Aurora, CO

• 2008-present Co- Director, Deep Brain Stimulation Center, University of Colorado Hospital, Aurora, CO

• 2014-present Associate Professor Department of Neurology, University of Colorado Denver, Aurora, CO

3. Hospital, government or other professional positions: • 1989-1990 Research Associate, Central Research Laboratory, Far Eastern State Medical

University, Khabarovsk, Russia

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• 1989-1996 Teaching Assistant, Department of Neurology, Far Eastern State Medical University, Khabarovsk, Russia

• 1992-1994 Director of Public Relations Department, Far Eastern Association of Medical Workers, Khabarovsk, Russia

• 1992-1994 Medical Journalist and Editor, Far Eastern TV/Radio Station, Khabarovsk, Russia

• 1994-1998 Attending Neurologist, Department of Neurology, Regional Hospital #1, Khabarovsk, Russia

• 1996-1998 Director, Electroencephalography Laboratory, Department of Neurodiagnositcs, Regional Hospital #1, Khabarovsk, Russia

• 1996-1998 Neurophysiologist, Department of Neurodiagnostics, Regional Hospital #1, Khabarovsk, Russia

• 1998-1999 Research Assistant, Department of Neuroscience, Sleep Laboratory, Washington State University, Pullman, Washington

• 1999-2001 Medical and Social Interpreter, Social and Health Services, State of Washington, Spokane, Washington

• 2000 Medical Consultant, Ukrainian-American Educational Project, Washington State University, Pullman, Washington

• 2000-2001 Electroencephalography Technician, Gritman Medical Center, Moscow, Idaho • 2006-present Attending Neurologist, University of Colorado Hospital, Aurora, Colorado • 2007-2008 Attending Neurologist, The Children’s Hospital, Aurora, Colorado • 2007-present Staff Neurologist, Veterans Administration Hospital, Denver, Colorado

4. Honors, Special Recognitions, and Awards:

• 1983 Gold Medal for Excellence, High School # 5, Khabarovsk, Russia • 1983 First Place Award of All-Russian Academic Olympiad in Chemistry • 1985-1989 Federal Highest Individual Scholarship, named by V.I. Lenin, Far Eastern State

Medical University, Khabarovsk, Russia • 1989 Graduated with Honors, Far Eastern State Medical University, Khabarovsk,

Russia • 2011 Research Abstract Selected by Faculty 1000 as a “Particularly Important

Development in the Field” at the 10th International Congress on Alzheimer’s and Parkinson Diseases at http://f1000.com/about/whatis

• 2011 Scholarship from the American Neurological Association for the Translational and Clinical Research Course for Clinician, Scientists, Baltimore, Maryland (declined attendance)

• 2011 “Doctor of the Month,” University Physician’s Incorporated CU Doctors Website http://www.cudoctors.com/find-a-doctor/?keywords=olga%20klepitskaya

• 2012 Leadership Development Scholarship from the American Academy of Neurology for the Course in Leading Others, New Orleans, Louisiana

• 2012 Scholarship from the National Institute of Health for the National Institute of Neurological Disorders and Stroke (NINDS) Clinical Trial Methods Course (CTMC), Vail, Colorado

• 2012 Best Doctors in America 2012-2015 database, selected by peers • 2012 Best Doctors for executives, selected by Colorado Biz magazine • 2013 Listed in Guide to America’s Top Physicians by SLD Industries, Inc. • 2014 Michael J. Fox Foundation Challenge winner, of all institutions worldwide

with Parkinson populations

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5. Professional Organizations and Affiliations:

• 1999-indefinite Russian Association of Neurologists and Neurosurgeons • 2003-present American Academy of Neurology (AAN) • 2006-present Movement Disorders Society (MDS) • 2006-2007 International Society of History of Neurology • 2006-present Parkinson Association of the Rockies (PAR) • 2007-present Parkinson Study Group (PSG) – membership by credentialing • 2006-present Colorado Society of Clinical Neurology • 2013-present American Neurological Association (ANA)

6. Major Committee and Service Responsibilities:

• University of Colorado School of Medicine: o 2008-present Co-Director, University of Colorado Hospital Deep Brain Stimulation

Program o 2014 – present University of Colorado Movement Disorders Center, Associate

Director for surgical treatments of movement disorders o 2015- present University of Colorado Movement Disorders Center, Associate

Director for Advanced Treatments for Parkinson Disease program • Denver Veteran Administration Hospital:

o 2007-present Director, Eastern Colorado satellite of Parkinson Disease Research, Education and Clinical Center (PADRECC)

• Colorado Society of Clinical Neurology o 2015 – present Moderator of the Movement disorders journal club

7. Licensure and Board Certification:

• 1996-indefinite Medical Doctor-Neurologist, Government of Russian Federation, Ministry of Healthcare, Far Eastern Office

• 1998-2008 Medical Doctor-Neurologist of the First Qualification Level, Government of Russian Federation, Ministry of Healthcare, Far Eastern Office

• 1999-indefinite Medical and Social Interpreter (English- Russian), Department of Social and Health Care Services, State of Washington

• 2001-2002 State of Illinois – Physician Training License • 2002-2005 State of Colorado – Physician Training License • 2005-2007 State of California – Physician and Surgeon License • 2006-present State of Colorado – Medical License • 2008-2018 Diplomat of American Board of Psychiatry and Neurology

8. Review and Referee Work:

• Ad Hoc:Reviewer: o American Journal of Speech Language Pathology o Cephalgia

• Editorial Board Member:

o Brain Disorders and Therapy 9. Invited Lectures and Presentations:

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• Local: o Klepitskaya O. Tick-Born Encephalitis: What can we Learn from it About the West Nile

Virus Infection? Neurology Grand Rounds, University of Colorado Denver, March 2005. o Klepitskaya O. Deep Brain Stimulation: Past, Present, and Future. Neurology Grand

Rounds, University of Colorado Denver, April 2007. o Klepitskaya O. Parkinsonism, Misinterpreted as Status Epilepticus. Neurology Grand

Rounds, University of Colorado Denver, October 2007. o Klepitskaya O. Neurosurgery for Parkinson Disease beyond DBS. Neurology Grand

Rounds, University of Colorado Denver, August 2009. o Klepitskaya O. Neurosurgery for Parkinson Disease. Neurosurgery Grand Rounds,

University of Colorado Denver, March 2009. o Grier L., Hoyt B., Klepitskaya O. Psychiatric Considerations in Deep Brain Stimulation

Surgery for Parkinson Disease. Psychiatry Grand Rounds, University of Colorado Denver, April 2009.

o Klepitskaya O. Dopamine Dysregulation Syndrome. Neurology Grand Rounds, University of Colorado Denver, March 2011.

o Klepitskaya O. Update on Neurosurgery for Parkinson Disease. Neurosciences Seminar, Denver, CO, April 2011.

o Klepitskaya O. Deep Brain Stimulation for Early Parkinson Disease. Neurology Grand Rounds, University of Colorado Denver, July 2012.

o Berman B., Hedeman J., Klepitskaya O., et al. Movement Disorders Phenomenology via YouTube. Neurology Grand Rounds, University of Colorado Denver. February 2013.

o Leehey M., Hedeman J., Klepitskaya O., et al. Medication Adherence in Parkinson Disease. Quality Improvement Report. Neurology Grand Rounds, University of Colorado Denver, May 2013.

o Klepitskaya O. Deep Brain stimulation for neuropsychiatric conditions. Behavioral Neurology conference series. University of Colorado. November 2014

o Klepitskaya O, Ojemann S, Davis R. 25 years of DBS: new techniques, new indications new perspectives. Neurology Grand Rounds, University of Colorado Denver, June 2015.

o • Regional:

o Klepitskaya O. Deep Brain Stimulation: Past, Present, and Future. Colorado Society of Clinical Neurology, Denver, CO, April 2007.

o Klepitskaya O. Deep Brain Stimulation: Past, Present, and Future. 20th Annual Conference, ‘Neurosurgery of the Rockies,’ Vail, CO, February 2007.

o Klepitskaya O. Neurosurgery for Parkinson Disease beyond DBS. 22nd Annual Conference, ‘Neurosurgery of the Rockies,’ Beaver Creek, CO, February 2009.

o Klepitskaya O. Update on Neurosurgery for Parkinson Disease. Colorado Society of Clinical Neurology, Denver, CO, November 2010.

o Klepitskaya O. Deep Brain Stimulation for Early Parkinson Disease. 25th Annual Conference, ‘Neurosurgery of the Rockies,’ Beaver Creek, CO, February 2012.

o Klepitskaya O. Programming of Deep Brain Stimulation for Parkinson disease. Practical clues and Case Presentations. Regional DBS Programming Workshop. December 2012, Denver, CO.

• National: o Klepitskaya O. Tick-Born Encephalitis: What can we learn from it about the West Nile

Virus Infection? Department of Neurology, Stanford University, December 2005. o Klepitskaya O. Parkinsonism, Misinterpreted as Status Epilepticus. Department of

Neurology, Stanford University, May 2006.

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o Klepitskaya O. Primary Dystonia Misdiagnosed as Parkinson Disease. National VA Parkinson Disease Consortium Meeting, San Francisco, CA, September 2010.

o Klepitskaya O. Deep Brain Stimulation: Patient Selection Workshop. National DBS Forum, San Francisco, CA, October 2011.

o Klepitskaya O. Deep Brain Stimulation for Early Parkinson Disease, invited lecture, Banner Sun Health Research Institute, Phoenix, AZ, April 2012.

• International: o Klepitskaya O. Response of the Subthalamic Nucleus Neurons to Vocalization. 1st

international symposium, “Basal Ganglia Speech Disorders and Deep Brain Stimulation.” London, England, July 2007.

o Klepitskaya O, Ying Liu, Sillau S, Tsai J, Walters A. Deep Brain Stimulation of the Subthalamic nucleus improves Restless Leg Syndrome in patients with Parkinson disease. 2015 International Movement Disorders Congress. San Diego, CA, June 2015.

o 10. Teaching Record Presentations to Medical Students:

• 2009 Phenomenology of Movement Disorders, 2nd year medical students core curriculum. • 2010 Phenomenology of Movement Disorders, 2nd year medical students core curriculum. • 2011 Phenomenology of Movement Disorders, 2nd year medical students core curriculum. • 2014 Phenomenology of Movement Disorders, 2nd year medical students core curriculum. • 2015 Phenomenology of Movement Disorders, 2nd year medical students core curriculum

Presentations to Residents: • September 2007 Deep Brain Stimulation, Physical Medicine and Rehabilitation Residents • August 2008 Deep Brain Stimulation, Neurology Residents • May 2009 Psychogenic Movement Disorders and Tardive Syndromes, Neurology

Residents • October 2009 Dystonia, Neurology Residents

Psychogenic Movement Disorders, Neurology Residents • January 2010 Overview of Movement Disorders, Family Medicine Residency program • February 2010 Deep Brain Stimulation, Neurology Residents • January 2011 Overview of Movement Disorders, Family Medicine Residency program • January 2012 Psychogenic Movement Disorders, Neurology Residents

Surgical treatment of Movement Disorders, Neurology Residents • January 2012 Overview of Movement Disorders, Family Medicine Residency program • September 2012 Surgical treatment of Movement Disorders, Neurology Residents • September 2013 Surgical treatment of Movement Disorders, Neurology Residents • September 2014 Surgical treatment of Movement Disorders and DBS Programming

Workshop, Neurology Surgical treatment of Movement Disorders and DBS Programming Workshop, Neurology

Teaching CME courses:

• September 2009 Pharmacological Treatment of Parkinson disease. University of Colorado Denver CME course, “Advances in Parkinson Disease and Multiple sclerosis,” Denver, CO

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• July 2010 Advances in treatment of Movement disorders. St. Mary Hospital, Grand Junction, CO

• April 2009 Deep Brain Stimulation. Continued Nursing Education course, Aurora, CO

• September 2012 Surgical Treatment of Parkinson disease. University of Colorado Denver CME course, “Advances in Parkinson Disease and Multiple sclerosis,” Denver, CO

• September 2013 Treatment of Tremor. University of Colorado Denver CME course, “Movement Disorders and Epilepsy,” Denver, CO

Ward/Clinic Attending Duties: • 2006-present Supervision and bedside teaching of medical students, pharmacy

students, Neurology and Internal Medicine residents, and Movement disorders Fellow. University of Colorado Hospital Movement Disorders

Clinic. 16 hours/week average. • 2006-present Teaching and training of Movement Disorders fellows, physician

assistants, and nurse practitioners in subcortical mapping with microelectrode recording for Deep Brain Stimulation (DBS) implantation, University of Colorado Hospital Operative Room, 8 hours/week average.

• 2006-present Teaching and training of movement disorders fellows, nurse practitioners and physician assistants in DBS programming, University of Colorado Hospital Movement Disorders Clinic. 16 hours/week average.

• 2006-present Teaching and training of movement disorders fellows, and neurology residents in botulinum toxin.

• 2008- present Attending on inpatient Neurology ward, and bedside teaching medical students and neurology residents, University of Colorado Hospital. 4-6

weeks per year. Research mentorship:

• Movement Disorders Fellows: o Heather Ene, 2007-2009 Project title: “The effect of yoga on quality of life in Parkinson disease patients, and Gait

and balance outcome after DBS for Parkinson disease.” o Aaron Haug, 2011-2012

Project title: “Number of microelectrode recording passes during bilateral staged vs. unstaged deep-brain stimulation surgery for Parkinson's disease.” Andreas Michas- Martin, 2012 -2015 Project Title: Possibility of disease modifying effect of Deep Brian Stimulation.

• Neurology Residents: o Christy Young, 2009- 2010

Project title: Residency graduation project: Possibility of disease modifying effect of Deep Brian Stimulation. o Drew Kern, 2011 – 2012.

Project title: An Objective Double-Blind Evaluation of Bupropion and Citalopram in an Individual with Friedreich Ataxia

• Medical Students:

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o Kathleen Reid, 2008-2009. Project title: Prevalence of dopamine dysregulation syndrome in Parkinson’s disease

patients-candidates for Deep Brain Stimulation. o John Fowler, 2008-2010.

Project title: Number of microelectrode recording passes during bilateral staged vs. unstaged deep-brain stimulation surgery for Parkinson's disease. o Tyson Oberdorfer, 2011- 2012.

Project title: “Microvascular white matter disease as a predictive factors for cognitive outcome after bilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson Disease.”

Tam Nguen, 2011-2012. Project title: Primary Dystonia Misdiagnosed as Parkinson Disease.

o Alexander Neuwelt, 2012 . Project title: Primary Dystonia Misdiagnosed as Parkinson Disease.

o Thomas Ragole, 2012-2014. Project title: Disease modifying effect of Deep Brain Stimulation. Markus Hannan. 2015- present Project title: Disease modifying effect of Deep Brain Stimulation.

Patient Outreach and Education:

• Treatment of Essential Tremor: International Essential Tremor Foundation. Patient education seminar, September 2007, Colorado Springs, CO, 70 attendees

• Deep Brain Stimulation for Parkinson’s disease: Parkinson Association of the Rockies (PAR). October 2007, Denver, CO, 70 attendees

• PD 101: Parkinson Association of the Rockies (PAR). October 2008, Denver, CO, 30 attendees • Treatment of Essential Tremor: International Essential Tremor Foundation. Patient education

seminar, October 2009, Denver, CO, 200 attendees • DBS for Parkinson disease: Davis Phinney Foundation. Victory Summit, October 2009,

Westminster, CO, 200 attendees • Neurologists speak about Yoga therapy: Publication in “Yoga Therapy Today,” Journal by The

International Association of Yoga Therapists. March 2009; 5(1):8 • Deep Brain Stimulation: Parkinson Support Group. June 2010, Pueblo, CO, 30 attendees • Deep Brain Stimulation for Dystonia: Dystonia Support Group. June 2010, 25 attendees • Deep Brain Stimulation for Movement Disorders: Patient symposium. July 2010, Grand

Junction, CO, 300 attendees • Deep Brain Stimulation: University of Colorado Denver patient education symposium. November

2010, Denver, CO • Deep Brain Stimulation: Patient education symposium. July 2011, Basalt, CO • Deep Brain Stimulation: Parkinson’s Association of the Rockies (PAR). “Doctor is In,” November

2011, Colorado Springs, CO, 100 attendees • Deep Brain Stimulation: Parkinson’s Association of the Rockies (PAR). “Doctor is In,” February

2012, Loveland, CO, 45 attendees • Deep Brain Stimulation for Movement Disorders: Parkinson Support Group. July 2012, Edwards,

CO, 15 attendees • Deep Brain Stimulation for Parkinson disease: Davis Phinney Foundation. Victory Summit,

November 2012, Denver CO, 400 attendees • Surgical Treatments for Parkinson’s disease: The Present & Future. Michael J Fox Foundation.

University of Colorado Movement Disorders Center, September 2014, Aurora, CO

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• New Developments in Surgical Treatments for Parkinson Disease: University of Colorado Denver, “Advances in Parkinson Disease and Essential Tremor,” July 2015, Glenwood Springs, CO

• Deep Brain Stimulation for Essential Tremor: University of Colorado Denver, “Advances in Parkinson Disease and Essential Tremor,” July 2015, Glenwood Springs, CO

• New Medications and Current Research: “Recent Advances in Parkinson’s & Essential Tremor Treatments, August 2015, Cheyenne, WY

• Surgical Treatments for Parkinson’s disease: The Present & Future. Michael J Fox Foundation. University of Colorado Movement Disorders Center, September 2015, Aurora, CO

Physicians Outreach and Education: Visiting lectures to local physicians’ offices with discussions regarding patients’ selection, outcomes and referral process to Deep Brain Stimulation surgery:

• Kaiser Permanente Neurology Group. Denver, CO • Drs. London, Nitka, Renkin, Ament, & Smith. Lakewood, CO • Drs. Zacaryas & Miller. Boulder, CO • Drs. Redosh & Seibert. Wheatridge, CO • Drs. Poiscne & Fedor. Thornton, CO • Drs. Sunku, Rawat, Smith, & Cohen. Pueblo, CO • Drs. Shaffer & Kerber. Cheyenne, WY • Drs. Lopresti, Himes, & Ball. Scottsbluff, NE • Drs. Schmitt & Jacobs. Loveland, CO • Dr. Siegel. Greeley, CO • Drs. Round, Ginsburg, Stambuck, & McNutt. Denver, CO • Drs. Dean, Burnbaum & Gilman. Grand Junction, CO • Dr. Gipson. Edwards, CO

Public Relations and Marketing: • Deep Brain Stimulation eases Parkinson’s: Denver Post and Colorado Channel 4 News, May

2008, Denver, CO • Her Colors flying: Denver Post, January 2009, Denver, CO • Deep Brain Stimulation for Movement Disorders: Report from the Patient Symposium, July 2010,

Grand Junction, CO, featured on Grand Junction Channel 11 News • “7 Everyday Hero” Award Presentation to DBS patient and family liaisons and DBS patients’

support group coordinators Valerie Graham and Kate Kelsall, featured on Colorado Channel 7 News.

• Yoga Used to Treat Parkinson’s Disease: Channel 7 News, August 2010, Denver, CO • Neurologists Speak about Yoga therapy. Yoga Therapy Today, March 2009 • Deep Brain Stimulation at University of Colorado: Public Broadcasting Service, March 13, 2014:

https://www.youtube.com/watch?v=aKYygRBm2nU • An Inside Look At A Life-Changing Brain Surgery: Channel 9 News, May 24, 2015, Denver

Colorado: http://www.9news.com/story/news/local/storytellers/2015/05/26/parkinsons-disease-deep-brain-stimulation/27898469/

Research and Scholarly activities:

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Sponsored research and clinical trials: Ongoing Research Support

• Efficacy and Safety Study of ADS-5102 (amantadine HCl) Extended Release (ER) Capsules for the Treatment of Levodopa-Induced Dyskinesia in Parkinson’s Disease Patients, Adamas Pharmaceuticals, Role: Site Co-PI

• Neurophysiology of Parkinson’s Disease: From Mouse to Man, Congress of Neurological

Surgeons, Role: Co-I

• A Phase 3, Multicenter, Double-Blind, Placebo-Controlled, Single-Treatment Efficacy and Safety Study of MYOBLOC Followed by Open-Label, Multiple-Treatment with MYOBLOC in the Treatment of Troublesome Sialorrhea in Adult Subjects, Solstice Neurosciences, Role: Site PI

• A Phase 3, Open-Label Study of the Safety, Efficacy, and Tolerability of Apomorphine

Administered by Continuous Subcutaneous Infusion in Advanced Parkinson’s Disease Patients with Unsatisfactory Control on Available Therapy, US WorldMeds, LLC, Role: Site PI

Completed Research Support

• NIH/University of Washington, Using Multiplex Families to Map Genes that Modify Susceptibility and Age at Onset in PD, NIH/University of Washington, Role: Site PI

• University of Colorado, Denver, An Objective Double-blind Evaluation of Bupropion and

Citalopram in Individuals with Friedreich Ataxia University of Colorado Denver, Role: PI

• A double-blind, randomized, placebo-controlled study of the safety and efficacy of SYN115 as adjunctive therapy in levodopa-treated Parkinson’s subjects with end of dose wearing off , Biotie, Role: Site PI

• Tercica, Ipsen, DYSPORT™ for Injection AbobotulinumtoxinA Neurotoxin Clinical & Health

Economics Outcomes Registry in Cervical Dystonia, Tercica/Ipsen, Role: Site PI

• University of Colorado, Denver, Virtual Reality Assessment of Visuospatial Disorientation in Patients Undergoing Deep Brain (DBS), University of Colorado Denver, Role: Co-PI

• IMPAX Laboratories, Inc., A Study to Evaluate The Safety And Efficacy Of IPX066 In

Advanced Parkinson's Disease, IMPAX Laboratories, Inc., Role: Site PI

• Neurologix, Inc., Study of AAV-GAD Gene Transfer Into the Subthalamic Nucleus for Parkinson's Disease, Neurologix, Role: Site Co-PI

• Pico-tesla Magnetic Therapies, LLC, A Double-blind, Sham-stimulation Controlled Study of the

Application of Magnetic Fields Using the Jacobson Resonator for the Treatment of Parkinson's Disease, Pico-tesla Magnetic Therapies, LLC, Role: PI

• A Multi-Center Study of MYOBLOC for the Treatment of Sialorrhea in Parkinson's Disease Patients, Solstice Neurosciences, Role: Site Co-PI

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• A Multicenter, Randomized, Double-blind, Placebo-controlled, 5-arm, Parallel-group Trial to Assess Rotigotine Transdermal System Dose Response in Subjects With Advanced-stage Parkinson's Disease, UCB, Inc., Role: Site Co-PI

• A Phase 2B, Twelve-week Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study, To Determine the Safety, Tolerability and Efficacy of Two Doses of Once Daily P2B001 in Subjects With Early Parkinson’s Disease (PD), Pharma Two B Ltd., Role: Site PI

• A Phase IIIb, Prospective, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Dysport Using 2 ml Dilution in Adults with Cervical Dystonia, Ipsen Biopharmaceuticals, Inc., Role: Site PI

• A Phase IIIb, Prospective, Multicenter, Open-Label, Extension Study to Assess Long Term Safety and Effectiveness of Dysport Using 2 ml Dilution in Adults with Cervical Dystonia, Ipsen Biopharmaceuticals, Role: Site PI

Research Grants:

• Boedecker Foundation Parkinson Research Grant. 2009-2011 Donated to the University of Colorado Denver Movement Disorders group for Parkinson Disease related research in honor of Julie Berardi, Deep Brain Stimulation patient. Total award $200,000

Investigator Initiated Research: • 1/06 – 12/07 Total Award: N/A

Response of the Subthalamic Nulcleus Neurons to Vocalization Role Co-I

• 1/08- 5/09 Total Award: N/A Three-Dimensional Computerized Model of Human Basal Ganglia for Microelectrode Recording During Deep Brain Stimulation Surgery Role: PI

• 01/08- 5/09 Total Award: N/A Development of Mock microelectrode recording software for sham surgery controlled clinical trials of surgical treatments for Parkinson’s disease Role: Co-I

• 12/09-12/11 Total Award: $200,000 Magnetoencephalography (MEG) and Deep Brain Stimulation (DBS) in Parkinson’s Disease (PD) Role: Co-I

• 12/09-12/11 Total award: $200,000 Gait and balance outcomes after bilateral Subthalmic Nucleus Deep Brain Stimulation surgery for Parkinson disease Role: PI

• 12/09-12/11 Total award: $200,000 Number of microelectrode recording passes during bilateral staged vs. unstaged deep-brain stimulation surgery for Parkinson's disease.

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Role: PI

• 12/09-12/11 Total award: $200,000 Prevalence of dopamine dysregulation syndrome in Parkinson’s disease patients-candidates for deep brain stimulation Role: PI

• 12/09-12/11 Total award: $200,000 Predictive Factors for Cognitive Outcome after Bilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson Disease Role: PI

• 9/12 -10/13 Total Award: N/A

An Objective Double-Blind Evaluation of Bupropion and Citalopram in an Individual with Friedreich Ataxia Role: PI Bibliography: Peer-reviewed Articles:

1. Klepitskaya OS, Shishmakov, YV. Biological Activity of Pine-Tree Oil. Questions of the Ecological Biochemistry and Physiology;1988: 45-49 Article in Russian

2. Klepitskaya OS, Ottieva, EN. Neurological Disorders in Patients with Lupus Erythematosus. Far Eastern Medical Journal;1998(2):67-68 Article in Russian

3. Klepitskaya OS, Rykova MG. Modern Clinical Variations of Conversion Disorder. Topics in Psychopathology. Publication of the Russian Institute of Mental Diseases named after Serbskiy;

1998:22-28 Article in Russian 4. Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez-Martin P, Poewe W,

Sampaio C, Stern MB, Dodel R, Dubois B, Holloway R, Klepitskaya O,Jankovic J, Kulisevsky J, Lang AE, Lees A, Leurgans S, LeWitt PA, Nyenhuis D, Olanow CW, Rascol O, Schrag A, Teresi JA, van Hilten JJ, LaPelle N; Movement Disorder Society UPDRS Revision Task Force. Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Movement Disorders. 2008; 23 (15): 2129 - 2170

5. Kluger BM, Klepitskaya O, Okun MS. Surgical Treatment of Movement Disorders. Neurologic Clinics of North America; 2009:633-677

6. Patel SG, Stickrath CR, Anderson M, Klepitskaya O. How Should Parkinson’s Disease be Managed Perioperatively? The Hospitalist. 2010;15(6):19-22 http://www.thehospitalist.org/details/article/704937/How_should_Parkinsons_disease_be_managed_perioperatively.html

7. Spielman J, Mahler L, Halpern, A, Gilley P, Klepitskaya O, Ramig L. Intensive Voice Treatment (LSVT®LOUD) for Parkinson's disease following Deep Brain Stimulation of the Subthalamic Nucleus. Journal of Communication Disorders. 2011; doi:10.1016/j.jcomdis.2010.05.003

8. Klepitskaya OS, Cole W, Henderson J, Bronte-Stewart H. Deep Brain Stimulation in “On”- Parkinson Hyperpyrexia. Neurology. 2011;76(7): s69-s71

9. Hall D, Klepitskaya O, Leehey M. Fragile X-Associated Tremor Ataxia Syndrome in FMR1 Gray Zone Allele Carriers. Movement Disorders. 2011;27(2):297-301

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10. Klepitskaya O, Neuwelt AJ, Nguyen T, Leehey M. Primary dystonia misinterpreted as Parkinson disease: Video case presentation and practical clues. Neurology: Clinical Practice. 2013; 3(6), 469-474.

11. Mata I, Jan Y, Kim C, Hanna D, Dorschner M, Samii A, Agarwal P, Roberts J, Klepitskaya O, Shprecher D, Chung K, Factor S, Espay A, Revilla F, Higgins D, Litvan I, Leverenz J, Yearout D, Inca-Martinez M, Martinez E, Thompson T, Cholerton B, Hu S, Edwards K, Kim K, Zabetian C. The RAB39B p.G192R mutation causes X-linked dominant Parkinson’s disease. Molecular Neurodegeneration. 2015; 10(50)

Book Chapters: 1. Klepitskaya O. Parkinsonism- Hyperpyrexia syndrome. In: Kompoliti K, and Verhagen Metman

L (eds.) Encyclopedia of Movement disorders. 2010; vol. 1, pp. 399-401 Oxford: Academic Press. 2. Klepitskaya O. Dopamine Dysregulation syndrome. In: Kompoliti K, and Verhagen Metman L.

(eds.) Encyclopedia of Movement disorders. 2010; vol. 1, pp. 323-326 Oxford: Academic Press. 3. Berk J, Klepitskaya O. Thalamotomy. In: Mechanisms and emerging therapies of tremor

disorders. New York: Springer; 2013(24):431-461 4. Klepitskaya O. Restless Leg Syndrome. In: Barton B and Hall D (eds.) Non-Parkinsonian

Movement Disorders. 2013; Oxford: Wiley-Blackwell (in print)

Scientific Abstracts and Poster Presentations (competitive): 1. Klepitskaya OS, Maa EH, Tyler KL. Delayed Seroconversion in Immunocompromised Patient

with West Nile Virus-Associated Brainstem Encephalitis. 57th Annual Meeting of the American Academy of Neurology, April 2005, Miami, Fl, USA

2. Klepitskaya OS, Proskokova TN. Hepatolenticular Degeneration: Wilson- Konovalov’s Disease. 58th Annual Meeting of the American Academy of Neurology, April 2006, San Diego, CA, USA

Neurology;2006(66):A2 3. Grenier Y, Spielman JL, Klepitskaya OS, Ramig LO, Henderson JM, Bronte-Stewart HM.

Methodology for objective motor speech assessment outcome after deep brain stimulation for Parkinson’s disease. 10th International Movement Disorders Congress, Kyoto, Japan, October 2006 Movement Disorders;2006(21):S655

4. Klepitskaya OS, Cole WL, Bronte-Stewart HM Evolution of Parkinson disease during 4 years of Deep Brain Stimulation: a case report. 10th International Movement Disorders Congress, Kyoto, Japan, October, 2006 Movement Disorders;2006(21):S665

5. Klepitskaya OS, Fischbein NJ, Hall DA, Bronte-Stewart HM. Superficial Siderosis with supranuclear palsy, parkinsonism and falls. 10th International Movement Disorders Congress, Kyoto, Japan, October, 2006 Movement Disorders;2006(21):S525- S526

6. Klepitskaya OS, Cole WL, Henderson JM, Bronte-Stewart HM. Deep brain stimulation decreases the risks for Parkinsonism-Hyperpyrexia syndrome and suppresses levodopa-induced dyskinesias: a case report. 10th International Movement Disorders Congress, Kyoto, Japan, October, 2006.Movement Disorders;2006(21):S666-S667 and Annual meeting of Parkinson Study Group, Chicago IL, USA, 2006 Movement Disorders;2006(21):1552

7. Richardson MS, Ojemann SG, Klepitskaya OS. Response of the subthalamic nulcleus neurons to vocalization. 11th International Movement Disorders Congress, Istanbul, Turkey, June 2007.Movement Disorders;2007(22):S53 and 1st international symposium “Basal ganglia speech disorders and Deep Brain Stimulation,” July 2007, London, UK

8. Klepitskaya OS, Kim Z, Richardson MD, Ojemann SG. Three-dimensional computerized model of subthalamic nucleus. 12th International Movement Disorders Congress, Chicago, IL,

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USA, June 2008.Movement Disorders;2008(23):S108 – Poster was selected for guided poster tour

9. Klepitskaya O, Kumar R. Efficacy and Safety of Low Level Electromagnetic Fields Treatment in Parkinson’s Disease. Annual meeting of Parkinson’s Study Group, Salt Lake City, UT, USA. Movement Disorders;2008(11):1633

10. Klepitskaya OS, Fowler JJ, Kluger BM, Ojemann SG. Number of microelectrode recording passes during bilateral staged vs. unstaged deep-brain stimulation surgery for Parkinson's disease. 13th International Movement Disorders Congress, Paris, France, June 2009. Movement Disorders;2009(24):S485-S486

11. Klepitskaya OS, Koop MM, Bronte-Stewart HM. Longitudinal study of Microlesion Effect on Bradykinesia after Subthalamic Nucleus Deep Brain Stimulation Surgery for Parkinson's disease. 13th International Movement Disorders Congress, Paris, France, June 2009 Movement Disorders;2009(24):S485

12. Reid KA, Hoyt B, Tanabe J, Ojemann SG, Legenska A, Klepitskaya OS. Prevalence of dopamine dysregulation syndrome in Parkinson’s disease patients-candidates for deep brain stimulation. 14th International Movement Disorders Congress, Buenos Aires, Argentina, June 2010 Movement Disorders;2010(25):S282

13. Klepitskaya OS, Hoyt B, Berk JJ, Ojemann SG. Reversible cognitive impairment induced by deep brain stimulation of subthalamic nucleus. 14th International Movement Disorders Congress, Buenos Aires, Argentina, June 2010 Movement Disorders;2010(25):S446

14. Pelak VS, Choi M, Jung S, Halliday B, Hager E, Klepitskaya O, Ojemann S, Filley C, Dubin M. “Visuospatial Assessment By Virtual 3D Radial Optic Flow Illusion In Healthy Aging, Mild Alzheimer’s Disease (AD), And Pre-Deep-Brain Stimulation (DBS) Parkinson’s Disease (PD) Subjects.” Abstract A-316-0002-01523. 10th Annual International Conference on Alzheimer’s

and Parkinson’s Disease. Barcelona, Spain. March 9-13th, 2011 15. Hall D, Klepitskaya OS, Tassone F, Spector E, Leehey M. FXTAS in Patients with Fragile X

Gray Zone Alleles. 63rd Annual AAN Meeting, Honolulu, Hawaii, March 2011. Neurology; 2011(76)9:SA399

16. O.S. Klepitskaya, Z. Kim, S.G. Ojemann. Mock microelectrode recording is undistinguishable from a real time recording in sham surgery controlled clinical trial of new surgical treatment for Parkinson’s disease [Abstract 221]. International Movement Disorders Congress. Toronto, Canada, June 2011. Movement Disorders; 2011;26(Suppl 2): page S73

17. Ragole T, Michas-Martin A, Moss A, Juarez-Colunga E, Klepitskaya O. “Review of published outcomes of subthalamic nucleus deep brain stimulation in Parkinson disease supports hypothesis of disease-modifying effect.” 2013 International Movement Disorders Congress. Sydney, Australia, June 2013. Movement Disorders; 2013(25):1316, 25th Annual meeting of Parkinson’s Study Group & 27th Annual PSG Symposium, Montreal, Canada.

18. Klepitskaya O, Ying Liu, Sillau S, Tsai J, Walters A. Deep Brain Stimulation of the Subthalamic nucleus improves Restless Leg Syndrome in patients with Parkinson disease. 2015 International Movement Disorders Congress. San Diego, CA, June 2015. Movement Disorders; DOI: 10.1002/mds.26295